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BMC Medical Research Methodology

Issue 1/2022

Content (339 Articles)

The impact of lookback windows on the prevalence and incidence of chronic diseases among people living with HIV: an exploration in administrative health data in Canada

Ni Gusti Ayu Nanditha, Xinzhe Dong, Taylor McLinden, Paul Sereda, Jacek Kopec, Robert S. Hogg, Julio S. G. Montaner, Viviane D. Lima

Non-parametric estimation of reference adjusted, standardised probabilities of all-cause death and death due to cancer for population group comparisons

Mark J. Rutherford, Therese M.-L. Andersson, Tor Åge Myklebust, Bjørn Møller, Paul C. Lambert

A validation study of data in the National Tonsil Surgery Register in Sweden: high agreement with medical records ensures that data can be used to monitor clinical practices and outcomes

Filip Lundström, Erik Odhagen, Fredrik Alm, Claes Hemlin, Pia Nerfeldt, Ola Sunnergren

Simple Excel and ICD-10 based dataset calculator for the Charlson and Elixhauser comorbidity indices

  • Open Access
  • Research

Pärt Prommik, Kaspar Tootsi, Toomas Saluse, Eiki Strauss, Helgi Kolk, Aare Märtson

Oncologic patients’ misconceptions may impede enrollment into clinical trials: a cross-sectional study

  • Open Access
  • Research article

Nethanel Asher, Ari Raphael, Ido Wolf, Sharon Pelles, Ravit Geva

Reporting of abstracts in studies that used routinely collected data for exploring drug treatment effects: a cross-sectional survey

Mei Liu, Wen Wang, Mingqi Wang, Qiao He, Ling Li, Guowei Li, Lin He, Kang Zou, Xin Sun

Identification of causal effects in case-control studies

  • Open Access
  • Research

Bas B. L. Penning de Vries, Rolf H. H. Groenwold

Development of a data classification system for preterm birth cohort studies: the RECAP Preterm project

Deborah Bamber, Helen E. Collins, Charlotte Powell, Gonçalo Campos Gonçalves, Samantha Johnson, Bradley Manktelow, José Pedro Ornelas, João Correia Lopes, Artur Rocha, Elizabeth S. Draper

Leveraging pleiotropic association using sparse group variable selection in genomics data

  • Open Access
  • Research

Matthew Sutton, Pierre-Emmanuel Sugier, Therese Truong, Benoit Liquet

Stacked survival models for residual lifetime data

  • Open Access
  • Research

James H. McVittie, David B. Wolfson, Vittorio Addona, Zhaoheng Li

K-means for shared frailty models

  • Open Access
  • Research

Usha Govindarajulu, Sandeep Bedi

Completeness of reporting of clinical prediction models developed using supervised machine learning: a systematic review

  • Open Access
  • Research

Constanza L. Andaur Navarro, Johanna A. A. Damen, Toshihiko Takada, Steven W. J. Nijman, Paula Dhiman, Jie Ma, Gary S. Collins, Ram Bajpai, Richard D. Riley, Karel G. M. Moons, Lotty Hooft

Spatiotemporal variations in exposure: Chagas disease in Colombia as a case study

  • Open Access
  • Research

Julia Ledien, Zulma M. Cucunubá, Gabriel Parra-Henao, Eliana Rodríguez-Monguí, Andrew P. Dobson, María-Gloria Basáñez, Pierre Nouvellet

Sample attrition analysis in a prospective cohort study of medical graduates in China

  • Open Access
  • Research

Mingyue Li, Ziyue Wang, Baisong Zhang, Tiantian Wei, Dan Hu, Xiaoyun Liu

COVID-19 impact on mental health

Jingyu Cui, Jingwei Lu, Yijia Weng, Grace Y. Yi, Wenqing He

Are there non-linear relationships between alcohol consumption and long-term health?: a systematic review of observational studies employing approaches to improve causal inference

  • Open Access
  • Research

Rachel Visontay, Matthew Sunderland, Tim Slade, Jack Wilson, Louise Mewton

Developing a toolkit for increasing the participation of black, Asian and minority ethnic communities in health and social care research

  • Open Access
  • Research

Azhar Farooqi, Karan Jutlla, Raghu Raghavan, Andrew Wilson, Mohammud Shams Uddin, Carol Akroyd, Naina Patel, Pamela Peggy Campbell-Morris, Aaisha Tasneem Farooqi

Prediction of acute appendicitis among patients with undifferentiated abdominal pain at emergency department

Dai Su, Qinmengge Li, Tao Zhang, Philip Veliz, Yingchun Chen, Kevin He, Prashant Mahajan, Xingyu Zhang

A proportional odds model of risk behaviors associated with recurrent road traffic crashes among young adults in Kuwait

  • Open Access
  • Research

Saeed Akhtar, Eisa Aldhafeeri, Farah Alshammari, Hana Jafar, Haya Malhas, Marina Botras, Noor Alnasrallah

Left-censored recurrent event analysis in epidemiological studies: a proposal for when the number of previous episodes is unknown

  • Open Access
  • Research

Gilma Hernández-Herrera, David Moriña, Albert Navarro

Reporting methodological issues of the mendelian randomization studies in health and medical research: a systematic review

  • Open Access
  • Research

Shabab Noor Islam, Tanvir Ahammed, Aniqua Anjum, Olayan Albalawi, Md. Jamal Uddin

A blinded evaluation of privacy preserving record linkage with Bloom filters

  • Open Access
  • Research

Sean Randall, Helen Wichmann, Adrian Brown, James Boyd, Tom Eitelhuber, Alexandra Merchant, Anna Ferrante

Poor reporting quality of observational clinical studies comparing treatments of COVID-19 – a retrospective cross-sectional study

Sebastian Ziemann, Irina Paetzolt, Linda Grüßer, Mark Coburn, Rolf Rossaint, Ana Kowark

Comparison of statistical methods for the analysis of recurrent adverse events in the presence of non-proportional hazards and unobserved heterogeneity: a simulation study

Noel Patson, Mavuto Mukaka, Lawrence Kazembe, Marinus J. C. Eijkemans, Don Mathanga, Miriam K. Laufer, Tobias Chirwa

Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic

  • Open Access
  • Research

Sean Ewings, Geoff Saunders, Thomas Jaki, Pavel Mozgunov

Feasibility study for interactive reporting of network meta-analysis: experiences from the development of the MetaInsight COVID-19 app for stakeholder exploration, re-analysis and sensitivity analysis from living systematic reviews

Yiqiao Xin, Clareece R. Nevill, Janion Nevill, Ewan Gray, Nicola J. Cooper, Naomi Bradbury, Alex J. Sutton

Study retention and attrition in a longitudinal cohort study including patient-reported outcomes, fieldwork and biobank samples: results of the Netherlands quality of life and Biomedical cohort study (NET-QUBIC) among 739 head and neck cancer patients and 262 informal caregivers

  • Open Access
  • Research

Femke Jansen, Ruud H. Brakenhoff, Rob J. Baatenburg de Jong, Johannes A. Langendijk, C. René Leemans, Robert P. Takes, Chris H. J. Terhaard, Jan H. Smit, Irma M. Verdonck-de Leeuw

Unifying the analysis of continuous and categorical measures of weight loss and incorporating group effect: a secondary re-analysis of a large cluster randomized clinical trial using Bayesian approach

  • Open Access
  • Research

Fengming Tang, Christie A. Befort, Jo Wick, Byron J. Gajewski

Correction to: Moving beyond the classic diferencein-diferences model: a simulation study comparing statistical methods for estimating efectiveness of state-level policies

  • Open Access
  • Correction

Beth Ann Grifn, Megan S. Schuler, Elizabeth A. Stuart, Stephen Patrick, Elizabeth McNeer, Rosanna Smart, David Powell, Bradley D. Stein, Terry L. Schell, Rosalie Liccardo Pacula

Sex-specific analysis of traumatic brain injury events: applying computational and data visualization techniques to inform prevention and management

Tatyana Mollayeva, Andrew Tran, Vincy Chan, Angela Colantonio, Michael D. Escobar

Health and study dropout: health aspects differentially predict attrition

Johannes Beller, Siegfried Geyer, Jelena Epping

Comparisons of statistical distributions for cluster sizes in a developing pandemic

M. J. Faddy, A. N. Pettitt

A new infodemiological approach through Google Trends: longitudinal analysis of COVID-19 scientific and infodemic names in Italy

Alessandro Rovetta, Lucia Castaldo

Which test for crossing survival curves? A user’s guideline

  • Open Access
  • Research

Ina Dormuth, Tiantian Liu, Jin Xu, Menggang Yu, Markus Pauly, Marc Ditzhaus

Seek COVER: using a disease proxy to rapidly develop and validate a personalized risk calculator for COVID-19 outcomes in an international network

Ross D. Williams, Aniek F. Markus, Cynthia Yang, Talita Duarte-Salles, Scott L. DuVall, Thomas Falconer, Jitendra Jonnagaddala, Chungsoo Kim, Yeunsook Rho, Andrew E. Williams, Amanda Alberga Machado, Min Ho An, María Aragón, Carlos Areia, Edward Burn, Young Hwa Choi, Iannis Drakos, Maria Tereza Fernandes Abrahão, Sergio Fernández-Bertolín, George Hripcsak, Benjamin Skov Kaas-Hansen, Prasanna L. Kandukuri, Jan A. Kors, Kristin Kostka, Siaw-Teng Liaw, Kristine E. Lynch, Gerardo Machnicki, Michael E. Matheny, Daniel Morales, Fredrik Nyberg, Rae Woong Park, Albert Prats-Uribe, Nicole Pratt, Gowtham Rao, Christian G. Reich, Marcela Rivera, Tom Seinen, Azza Shoaibi, Matthew E. Spotnitz, Ewout W. Steyerberg, Marc A. Suchard, Seng Chan You, Lin Zhang, Lili Zhou, Patrick B. Ryan, Daniel Prieto-Alhambra, Jenna M. Reps, Peter R. Rijnbeek

Stroke survivors’ preferences regarding study participation in rehabilitation research

Emma Carlstedt, Eva Månsson Lexell, Agneta Ståhl, Arne Lindgren, Susanne Iwarsson

Responsiveness of different pain measures and recall periods in people undergoing surgery after a period of splinting for basal thumb joint osteoarthritis

Jenni Pajari, Jarkko Jokihaara, Eero Waris, Simo Taimela, Teppo L. N. Järvinen, Rachelle Buchbinder, Teemu Karjalainen

Weighted composite time to event endpoints with recurrent events: comparison of three analytical approaches

  • Open Access
  • Research

Ann-Kathrin Ozga, Geraldine Rauch

Approaches to multiplicity in publicly funded pragmatic randomised controlled trials: a survey of clinical trials units and a rapid review of published trials

  • Open Access
  • Research

Katie Pike, Barnaby C. Reeves, Chris A. Rogers

Statistical methods for evaluating the fine needle aspiration cytology procedure in breast cancer diagnosis

Carolla El Chamieh, Philippe Vielh, Sylvie Chevret

Registration and primary outcome reporting in behavioral health trials

Nicholas J. Taylor, Dennis M. Gorman

Recruitment methods and yield rates in a clinical trial of physical exercise for older adults with hypertension—HAEL Study: a study within a trial

Cíntia E. Botton, Lucas P. Santos, Bruna G. Moraes, Raíssa B. Monteiro, Maria Laura B. Gomes, Eurico N. Wilhelm, Stephanie S. Pinto, Daniel Umpierre

Robust meta-analysis for large-scale genomic experiments based on an empirical approach

  • Open Access
  • Research

Sinjini Sikdar

Converting from face-to-face to postal follow-up and its effects on participant retention, response rates and errors: lessons from the EQUAL study in the UK

Emer Gates, Barnaby Hole, Samantha Hayward, Nicholas C. Chesnaye, Yvette Meuleman, Friedo W. Dekker, Marie Evans, Olof Heimburger, Claudia Torino, Gaetana Porto, Maciej Szymczak, Christiane Drechsler, Christoph Wanner, Kitty J. Jager, Paul Roderick, Fergus Caskey

Inverse probability weighting to handle attrition in cohort studies: some guidance and a call for caution

  • Open Access
  • Research

Marie-Astrid Metten, Nathalie Costet, Luc Multigner, Jean-François Viel, Guillaume Chauvet

Analysis approaches to address treatment nonadherence in pragmatic trials with point-treatment settings: a simulation study

  • Open Access
  • Research

Md. Belal Hossain, Lucy Mosquera, Mohammad Ehsanul Karim

Answering complex hierarchy questions in network meta-analysis

Theodoros Papakonstantinou, Georgia Salanti, Dimitris Mavridis, Gerta Rücker, Guido Schwarzer, Adriani Nikolakopoulou

The injury severity score: an operations perspective

  • Open Access
  • Triage
  • Research article

Nassim Dehouche

Borrowing information across patient subgroups in clinical trials, with application to a paediatric trial

Rebecca M. Turner, Anna Turkova, Cecilia L. Moore, Alasdair Bamford, Moherndran Archary, Linda N. Barlow-Mosha, Mark F. Cotton, Tim R. Cressey, Elizabeth Kaudha, Abbas Lugemwa, Hermione Lyall, Hilda A. Mujuru, Veronica Mulenga, Victor Musiime, Pablo Rojo, Gareth Tudor-Williams, Steven B. Welch, Diana M. Gibb, Deborah Ford, Ian R. White

Adaptive treatment allocation and selection in multi-arm clinical trials: a Bayesian perspective

  • Open Access
  • Research

Elja Arjas, Dario Gasbarra

A novel graphical evaluation of agreement

  • Open Access
  • Research article

Jongphil Kim, Ji-Hyun Lee

Assessing transferability in systematic reviews of health economic evaluations – a review of methodological guidance

  • Open Access
  • Research

Alina Weise, Roland Brian Büchter, Dawid Pieper, Tim Mathes

Comparative analysis of explainable machine learning prediction models for hospital mortality

  • Open Access
  • Research article

Eline Stenwig, Giampiero Salvi, Pierluigi Salvo Rossi, Nils Kristian Skjærvold

Enrichment Bayesian design for randomized clinical trials using categorical biomarkers and a binary outcome

  • Open Access
  • Research

Valentin Vinnat, Sylvie Chevret

Interchangeability and optimization of heart rate methods for estimating oxygen uptake in ergometer cycling, level treadmill walking and running

  • Open Access
  • Research article

Karin Sofia Elisabeth Olsson, Hans Rosdahl, Peter Schantz

Distributional regression in clinical trials: treatment effects on parameters other than the mean

Gillian Z. Heller, Kristy P. Robledo, Ian C. Marschner

Locating and testing the healthy context paradox: examples from the INCLUSIVE trial

  • Open Access
  • Research

G. J. Melendez-Torres, Emily Warren, Obioha C Ukoumunne, Russell Viner, Chris Bonell

Bayesian identification of structural coefficients in causal models and the causal false-positive risk of confounders and colliders in linear Markovian models

  • Open Access
  • Research

Riko Kelter

What is the empirical basis for converting banded ordinal data on numbers of sex partners among MSM into a continuous scale level variable? A secondary analysis of 13 surveys across 17 countries

  • Open Access
  • Research

Ana Mendez-Lopez, Ford Hickson, Klaus Jansen, Nathan Lachowsky, Fiona Burns, Cinta Folch, Annie Velter, Peter Weatherburn, Ulrich Marcus, Ursula von Rüden, Massimo Mirandola, Lorenzo Gios, Jamie Frankis, David J. Brennan, Axel J. Schmidt

Detecting the patient’s need for help with machine learning based on expressions

Lauri Lahti

Impact of different cover letter content and incentives on non-response bias in a sample of Veterans applying for Department of Veterans Affairs disability benefits: a randomized, 3X2X2 factorial trial

Maureen Murdoch, Barbara A. Clothier, Timothy J. Beebe, Ann K. Bangerter, Siamak Noorbaloochi

Individual-specific networks for prediction modelling – A scoping review of methods

Mariella Gregorich, Federico Melograna, Martina Sunqvist, Stefan Michiels, Kristel Van Steen, Georg Heinze

Should samples be weighted to decrease selection bias in online surveys during the COVID-19 pandemic? Data from seven datasets

Chadia Haddad, Hala Sacre, Rony M. Zeenny, Aline Hajj, Marwan Akel, Katia Iskandar, Pascale Salameh

Documenting patients’ and providers’ preferences when proposing a randomized controlled trial: a qualitative exploration

Devesh Oberoi, Cynthia Kwok, Yong Li, Cindy Railton, Susan Horsman, Kathleen Reynolds, Anil A. Joy, Karen Marie King, Sasha Michelle Lupichuk, Michael Speca, Nicole Culos-Reed, Linda E. Carlson, Janine Giese-Davis

The effect of personalised versus non-personalised study invitations on recruitment within the ENGAGE feasibility trial: an embedded randomised controlled recruitment trial

  • Open Access
  • Research

Ella Thiblin, Joanne Woodford, Mattias Öhman, Louise von Essen

The role of analytic direction in qualitative research

  • Open Access
  • Research

Joanna E. M. Sale

Using a consistency check during data collection to identify invalid responding in an online cannabis screening survey

  • Open Access
  • Research

Christina Schell, Alexandra Godinho, John A. Cunningham

Using linear and natural cubic splines, SITAR, and latent trajectory models to characterise nonlinear longitudinal growth trajectories in cohort studies

  • Open Access
  • Research article

Ahmed Elhakeem, Rachael A. Hughes, Kate Tilling, Diana L. Cousminer, Stefan A. Jackowski, Tim J. Cole, Alex S. F. Kwong, Zheyuan Li, Struan F. A. Grant, Adam D. G. Baxter-Jones, Babette S. Zemel, Deborah A. Lawlor

The first step is recognizing there is a problem: a methodology for adjusting for variability in disease severity when estimating clinician performance

  • Open Access
  • Care
  • Research article

Meagan Bechel, Adam R. Pah, Stephen D. Persell, Curtis H. Weiss, Luís A. Nunes Amaral

Adjusting for verification bias in diagnostic accuracy measures when comparing multiple screening tests - an application to the IP1-PROSTAGRAM study

Emily Day, David Eldred-Evans, A. Toby Prevost, Hashim U. Ahmed, Francesca Fiorentino

Analyzing differences between restricted mean survival time curves using pseudo-values

  • Open Access
  • Research

Federico Ambrogi, Simona Iacobelli, Per Kragh Andersen

Ripple effects mapping: capturing the wider impacts of systems change efforts in public health

James Nobles, Jessica Wheeler, Kirsty Dunleavy-Harris, Richard Holmes, Alan Inman-Ward, Alexandra Potts, Jennifer Hall, Sabi Redwood, Russell Jago, Charlie Foster

Implications of analysing time-to-event outcomes as binary in meta-analysis: empirical evidence from the Cochrane Database of Systematic Reviews

  • Open Access
  • Research

Theodosia Salika, Rebecca M. Turner, David Fisher, Jayne F. Tierney, Ian R. White

Research monitoring practices in critical care research: a survey of current state and attitudes

  • Open Access
  • Care
  • Research

Renate Le Marsney, Tara Williams, Kerry Johnson, Shane George, Kristen S. Gibbons

Methodological approaches to measuring the incidence of unplanned emergency department presentations by cancer patients receiving systemic anti-cancer therapy: a systematic review

P. H. Dufton, M. F. Gerdtz, R. Jarden, M. Krishnasamy

Functional principal component analysis for identifying the child growth pattern using longitudinal birth cohort data

  • Open Access
  • Research

Reka Karuppusami, Belavendra Antonisamy, Prasanna S. Premkumar

Big data ordination towards intensive care event count cases using fast computing GLLVMS

  • Open Access
  • Care
  • Research

Rezzy Eko Caraka, Rung-Ching Chen, Su-Wen Huang, Shyue-Yow Chiou, Prana Ugiana Gio, Bens Pardamean

Developing a tool to assess the skills to perform a health technology assessment

  • Open Access
  • Research

Julia Bidonde, Jose Francisco Meneses-Echavez, Brian Asare, Lumbwe Chola, Mohamed Gad, Lieke Fleur Heupink, Elizabeth Fleur Peacocke, Angela Ackon, Akuba Dolphyne, Francis Ruiz, Ingvil Sæterdal, Anne Lien Espeland, Eia Elena Skjønsberg, Marit Johansen

Development and validation of search filters to identify articles on deprescribing in Medline and Embase

  • Open Access
  • Research

Thomas Morel, Jérôme Nguyen-Soenen, Wade Thompson, Jean-Pascal Fournier

MedMinas project: design and use of mixed methods in the evaluation of pharmaceutical services in primary health care in Minas Gerais, Brazil

  • Open Access
  • Care
  • Research

Tatiana Chama Borges Luz, Noemia Urruth Leão Tavares, Ana Karine Sarvel de Castro, Isabela Cristina Marques, Elizabeth Moreira dos Santos, Betania Barros Cota

The effect of missing data and imputation on the detection of bias in cognitive testing using differential item functioning methods

  • Open Access
  • Research

E. Nichols, J. A. Deal, B. K. Swenor, A. G. Abraham, N. M. Armstrong, K. Bandeen-Roche, M. C. Carlson, M. Griswold, F. R. Lin, T. H. Mosley, P. Y. Ramulu, N. S. Reed, A. R. Sharrett, A. L. Gross

Impute the missing data using retrieved dropouts

  • Open Access
  • Research

Shuai Wang, Haoyan Hu

Developing a dynamic simulation model to support the nationwide implementation of whole genome sequencing in lung cancer

Michiel van de Ven, Maarten IJzerman, Valesca Retèl, Wim van Harten, Hendrik Koffijberg

Using group model building to frame the commercial determinants of dietary behaviour in adolescence – proposed methods for online system mapping workshops

Yanaina Chavez-Ugalde, Zoi Toumpakari, Martin White, Frank De Vocht, Russell Jago

Estimation of invasive Group B Streptococcus disease risk in young infants from case-control serological studies

Alane Izu, Gaurav Kwatra, Shabir A. Madhi, Fabio Rigat

Immortal time bias for life-long conditions in retrospective observational studies using electronic health records

Freya Tyrer, Krishnan Bhaskaran, Mark J. Rutherford

Evaluation of multiple imputation approaches for handling missing covariate information in a case-cohort study with a binary outcome

  • Open Access
  • Research

Melissa Middleton, Cattram Nguyen, Margarita Moreno-Betancur, John B. Carlin, Katherine J. Lee

The impact of moderator by confounder interactions in the assessment of treatment effect modification: a simulation study

Antonia Mary Marsden, William G. Dixon, Graham Dunn, Richard Emsley

Methodology and experiences of rapid advice guideline development for children with COVID-19: responding to the COVID-19 outbreak quickly and efficiently

Qi Zhou, Qinyuan Li, Janne Estill, Qi Wang, Zijun Wang, Qianling Shi, Jingyi Zhang, Xiaobo Zhang, Joseph L. Mathew, Rosalind L. Smyth, Detty Nurdiati, Zhou Fu, Hongmei Xu, Xianlan Zheng, Xiaodong Zhao, Quan Lu, Hui Liu, Yangqin Xun, Weiguo Li, Shu Yang, Xixi Feng, Mengshu Wang, Junqiang Lei, Xiaoping Luo, Liqun Wu, Xiaoxia Lu, Myeong Soo Lee, Shunying Zhao, Edwin Shih-Yen Chan, Yuan Qian, Wenwei Tu, Xiaoyan Dong, Guobao Li, Ruiqiu Zhao, Zhihui He, Siya Zhao, Xiao Liu, Qiu Li, Kehu Yang, Zhengxiu Luo, Enmei Liu, Yaolong Chen

Comparing single and multiple imputation strategies for harmonizing substance use data across HIV-related cohort studies

Marjan Javanbakht, Johnny Lin, Amy Ragsdale, Soyeon Kim, Suzanne Siminski, Pamina Gorbach

|tPRiors |: a tool for prior elicitation and obtaining posterior distributions of true disease prevalence

  • Open Access
  • Software

Konstantinos Pateras, Polychronis Kostoulas

BivRec: an R package for the nonparametric and semiparametric analysis of bivariate alternating recurrent events

  • Open Access
  • Software

Sandra Castro-Pearson, Aparajita Sur, Chi Hyun Lee, Chiung-Yu Huang, Xianghua Luo

KMSubtraction: reconstruction of unreported subgroup survival data utilizing published Kaplan-Meier survival curves

  • Open Access
  • Research

Joseph J. Zhao, Nicholas L. Syn, Benjamin Kye Jyn Tan, Dominic Wei Ting Yap, Chong Boon Teo, Yiong Huak Chan, Raghav Sundar

Moving towards a single-frame cell phone design in random digit dialing surveys: considerations from a French general population health survey

  • Open Access
  • Research

Noémie Soullier, Stéphane Legleye, Jean-Baptiste Richard

Bayesian variable selection and survival modeling: assessing the Most important comorbidities that impact lung and colorectal cancer survival in Spain

Francisco Javier Rubio, Danilo Alvares, Daniel Redondo-Sanchez, Rafael Marcos-Gragera, María-José Sánchez, Miguel Angel Luque-Fernandez

Evaluating the psychometric properties of the German adaptation of the client attachment to therapist scale

Katja Petrowski, Bjarne Schmalbach, Joram Ronel, Ileana Schmalbach, Elisabeth Olliges

Adaptive design for identifying maximum tolerated dose early to accelerate dose-finding trial

  • Open Access
  • Research

Masahiro Kojima

Investigating treatment-effect modification by a continuous covariate in IPD meta-analysis: an approach using fractional polynomials

Willi Sauerbrei, Patrick Royston

Design of a new Z-test for the uncertainty of Covid-19 events under Neutrosophic statistics

Muhammad Aslam

Identification of tools used to assess the external validity of randomized controlled trials in reviews: a systematic review of measurement properties

  • Open Access
  • Research

Andres Jung, Julia Balzer, Tobias Braun, Kerstin Luedtke

Methodological conduct of prognostic prediction models developed using machine learning in oncology: a systematic review

Paula Dhiman, Jie Ma, Constanza L. Andaur Navarro, Benjamin Speich, Garrett Bullock, Johanna A. A. Damen, Lotty Hooft, Shona Kirtley, Richard D. Riley, Ben Van Calster, Karel G. M. Moons, Gary S. Collins

The validity, reliability and feasibility of four instruments for assessing the consciousness of stroke patients in a neurological intensive care unit compared

Xiaoxiang Yan, Lingjun Xiao, Meixin Liao, Jiajian Huang, Zhijie He, Tiebin Yan

Estimation of treatment effects in observational stroke care data: comparison of statistical approaches

Marzyeh Amini, Nikki van Leeuwen, Frank Eijkenaar, Rob van de Graaf, Noor Samuels, Robert van Oostenbrugge, Ido R. van den Wijngaard, Pieter Jan van Doormaal, Yvo B. W. E. M. Roos, Charles Majoie, Bob Roozenbeek, Diederik Dippel, James Burke, Hester F. Lingsma, Diederik W. J. Dippel, Aad van der Lugt, Charles B. L. M. Majoie, Yvo B. W. E. M. Roos, Robert J. van Oostenbrugge, Wim H. van Zwam, Jelis Boiten, Jan Albert Vos, Josje Brouwer, Sanne J. den Hartog, Wouter H. Hinsenveld, Manon Kappelhof, Kars C. J. Compagne, Robert-Jan B. Goldhoorn, Maxim J. H. L. Mulder, Ivo G. H. Jansen, Diederik W. J. Dippel, Bob Roozenbeek, Aad van der Lugt, Adriaan C. G. M. van Es, Charles B. L. M. Majoie, Yvo B. W. E. M. Roos, Bart J. Emmer, Jonathan M. Coutinho, Wouter J. Schonewille, Jan Albert Vos, Marieke J. H. Wermer, Marianne A. A. van Walderveen, Julie Staals, Robert J. van Oostenbrugge, Wim H. van Zwam, Jeannette Hofmeijer, Jasper M. Martens, Geert J. Lycklama à Nijeholt, Jelis Boiten, Sebastiaan F. de Bruijn, Lukas C. van Dijk, H. Bart van der Worp, Rob H. Lo, Ewoud J. van Dijk, Hieronymus D. Boogaarts, J. de Vries, Paul L. M. de Kort, Julia van Tuijl, Jo Jo P. Peluso, Puck Fransen, Jan S. P. van den Berg, Boudewijn A. A. M. van Hasselt, Leo A. M. Aerden, René J. Dallinga, Maarten Uyttenboogaart, Omid Eschgi, Reinoud P. H. Bokkers, Tobien H. C. M. L. Schreuder, Roel J. J. Heijboer, Koos Keizer, Lonneke S. F. Yo, Heleen M. den Hertog, Emiel J. C. Sturm, Paul Brouwers, Charles B. L. M. Majoie, Wim H. van Zwam, Aad van der Lugt, Geert J. Lycklama à Nijeholt, Marianne A. A. van Walderveen, Marieke E. S. Sprengers, Sjoerd F. M. Jenniskens, René van den Berg, Albert J. Yoo, Ludo F. M. Beenen, Alida A. Postma, Stefan D. Roosendaal, Bas F. W. van der Kallen, Ido R. van den Wijngaard, Adriaan C. G. M. van Es, Bart J. Emmer, Jasper M. Martens, Lonneke S. F. Yo, Jan Albert Vos, Joost Bot, Pieter-Jan van Doormaal, Anton Meijer, Elyas Ghariq, Reinoud P. H. Bokkers, Marc P. van Proosdij, G. Menno Krietemeijer, Jo P. Peluso, Hieronymus D. Boogaarts, Rob Lo, Dick Gerrits, Wouter Dinkelaar, Auke P. A. Appelman, Bas Hammer, Sjoert Pegge, Anouk van der Hoorn, Saman Vinke, Diederik W. J. Dippel, Aad van der Lugt, Charles B. L. M. Majoie, Yvo B. W. E. M. Roos, Robert J. van Oostenbrugge, Wim H. van Zwam, Geert J. Lycklama à Nijeholt, Jelis Boiten, Jan Albert Vos, Wouter J. Schonewille, Jeannette Hofmeijer, Jasper M. Martens, H. Bart van der Worp, Rob H. Lo, Robert J. van Oostenbrugge, Jeannette Hofmeijer, H. Zwenneke Flach, Hester F. Lingsma, Naziha el Ghannouti, Martin Sterrenberg, Corina Puppels, Wilma Pellikaan, Rita Sprengers, Marjan Elfrink, Michelle Simons, Marjolein Vossers, Joke de Meris, Tamara Vermeulen, Annet Geerlings, Gina van Vemde, Tiny Simons, Cathelijn van Rijswijk, Gert Messchendorp, Nynke Nicolaij, Hester Bongenaar, Karin Bodde, Sandra Kleijn, Jasmijn Lodico, Hanneke Droste, Maureen Wollaert, Sabrina Verheesen, D. Jeurrissen, Erna Bos, Yvonne Drabbe, Michelle Sandiman, Marjan Elfrink, Nicoline Aaldering, Berber Zweedijk, Mostafa Khalilzada, Jocova Vervoort, Hanneke Droste, Nynke Nicolaij, Michelle Simons, Eva Ponjee, Sharon Romviel, Karin Kanselaar, Erna Bos, Denn Barning, Esmee Venema, Vicky Chalos, Ralph R. Geuskens, Tim van Straaten, Saliha Ergezen, Roger R. M. Harmsma, Daan Muijres, Anouk de Jong, Olvert A. Berkhemer, Anna M. M. Boers, J. Huguet, P. F. C. Groot, Marieke A. Mens, Katinka R. van Kranendonk, Kilian M. Treurniet, Ivo G. H. Jansen, Manon L. Tolhuisen, Heitor Alves, Annick J. Weterings, Eleonora L. F. Kirkels, Eva J. H. F. Voogd, Lieve M. Schupp, Sabine Collette, Adrien E. D. Groot, Natalie E. LeCouffe, Praneeta R. Konduri, Haryadi Prasetya, Nerea Arrarte-Terreros, Lucas A. Ramos

Adopting AMSTAR 2 critical appraisal tool for systematic reviews: speed of the tool uptake and barriers for its adoption

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Ruzica Bojcic, Mate Todoric, Livia Puljak

Systematic reviews and meta-analysis published in indexed Portuguese medical journals: time trends and critical appraisal

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Luísa Prada, Ana Prada, Miguel Marques Antunes, Ricardo M. Fernandes, João Costa, Joaquim J. Ferreira, Daniel Caldeira

Comparison of reference distributions acquired by direct and indirect sampling techniques: exemplified with the Pediatric Reference Interval in China (PRINCE) study

  • Open Access
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Ruohua Yan, Kun Li, Yaqi Lv, Yaguang Peng, Nicholas Van Halm-Lutterodt, Wenqi Song, Xiaoxia Peng, Xin Ni

Development and evaluation of a search filter to identify prognostic factor studies in Ovid MEDLINE

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Elena Stallings, Andrea Gaetano-Gil, Noelia Alvarez-Diaz, Ivan Solà, Jesús López-Alcalde, Daniel Molano, Javier Zamora

Clearing the air: underestimation of youth smoking prevalence associated with proxy-reporting compared to youth self-report

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Eden M. Barrett, Raglan Maddox, Joanne Thandrayen, Emily Banks, Raymond Lovett, Christina Heris, Katherine A. Thurber

Correction to: Ethnographic research as an evolving method for supporting healthcare improvement skills: a scoping review

  • Open Access
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Georgia B. Black, Sandra van Os, Samantha Machen, Naomi J. Fulop

Methodological assessment of systematic reviews of in-vitro dental studies

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Christopher Hammel, Nikolaos Pandis, Dawid Pieper, Clovis Mariano Faggion Jr

Mind the gap: covariate constrained randomisation can protect against substantial power loss in parallel cluster randomised trials

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Caroline Kristunas, Michael Grayling, Laura J. Gray, Karla Hemming

Evaluating the performance of Bayesian and restricted maximum likelihood estimation for stepped wedge cluster randomized trials with a small number of clusters

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Kelsey L. Grantham, Jessica Kasza, Stephane Heritier, John B. Carlin, Andrew B. Forbes

Estimation and inference for the mediation effect in a time-varying mediation model

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Xizhen Cai, Donna L. Coffman, Megan E. Piper, Runze Li

Correction to: Big data ordination towards intensive care event count cases using fast computing GLLVMS

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Rezzy Eko Caraka, Rung-Ching Chen, Su-Wen Huang, Shyue-Yow Chiou, Prana Ugiana Gio, Bens Pardamean

Blinded sample size re-estimation in a comparative diagnostic accuracy study

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Maria Stark, Mailin Hesse, Werner Brannath, Antonia Zapf

Data-driven prediction of COVID-19 cases in Germany for decision making

Lukas Refisch, Fabian Lorenz, Torsten Riedlinger, Hannes Taubenböck, Martina Fischer, Linus Grabenhenrich, Martin Wolkewitz, Harald Binder, Clemens Kreutz

Comparison of generic and specific instruments to assess the quality of life in patients with melasma

Silmara Meneguin, Ioana Bitencourt Mourão, Camila Fernandes Pollo, Helio Amante Miot, Miriane Garuzi, Cesar de Oliveira

Bayesian adaptive design for pediatric clinical trials incorporating a community of prior beliefs

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Yu Wang, James Travis, Byron Gajewski

Synthesis of evidence on the use of ecological momentary assessments to monitor health outcomes after traumatic injury: rapid systematic review

Rebecca J. Mitchell, Rory Goggins, Reidar P. Lystad

Bias amplification in the g-computation algorithm for time-varying treatments: a case study of industry payments and prescription of opioid products

Kosuke Inoue, Atsushi Goto, Naoki Kondo, Tomohiro Shinozaki

Instrumental variable analysis to estimate treatment effects: a simulation study showing potential benefits of conditioning on hospital

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I. E. Ceyisakar, N. van Leeuwen, E. W. Steyerberg, H. F. Lingsma

The reporting and handling of missing data in longitudinal studies of older adults is suboptimal: a methodological survey of geriatric journals

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Chinenye Okpara, Chidozie Edokwe, George Ioannidis, Alexandra Papaioannou, Jonathan D. Adachi, Lehana Thabane

Comparison of statistical models for estimating intervention effects based on time-to-recurrent-event in stepped wedge cluster randomized trial using open cohort design

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Shunsuke Oyamada, Shih-Wei Chiu, Takuhiro Yamaguchi

Opportunities and obstacles in linking large health care registries: the primary secondary cancer care registry - breast cancer

Marianne J. Heins, Kelly M. de Ligt, Janneke Verloop, Sabine Siesling, Joke C. Korevaar

Does imbalance in chest X-ray datasets produce biased deep learning approaches for COVID-19 screening?

Lorena Álvarez-Rodríguez, Joaquim de Moura, Jorge Novo, Marcos Ortega

Applications of Bayesian shrinkage prior models in clinical research with categorical responses

Arinjita Bhattacharyya, Subhadip Pal, Riten Mitra, Shesh Rai

Minimal important difference and patient acceptable symptom state for the Numerical Rating Scale (NRS) for pain and the Patient-Rated Wrist/Hand Evaluation (PRWHE) for patients with osteoarthritis at the base of thumb

Susanna Stjernberg-Salmela, Teemu Karjalainen, Joona Juurakko, Pirjo Toivonen, Eero Waris, Simo Taimela, Clare L. Ardern, Teppo L. N. Järvinen, Jarkko Jokihaara

Learning from COVID-19 related trial adaptations to inform efficient trial design—a sequential mixed methods study

Robin Chatters, Cindy L. Cooper, Alicia O’Cathain, Caroline Murphy, Athene Lane, Katie Sutherland, Christopher Burton, Angela Cape, Louis Tunnicliffe

A tutorial on the case time series design for small-area analysis

Antonio Gasparrini

Assessing the impact of including variation in general population mortality on standard errors of relative survival and loss in life expectancy

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Yuliya Leontyeva, Hannah Bower, Oskar Gauffin, Paul C Lambert, Therese M.-L. Andersson

Inadequate reporting quality of registered genome editing trials: an observational study

Diana Jurić, Michael Zlatin, Ana Marušić

A flexible approach for variable selection in large-scale healthcare database studies with missing covariate and outcome data

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Jung-Yi Joyce Lin, Liangyuan Hu, Chuyue Huang, Ji Jiayi, Steven Lawrence, Usha Govindarajulu

Improving clinical trials using Bayesian adaptive designs: a breast cancer example

Wei Hong, Sue-Anne McLachlan, Melissa Moore, Robert K. Mahar

The International Guideline Evaluation Screening Tool (IGEST): development and validation

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Daniela D’angelo, Daniela Coclite, Antonello Napoletano, Silvia Gianola, Greta Castellini, Roberto Latina, Laura Iacorossi, Alice Josephine Fauci, Primiano Iannone

Test–retest reliability of selected HBSC items in Vietnam: well-being, physical and sedentary activities, and eating behaviours

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Jaroslav Kohoutek, Marek Maráček, Kwok Ng, Zdenek Hamrik

Automated medical chart review for breast cancer outcomes research: a novel natural language processing extraction system

Yifu Chen, Lucy Hao, Vito Z. Zou, Zsuzsanna Hollander, Raymond T. Ng, Kathryn V. Isaac

Global prediction model for COVID-19 pandemic with the characteristics of the multiple peaks and local fluctuations

Haoran Dai, Wen Cao, Xiaochong Tong, Yunxing Yao, Feilin Peng, Jingwen Zhu, Yuzhen Tian

Minimizing sample bias due to stigmatized behaviours: the representativeness of participants in a cohort study of alcohol in pregnancy

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David Tappin, Daniel Mackay, Lucy Reynolds, Niamh Fitzgerald

Spontaneously generated online patient experience data - how and why is it being used in health research: an umbrella scoping review

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Julia Walsh, Christine Dwumfour, Jonathan Cave, Frances Griffiths

Raking of data from a large Australian cohort study improves generalisability of estimates of prevalence of health and behaviour characteristics and cancer incidence

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Sarsha Yap, Qingwei Luo, Stephen Wade, Marianne Weber, Emily Banks, Karen Canfell, Dianne L. O’Connell, Julia Steinberg

ELaPro, a LOINC-mapped core dataset for top laboratory procedures of eligibility screening for clinical trials

Ahmed Rafee, Sarah Riepenhausen, Philipp Neuhaus, Alexandra Meidt, Martin Dugas, Julian Varghese

Scoping review and characteristics of publicly available checklists for assessing clinical trial feasibility

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Viktoria Gloy, Benjamin Speich, Alexandra Griessbach, Ala Taji Heravi, Alexandra Schulz, Thomas Fabbro, Christiane Pauli Magnus, Stuart McLennan, Wendy Bertram, Matthias Briel

Meta-analysis under imbalance in measurement of confounders in cohort studies using only summary-level data

Debashree Ray, Alvaro Muñoz, Mingyu Zhang, Xiuhong Li, Nilanjan Chatterjee, Lisa P. Jacobson, Bryan Lau

A systematic review of methods to estimate colorectal cancer incidence using population-based cancer registries

Norah Alsadhan, Alaa Almaiman, Mar Pujades-Rodriguez, Cathy Brennan, Farag Shuweihdi, Sultana A. Alhurishi, Robert M. West

Managing missing items in the Fagerström Test for Nicotine Dependence: a simulation study

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Shannon L. Gutenkunst, Melanie L. Bell

A compelling demonstration of why traditional statistical regression models cannot be used to identify risk factors from case data on infectious diseases: a simulation study

Solveig Engebretsen, Gunnar Rø, Birgitte Freiesleben de Blasio

Detecting accelerometer non-wear periods using change in acceleration combined with rate-of-change in temperature

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Adam Vert, Kyle S. Weber, Vanessa Thai, Erin Turner, Kit B. Beyer, Benjamin F Cornish, F. Elizabeth Godkin, Christopher Wong, William E. McIlroy, Karen Van Ooteghem

Inference following multiple imputation for generalized additive models: an investigation of the median p-value rule with applications to the Pulmonary Hypertension Association Registry and Colorado COVID-19 hospitalization data

Matthew A. Bolt, Samantha MaWhinney, Jack W. Pattee, Kristine M. Erlandson, David B. Badesch, Ryan A. Peterson

Comment on “Bayesian additional evidence for decision making under small sample uncertainty”

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Samuel Pawel, Leonhard Held, Robert Matthews

Relationship between risk, cumulative burden of exacerbations and mortality in patients with COPD: modelling analysis using data from the ETHOS study

Kirsty Rhodes, Martin Jenkins, Enrico de Nigris, Magnus Aurivillius, Mario Ouwens

Multi-dimensional vulnerability analysis on catastrophic health expenditure among middle-aged and older adults with chronic diseases in China

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Wenqing Miao, Xiyu Zhang, Baoguo Shi, Wanxin Tian, Bing Wu, Yongqiang Lai, Yuze Li, Zhipeng Huang, Qi Xia, Huiqi Yang, Fan Ding, Linghan Shan, Ling Xin, Jingying Miao, Chenxi Zhang, Ye Li, Xiaodong Li, Qunhong Wu

Using observational study data as an external control group for a clinical trial: an empirical comparison of methods to account for longitudinal missing data

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Vibeke Norvang, Espen A. Haavardsholm, Sara K. Tedeschi, Houchen Lyu, Joseph Sexton, Maria D. Mjaavatten, Tore K. Kvien, Daniel H. Solomon, Kazuki Yoshida

A comparison of methods for multiple degree of freedom testing in repeated measures RNA-sequencing experiments

Elizabeth A. Wynn, Brian E. Vestal, Tasha E. Fingerlin, Camille M. Moore

An approach to exploring patterns of imbalance and potential missingness in reports of the randomized baseline values for primary outcomes measurable at baseline in randomized controlled trials for meta-analyses

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Eun-Gee Park, Seokyung Hahn

Impact of methodological choices in comparative effectiveness studies: application in natalizumab versus fingolimod comparison among patients with multiple sclerosis

M. Lefort, S. Sharmin, J. B. Andersen, S. Vukusic, R. Casey, M. Debouverie, G. Edan, J. Ciron, A. Ruet, J. De Sèze, E. Maillart, H. Zephir, P. Labauge, G. Defer, C. Lebrun-Frenay, T. Moreau, E. Berger, P. Clavelou, J. Pelletier, B. Stankoff, O. Gout, E. Thouvenot, O. Heinzlef, A. Al-Khedr, B. Bourre, O. Casez, P. Cabre, A. Montcuquet, A. Wahab, J. P. Camdessanché, A. Maurousset, H. Ben Nasr, K. Hankiewicz, C. Pottier, N. Maubeuge, D. Dimitri-Boulos, C. Nifle, D. A. Laplaud, D. Horakova, E. K. Havrdova, R. Alroughani, G. Izquierdo, S. Eichau, S. Ozakbas, F. Patti, M. Onofrj, A. Lugaresi, M. Terzi, P. Grammond, F. Grand’Maison, B. Yamout, A. Prat, M. Girard, P. Duquette, C. Boz, M. Trojano, P. McCombe, M. Slee, J. Lechner-Scott, R. Turkoglu, P. Sola, D. Ferraro, F. Granella, V. Shaygannejad, J. Prevost, D. Maimone, O. Skibina, K. Buzzard, A. Van der Walt, R. Karabudak, B. Van Wijmeersch, T. Csepany, D. Spitaleri, S. Vucic, N. Koch-Henriksen, F. Sellebjerg, P. S. Soerensen, C. C. Hilt Christensen, P. V. Rasmussen, M. B. Jensen, J. L. Frederiksen, S. Bramow, H. K. Mathiesen, K. I. Schreiber, H. Butzkueven, M. Magyari, T. Kalincik, E. Leray

A multistate competing risks framework for preconception prediction of pregnancy outcomes

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Kaitlyn Cook, Neil J. Perkins, Enrique Schisterman, Sebastien Haneuse

Estimating risk ratio from any standard epidemiological design by doubling the cases

Yilin Ning, Anastasia Lam, Marie Reilly

Correction: Sampling strategies to evaluate the prognostic value of a new biomarker on a time-to-event end-point

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  • Correction

Francesca Graziano, Maria Grazia Valsecchi, Paola Rebora

A framework to model global, regional, and national estimates of intimate partner violence

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  • Technical advance

Mathieu Maheu-Giroux, Lynnmarie Sardinha, Heidi Stöckl, Sarah R. Meyer, Arnaud Godin, Monica Alexander, Claudia García-Moreno

Abstract screening using the automated tool Rayyan: results of effectiveness in three diagnostic test accuracy systematic reviews

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Amir Valizadeh, Mana Moassefi, Amin Nakhostin-Ansari, Seyed Hossein Hosseini Asl, Mehrnush Saghab Torbati, Reyhaneh Aghajani, Zahra Maleki Ghorbani, Shahriar Faghani

TIDieR-telehealth: precision in reporting of telehealth interventions used in clinical trials - unique considerations for the Template for the Intervention Description and Replication (TIDieR) checklist

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Daniel I. Rhon, Julie M. Fritz, Robert D. Kerns, Donald D. McGeary, Brian C. Coleman, Shawn Farrokhi, Diana J. Burgess, Christine M. Goertz, Stephanie L. Taylor, Tammy Hoffmann

Bayesian mendelian randomization with study heterogeneity and data partitioning for large studies

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Linyi Zou, Hui Guo, Carlo Berzuini

Enhancing and assessing fidelity in the TANDEM (Tailored intervention for ANxiety and DEpression Management in COPD) trial: development of methods and recommendations for research design

Steed L., Wileman V., Sohanpal R., Kelly MJ., Pinnock H., Taylor SJC

A comparison of survival models for prediction of eight-year revision risk following total knee and hip arthroplasty

Alana R. Cuthbert, Lynne C. Giles, Gary Glonek, Lisa M. Kalisch Ellett, Nicole L. Pratt

The effect of disease co-occurrence measurement on multimorbidity networks: a population-based study

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Barret A. Monchka, Carson K. Leung, Nathan C. Nickel, Lisa M. Lix

A data-driven pipeline to extract potential adverse drug reactions through prescription, procedures and medical diagnoses analysis: application to a cohort study of 2,010 patients taking hydroxychloroquine with an 11-year follow-up

P. Sabatier, M. Wack, J. Pouchot, N. Danchin, AS. Jannot

Automating risk of bias assessment in systematic reviews: a real-time mixed methods comparison of human researchers to a machine learning system

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Patricia Sofia Jacobsen Jardim, Christopher James Rose, Heather Melanie Ames, Jose Francisco Meneses Echavez, Stijn Van de Velde, Ashley Elizabeth Muller

An investigation of penalization and data augmentation to improve convergence of generalized estimating equations for clustered binary outcomes

Angelika Geroldinger, Rok Blagus, Helen Ogden, Georg Heinze

On estimation for accelerated failure time models with small or rare event survival data

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Tasneem Fatima Alam, M. Shafiqur Rahman, Wasimul Bari

Investigating factors associated with the number of rehospitalizations among patients with schizophrenia disorder using penalized count regression models

Mahya Arayeshgari, Ghodratollah Roshanaei, Ali Ghaleiha, Jalal Poorolajal, Leili Tapak

Trial-level characteristics associate with treatment effect estimates: a systematic review of meta-epidemiological studies

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Huan Wang, Jinlu Song, Yali Lin, Wenjie Dai, Yinyan Gao, Lang Qin, Yancong Chen, Wilson Tam, Irene XY Wu, Vincent CH Chung

Risk of selection bias assessment in the NINDS rt-PA stroke study

Ravi Garg, Steffen Mickenautsch

Standard of care for COVID-19 in randomized clinical trials registered in trial registries and published in preprint servers and scholarly journals: a cross-sectional study

Mahir Fidahic, Danijela Nujic, Marta Civljak, Renata Runjic, Filipa Markotic, Marin Vidak, Livia Puljak

Identifying Potential Factors Associated with High HIV viral load in KwaZulu-Natal, South Africa using Multiple Correspondence Analysis and Random Forest Analysis

Adenike O. Soogun, Ayesha B. M. Kharsany, Temesgen Zewotir, Delia North, Ropo Ebenezer Ogunsakin

The implementation and validation of the NoMAD during a complex primary care intervention

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Larkin Lamarche, Rebecca E. Clark, Fiona Parascandalo, Dee Mangin

Generating high-fidelity synthetic time-to-event datasets to improve data transparency and accessibility

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Aiden Smith, Paul C. Lambert, Mark J. Rutherford

Prior test experience confounds longitudinal tracking of adolescent cognitive and motor development

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Edith V. Sullivan, Wesley K. Thompson, Ty Brumback, Devin Prouty, Susan F. Tapert, Sandra A. Brown, Michael D. De Bellis, Kate B. Nooner, Fiona C. Baker, Ian M. Colrain, Duncan B. Clark, Bonnie J. Nagel, Kilian M. Pohl, Adolf Pfefferbaum

Making implementation science more real

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Mitchell N. Sarkies, Emilie Francis-Auton, Janet C. Long, Chiara Pomare, Rebecca Hardwick, Jeffrey Braithwaite

A progressive three-state model to estimate time to cancer: a likelihood-based approach

Eddymurphy U. Akwiwu, Thomas Klausch, Henriette C. Jodal, Beatriz Carvalho, Magnus Løberg, Mette Kalager, Johannes Berkhof, Veerle M.H. Coupé

A novel simulation-based approach to training for recruitment of older adults to clinical trials

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Harriet Fisher, Sondra Zabar, Joshua Chodosh, Aisha Langford, Chau Trinh-Shevrin, Scott Sherman, Lisa Altshuler

A comparative study on deep learning models for text classification of unstructured medical notes with various levels of class imbalance

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Hongxia Lu, Louis Ehwerhemuepha, Cyril Rakovski

Empirical assessment of alternative methods for identifying seasonality in observational healthcare data

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Anthony Molinaro, Frank DeFalco

Machine learning approach for the prediction of 30-day mortality in patients with sepsis-associated encephalopathy

Liwei Peng, Chi Peng, Fan Yang, Jian Wang, Wei Zuo, Chao Cheng, Zilong Mao, Zhichao Jin, Weixin Li

More than one third of clinical practice guidelines on low back pain overlap in AGREE II appraisals. Research wasted?

Silvia Gianola, Silvia Bargeri, Michela Cinquini, Valerio Iannicelli, Roberto Meroni, Greta Castellini

Validation of remote height and weight assessment in a rural randomized clinical trial

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Bethany Forseth, Ann M. Davis, Dana M. Bakula, Megan Murray, Kelsey Dean, Rebecca E. Swinburne Romine, Kandace Fleming

Bayesian network meta-analysis methods for combining individual participant data and aggregate data from single arm trials and randomised controlled trials

Janharpreet Singh, Sandro Gsteiger, Lorna Wheaton, Richard D. Riley, Keith R. Abrams, Clare L. Gillies, Sylwia Bujkiewicz

Is age at menopause decreasing? – The consequences of not completing the generational cohort

Rui Martins, Bruno de Sousa, Thomas Kneib, Maike Hohberg, Nadja Klein, Elisa Duarte, Vítor Rodrigues

Individual dynamic prediction of clinical endpoint from large dimensional longitudinal biomarker history: a landmark approach

Anthony Devaux, Robin Genuer, Karine Peres, Cécile Proust-Lima

Methodology for the development of National Multidisciplinary Management Recommendations using a multi-stage meta-consensus initiative

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John C. Hardman, Kevin Harrington, Tom Roques, Sanjai Sood, Jemy Jose, Shane Lester, Paul Pracy, Ricard Simo, Costa Repanos, Frank Stafford, Chris Jennings, Stuart C. Winter, Hugh Wheatly, Jarrod Homer, B. Nirmal Kumar, Vinidh Paleri

Assessing the ability of an instrumental variable causal forest algorithm to personalize treatment evidence using observational data: the case of early surgery for shoulder fracture

John M. Brooks, Cole G. Chapman, Sarah B. Floyd, Brian K. Chen, Charles A. Thigpen, Michael Kissenberth

Coding linguistic elements in clinical interactions: a step-by-step guide for analyzing communication form

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Inge Stortenbeker, Lisa Salm, Tim olde Hartman, Wyke Stommel, Enny Das, Sandra van Dulmen

Comparing outcomes from tailored meta-analysis with outcomes from a setting specific test accuracy study using routine data of faecal calprotectin testing for inflammatory bowel disease

Karoline Freeman, Brian H. Willis, Ronan Ryan, Sian Taylor-Phillips, Aileen Clarke

Meta-analysis using Python: a hands-on tutorial

Safoora Masoumi, Saeid Shahraz

Does group-based trajectory modeling estimate spurious trajectories?

  • Open Access
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Miceline Mésidor, Marie-Claude Rousseau, Jennifer O’Loughlin, Marie-Pierre Sylvestre

Machine learning is an effective method to predict the 90-day prognosis of patients with transient ischemic attack and minor stroke

Si-Ding Chen, Jia You, Xiao-Meng Yang, Hong-Qiu Gu, Xin-Ying Huang, Huan Liu, Jian-Feng Feng, Yong Jiang, Yong-jun Wang

The effect of high prevalence of missing data on estimation of the coefficients of a logistic regression model when using multiple imputation

Peter C. Austin, Stef van Buuren

Relationship between patient experience and hospital readmission: system-level survey with deterministic data linkage method

  • Open Access
  • Care
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Eliza Lai-Yi Wong, Chin-Man Poon, Annie Wai-Ling Cheung, Frank Youhua Chen, Eng-Kiong Yeoh

Development of a factorial survey for use in an international study examining clinicians’ likelihood to support the decision to initiate invasive long-term ventilation for a child (the TechChild study)

  • Open Access
  • Care
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Mary Brigid Quirke, Denise Alexander, Kate Masterson, Jo Greene, Cathal Walsh, Piet Leroy, Jay Berry, Lee Polikoff, Maria Brenner

Methodological perspectives on the study of the health effects of unemployment – reviewing the mode of unemployment, the statistical analysis method and the role of confounding factors

  • Open Access
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Fredrik Norström, Anne Hammarström

Accommodating heterogeneous missing data patterns for prostate cancer risk prediction

Matthias Neumair, Michael W. Kattan, Stephen J. Freedland, Alexander Haese, Lourdes Guerrios-Rivera, Amanda M. De Hoedt, Michael A. Liss, Robin J. Leach, Stephen A. Boorjian, Matthew R. Cooperberg, Cedric Poyet, Karim Saba, Kathleen Herkommer, Valentin H. Meissner, Andrew J. Vickers, Donna P. Ankerst

Comparing statistical methods in assessing the prognostic effect of biomarker variability on time-to-event clinical outcomes

Feng Gao, Jingqin Luo, Jingxia Liu, Fei Wan, Guoqiao Wang, Mae Gordon, Chengjie Xiong

Distributed lag interrupted time series model for unclear intervention timing: effect of a statement of emergency during COVID-19 pandemic

Daisuke Yoneoka, Takayuki Kawashima, Yuta Tanoue, Shuhei Nomura, Akifumi Eguchi

An investigation of the constancy of effect in Cochrane systematic reviews in context with the assumptions for noninferiority trials

  • Open Access
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Enass M. Duro, Steven A. Julious, Shijie Ren

Nested and multipart prospective observational studies, flaming fiasco or efficiently economical?: The Brain, Bone, Heart case study

C. Christina Mehta, Kimberly S. Hagen, Lauren F. Collins, Renee’ H. Moore, Ighovwerha Ofotokun

Sample size recalculation based on the prevalence in a randomized test-treatment study

  • Open Access
  • Research

Amra Hot, Norbert Benda, Patrick M. Bossuyt, Oke Gerke, Werner Vach, Antonia Zapf

Evaluating methods for Lasso selective inference in biomedical research: a comparative simulation study

Michael Kammer, Daniela Dunkler, Stefan Michiels, Georg Heinze

Survival prediction models: an introduction to discrete-time modeling

  • Open Access
  • Research article

Krithika Suresh, Cameron Severn, Debashis Ghosh

Assessing the effectiveness of empirical calibration under different bias scenarios

  • Open Access
  • Research

Hon Hwang, Juan C. Quiroz, Blanca Gallego

Sample size calculation for prevalence studies using Scalex and ScalaR calculators

  • Open Access
  • Software

Lin Naing, Rusli Bin Nordin, Hanif Abdul Rahman, Yuwadi Thein Naing

Correction: Analysis of zero inflated dichotomous variables from a Bayesian perspective: application to occupational health

  • Open Access
  • Correction

David Moriña, Pedro Puig, Albert Navarro

A comparison of statistical methods for modeling count data with an application to hospital length of stay

Gustavo A. Fernandez, Kristina P. Vatcheva

Selecting implementation models, theories, and frameworks in which to integrate intersectional approaches

  • Open Access
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Justin Presseau, Danielle Kasperavicius, Isabel Braganca Rodrigues, Jessica Braimoh, Andrea Chambers, Cole Etherington, Lora Giangregorio, Jenna C. Gibbs, Anik Giguere, Ian D. Graham, Olena Hankivsky, Alison M. Hoens, Jayna Holroyd-Leduc, Christine Kelly, Julia E. Moore, Matteo Ponzano, Malika Sharma, Kathryn M. Sibley, Sharon Straus

Developing an Unstructured Supplementary Service Data-based mobile phone app to provide adolescents with sexual reproductive health information: a human-centered design approach

  • Open Access
  • Research

Paul Macharia, Antoni Pérez-Navarro, Irene Inwani, Ruth Nduati, Carme Carrion

A simple pooling method for variable selection in multiply imputed datasets outperformed complex methods

A. M. Panken, M. W. Heymans

Pharmacokinetic parameter driven outcomes model predicts a reduction in bleeding events associated with BAY 81–8973 versus antihemophilic factor (recombinant) plasma/albumin-free method in a Chinese healthcare setting

Rong Chen, Dmitry Gultyaev, Johanna Lister, Rong Han, Nan Hu, Jean Malacan, Alexander Solms, Parth Vashi, Jamie O’Hara, Shanlian Hu

Should RECOVERY have used response adaptive randomisation? Evidence from a simulation study

Tamir Sirkis, Benjamin Jones, Jack Bowden

Two-stage matching-adjusted indirect comparison

  • Open Access
  • Research

Antonio Remiro-Azócar

Urinary tract infections in children: building a causal model-based decision support tool for diagnosis with domain knowledge and prospective data

Jessica A. Ramsay, Steven Mascaro, Anita J. Campbell, David A. Foley, Ariel O. Mace, Paul Ingram, Meredith L. Borland, Christopher C. Blyth, Nicholas G. Larkins, Tim Robertson, Phoebe C. M. Williams, Thomas L. Snelling, Yue Wu

Differences between experimental and placebo arms in manual therapy trials: a methodological review

Giandomenico D’Alessandro, Nuria Ruffini, Alessandro Aquino, Matteo Galli, Mattia Innocenti, Marco Tramontano, Francesco Cerritelli

A methodologic survey on use of the GRADE approach in evidence syntheses published in high-impact factor urology and nephrology journals

  • Open Access
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Shuang Zhang, Qi-Jun Wu, Shu-Xin Liu

regCOVID: Tracking publications of registered COVID-19 studies

Craig S. Mayer, Vojtech Huser

Cluster randomised trials with a binary outcome and a small number of clusters: comparison of individual and cluster level analysis method

  • Open Access
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Jennifer A. Thompson, Clemence Leyrat, Katherine L. Fielding, Richard J. Hayes

Predicting the presence of depressive symptoms in the HIV-HCV co-infected population in Canada using supervised machine learning

Gayatri Marathe, Erica E. M. Moodie, Marie-Josée Brouillette, Joseph Cox, Curtis Cooper, Charlotte Lanièce Delaunay, Brian Conway, Mark Hull, Valérie Martel-Laferrière, Marie-Louise Vachon, Sharon Walmsley, Alexander Wong, Marina B. Klein, Lisa Barrett, Jeff Cohen, Pierre Côté, John Gill, Shariq Haider, Neora Pick, Danielle Rouleau, Steve Sanche, Roger Sandre

Evaluating the impact of calibration of patient-reported outcomes measures on results from randomized clinical trials: a simulation study based on Rasch measurement theory

  • Open Access
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Angély Loubert, Antoine Regnault, Véronique Sébille, Jean-Benoit Hardouin

Harmonized procedure coding system for surgical procedures and analysis of surgical site infections (SSI) of five European countries

Sibylle C. Mellinghoff, Caroline Bruns, Rouvier Al-Monajjed, Florian B. Cornely, Maria Grosheva, Jürgen A. Hampl, Carolin Jakob, Felix C. Koehler, Max Lechmann, Bijan Maged, Christina Otto-Lambertz, Robert Rongisch, Jule Rutz, Jon Salmanton-Garcia, Georg Schlachtenberger, Jannik Stemler, Janne Vehreschild, Sophia Wülfing, Oliver A. Cornely, Blasius J. Liss

Estimating causal effects in the presence of competing events using regression standardisation with the Stata command standsurv

Elisavet Syriopoulou, Sarwar I. Mozumder, Mark J. Rutherford, Paul C. Lambert

Measuring and controlling medical record abstraction (MRA) error rates in an observational study

  • Open Access
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Maryam Y. Garza, Tremaine Williams, Sahiti Myneni, Susan H. Fenton, Songthip Ounpraseuth, Zhuopei Hu, Jeannette Lee, Jessica Snowden, Meredith N. Zozus, Anita C. Walden, Alan E. Simon, Barbara McClaskey, Sarah G. Sanders, Sandra S. Beauman, Sara R. Ford, Lacy Malloch, Amy Wilson, Lori A. Devlin, Leslie W. Young

On model-based time trend adjustments in platform trials with non-concurrent controls

  • Open Access
  • Research

Marta Bofill Roig, Pavla Krotka, Carl-Fredrik Burman, Ekkehard Glimm, Stefan M. Gold, Katharina Hees, Peter Jacko, Franz Koenig, Dominic Magirr, Peter Mesenbrink, Kert Viele, Martin Posch

Evaluation of data imputation strategies in complex, deeply-phenotyped data sets: the case of the EU-AIMS Longitudinal European Autism Project

  • Open Access
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A. Llera, M. Brammer, B. Oakley, J. Tillmann, M. Zabihi, J. S. Amelink, T. Mei, T. Charman, C. Ecker, F. Dell’Acqua, T. Banaschewski, C. Moessnang, S. Baron-Cohen, R. Holt, S. Durston, D. Murphy, E. Loth, J. K. Buitelaar, D. L. Floris, C. F. Beckmann

Restrictions and their reporting in systematic reviews of effectiveness: an observational study

  • Open Access
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Jasmin Helbach, Dawid Pieper, Tim Mathes, Tanja Rombey, Hajo Zeeb, Katharina Allers, Falk Hoffmann

What influences communication about retention in randomised trials: a multi-trial, theory-based analysis exploring trial staff perspectives

  • Open Access
  • Research

Taylor Coffey, Eilidh Duncan, Heather Morgan, Katie Gillies

Interrater reliability estimators tested against true interrater reliabilities

  • Open Access
  • Research

Xinshu Zhao, Guangchao Charles Feng, Song Harris Ao, Piper Liping Liu

The Mann-Kendall-Sneyers test to identify the change points of COVID-19 time series in the United States

Xiang Chen, Hui Wang, Weixuan Lyu, Ran Xu

Assessing the quality of evidence on safety: specifications for application and suggestions for adaptions of the GRADE-criteria in the context of preparing a list of potentially inappropriate medications for older adults

  • Open Access
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Tim Mathes, Nina-Kristin Mann, Petra Thürmann, Andreas Sönnichsen, Dawid Pieper

Estimating effects of health policy interventions using interrupted time-series analyses: a simulation study

  • Open Access
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Huan Jiang, Xinyang Feng, Shannon Lange, Alexander Tran, Jakob Manthey, Jürgen Rehm

Measuring and exploring mental health determinants: a closer look at co-residents’ effect using a multilevel structural equations model

  • Open Access
  • Research

Hend Gabr, Mohammed Baragilly, Brian H. Willis

“We’re already doing this work”: ethical research with community-based organizations

Rebecca Fielding-Miller, Sarah Kim, Jeanette Bowles, Samantha Streuli, Peter Davidson

Informed Bayesian survival analysis

  • Open Access
  • Research

František Bartoš, Frederik Aust, Julia M. Haaf

The value of time-dependent risk predictions in a screening context - a comprehensive simulation analysis validated on German cancer registry data

Vinzenz Voelkel, Teresa Draeger, Sietse van Mossel, Sabine Siesling, Hendrik Koffijberg

Conclusiveness, linguistic characteristics and readability of Cochrane plain language summaries of intervention reviews: a cross-sectional study

Aleksandra Banić, Mahir Fidahić, Jelena Šuto, Rea Roje, Ivana Vuka, Livia Puljak, Ivan Buljan

Improving the accuracy of self-reported height and weight in surveys: an experimental study

  • Open Access
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Nina Van Dyke, Eric J. Drinkwater, Jerome N. Rachele

A descriptive study of samples sizes used in agreement studies published in the PubMed repository

  • Open Access
  • Research

Oscar Han, Hao Wei Tan, Steven Julious, Laura Sutton, Richard Jacques, Ellen Lee, Jen Lewis, Stephen Walters

Implementation fidelity in a multifaceted program to foster rational antibiotics use in primary care: an observational study

Lukas Kühn, Dorothea Kronsteiner, Petra Kaufmann-Kolle, Edith Andres, Joachim Szecsenyi, Michel Wensing, Regina Poss-Doering

A logical analysis of null hypothesis significance testing using popular terminology

  • Open Access
  • Research

Richard McNulty

Joint models for dynamic prediction in localised prostate cancer: a literature review

Harry Parr, Emma Hall, Nuria Porta

Posttraumatic growth inventory: challenges with its validation among French cancer patients

Yseulys Dubuy, Véronique Sébille, Marianne Bourdon, Jean-Benoit Hardouin, Myriam Blanchin

Evaluating sensitivity to classification uncertainty in latent subgroup effect analyses

  • Open Access
  • Research

Wen Wei Loh, Jee-Seon Kim

Development and pilot implementation of guidelines for culturally tailored research recruitment materials for African Americans and Latinos

  • Open Access
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Jennifer Cunningham-Erves, Sheila V. Kusnoor, Victoria Villalta-Gil, Sarah C. Stallings, Jabari S. Ichimura, Tiffany L. Israel, Paul A. Harris, Consuelo H. Wilkins

A photograph of the researcher on the invitation letter did not affect the participation rate of a postal survey: a randomized study within a trial (SWAT)

  • Open Access
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Barbara Prediger, Nadja Könsgen, Ana-Mihaela Bora, Anna Schlimbach, Dawid Pieper

Sensitivity analyses for data missing at random versus missing not at random using latent growth modelling: a practical guide for randomised controlled trials

  • Open Access
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Andreas Staudt, Jennis Freyer-Adam, Till Ittermann, Christian Meyer, Gallus Bischof, Ulrich John, Sophie Baumann

Prospective sampling bias in COVID-19 recruitment methods: experimental evidence from a national randomized survey testing recruitment materials

Eric B. Kennedy, Mia Charifson, Megan Jehn, Eric A. Jensen, Jenna Vikse

Impact of different unconditional monetary incentives on survey response rates in men with prostate cancer: a 2-arm randomised trial

Megan McIntosh, Melissa J. Opozda, Michael O’Callaghan, Andrew D. Vincent, Daniel A. Galvão, Camille E. Short

Item response theory and differential test functioning analysis of the HBSC-Symptom-Checklist across 46 countries

  • Open Access
  • Research

Andreas Heinz, Philipp E. Sischka, Carolina Catunda, Alina Cosma, Irene García-Moya, Nelli Lyyra, Anne Kaman, Ulrike Ravens-Sieberer, William Pickett

Case-only approach applied in environmental epidemiology: 2 examples of interaction effect using the US National Health and Nutrition Examination Survey (NHANES) datasets

Jinyoung Moon, Hwan-Cheol Kim

Qualitative longitudinal research in health research: a method study

  • Open Access
  • Research

Åsa Audulv, Elisabeth O. C. Hall, Åsa Kneck, Thomas Westergren, Liv Fegran, Mona Kyndi Pedersen, Hanne Aagaard, Kristianna Lund Dam, Mette Spliid Ludvigsen

Group sequential designs in pragmatic trials: feasibility and assessment of utility using data from a number of recent surgical RCTs

Nick R. Parsons, Nigel Stallard, Helen Parsons, Aminul Haque, Martin Underwood, James Mason, Iftekhar Khan, Matthew L. Costa, Damian R. Griffin, James Griffin, David J. Beard, Jonathan A. Cook, Loretta Davies, Jemma Hudson, Andrew Metcalfe

Prediction of congenital heart disease for newborns: comparative analysis of Holt-Winters exponential smoothing and autoregressive integrated moving average models

Weize Xu, Zehua Shao, Hongliang Lou, Jianchuan Qi, Jihua Zhu, Die Li, Qiang Shu

A dose-finding design for phase I clinical trials based on Bayesian stochastic approximation

  • Open Access
  • Research

Jin Xu, Dapeng Zhang, Rongji Mu

Statistical methods and graphical displays of quality of life with survival outcomes in oncology clinical trials for supporting the estimand framework

  • Open Access
  • Research

Kentaro Sakamaki, Takuya Kawahara

The case against censoring of progression-free survival in cancer clinical trials – A pandemic shutdown as an illustration

  • Open Access
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Corinne Jamoul, Laurence Collette, Elisabeth Coart, Koenraad D’Hollander, Tomasz Burzykowski, Everardo D. Saad, Marc Buyse

Count data models for outpatient health services utilisation

  • Open Access
  • Research

Nurul Salwana Abu Bakar, Ab Hamid Jabrullah, Mohd Nor Sham Mohd Shaiful Jefri, Mohd Nor Sham, Jailani Anis Syakira

Reporting of the safety from allergic rhinitis trials registered on ClinicalTrials.gov and in publications: An observational study

Ivan Paladin, Shelly Melissa Pranić

Network analysis for estimating standardization trends in genomics using MEDLINE

  • Open Access
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Eun Bit Bae, Sejin Nam, Sungin Lee, Sun-Ju Ahn

Joint analysis of PK and immunogenicity outcomes using factorization model − a powerful approach for PK similarity study

  • Open Access
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Halimu N. Haliduola, Fausto Berti, Heimo Stroissnig, Eric Guenzi, Hendrik Otto, Abid Sattar, Ulrich Mansmann

Infrastructure challenges to doing health research “where populations with the most disease live” in Covid times—a response to Rai et al. (2021)

Jennifer MacLellan, Joanne Turnbull, Catherine Pope

Improving outcomes for patients with lymphoma: design and development of the Australian and New Zealand Lymphoma and Related Diseases Registry

Mary Ann Anderson, Leanne Berkahn, Chan Cheah, Michael Dickinson, Maher K. Gandhi, Pratyush Giri, Eliza A. Hawkes, Anna Johnston, Colm Keane, Zoe K. McQuilten, Stephen P. Mulligan, Stephen Opat, Dipti Talaulikar, Judith Trotman, Janne Williams, Erica M. Wood, Tasman Armytage, Allison Barraclough, Duncan Carradice, Geoffrey Chong, Tara Cochrane, Nada Hamad, Matthew Ku, Denise Lee, Susan Morgan, Howard Mutsando, Manjunath Narayana, H. Miles Prince, Sumita Ratnasingam, Joel Wight, Xavier Badoux, Gavin Cull, Bryone Kuss, Paula Marlton, Constantine Tam, Joshua Casan, Tania Cushion, Aditya Tedjaseputra, Simone Birch, Christina Brown, David Ellis, Yasmin Harvey, Sam Hitchins, Sanjiv Jain, Peter Jessup, Surender Juneja, Daniel Kearney, Beena Kumar, Stephen Lade, Kenneth Lee, Connull Leslie, Eileen Long, Adrienne Morey, Lakshmi Nath, Debra Norris, Andrew Parker, Jeremy Parry, Fiona Pin-Yen Chen, Eliza Chung, Jessica Morison, Luke Rowsell, Gayathri St George, Christianto Thu, Neil Waters, Cameron Wellard, Michelle Zheng

The conduct and reporting of qualitative evidence syntheses in health and social care guidelines: a content analysis

  • Open Access
  • Care
  • Research

Chris Carmona, Susan Baxter, Christopher Carroll

Comparison of unweighted and item response theory-based weighted sum scoring for the Nine-Questions Depression-Rating Scale in the Northern Thai Dialect

Suttipong Kawilapat, Benchalak Maneeton, Narong Maneeton, Sukon Prasitwattanaseree, Thoranin Kongsuk, Suwanna Arunpongpaisal, Jintana Leejongpermpoon, Supattra Sukhawaha, Patrinee Traisathit

A bayesian approach to model the underlying predictors of early recurrence and postoperative death in patients with colorectal Cancer

Leila Mahmoudi, Ramezan Fallah, Ghodratollah Roshanaei, Mohammad Asghari-Jafarabadi

A stabilized spatiotemporal kriging method for disease mapping and application to male oral cancer and female breast cancer in Taiwan

Dai-Rong Tsai, Jing-Rong Jhuang, Shih-Yung Su, Chun-Ju Chiang, Ya-Wen Yang, Wen-Chung Lee

The failure of four bootstrap procedures for estimating confidence intervals for predicted-to-expected ratios for hospital profiling

  • Open Access
  • Research

Peter C. Austin

Structured expert elicitation to inform long-term survival extrapolations using alternative parametric distributions: a case study of CAR T therapy for relapsed/ refractory multiple myeloma

Dieter Ayers, Shannon Cope, Kevin Towle, Ali Mojebi, Thomas Marshall, Devender Dhanda

Group-level comparison of brain connectivity networks

  • Open Access
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Fatemeh Pourmotahari, Hassan Doosti, Nasrin Borumandnia, Seyyed Mohammad Tabatabaei, Hamid Alavi Majd

Reliability of the evidence to guide decision-making in foot ulcer prevention in diabetes: an overview of systematic reviews

Fay Crawford, Donald J. Nicolson, Aparna E. Amanna, Marie Smith

An innovative approach based on real-world big data mining for calculating the sample size of the reference interval established using transformed parametric and non-parametric methods

  • Open Access
  • Research

Chaochao Ma, Li’an Hou, Yutong Zou, Xiaoli Ma, Danchen Wang, Yingying Hu, Ailing Song, Xinqi Cheng, Ling Qiu

How can clinicians choose between conflicting and discordant systematic reviews? A replication study of the Jadad algorithm

  • Open Access
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C Lunny, Sai Surabi Thirugnanasampanthar, S Kanji, N Ferri, D Pieper, S Whitelaw, S Tasnim, H Nelson, EK Reid, Jia He (Janet) Zhang, Banveer Kalkat, Yuan Chi, Reema Abdoulrezzak, Di Wen Zheng, Lindy R.S. Pangka, Dian (Xin Ran) Wang, Parisa Safavi, Anmol Sooch, Kevin T. Kang, Andrea C, Tricco

Mapping between headache specific and generic preference-based health-related quality of life measures

Kamran Khan, Hema Mistry, Manjit Matharu, Chloe Norman, Stavros Petrou, Kimberley Stewart, Martin Underwood, Felix Achana

A stratified adaptive two-stage design with co-primary endpoints for phase II clinical oncology trials

  • Open Access
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Bastien Cabarrou, Eve Leconte, Patrick Sfumato, Jean-Marie Boher, Thomas Filleron

Conditional wealth to estimate association of wealth mobility with health and human capital in low- and middle-income country cohorts

  • Open Access
  • Research

Jithin Sam Varghese, Clive Osmond, Aryeh D. Stein

Correction: Two-stage matching-adjusted indirect comparison

  • Open Access
  • Correction

Antonio Remiro‑Azócar

Forecasting COVID-19 cases using time series modeling and association rule mining

Rachasak Somyanonthanakul, Kritsasith Warin, Watchara Amasiri, Karicha Mairiang, Chatchai Mingmalairak, Wararit Panichkitkosolkul, Krittin Silanun, Thanaruk Theeramunkong, Surapon Nitikraipot, Siriwan Suebnukarn

Machine learning in medicine: a practical introduction to techniques for data pre-processing, hyperparameter tuning, and model comparison

André Pfob, Sheng-Chieh Lu, Chris Sidey-Gibbons

Zero-augmented beta-prime model for multilevel semi-continuous data: a Bayesian inference

  • Open Access
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Naser Kamyari, Ali Reza Soltanian, Hossein Mahjub, Abbas Moghimbeigi, Maryam Seyedtabib

Dementia risk prediction in individuals with mild cognitive impairment: a comparison of Cox regression and machine learning models

Meng Wang, Matthew Greenberg, Nils D. Forkert, Thierry Chekouo, Gabriel Afriyie, Zahinoor Ismail, Eric E. Smith, Tolulope T. Sajobi

Rescaling pain intensity measures for meta-analyses of analgesic medicines for low back pain appears justified: an empirical examination from randomised trials

Michael A. Wewege, Matthew D. Jones, Sam A. Williams, Steven J. Kamper, James H. McAuley

AutoScore-Ordinal: an interpretable machine learning framework for generating scoring models for ordinal outcomes

  • Open Access
  • Research

Seyed Ehsan Saffari, Yilin Ning, Feng Xie, Bibhas Chakraborty, Victor Volovici, Roger Vaughan, Marcus Eng Hock Ong, Nan Liu

Real-world data: a brief review of the methods, applications, challenges and opportunities

Fang Liu, Demosthenes Panagiotakos

Applying the 4Ps of social marketing to retain and engage participants in longitudinal cohort studies: generation 2 Raine study participant perspectives

  • Open Access
  • Research article

Leesa Costello, Julie Dare, Manon Dontje, Claire Lambert, Leon Straker

Short-form development of the specific module of the QLICD-CRF(V2.0) for assessing the quality of life of patients with chronic renal failure

  • Open Access
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Zhengqin Xiao, Yuxi Liu, Daniel Yee-Tak Fong, Xinping Huang, Min Weng, Chonghua Wan

Modelling multiple time-scales with flexible parametric survival models

  • Open Access
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Nurgul Batyrbekova, Hannah Bower, Paul W. Dickman, Anna Ravn Landtblom, Malin Hultcrantz, Robert Szulkin, Paul C. Lambert, Therese M-L. Andersson

Minimal important difference and patient acceptable symptom state for common outcome instruments in patients with a closed humeral shaft fracture - analysis of the FISH randomised clinical trial data

Thomas Ibounig, Joona Juurakko, Tuomas Lähdeoja, Bakir O. Sumrein, Teppo L. N. Järvinen, Mika Paavola, Clare L. Ardern, Teemu Karjalainen, Simo Taimela, Lasse Rämö

A proposed methodology for uncertainty extraction and verification in priority setting partnerships with the James Lind Alliance: an example from the Common Conditions Affecting the Hand and Wrist Priority Setting Partnership

  • Open Access
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D. J. C. Grindlay, T. R. C. Davis, D. Kennedy, D. Larson, D. Furniss, K. Cowan, G. Giddins, A. Jain, R. W. Trickett, A. Karantana

Prioritizing population-based nutrition-related interventions to prevent and control hypertension in Iran: a multi-criteria decision-making approach

Soghra Aliasgharzadeh, Mehrangiz Ebrahimi-Mameghani, Reza Mahdavi, Hossein Karimzadeh, Leila Nikniaz, Jafar Sadegh Tabrizi, Fathollah Pourali

Comparison of analysis methods and design choices for treatment-by-period interaction in unidirectional switch designs: a simulation study

  • Open Access
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Zhuozhao Zhan, Geertruida H. de Bock, Edwin R. van den Heuvel

Using joint models to study the association between CD4 count and the risk of death in TB/HIV data

  • Open Access
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Nobuhle N. Mchunu, Henry G. Mwambi, Dimitris Rizopoulos, Tarylee Reddy, Nonhlanhla Yende-Zuma

“The problem is that our culture is just so messed up about aging.” Recruiting older men who have sex with men (MSM) into research studies: an example from a study of aging, HIV, and anal HPV.

Alexandra L. Hernandez, Christopher Scott Weatherly, Sahai Burrowes, Jessica Lopez Jimenez, Ryan Gonzalez, Joel M. Palefsky

Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation

Samantha Malatesta, Isabelle R. Weir, Sarah E. Weber, Tara C. Bouton, Tara Carney, Danie Theron, Bronwyn Myers, C. Robert Horsburgh, Robin M. Warren, Karen R. Jacobson, Laura F. White

A systematic review and psychometric evaluation of resilience measurement scales for people living with dementia and their carers

Gill Windle, Catherine MacLeod, Katherine Algar-Skaife, Joshua Stott, Claire Waddington, Paul M. Camic, Mary Pat Sullivan, Emilie Brotherhood, Sebastian Crutch

Using information from network meta-analyses to optimize the power and sample allocation of a subsequent trial with a new treatment

  • Open Access
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Dapeng Hu, Chong Wang, Fangshu Ye, Annette M. O’Connor

Using a cohort study of diabetes and peripheral artery disease to compare logistic regression and machine learning via random forest modeling

Andrea M. Austin, Niveditta Ramkumar, Barbara Gladders, Jonathan A. Barnes, Mark A. Eid, Kayla O. Moore, Mark W. Feinberg, Mark A. Creager, Marc Bonaca, Philip P. Goodney

Applied causal inference methods for sequential mediators

D Zugna, M Popovic, F Fasanelli, B Heude, G Scelo, L Richiardi

What do we want to get out of this? a critical interpretive synthesis of the value of process evaluations, with a practical planning framework

  • Open Access
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Caroline French, Anna Dowrick, Nina Fudge, Hilary Pinnock, Stephanie J. C. Taylor

Quality appraisal for systematic literature reviews of health state utility values: a descriptive analysis

  • Open Access
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Muchandifunga Trust Muchadeyi, Karla Hernandez-Villafuerte, Michael Schlander

Evaluating the sensitivity of jurisdictional heterogeneity and jurisdictional mixing in national level HIV prevention analyses: context of the U.S. ending the HIV epidemic plan

  • Open Access
  • Care
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Hanisha Tatapudi, Chaitra Gopalappa

Laboratory-based and office-based Globorisk scores to predict 10-year risk of cardiovascular diseases among Iranians: results from the Fasa PERSIAN cohort

  • Open Access
  • Research

Leila Jahangiry, Azizallah Dehghan, Mojtaba Farjam, Dagfinn Aune, Fatemeh Rezaei

Meta-DiSc 2.0: a web application for meta-analysis of diagnostic test accuracy data

  • Open Access
  • Software

Maria N. Plana, Ingrid Arevalo-Rodriguez, Silvia Fernández-García, Javier Soto, Martin Fabregate, Teresa Pérez, Marta Roqué, Javier Zamora

Case study research and causal inference

Judith Green, Benjamin Hanckel, Mark Petticrew, Sara Paparini, Sara Shaw

Impact of different cover letter information and incentives on Veterans’ emotional responses to an unsolicited mailed survey about military traumas: a randomized, 3x2x2 factorial trial

  • Open Access
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Maureen Murdoch, Barbara A Clothier, Shannon Kehle-Forbes, Derek Vang, Siamak Noorbaloochi

A multisource approach to health care use: concordance between register and self-reported physician visits in the foreign-born population in Finland

  • Open Access
  • Care
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Regina García-Velázquez, Valentina Kieseppä, Eero Lilja, Päivikki Koponen, Natalia Skogberg, Hannamaria Kuusio

Development and validation of paired MEDLINE and Embase search filters for cost-utility studies

  • Open Access
  • Research

Wesley Hubbard, Nicola Walsh, Thomas Hudson, Andrea Heath, Jeremy Dietz, Gabriel Rogers

External validation of existing dementia prediction models on observational health data

Luis H. John, Jan A. Kors, Egill A. Fridgeirsson, Jenna M. Reps, Peter R. Rijnbeek

Generating real-world evidence compatible with evidence from randomized controlled trials: a novel observational study design applicable to surgical transfusion research

  • Open Access
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Xiaochu Yu, Zixing Wang, Lei Wang, Yuguang Huang, Yipeng Wang, Shijie Xin, Guanghua Lei, Shengxiu Zhao, Yali Chen, Xiaobo Guo, Wei Han, Xuerong Yu, Fang Xue, Peng Wu, Wentao Gu, Jingmei Jiang

Quality of observational studies of clinical interventions: a meta-epidemiological review

  • Open Access
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Sergei Grosman, Ian A. Scott

A systematic review of randomisation method use in RCTs and association of trial design characteristics with method selection

  • Open Access
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Cydney L. Bruce, Edmund Juszczak, Reuben Ogollah, Christopher Partlett, Alan Montgomery

Correction: Laboratory-based and office-based Globorisk scores to predict 10-year risk of cardiovascular diseases among Iranians: results from the Fasa PERSIAN cohort

  • Open Access
  • Correction

Leila Jahangiry, Azizallah Dehghan, Mojtaba Farjam, Dagfinn Aune, Fatemeh Rezaei

Methodological guidance for the evaluation and updating of clinical prediction models: a systematic review

  • Open Access
  • Research

M. A. E. Binuya, E. G. Engelhardt, W. Schats, M. K. Schmidt, E. W. Steyerberg

Methodology of the INVestigating traIning assoCiated blasT pAthology (INVICTA) study

Michael J. Roy, David O. Keyser, Sheilah S. Rowe, Rene S. Hernandez, Marcia Dovel, Holland Romero, Diana Lee, Matthew Menezes, Elizabeth Magee, Danielle J. Brooks, Chen Lai, Jessica Gill, Suthee Wiri, Elizabeth Metzger, J. Kent Werner, Douglas Brungart, Devon M. Kulinski, Dominic Nathan, Walter S. Carr

Inferences for current chronic graft-versus-host-disease free and relapse free survival

Xu Zhang, Scott R. Solomon, Connie Sizemore

Performance of several types of beta-binomial models in comparison to standard approaches for meta-analyses with very few studies

  • Open Access
  • Research

Moritz Felsch, Lars Beckmann, Ralf Bender, Oliver Kuss, Guido Skipka, Tim Mathes

Methodological approaches to study context in intervention implementation studies: an evidence gap map

  • Open Access
  • Research

Juliane Mielke, Thekla Brunkert, Franziska Zúñiga, Michael Simon, Leah L. Zullig, Sabina De Geest

Challenges of using external data in clinical trials- an illustration in patients with COVID-19

Sylvie Chevret, Jean-François Timsit, Lucie Biard

Machine learning computational tools to assist the performance of systematic reviews: A mapping review

  • Open Access
  • Research

Ramon Cierco Jimenez, Teresa Lee, Nicolás Rosillo, Reynalda Cordova, Ian A Cree, Angel Gonzalez, Blanca Iciar Indave Ruiz

How do study design features and participant characteristics influence willingness to participate in clinical trials? Results from a choice experiment

  • Open Access
  • Research

Caitlin Thomas, Sarah Mulnick, Nicolas Krucien, Kevin Marsh

Using group testing in a two-phase epidemiologic design to identify the effects of a large number of antibody reactions on disease risk

  • Open Access
  • Research

Tanvi Mehta, Yaakov Malinovsky, Christian C. Abnet, Paul S. Albert

Personalized prediction of incident hospitalization for cardiovascular disease in patients with hypertension using machine learning

Yuanchao Feng, Alexander A. Leung, Xuewen Lu, Zhiying Liang, Hude Quan, Robin L. Walker

Treatment of missing data in Bayesian network structure learning: an application to linked biomedical and social survey data

  • Open Access
  • Research

Xuejia Ke, Katherine Keenan, V. Anne Smith

Evaluation of two-stage designs of Phase 2 single-arm trials in glioblastoma: a systematic review

Wonsuk Yoo, Seongho Kim, Michael Garcia, Shwetal Mehta, Nader Sanai

Model selection for survival individualized treatment rules using the jackknife estimator

  • Open Access
  • Research

Gilson D. Honvoh, Hunyong Cho, Michael R. Kosorok

Intervention effect estimates in randomised controlled trials conducted in primary care versus secondary or tertiary care settings: a meta-epidemiological study

  • Open Access
  • Care
  • Research

Amandine Dugard, Elsa Tavernier, Agnès Caille, Agnès Dechartres, Adeline Hoang, Bruno Giraudeau, Clarisse Dibao-Dina

Going virtual during the COVID-19 pandemic: adaptation of a mixed-methods dietary behavior study within a community-based participatory research study of African-American adults at risk for cardiovascular disease

Nicole Farmer, Ralph Thadeus Tuason, Narjis Kazmi, Sharon Flynn, Valerie Mitchell, Kimberly Middleton, Robert Cox, Kristina Franklin, Talya Gordon, Alyssa Baginski, Gwenyth R. Wallen

Machine learning-based techniques to improve lung transplantation outcomes and complications: a systematic review

  • Open Access
  • Research

Marsa Gholamzadeh, Hamidreza Abtahi, Reza Safdari

Transformation of Rasch model logits for enhanced interpretability

  • Open Access
  • Research

Joakim Ekstrand, Albert Westergren, Kristofer Årestedt, Amanda Hellström, Peter Hagell

Combinational Regularity Analysis (CORA) — a new method for uncovering complex causation in medical and health research

  • Open Access
  • Research

Alrik Thiem, Lusine Mkrtchyan, Zuzana Sebechlebská

CAT HPPR: a critical appraisal tool to assess the quality of systematic, rapid, and scoping reviews investigating interventions in health promotion and prevention

  • Open Access
  • Research

Thomas L. Heise, Andreas Seidler, Maria Girbig, Alice Freiberg, Adrienne Alayli, Maria Fischer, Wolfgang Haß, Hajo Zeeb

External control arm analysis: an evaluation of propensity score approaches, G-computation, and doubly debiased machine learning

  • Open Access
  • Research article

Nicolas Loiseau, Paul Trichelair, Maxime He, Mathieu Andreux, Mikhail Zaslavskiy, Gilles Wainrib, Michael G. B. Blum

MetaAnalyst: a user-friendly tool for metagenomic biomarker detection and phenotype classification

Mustafa Alshawaqfeh, Salahelden Rababah, Abdullah Hayajneh, Ammar Gharaibeh, Erchin Serpedin

Estimation of average treatment effect based on a multi-index propensity score

  • Open Access
  • Research

Jiaqin Xu, Kecheng Wei, Ce Wang, Chen Huang, Yaxin Xue, Rui Zhang, Guoyou Qin, Yongfu Yu

The factor structure of the cardiac anxiety questionnaire, and validation in a post-MI population

Philip Leissner, Claes Held, Elisabet Rondung, Erik M. G. Olsson

Interpretable generalized neural additive models for mortality prediction of COVID-19 hospitalized patients in Hamadan, Iran

Samad Moslehi, Hossein Mahjub, Maryam Farhadian, Ali Reza Soltanian, Mojgan Mamani

Dec 21
Issue: 1/2021
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Issue: 1/2023

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