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BMC Medical Research Methodology

Issue 1/2021

Content (287 Articles)

COVID-19-related medical research: a meta-research and critical appraisal

Marc Raynaud, Huanxi Zhang, Kevin Louis, Valentin Goutaudier, Jiali Wang, Quentin Dubourg, Yongcheng Wei, Zeynep Demir, Charlotte Debiais, Olivier Aubert, Yassine Bouatou, Carmen Lefaucheur, Patricia Jabre, Longshan Liu, Changxi Wang, Xavier Jouven, Peter Reese, Jean-Philippe Empana, Alexandre Loupy

Alternative adjustment for seasonality and long-term time-trend in time-series analysis for long-term environmental exposures and disease counts

  • Open Access
  • Research article

Honghyok Kim, Jong-Tae Lee, Kelvin C. Fong, Michelle L. Bell

Virtual controls as an alternative to randomized controlled trials for assessing efficacy of interventions

  • Open Access
  • Review

Joseph M. Strayhorn Jr.

Ordinal outcome analysis improves the detection of between-hospital differences in outcome

I. E. Ceyisakar, N. van Leeuwen, Diederik W. J. Dippel, Ewout W. Steyerberg, H. F. Lingsma

Multiple imputation validation study: addressing unmeasured survey data in a longitudinal design

Claire A. Kolaja, Ben Porter, Teresa M. Powell, Rudolph P. Rull, Richard Armenta, Satbir Boparai, Felicia Carey, Toni Rose Geronimo, Isabel Jacobson, Cynthia LeardMann, Rayna Matsuno, Deanne Millard, Chiping Nieh, Anna Rivera, Beverly Sheppard, Daniel Trone, Jennifer Walstrom, Steven Warner

Quantifying the under-reporting of uncorrelated longitudal data: the genital warts example

  • Open Access
  • Wart
  • Research article

David Moriña, Amanda Fernández-Fontelo, Alejandra Cabaña, Pedro Puig, Laura Monfil, Maria Brotons, Mireia Diaz

Improved selection of participants in genetic longevity studies: family scores revisited

  • Open Access
  • Research article

Mar Rodríguez-Girondo, Niels van den Berg, Michel H. Hof, Marian Beekman, Eline Slagboom

Development and validation of prediction model to estimate 10-year risk of all-cause mortality using modern statistical learning methods: a large population-based cohort study and external validation

  • Open Access
  • Research article

Olesya Ajnakina, Deborah Agbedjro, Ryan McCammon, Jessica Faul, Robin M. Murray, Daniel Stahl, Andrew Steptoe

Re-evaluation of the comparative effectiveness of bootstrap-based optimism correction methods in the development of multivariable clinical prediction models

  • Open Access
  • Research article

Katsuhiro Iba, Tomohiro Shinozaki, Kazushi Maruo, Hisashi Noma

Methodology in core outcome set (COS) development: the impact of patient interviews and using a 5-point versus a 9-point Delphi rating scale on core outcome selection in a COS development study

  • Open Access
  • Research article

Alexandria Remus, Valerie Smith, Francesca Wuytack

Incorporating and addressing testing bias within estimates of epidemic dynamics for SARS-CoV-2

Yasir Suhail, Junaid Afzal, Kshitiz

Pattern-mixture model in network meta-analysis of binary missing outcome data: one-stage or two-stage approach?

  • Open Access
  • Research article

Loukia M. Spineli, Katerina Papadimitropoulou, Chrysostomos Kalyvas

Missing not at random in end of life care studies: multiple imputation and sensitivity analysis on data from the ACTION study

  • Open Access
  • Care
  • Research article

Giulia Carreras, Guido Miccinesi, Andrew Wilcock, Nancy Preston, Daan Nieboer, Luc Deliens, Mogensm Groenvold, Urska Lunder, Agnes van der Heide, Michela Baccini, Agnes van der Heide, Ida J. Korfage, Judith A. C. Rietjens, Lea J. Jabbarian, Suzanne Polinder, Hans van Delden, Marijke Kars, Marieke Zwakman, Luc Deliens, Mariëtte N. Verkissen, Kim Eecloo, Kristof Faes, Kristian Pollock, Jane Seymour, Glenys Caswell, Andrew Wilcock, Louise Bramley, Sheila Payne, Nancy Preston, Lesley Dunleavy, Eleanor Sowerby, Guido Miccinesi, Francesco Bulli, Francesca Ingravallo, Giulia Carreras, Alessandro Toccafondi, Giuseppe Gorini, Urška Lunder, Branka Červ, Anja Simonič, Alenka Mimić, Hana Kodba-Čeh, Polona Ozbič, Mogens Groenvold, Caroline Arnfeldt, Anna Thit Johnsen

Impact of time-varying cumulative bevacizumab exposures on survival: re-analysis of data from randomized clinical trial in patients with metastatic colo-rectal cancer

Adrien Guilloteau, Michal Abrahamowicz, Olayide Boussari, Valérie Jooste, Thomas Aparicio, Catherine Quantin, Karine Le Malicot, Christine Binquet

Short-term real-time prediction of total number of reported COVID-19 cases and deaths in South Africa: a data driven approach

Tarylee Reddy, Ziv Shkedy, Charl Janse van Rensburg, Henry Mwambi, Pravesh Debba, Khangelani Zuma, Samuel Manda

Relaxing the assumption of constant transition rates in a multi-state model in hospital epidemiology

Micki Hill, Paul C. Lambert, Michael J. Crowther

Flexible modelling of risk factors on the incidence of pneumonia in young children in South Africa using piece-wise exponential additive mixed modelling

Jordache Ramjith, Kit C.B. Roes, Heather J. Zar, Marianne A. Jonker

Fitting a shared frailty illness-death model to left-truncated semi-competing risks data to examine the impact of education level on incident dementia

Catherine Lee, Paola Gilsanz, Sebastien Haneuse

Understanding participation in European cohort studies of preterm children: the views of parents, healthcare professionals and researchers

  • Open Access
  • Research article

Sandra C. S. Marques, Julia Doetsch, Georgia Abate, Anne Brødsgaard, Grazia Colombo, Marina Cuttini, Pernille Pedersen, Henrique Barros, Sandra C. S. Marques, Julia Doetsch, Raquel Teixeira, Georgia Abate, Grazia Colombo, Marina Cuttini, Anne Brødsgaard, Elizabeth S. Draper, Sylvia van der Pal, Ilona Wildeman, Pernille Pedersen, Kari Anne I. Evensen, Ann-Mari Brubakk, Marit S. Indredavik, Eero Kajantie, Eeva Virtanen, Jo Lebeer, Vicky Hennissen, Iemke Sarrechia, Henrique Barros

Informing the research agenda for optimizing audit and feedback interventions: results of a prioritization exercise

  • Open Access
  • Research article

Heather L. Colquhoun, Kelly Carroll, Kevin W. Eva, Jeremy M. Grimshaw, Noah Ivers, Susan Michie, Jamie C. Brehaut

When does the use of individual patient data in network meta-analysis make a difference? A simulation study

  • Open Access
  • Research article

Steve Kanters, Mohammad Ehsanul Karim, Kristian Thorlund, Aslam Anis, Nick Bansback

Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England

M. S. M. Persson, K. E. Harman, K. S. Thomas, J. R. Chalmers, Y. Vinogradova, S. M. Langan, J. Hippisley-Cox, S. Gran

National surveillance of stroke quality of care and outcomes by applying post-stratification survey weights on the Get With The Guidelines-Stroke patient registry

Boback Ziaeian, Haolin Xu, Roland A. Matsouaka, Ying Xian, Yosef Khan, Lee S. Schwamm, Eric E. Smith, Gregg C. Fonarow

Methodological approaches to imputing early-pregnancy weight based on weight measures collected during pregnancy

  • Open Access
  • Research article

Jiaxi Yang, Dongqing Wang, Anne Marie Darling, Enju Liu, Nandita Perumal, Wafaie W. Fawzi, Molin Wang

Telephone peer recruitment and interviewing during a respondent-driven sampling (RDS) survey: feasibility and field experience from the first phone-based RDS survey among men who have sex with men in Côte d’Ivoire

  • Open Access
  • Research article

Maxime Inghels, Arsène Kra Kouassi, Serge Niangoran, Anne Bekelynck, Séverine Carillon, Lazare Sika, Mariatou Koné, Christine Danel, Annabel Desgrées du Loû, Joseph Larmarange, Nelly ASSOUMOU, Anne BEKELYNCK, Christine DANEL, Mohamed DOUMBIA, Mariatou KONE, Alexis KOUADIO, Arsène Kra Kouassi, Serge NIANGORAN, Honoré OUANTCHI, Lazare SIKA, Séverine CARILLON, Maxime INGHELS, Joseph LARMARANGE

Psychometric validation techniques applied to the IND-VFQ-33 visual function questionnaire: the Hyderabad ocular morbidity in the elderly study (HOMES)

William Mitchell, Srinivas Marmamula, Nazlee Zebardast, Weiwen Ng, Joseph J. Locascio, Thirupathi Kumbam, Satya Brahmanandam, Navya Rekha Barrenkala

The STS case study: an analysis method for longitudinal qualitative research for implementation science

  • Open Access
  • Care
  • Research article

Jennifer M. Van Tiem, Heather Schacht Reisinger, Julia E. Friberg, Jaime R. Wilson, Lynn Fitzwater, Ralph J. Panos, Jane Moeckli

The unintended consequences of COVID-19 mitigation measures matter: practical guidance for investigating them

Anne-Marie Turcotte-Tremblay, Idriss Ali Gali Gali, Valéry Ridde

Revisiting methods for modeling longitudinal and survival data: Framingham Heart Study

  • Open Access
  • Research article

Julius S. Ngwa, Howard J. Cabral, Debbie M. Cheng, David R. Gagnon, Michael P. LaValley, L. Adrienne Cupples

Inferencing superspreading potential using zero-truncated negative binomial model: exemplification with COVID-19

Shi Zhao, Mingwang Shen, Salihu S. Musa, Zihao Guo, Jinjun Ran, Zhihang Peng, Yu Zhao, Marc K. C. Chong, Daihai He, Maggie H. Wang

Examining the effectiveness of telemonitoring with routinely acquired blood pressure data in primary care: challenges in the statistical analysis

  • Open Access
  • Care
  • Research article

Richard A. Parker, Paul Padfield, Janet Hanley, Hilary Pinnock, John Kennedy, Andrew Stoddart, Vicky Hammersley, Aziz Sheikh, Brian McKinstry

Conceptualising natural and quasi experiments in public health

Frank de Vocht, Srinivasa Vittal Katikireddi, Cheryl McQuire, Kate Tilling, Matthew Hickman, Peter Craig

There is still room for improvement in the completeness of abstract reporting according to the PRISMA-A checklist: a cross-sectional study on systematic reviews in periodontology

  • Open Access
  • Research article

Milagros Adobes Martin, Sala Santamans Faustino, Inmaculada Llario Almiñana, Riccardo Aiuto, Roberto Rotundo, Daniele Garcovich

Ensemble bootstrap methodology for forecasting dynamic growth processes using differential equations: application to epidemic outbreaks

Gerardo Chowell, Ruiyan Luo

Causal inference concepts applied to three observational studies in the context of vaccine development: from theory to practice

Emilia Gvozdenović, Lucio Malvisi, Elisa Cinconze, Stijn Vansteelandt, Phoebe Nakanwagi, Emmanuel Aris, Dominique Rosillon

Regression models for interval censored data using parametric pseudo-observations

Martin Nygård Johansen, Søren Lundbye-Christensen, Jacob Moesgaard Larsen, Erik Thorlund Parner

A framework for exploring non-response patterns over time in health surveys

  • Open Access
  • Research article

Famke J. M. Mölenberg, Chris de Vries, Alex Burdorf, Frank J. van Lenthe

Conducting household surveys on reproductive health in urban settings: lessons from Karachi, Pakistan

  • Open Access
  • Research article

Mir Baz Khan, Sidrah Nausheen, Imtiaz Hussain, Kristy Hackett, Kaneez Zehra, Khalid Feroze, David Canning, Iqbal Shah, Sajid Bashir Soofi

A scoping review of studies using observational data to optimise dynamic treatment regimens

Robert K. Mahar, Myra B. McGuinness, Bibhas Chakraborty, John B. Carlin, Maarten J. IJzerman, Julie A. Simpson

Body mass index changes: an assessment of the effects of age and gender using the e-norms method

  • Open Access
  • Obesity
  • Research article

Joe F. Jabre, Jeremy D.P. Bland

Using a distribution-based approach and systematic review methods to derive minimum clinically important differences

Jennifer A. Watt, Areti Angeliki Veroniki, Andrea C. Tricco, Sharon E. Straus

Analysis of clinical and methodological characteristics of early COVID-19 treatment clinical trials: so much work, so many lost opportunities

Beatrice Mainoli, Tiago Machado, Gonçalo S. Duarte, Luísa Prada, Nilza Gonçalves, Joaquim J. Ferreira, João Costa

A data visualisation method for assessing exposure misclassification in case-crossover studies: the example of tricyclic antidepressants and the risk of hip fracture in older people

Michael J. Leach, Elizabeth E. Roughead, Nicole L. Pratt

Design and implementation of a massive open online course on enhancing the recruitment of minorities in clinical trials – Faster Together

  • Open Access
  • Research article

Sheila V. Kusnoor, Victoria Villalta-Gil, Margo Michaels, Yvonne Joosten, Tiffany L. Israel, Marcia I. Epelbaum, Patricia Lee, Elizabeth T. Frakes, Jennifer Cunningham-Erves, Stephanie A. Mayers, Sarah C. Stallings, Nunzia B. Giuse, Paul A. Harris, Consuelo H. Wilkins

Minimal important difference and patient acceptable symptom state for pain, Constant-Murley score and Simple Shoulder Test in patients with subacromial pain syndrome

Kari Kanto, Tuomas Lähdeoja, Mika Paavola, Pasi Aronen, Teppo L. N. Järvinen, Jarkko Jokihaara, Clare L. Ardern, Teemu V. Karjalainen, Simo Taimela

Investigating psychometric properties of the arm activity measure – Thai version (ArmA-TH) sub‐scales using the Rasch model

Montana Buntragulpoontawee, Jeeranan Khunachiva, Patreeya Euawongyarti, Nahathai Wongpakaran, Tinakon Wongpakaran, Atcharee Kaewma, Stephen Ashford

Waist circumference prediction for epidemiological research using gradient boosted trees

Weihong Zhou, Spencer Eckler, Andrew Barszczyk, Alex Waese-Perlman, Yingjie Wang, Xiaoping Gu, Zhong-Ping Feng, Yuzhu Peng, Kang Lee

Reduction in number to treat versus number needed to treat

Chenyang Zhang, Guosheng Yin

Population segmentation of type 2 diabetes mellitus patients and its clinical applications - a scoping review

Jun Jie Benjamin Seng, Amelia Yuting Monteiro, Yu Heng Kwan, Sueziani Binte Zainudin, Chuen Seng Tan, Julian Thumboo, Lian Leng Low

Outbreaks of publications about emerging infectious diseases: the case of SARS-CoV-2 and Zika virus

Aziz Mert Ipekci, Diana Buitrago-Garcia, Kaspar Walter Meili, Fabienne Krauer, Nirmala Prajapati, Shabnam Thapa, Lea Wildisen, Lucia Araujo-Chaveron, Lukas Baumann, Sanam Shah, Tessa Whiteley, Gonzalo Solís-García, Foteini Tsotra, Ivan Zhelyazkov, Hira Imeri, Nicola Low, Michel Jacques Counotte

Measuring test-retest reliability (TRR) of AMSTAR provides moderate to perfect agreement – a contribution to the discussion of the importance of TRR in relation to the psychometric properties of assessment tools

  • Open Access
  • Research article

Stefanie Bühn, Peggy Ober, Tim Mathes, Uta Wegewitz, Anja Jacobs, Dawid Pieper

Estimating restricted mean survival time and expected life-years lost in the presence of competing risks within flexible parametric survival models

  • Open Access
  • Research article

Sarwar I. Mozumder, Mark J. Rutherford, Paul C. Lambert

Accounting for confounding by time, early intervention adoption, and time-varying effect modification in the design and analysis of stepped-wedge designs: application to a proposed study design to reduce opioid-related mortality

  • Open Access
  • Opioids
  • Research article

Lior Rennert, Moonseong Heo, Alain H. Litwin, Victor De Gruttola

Challenges, facilitators and barriers to screening study participants in early disease stages-experience from the MACUSTAR study

Jan Henrik Terheyden, Charlotte Behning, Anna Lüning, Ludmila Wintergerst, Pier G. Basile, Diana Tavares, Beatriz A. Melício, Sergio Leal, George Weissgerber, Ulrich F. O. Luhmann, David P. Crabb, Adnan Tufail, Carel Hoyng, Moritz Berger, Matthias Schmid, Rufino Silva, Cecília V. Martinho, José Cunha-Vaz, Frank G. Holz, Robert P. Finger, H. Agostini, F. Bandello, P. Basile, C. Behning, M. Berger, A. Binns, M. Böttger, C. Bouchet, J. E. Brazier, T. Butt, C. Carapezzi, J. Carlton, A. Carneiro, A. Charil, R. Coimbra, D. P. Crabb, J. Cunha-Vaz, C. Dahlke, H. Dunbar, M. Durbin, R. P. Finger, E. Fletcher, H. Floyd, R. Hogg, F. G. Holz, C. Hoyng, J. Krätzschmar, L. Kühlewein, M. Larsen, S. Leal, U. Luhmann, A. Lüning, C. Martinho, B. Melício, S. Mohand-Said, S. Nunes, M. Parravano, D. Pauleikhoff, M. Pfau, S. Pondorfer, S. Poor, S. Priglinger, D. Rowen, G. S. Rubin, J. Sahel, D. Sanches Fernandes, C. Sánchez, M. Saßmannshausen, M. Schmid, S. Schmitz-Valckenberg, H. Schrinner-Fenske, R. Silva, A. Skelly, E. Souied, G. Staurenghi, L. Stöhr, D. Tavares, D. J. Taylor, J. H. Terheyden, S. Thiele, A. Tufail, J. Werner, G. Weissgerber, L. Wintergerst, C. Wojek, N. Zakaria

Group testing can improve the cost-efficiency of prospective-retrospective biomarker studies

Wei Zhang, Zhiwei Zhang, Julia Krushkal, Aiyi Liu

Time dependent hazard ratio estimation using instrumental variables without conditioning on an omitted covariate

  • Open Access
  • Research article

Todd A. MacKenzie, Pablo Martinez-Camblor, A. James O’Malley

International representation of authors, editors and research in neurology journals

  • Open Access
  • Research article

Teodora Bojanic, Aidan Christopher Tan

Interrupted time series analysis using autoregressive integrated moving average (ARIMA) models: a guide for evaluating large-scale health interventions

Andrea L. Schaffer, Timothy A. Dobbins, Sallie-Anne Pearson

Estimates of the mean difference in orthopaedic randomized trials: obligatory yet obscure

Lauri Raittio, Antti Launonen, Ville M. Mattila, Aleksi Reito

Comparing the use of aggregate data and various methods of integrating individual patient data to network meta-analysis and its application to first-line ART

Steve Kanters, Mohammad Ehsanul Karim, Kristian Thorlund, Aslam H. Anis, Michael Zoratti, Nick Bansback

Recruiting general practitioners and patients with dementia into a cluster randomised controlled trial: strategies, barriers and facilitators

  • Open Access
  • Care
  • Research article

Sonia Lech, Julie L. O’Sullivan, Leonard Wellmann, Juliana Supplieth, Susanne Döpfmer, Paul Gellert, Adelheid Kuhlmey, Johanna Nordheim

Fast and optimal algorithm for case-control matching using registry data: application on the antibiotics use of colorectal cancer patients

Pavlos Mamouris, Vahid Nassiri, Geert Molenberghs, Marjan van den Akker, Joep van der Meer, Bert Vaes

Facilitating harmonized data quality assessments. A data quality framework for observational health research data collections with software implementations in R

  • Open Access
  • Research article

Carsten Oliver Schmidt, Stephan Struckmann, Cornelia Enzenbach, Achim Reineke, Jürgen Stausberg, Stefan Damerow, Marianne Huebner, Börge Schmidt, Willi Sauerbrei, Adrian Richter

Deep generative models in DataSHIELD

  • Open Access
  • Technical advance

Stefan Lenz, Moritz Hess, Harald Binder

Type I error control for cluster randomized trials under varying small sample structures

  • Open Access
  • Research article

Joshua R. Nugent, Ken P. Kleinman

Impact of comorbidity assessment methods to predict non-cancer mortality risk in cancer patients: a retrospective observational study using the National Health Insurance Service claims-based data in Korea

  • Open Access
  • Research article

Sanghee Lee, Yoon Jung Chang, Hyunsoon Cho

Comparative diagnostic accuracy studies with an imperfect reference standard – a comparison of correction methods

  • Open Access
  • Research article

Chinyereugo M. Umemneku Chikere, Kevin J. Wilson, A. Joy Allen, Luke Vale

A risk assessment tool for resumption of research activities during the COVID-19 pandemic for field trials in low resource settings

Suzanne M. Simkovich, Lisa M. Thompson, Maggie L. Clark, Kalpana Balakrishnan, Alejandra Bussalleu, William Checkley, Thomas Clasen, Victor G. Davila-Roman, Anaite Diaz-Artiga, Ephrem Dusabimana, Lisa de las Fuentes, Steven Harvey, Miles A. Kirby, Amy Lovvorn, Eric D. McCollum, Erick E. Mollinedo, Jennifer L. Peel, Ashlinn Quinn, Ghislaine Rosa, Lindsay J. Underhill, Kendra N. Williams, Bonnie N. Young, Joshua Rosenthal, Vigneswari Aravindalochanan, Kalpana Balakrishnan, Dana Boyd Barr, Vanessa Burrowes, Devan Campbell, Julia Mc Peek Campbell, Eduardo Canuz, Adly Castañaza, Howard Chang, William Checkley, Yunyun Chen, Marilú Chiang, Maggie L. Clark, Thomas Clasen, Rachel Craik, Mary Crocker, Victor Dávila-Román, Lisa de las Fuentes, Oscar De Léon, Anaité Diaz-Artiga, Ephrem Dusabimana, Lisa Elon, Juan Gabriel Espinoza, Irma Sayury Pineda Fuentes, Sarada Garg, Dina Goodman, Savannah Gupton, Meghan Hardison, Stella Hartinger, Steven A. Harvey, Mayari Hengstermann, Phabiola Herrera, Shakir Hossen, Penelope Howards, Lindsay Jaacks, Shirin Jabbarzadeh, Michael A. Johnson, Abigail Jones, Katherine Kearns, Miles Kirby, Jacob Kremer, Margaret Laws, Patricia M. Lenzen, Jiawen Liao, Amy Lovvorn, Fiona Majorin, Eric McCollum, John P. McCracken, Rachel M. Meyers, J. Jaime Miranda, Erick Mollinedo, Lawrence Moulton, Krishnendu Mukhopadhyay, Luke Naeher, Abidan Nambajimana, Florien Ndagijimana, Azhar Nizam, Jean de Dieu Ntivuguruzwa, Aris Papageorghiou, Jennifer Peel, Ricardo Piedrahita, Ajay Pillarisetti, Naveen Puttaswamy, Elisa Puzzolo, Ashlinn Quinn, Sarah Rajkumar, Usha Ramakrishnan, Davis Reardon, Ghislaine Rosa, Joshua Rosenthal, P. Barry Ryan, Zoe Sakas, Sankar Sambandam, Jeremy Sarnat, Suzanne Simkovich, Sheela Sinharoy, Kirk R. Smith, Kyle Steenland, Damien Swearing, Gurusamy Thangavel, Lisa M. Thompson, Ashley K. Toenjes, Lindsay Underhill, Jean Damascene Uwizeyimana, Viviane Valdes, Amit Verma, Lance Waller, Megan Warnock, Kendra Williams, Wenlu Ye, Bonnie N. Young

Phase I dose-escalation oncology trials with sequential multiple schedules

Burak Kürsad Günhan, Sebastian Weber, Abdelkader Seroutou, Tim Friede

The impact of grey zones on the accuracy of agreement measures for ordinal tables

  • Open Access
  • Research article

Quoc Duyet Tran, Anil Dolgun, Haydar Demirhan

Investigating factors affecting the interval between a burn and the start of treatment using data mining methods and logistic regression

Touraj Ahmadi-Jouybari, Somayeh Najafi-Ghobadi, Reza Karami-Matin, Saeid Najafian-Ghobadi, Khadijeh Najafi-Ghobadi,

A review of the use of controlled multiple imputation in randomised controlled trials with missing outcome data

  • Open Access
  • Research article

Ping-Tee Tan, Suzie Cro, Eleanor Van Vogt, Matyas Szigeti, Victoria R. Cornelius

A demonstration of using formal consensus methods within guideline development; a case study

  • Open Access
  • Research article

P. Carter, K. J. M. O’Donoghue, K. Dworzynski, L. O’Shea, V. Roberts, T. Reeves, A. Bastounis, M. A. Mugglestone, J. Fawke, S. Pilling

Utilizing machine learning dimensionality reduction for risk stratification of chest pain patients in the emergency department

  • Open Access
  • Research article

Nan Liu, Marcel Lucas Chee, Zhi Xiong Koh, Su Li Leow, Andrew Fu Wah Ho, Dagang Guo, Marcus Eng Hock Ong

Intention-to-treat analysis may be more conservative than per protocol analysis in antibiotic non-inferiority trials: a systematic review

Anthony D. Bai, Adam S. Komorowski, Carson K. L. Lo, Pranav Tandon, Xena X. Li, Vaibhav Mokashi, Anna Cvetkovic, Aidan Findlater, Laurel Liang, George Tomlinson, Mark Loeb, Dominik Mertz

Guidelines are needed for studies of pre-treatment HIV drug resistance: a methodological study

Lawrence Mbuagbaw, Clémence Ongolo-Zogo, Olivia C. Mendoza, Babalwa Zani, Frederick Morfaw, Agatha Nyambi, Annie Wang, Michel Kiflen, Hussein El-Kechen, Alvin Leenus, Mark Youssef, Nadia Rehman, Lucas Hermans, Virginia MacDonald, Silvia Bertagnolio

Characteristics and patient-reported outcomes associated with dropout in severely affected oncological patients: an exploratory study

  • Open Access
  • Research article

Pimrapat Gebert, Daniel Schindel, Johann Frick, Liane Schenk, Ulrike Grittner

Generative adversarial networks for imputing missing data for big data clinical research

  • Open Access
  • Research article

Weinan Dong, Daniel Yee Tak Fong, Jin-sun Yoon, Eric Yuk Fai Wan, Laura Elizabeth Bedford, Eric Ho Man Tang, Cindy Lo Kuen Lam

Growth mixture models: a case example of the longitudinal analysis of patient‐reported outcomes data captured by a clinical registry

Jae-Yung Kwon, Richard Sawatzky, Jennifer Baumbusch, Sandra Lauck, Pamela A. Ratner

Shifting research culture to address the mismatch between where trials recruit and where populations with the most disease live: a qualitative study

  • Open Access
  • Research article

Tanvi Rai, Sharon Dixon, Sue Ziebland

The use of experimental vignette studies to identify drivers of variations in the delivery of health care: a scoping review

  • Open Access
  • Care
  • Research article

Jessica Sheringham, Isla Kuhn, Jenni Burt

Instruments to measure fear of COVID-19: a diagnostic systematic review

Ashley Elizabeth Muller, Jan Peter William Himmels, Stijn Van de Velde

LASSO type penalized spline regression for binary data

Muhammad Abu Shadeque Mullah, James A. Hanley, Andrea Benedetti

Direct modelling of age standardized marginal relative survival through incorporation of time-dependent weights

Paul C. Lambert, Elisavet Syriopoulou, Mark R. Rutherford

Development of a temporally harmonized asset index: evidence from across 50 years of follow up of a birth cohort in Guatemala

  • Open Access
  • Research article

Jithin Sam Varghese, John A. Maluccio, Solveig A. Cunningham, Manuel Ramirez-Zea, Aryeh D. Stein

Neutral theory: applicability and neutrality of using generic health-related quality of life tools in diseases or conditions where specific tools are available

  • Open Access
  • Research article

Ravi Jandhyala

Using logic regression to characterize extreme heat exposures and their health associations: a time-series study of emergency department visits in Atlanta

Shan Jiang, Joshua L. Warren, Noah Scovronick, Shannon E. Moss, Lyndsey A. Darrow, Matthew J. Strickland, Andrew J. Newman, Yong Chen, Stefanie T. Ebelt, Howard H. Chang

Crowdsourcing citation-screening in a mixed-studies systematic review: a feasibility study

  • Open Access
  • Research article

Anna H. Noel-Storr, Patrick Redmond, Guillaume Lamé, Elisa Liberati, Sarah Kelly, Lucy Miller, Gordon Dooley, Andy Paterson, Jenni Burt

A systematic review of the quality of conduct and reporting of survival analyses of tuberculosis outcomes in Africa

Moses M. Ngari, Susanne Schmitz, Christopher Maronga, Lazarus K. Mramba, Michel Vaillant

Data quality assessment and subsampling strategies to correct distributional bias in prevalence studies

  • Open Access
  • Technical advance

A. D’Ambrosio, J. Garlasco, F. Quattrocolo, C. Vicentini, C. M. Zotti

Clinical research activities during COVID-19: the point of view of a promoter of academic clinical trials

Linda Valmorri, Bernadette Vertogen, Chiara Zingaretti, Anna Miserocchi, Roberta Volpi, Alberto Clemente, Isabella Bondi, Irene Valli, Britt Rudnas, Giovanni Martinelli, Oriana Nanni

Stakeholder-engaged process for refining the design of a clinical trial in home hospice

  • Open Access
  • Research article

Jennifer Tjia, Margaret Clayton, Germán Chiriboga, Brooke Staples, Geraldine Puerto, Lynley Rappaport, Susan DeSanto-Madeya

Sampling strategies to evaluate the prognostic value of a new biomarker on a time-to-event end-point

Francesca Graziano, Maria Grazia Valsecchi, Paola Rebora

Database selection and data gathering methods in systematic reviews of qualitative research regarding diabetes mellitus - an explorative study

Tobias Justesen, Josefine Freyberg, Anders N. Ø. Schultz

Intra-database validation of case-identifying algorithms using reconstituted electronic health records from healthcare claims data

Nicolas H. Thurin, Pauline Bosco-Levy, Patrick Blin, Magali Rouyer, Jérémy Jové, Stéphanie Lamarque, Séverine Lignot, Régis Lassalle, Abdelilah Abouelfath, Emmanuelle Bignon, Pauline Diez, Marine Gross-Goupil, Michel Soulié, Mathieu Roumiguié, Sylvestre Le Moulec, Marc Debouverie, Bruno Brochet, Francis Guillemin, Céline Louapre, Elisabeth Maillart, Olivier Heinzlef, Nicholas Moore, Cécile Droz-Perroteau

Application of machine learning in predicting hospital readmissions: a scoping review of the literature

  • Open Access
  • Research article

Yinan Huang, Ashna Talwar, Satabdi Chatterjee, Rajender R. Aparasu

Dealing with missing delirium assessments in prospective clinical studies of the critically ill: a simulation study and reanalysis of two delirium studies

Rameela Raman, Wencong Chen, Michael O. Harhay, Jennifer L. Thompson, E. Wesley Ely, Pratik P. Pandharipande, Mayur B. Patel

Evaluation by simulation of clinical trial designs for evaluation of treatment during a viral haemorrhagic fever outbreak

  • Open Access
  • Research article

Pauline Manchon, Drifa Belhadi, France Mentré, Cédric Laouénan

Using the geometric average hazard ratio in sample size calculation for time-to-event data with composite endpoints

  • Open Access
  • Research

Jordi Cortés Martínez, Ronald B. Geskus, KyungMann Kim, Guadalupe Gómez Melis

A strategy for optimal fitting of multiplicative and additive hazards regression models

François Lefebvre, Roch Giorgi

Quality assessment tools used in systematic reviews of in vitro studies: A systematic review

  • Open Access
  • Research article

Linh Tran, Dao Ngoc Hien Tam, Abdelrahman Elshafay, Thao Dang, Kenji Hirayama, Nguyen Tien Huy

Using random forests to model 90-day hometime in people with stroke

Jessalyn K. Holodinsky, Amy Y. X. Yu, Moira K. Kapral, Peter C. Austin

How to specify healthcare process improvements collaboratively using rapid, remote consensus-building: a framework and a case study of its application

  • Open Access
  • COVID-19
  • Technical advance

Jan W. van der Scheer, Matthew Woodward, Akbar Ansari, Tim Draycott, Cathy Winter, Graham Martin, Karolina Kuberska, Natalie Richards, Ruth Kern, Mary Dixon-Woods, André Sartori, Andy Paterson, Doro Unger-Lee, Joann Leeding, Luke Steer, Amanda Andrews, Rita Arya, Sarah F. Bell, Denise Chaffer, Andrew Cooney, Rachel Corry, Mair G. P. Davies, Lisa Duffy, Caroline Everden, Theresa Fitzpatrick, Courtney Grant, Mark Hellaby, Tracey A. Herlihey, Sue Hignett, Sarah Hookes, Fran R. Ives, Gyuchan T. Jun, Owen J. Marsh, Tanya R. Matthews, Celine McKeown, Alexandra Merriman, Giulia Miles, Susan Millward, Neil Muchatata, David Newton, Valerie G. Noble, Pamela Page, Vincent Pargade, Sharon P. Pickering, Laura Pickup, Dale Richards, Cerys Scarr, Jyoti Sidhu, James Stevenson, Ben Tipney, Stephen Tipper, Jo Wailling, Susan P. Whalley-Lloyd, Christian Wilhelm, Juliet J. Wood

Dynamic prediction based on variability of a longitudinal biomarker

Kristen R. Campbell, Rui Martins, Scott Davis, Elizabeth Juarez-Colunga

A population‐based study to develop juvenile arthritis case definitions for administrative health data using model‐based dynamic classification

Allison Feely, Lily SH Lim, Depeng Jiang, Lisa M. Lix

Methodology of the DCCSS later fatigue study: a model to investigate chronic fatigue in long-term survivors of childhood cancer

Adriaan Penson, Sylvia van Deuren, Ewald Bronkhorst, Ellen Keizer, Tom Heskes, Marieke J. H. Coenen, Judith G. M. Rosmalen, Wim J. E. Tissing, Helena J. H. van der Pal, Andrica C. H. de Vries, Marry M. van den Heuvel-Eibrink, Sebastian Neggers, Birgitta A. B. Versluys, Marloes Louwerens, Margriet van der Heiden-van der Loo, Saskia M. F. Pluijm, Martha Grootenhuis, Nicole Blijlevens, Leontien C. M. Kremer, Eline van Dulmen-den Broeder, Hans Knoop, Jacqueline Loonen

Classifying information-sharing methods

  • Open Access
  • Research article

Georgios F. Nikolaidis, Beth Woods, Stephen Palmer, Marta O. Soares

Classification of PR-positive and PR-negative subtypes in ER-positive and HER2-negative breast cancers based on pathway scores

Taobo Hu, Yan Chen, Yiqiang Liu, Danhua Zhang, Jiankang Pan, Mengping Long

Applied comparison of large‐scale propensity score matching and cardinality matching for causal inference in observational research

  • Open Access
  • Research article

Stephen P. Fortin, Stephen S Johnston, Martijn J Schuemie

Randomized test-treatment studies with an outlook on adaptive designs

Amra Hot, Patrick M. Bossuyt, Oke Gerke, Simone Wahl, Werner Vach, Antonia Zapf

IPDfromKM: reconstruct individual patient data from published Kaplan-Meier survival curves

  • Open Access
  • Software

Na Liu, Yanhong Zhou, J. Jack Lee

An ego-centred approach for the evaluation of spatial effects on health in urban areas based on parametric semi-variogram models: concept and validation

  • Open Access
  • Research

Odile Sauzet, Janne H. Breiding, Kim A. Zolitschka, Jürgen Breckenkamp, Oliver Razum

A method for assessing robustness of the results of a star-shaped network meta-analysis under the unidentifiable consistency assumption

  • Open Access
  • Technical advance

Jeong-Hwa Yoon, Sofia Dias, Seokyung Hahn

Incorporating single-arm studies in meta-analysis of randomised controlled trials: a simulation study

  • Open Access
  • Research

Janharpreet Singh, Keith R. Abrams, Sylwia Bujkiewicz

Validity of using mobile phone surveys to evaluate community health worker program in Mali

  • Open Access
  • Research article

Xiaomeng Chen, Diwakar Mohan, Abdoulaye Maïga, Emily Frost, Djeneba Coulibaly, Luay Basil, Birahim Yaguemar Gueye, Mariam Traore Guindo, Assa Sidibé Keita, Haoua Dembelé Keita, Melissa A. Marx

Discovering the underlying typology of emergency departments

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Marine Demarquet, Laurie Fraticelli, Julie Freyssenge, Clément Claustre, Mikaël Martinez, Jonathan Duchenne, Carlos El Khoury, Abdesslam Redjaline, Karim Tazarourte

Open science saves lives: lessons from the COVID-19 pandemic

Lonni Besançon, Nathan Peiffer-Smadja, Corentin Segalas, Haiting Jiang, Paola Masuzzo, Cooper Smout, Eric Billy, Maxime Deforet, Clémence Leyrat

Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age

Aurélie Piedvache, Stef van Buuren, Henrique Barros, Ana Isabel Ribeiro, Elizabeth Draper, Jennifer Zeitlin, E. Martens, G. Martens, P. Van Reempts, K. Boerch, A. Hasselager, L. D. Huusom, O. Pryds, T. Weber, L. Toome, H. Varendi, Ile-de France, P. Y. Ancel, B. Blondel, A. Burguet, P. H. Jarreau, P. Truffert, R. F. Maier, B. Misselwitz, S. Schmidt, L. Gortner, D. Baronciani, G. Gargano, R. Agostino, D. DiLallo, F. Franco, V. Carnielli, C. Koopman-Esseboom, A. van Heijst, J. Nijman, J. Gadzinowski, J. Mazela, L. M. Graça, M. C. Machado, Carina Rodrigues, T. Rodrigues, A. K. Bonamy, M. Norman, E. Wilson E Boyle, E. S. Draper, B. N. Manktelow, A. C. Fenton, D. W. A. Milligan, J. Zeitlin, M. Bonet, A. Piedvache

Social media attention and citations of published outputs from re-use of clinical trial data: a matched comparison with articles published in the same journals

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N. Anthony, C. Pellen, C. Ohmann, D. Moher, F. Naudet

Delays in reporting and publishing trial results during pandemics: cross sectional analysis of 2009 H1N1, 2014 Ebola, and 2016 Zika clinical trials

Christopher W. Jones, Amanda C. Adams, Elizabeth Murphy, Rachel P. King, Benjamin Saracco, Karen R. Stesis, Susan Cavanaugh, Brian W. Roberts, Timothy F. Platts-Mills

Development of a clinical tool for rating the body function categories of the ICF generic-30/rehabilitation set in Japanese rehabilitation practice and examination of its interrater reliability

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Yuki Senju, Masahiko Mukaino, Birgit Prodinger, Melissa Selb, Yuki Okouchi, Kouji Mizutani, Megumi Suzuki, Shin Yamada, Shin-Ichi Izumi, Shigeru Sonoda, Yohei Otaka, Eiichi Saitoh, Gerold Stucki

Systematic review and meta analysis of differential attrition between active and control arms in randomized controlled trials of lifestyle interventions in chronic disease

Bevens W, Shoushtari A, Jelinek P, Jelinek GA, Weiland TJ

Most published meta-regression analyses based on aggregate data suffer from methodological pitfalls: a meta-epidemiological study

Michael Geissbühler, Cesar A. Hincapié, Soheila Aghlmandi, Marcel Zwahlen, Peter Jüni, Bruno R. da Costa

Modelling hospital outcome: problems with endogeneity

  • Open Access
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John L. Moran, John D. Santamaria, Graeme J. Duke

A scoping review of Q-methodology in healthcare research

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Kate Churruca, Kristiana Ludlow, Wendy Wu, Kate Gibbons, Hoa Mi Nguyen, Louise A. Ellis, Jeffrey Braithwaite

Estimating age-specific COVID-19 fatality risk and time to death by comparing population diagnosis and death patterns: Australian data

Ian C. Marschner

Development and validation of a risk index to predict kidney graft survival: the kidney transplant risk index

  • Open Access
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Sameera Senanayake, Sanjeewa Kularatna, Helen Healy, Nicholas Graves, Keshwar Baboolal, Matthew P. Sypek, Adrian Barnett

The minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation

  • Open Access
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Antoine Vanier, Véronique Sébille, Myriam Blanchin, Jean-Benoit Hardouin

Psychometric properties of instruments to measure parenting practices and children’s movement behaviors in low-income families from Brazil

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Widjane Sheila Ferreira Goncalves, Rebecca Byrne, Pedro Israel Cabral de Lira, Marcelo Tavares Viana, Stewart G. Trost

How to analyze work productivity loss due to health problems in randomized controlled trials? A simulation study

  • Open Access
  • Technical advance

Wei Zhang, Huiying Sun

The INSPIRE Population Survey: development, dissemination and respondent characteristics

  • Open Access
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Flaka Siqeca, Katrina Obas, Olivia Yip, Samuel Stenz, Penelope Vounatsou, Matthias Briel, Matthias Schwenkglenks, Carlos Quinto, Eva Blozik, Andreas Zeller, Leah L. Zullig, Sabina De Geest, Mieke Deschodt

Multiple imputation to quantify misclassification in observational studies of the cognitively impaired: an application for pain assessment in nursing home residents

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Anthony P. Nunes, Danni Zhao, William M. Jesdale, Kate L. Lapane

Strengthening methods for tracking adaptations and modifications to implementation strategies

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Amber D. Haley, Byron J. Powell, Callie Walsh-Bailey, Molly Krancari, Inga Gruß, Christopher M. Shea, Arwen Bunce, Miguel Marino, Leah Frerichs, Kristen Hassmiller Lich, Rachel Gold

Comparison of six statistical methods for interrupted time series studies: empirical evaluation of 190 published series

Simon L. Turner, Amalia Karahalios, Andrew B. Forbes, Monica Taljaard, Jeremy M. Grimshaw, Joanne E. McKenzie

Risk prediction in multicentre studies when there is confounding by cluster or informative cluster size

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Menelaos Pavlou, Gareth Ambler, Rumana Z. Omar

Noncollapsibility and its role in quantifying confounding bias in logistic regression

Noah A. Schuster, Jos W. R. Twisk, Gerben ter Riet, Martijn W. Heymans, Judith J. M. Rijnhart

Bayesian updating: increasing sample size during the course of a study

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Mirjam Moerbeek

Comparing regression modeling strategies for predicting hometime

Jessalyn K. Holodinsky, Amy Y. X. Yu, Moira K. Kapral, Peter C. Austin

Consequences of ignoring clustering in linear regression

Georgia Ntani, Hazel Inskip, Clive Osmond, David Coggon

Managing overlap of primary study results across systematic reviews: practical considerations for authors of overviews of reviews

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Carole Lunny, Dawid Pieper, Pierre Thabet, Salmaan Kanji

Translation, transcultural adaptation and validation to Brazilian Portuguese of tools for adverse drug reaction assessment in children

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Elisangela da Costa Lima, Thais de Barros Fernandes, Adair Freitas, Juliana Freire de Lima Sias, Marcelo Gerardin Poirot Land, Mariana Tschoepke Aires, Louise Bracken, Matthew Peak

Evaluating the relationship between citation set size, team size and screening methods used in systematic reviews: a cross-sectional study

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Katie O’Hearn, Cameron MacDonald, Anne Tsampalieros, Leo Kadota, Ryan Sandarage, Supun Kotteduwa Jayawarden, Michele Datko, John M. Reynolds, Thanh Bui, Shagufta Sultan, Margaret Sampson, Misty Pratt, Nick Barrowman, Nassr Nama, Matthew Page, James Dayre McNally

RITS: a toolbox for assessing complex interventions via interrupted time series models

Maricela Cruz, Marco A. Pinto-Orellana, Daniel L. Gillen, Hernando C. Ombao

A new likelihood model for analyses of pharmacoepidemiologic case–control studies which avoids decision rules for determining latent exposure status

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Henrik Støvring, Anton Pottegård, Jesper Hallas

Survey design and analysis considerations when utilizing misclassified sampling strata

  • Open Access
  • Research article

Aya A. Mitani, Nathaniel D. Mercaldo, Sebastien Haneuse, Jonathan S. Schildcrout

Absolute mortality risk assessment of COVID-19 patients: the Khorshid COVID Cohort (KCC) study

Hamid Reza Marateb, Maja von Cube, Ramin Sami, Shaghayegh Haghjooy Javanmard, Marjan Mansourian, Babak Amra, Forogh Soltaninejad, Mojgan Mortazavi, Peyman Adibi, Nilufar Khademi, Nastaran Sadat Hosseini, Arash Toghyani, Razieh Hassannejad, Miquel Angel Mañanas, Harald Binder, Martin Wolkewitz

Need of care in interpreting Google Trends-based COVID-19 infodemiological study results: potential risk of false-positivity

Kenichiro Sato, Tatsuo Mano, Atsushi Iwata, Tatsushi Toda

Multivariate meta-analysis of critical care meta-analyses: a meta-epidemiological study

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  • Care
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John L. Moran

Assessing the risk of performance and detection bias in Cochrane reviews as a joint domain is less accurate compared to two separate domains

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Ognjen Barcot, Matija Boric, Svjetlana Dosenovic, Livia Puljak

Statistical analysis of two arm randomized pre-post designs with one post-treatment measurement

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Fei Wan

High performance implementation of the hierarchical likelihood for generalized linear mixed models: an application to estimate the potassium reference range in massive electronic health records datasets

  • Open Access
  • Technical advance

Cristian G. Bologa, Vernon Shane Pankratz, Mark L. Unruh, Maria Eleni Roumelioti, Vallabh Shah, Saeed Kamran Shaffi, Soraya Arzhan, John Cook, Christos Argyropoulos

Characteristics and practices of school-based cluster randomised controlled trials for improving health outcomes in pupils in the United Kingdom: a methodological systematic review

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Kitty Parker, Michael Nunns, ZhiMin Xiao, Tamsin Ford, Obioha C. Ukoumunne

A multiyear systematic survey of the quality of reporting for randomised trials in dentistry, neurology and geriatrics published in journals of Spain and Latin America

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Vivienne C. Bachelet, María S. Navarrete, Constanza Barrera-Riquelme, Víctor A. Carrasco, Matías Dallaserra, Rubén A. Díaz, Álvaro A. Ibarra, Francisca J. Lizana, Nicolás Meza-Ducaud, Macarena G. Saavedra, Camila Tapia-Davegno, Alonso F. Vergara, Julio Villanueva

Overcoming the problems caused by collinearity in mixed-effects logistic model: determining the contribution of various types of violence on depression in pregnant women

Sanaz Khalili, Javad Faradmal, Hossein Mahjub, Babak Moeini, Khadijeh Ezzati-Rastegar

A new hybrid record linkage process to make epidemiological databases interoperable: application to the GEMO and GENEPSO studies involving BRCA1 and BRCA2 mutation carriers

  • Open Access
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Yue Jiao, Fabienne Lesueur, Chloé-Agathe Azencott, Maïté Laurent, Noura Mebirouk, Lilian Laborde, Juana Beauvallet, Marie-Gabrielle Dondon, Séverine Eon-Marchais, Anthony Laugé, Nadia Boutry-Kryza, Alain Calender, Sophie Giraud, Mélanie Léone, Brigitte Bressac-de-Paillerets, Olivier Caron, Marine Guillaud-Bataille, Yves-Jean Bignon, Nancy Uhrhammer, Valérie Bonadona, Christine Lasset, Pascaline Berthet, Laurent Castera, Dominique Vaur, Violaine Bourdon, Catherine Noguès, Tetsuro Noguchi, Cornel Popovici, Audrey Remenieras, Hagay Sobol, Isabelle Coupier, Pierre-Olivier Harmand, Pascal Pujol, Paul Vilquin, Aurélie Dumont, Françoise Révillion, Danièle Muller, Emmanuelle Barouk-Simonet, Françoise Bonnet, Virginie Bubien, Michel Longy, Nicolas Sévenet, Laurence Gladieff, Rosine Guimbaud, Viviane Feillel, Christine Toulas, Hélène Dreyfus, Dominique Leroux, Magalie Peysselon, Christine Rebischung, Amandine Baurand, Geoffrey Bertolone, Fanny Coron, Laurence Faivre, Vincent Goussot, Caroline Jacquot, Caroline Sawka, Caroline Kientz, Marine Lebrun, Fabienne Prieur, Sandra Fert-Ferrer, Véronique Mari, Laurence Vénat-Bouvet, Stéphane Bézieau, Capucine Delnatte, Isabelle Mortemousque, Florence Coulet, Florent Soubrier, Mathilde Warcoin, Myriam Bronner, Sarab Lizard, Johanna Sokolowska, Marie-Agnès Collonge-Rame, Alexandre Damette, Paul Gesta, Hakima Lallaoui, Jean Chiesa, Denise Molina-Gomes, Olivier Ingster, Sylvie Manouvrier-Hanu, Sophie Lejeune, Catherine Noguès, Lilian Laborde, Pauline Pontois, Dominique Stoppa-Lyonnet, Marion Gauthier-Villars, Bruno Buecher, Olivier Caron, Emmanuelle Mouret-Fourme, Jean-Pierre Fricker, Christine Lasset, Valérie Bonadona, Pascaline Berthet, Laurence Faivre, Elisabeth Luporsi, Marc Frénay, Laurence Gladieff, Paul Gesta, Hagay Sobol, François Eisinger, Jessica Moretta, Michel Longy, Catherine Dugast, Chrystelle Colas, Florent Soubrier, Isabelle Coupier, Pascal Pujol, Alain Lortholary, Philippe Vennin, Claude Adenis, Tan Dat Nguyen, Capucine Delnatte, Annick Rossi, Julie Tinat, Isabelle Tennevet, Jean-Marc Limacher, Christine Maugard, Yves-Jean Bignon, Liliane Demange, Hélène Dreyfus, Odile Cohen-Haguenauer, Brigitte Gilbert, Dominique Leroux, Hélène Zattara-Cannoni, Catherine Noguès, Nadine Andrieu, Dominique Stoppa-Lyonnet, Sandrine M. Caputo

Correction to: How to specify healthcare process improvements collaboratively using rapid, remote consensus-building: a frame work and a case study of its application

  • Open Access
  • Correction

Jan W. van der Scheer, Matthew Woodward, Akbar Ansari, Tim Draycott, Cathy Winter, Graham Martin, Karolina Kuberska, Natalie Richards, Ruth Kern, Mary Dixon-Woods

A new method for testing reproducibility in systematic reviews was developed, but needs more testing

  • Open Access
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Dawid Pieper, Simone Heß, Clovis Mariano Faggion Jr.

Machine learning in medicine: a practical introduction to natural language processing

Conrad J. Harrison, Chris J. Sidey-Gibbons

Use of machine learning techniques to identify HIV predictors for screening in sub-Saharan Africa

Charles K. Mutai, Patrick E. McSharry, Innocent Ngaruye, Edouard Musabanganji

Central data monitoring in the multicentre randomised SafeBoosC-III trial – a pragmatic approach

  • Open Access
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Markus Harboe Olsen, Mathias Lühr Hansen, Sanam Safi, Janus Christian Jakobsen, Gorm Greisen, Christian Gluud, Adelina Pellicer, Agata Bargiel, Andrew Hopper, Anita Truttmann, Anja Klamer, Anne Marie Heuchan, Asli Memisoglu, Barbara Krolak-Olejnik, Beata Rzepecka, Bergona Loureiro, Chantal Lecart, Cornelia Hagmann, Ebru Ergenekon, Eleftheria Hatzidaki, Emmanuele Mastretta, Eugene Dempsey, Evangelina Papathoma, Fang Lou, Gabriel Dimitriou, Gerhard Pichler, Giovanni Vento, Gitte Holst Hahn, Gunnar Naulaers, Guoqiang Cheng, Hans Fuchs, Hilal Ozkan, Isabel De Las Cuevas, Iwona Sadowska-Krawczenko, Jakub Tkaczyk, Jan Sirc, Jinhua Zhang, Jonathan Mintzer, Julie De Buyst, Karen McCall, Klaudiusz Bober, Kosmas Sarafidis, Lars Bender, Laura Serrano Lopez, Lina Chalak, Ling Yang, Luc Cornette, Luis Arruza, Mariana Baserga, Martin Stocker, Massimo Agosti, Merih Cetinkaya, Miguel Alsina, Monica Fumagalli, Olalla Lóepez Suarez, Olalla Otero, Olivier Baud, Pamela Zafra, Peter Agergaard, Pierre Maton, Renaud Viellevoye, Ruth del Rio Florentino, Ryszard Lauterbach, Salvador Piris Borregas, Saudamini Nesargi, Segundo Rite, Shashidhar Rao, Shujuan Zeng, Silvia Pisoni, Simon Hyttel-Sørensen, Siv Fredly, Suna Oguz, Tanja Karen, Tomasz Szczapa, Xiaoyan Gao, Xin Xu, Zhaoqing Yin

Predisposing factors of long-term responsiveness in a cardio-metabolic cohort: Tehran Lipid and Glucose Study

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Leila Cheraghi, Parisa Amiri, Golnaz Vahedi-Notash, Sara Jalali-Farahani, Davood Khalili, Fereidoun Azizi

Comparison of prevalence and exposure-disease associations using self-report and hospitalization data among enrollees of the world trade center health registry

Howard E. Alper, Jennifer Brite, James E. Cone, Robert M. Brackbill

Hospital workers mental health during the COVID-19 pandemic: methods of data collection and characteristics of study sample in a university hospital in Milan (Italy)

A Fattori, F Cantù, A Comotti, V Tombola, E Colombo, C Nava, L Bordini, L Riboldi, M Bonzini, P Brambilla

Quantifying and communicating the burden of COVID-19

Maja von Cube, Jéan-Francois Timsit, Andreas Kammerlander, Martin Schumacher

Negative SARS-CoV-2 PCR or rapid antigen test result and the subsequent risk of being infectious: a mathematical simulation study

Ralf Krumkamp, Benno Kreuels, Veronika K. Jaeger, Jürgen May, Rafael Mikolajczyk, André Karch

Symptom clusters among cancer survivors: what can machine learning techniques tell us?

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Koen I. Neijenhuijs, Carel F. W. Peeters, Henk van Weert, Pim Cuijpers, Irma Verdonck-de Leeuw

Evaluation of a geriatrics primary care model using prospective matching to guide enrollment

  • Open Access
  • Care
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Valerie A. Smith, Courtney Harold Van Houtven, Jennifer H. Lindquist, Susan N. Hastings

A roadmap to using randomization in clinical trials

  • Open Access
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Vance W. Berger, Louis Joseph Bour, Kerstine Carter, Jonathan J. Chipman, Colin C. Everett, Nicole Heussen, Catherine Hewitt, Ralf-Dieter Hilgers, Yuqun Abigail Luo, Jone Renteria, Yevgen Ryeznik, Oleksandr Sverdlov, Diane Uschner, Robert A Beckman

Creating efficiencies in the extraction of data from randomized trials: a prospective evaluation of a machine learning and text mining tool

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Allison Gates, Michelle Gates, Shannon Sim, Sarah A. Elliott, Jennifer Pillay, Lisa Hartling

Modeling of atrophy size trajectories: variable transformation, prediction and age-of-onset estimation

Charlotte Behning, Monika Fleckenstein, Maximilian Pfau, Christine Adrion, Lukas Goerdt, Moritz Lindner, Steffen Schmitz-Valckenberg, Frank G Holz, Matthias Schmid

Bayesian Hodges-Lehmann tests for statistical equivalence in the two-sample setting: Power analysis, type I error rates and equivalence boundary selection in biomedical research

  • Open Access
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Riko Kelter

Using web conferencing to engage Aboriginal and Torres Strait Islander young people in research: a feasibility study

  • Open Access
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Kate Anderson, Alana Gall, Tamara Butler, Brian Arley, Kirsten Howard, Alan Cass, Gail Garvey

Two-stage sampling in the estimation of growth parameters and percentile norms: sample weights versus auxiliary variable estimation

  • Open Access
  • Article

George Vamvakas, Courtenay Norbury, Andrew Pickles

Correction to: Applied comparison of large-scale propensity score matching and cardinality matching for causal inference in observational research

  • Open Access
  • Correction

Stephen P. Fortin, Stephen S. Johnston, Martijn J. Schuemie

Use of research electronic data capture (REDCap) in a COVID-19 randomized controlled trial: a practical example

Sina Kianersi, Maya Luetke, Christina Ludema, Alexander Valenzuela, Molly Rosenberg

The effect of home visits as an additional recruitment step on the composition of the final sample: a cross-sectional analysis in two study centers of the German National Cohort (NAKO)

  • Open Access
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Lilian Krist, Ahmed Bedir, Julia Fricke, Alexander Kluttig, Rafael Mikolajczyk

Impact of a non-constant baseline hazard on detection of time-dependent treatment effects: a simulation study

  • Open Access
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Kim Jachno, Stephane Heritier, Rory Wolfe

Recruitment principles and strategies for supportive care research in pediatric oncology

  • Open Access
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Natalie Bradford, Christine Cashion, Paula Condon, Shelley Rumble, Alison Bowers

Predicting postoperative surgical site infection with administrative data: a random forests algorithm

Yelena Petrosyan, Kednapa Thavorn, Glenys Smith, Malcolm Maclure, Roanne Preston, Carl van Walravan, Alan J. Forster

Evaluating the impact of covariate lookback times on performance of patient-level prediction models

Jill Hardin, Jenna M. Reps

Evaluation of statistical methods used in the analysis of interrupted time series studies: a simulation study

Simon L. Turner, Andrew B. Forbes, Amalia Karahalios, Monica Taljaard, Joanne E. McKenzie

Investigator initiated trials versus industry sponsored trials - translation of randomized controlled trials into clinical practice (IMPACT)

  • Open Access
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Anette Blümle, Katharina Wollmann, Karin Bischoff, Philipp Kapp, Szimonetta Lohner, Edris Nury, Kai Nitschke, Jasmin Zähringer, Gerta Rücker, Martin Schumacher

Applying a novel approach to scoping review incorporating artificial intelligence: mapping the natural history of gonorrhoea

Jane Whelan, Mohammad Ghoniem, Nicolas Médoc, Mike Apicella, Ekkehard Beck

A meta-review demonstrates improved reporting quality of qualitative reviews following the publication of COREQ- and ENTREQ-checklists, regardless of modest uptake

  • Open Access
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Y. de Jong, E. M. van der Willik, J. Milders, C. G. N. Voorend, Rachael L. Morton, F. W. Dekker, Y. Meuleman, M. van Diepen

Strategies to maximise study retention and limit attrition bias in a prospective cohort study of men reporting a history of injecting drug use released from prison: the prison and transition health study

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Ashleigh Cara Stewart, Reece Cossar, Shelley Walker, Anna Lee Wilkinson, Brendan Quinn, Paul Dietze, Rebecca Winter, Amy Kirwan, Michael Curtis, James R. P. Ogloff, Stuart Kinner, Campbell Aitken, Tony Butler, Emma Woods, Mark Stoové

A Bayesian latent class mixture model with censoring for correlation analysis in antimicrobial resistance across populations

Min Zhang, Chong Wang, Annette M. O’Connor

Clinical researchers’ lived experiences with data quality monitoring in clinical trials: a qualitative study

  • Open Access
  • Research

Lauren Houston, Ping Yu, Allison Martin, Yasmine Probst

Patient-centered infertility questionnaire for female clients (PCIQ-F): part I: questionnaire development

Hana Hasan Webair, Tengku Alina Tengku Ismail, Shaiful Bahari Ismail, Azza Jameel Khaffaji, Nik Hazlina Nik Hussain, Azidah Abdul Kadir, Rosediani Muhamad, Fatin Aina Abu Bakar, Nur Raihan Ismail, Nagwa Badri

Conducting proportional meta-analysis in different types of systematic reviews: a guide for synthesisers of evidence

  • Open Access
  • Commentary

Timothy Hugh Barker, Celina Borges Migliavaca, Cinara Stein, Verônica Colpani, Maicon Falavigna, Edoardo Aromataris, Zachary Munn

Minimizing bias in massive multi-arm observational studies with BCAUS: balancing covariates automatically using supervision

  • Open Access
  • Research

Chinmay Belthangady, Will Stedden, Beau Norgeot

Mitigating selection bias in organ allocation models

  • Open Access
  • Research

Erin M. Schnellinger, Edward Cantu III, Michael O. Harhay, Douglas E. Schaubel, Stephen E. Kimmel, Alisa J. Stephens-Shields

An improved method for the effect estimation of the intermediate event on the outcome based on the susceptible pre-identification

Haixia Hu, Ling Wang, Chen Li, Wei Ge, Jielai Xia

A comparative study of forest methods for time-to-event data: variable selection and predictive performance

  • Open Access
  • Research

Yingxin Liu, Shiyu Zhou, Hongxia Wei, Shengli An

Measuring advance care planning behavior in Dutch adults: translation, cultural adaptation and validation of the Advance Care Planning Engagement Survey

  • Open Access
  • Care
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Doris van der Smissen, Agnes van der Heide, Rebecca L. Sudore, Judith A. C. Rietjens, Ida J. Korfage

Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents?

  • Open Access
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Asmita Bhattarai, Gina Dimitropoulos, Brian Marriott, Jaime Paget, Andrew G. M. Bulloch, Suzanne C. Tough, Scott B. Patten

Statistical model building: Background “knowledge” based on inappropriate preselection causes misspecification

Lorena Hafermann, Heiko Becher, Carolin Herrmann, Nadja Klein, Georg Heinze, Geraldine Rauch

Analytical challenges in estimating the effect of exposures that are bounded by follow-up time: experiences from the Blood Stream Infection—Focus on Outcomes study

  • Open Access
  • Research

Rebecca Evans, Katie Pike, Alasdair MacGowan, Chris A. Rogers

Joint latent class model: Simulation study of model properties and application to amyotrophic lateral sclerosis disease

Maéva Kyheng, Génia Babykina, Camille Ternynck, David Devos, Julien Labreuche, Alain Duhamel

To tune or not to tune, a case study of ridge logistic regression in small or sparse datasets

Hana Šinkovec, Georg Heinze, Rok Blagus, Angelika Geroldinger

Sequential Multiple Assignment Randomized Trial (SMART) to identify optimal sequences of telemedicine interventions for improving initiation of insulin therapy: A simulation study

Xiaoxi Yan, David B. Matchar, Nirmali Sivapragasam, John P. Ansah, Aastha Goel, Bibhas Chakraborty

Chi-square test under indeterminacy: an application using pulse count data

  • Open Access
  • Research

Muhammad Aslam

Patient-centered practices for engaging transgender and gender diverse patients in clinical research studies

  • Open Access
  • Research article

Andrew Asquith, Lauren Sava, Alexander B. Harris, Asa E. Radix, Dana J. Pardee, Sari L. Reisner

Embedding mentoring to support trial processes and implementation fidelity in a randomised controlled trial of vocational rehabilitation for stroke survivors

Kristelle Craven, Jain Holmes, Katie Powers, Sara Clarke, Rachel L. Cripps, Rebecca Lindley, Julie Phillips, Ruth Tyerman, Christopher McKevitt, David Clarke, Kathryn Radford

Assessing the hospital volume-outcome relationship in surgery: a scoping review

  • Open Access
  • Research

Mathieu Levaillant, Romaric Marcilly, Lucie Levaillant, Philippe Michel, Jean-François Hamel-Broza, Benoît Vallet, Antoine Lamer

Quantifying parent engagement in the randomized Fuel for Fun impact study identified design considerations and BMI relationships

  • Open Access
  • Research

Barbara Lohse, Leslie Cunningham-Sabo

Effects of different invitation strategies on participation in a cohort study of Iranian public sector employees: a cluster randomized trial

  • Open Access
  • Research

Rezvan Rajabzadeh, Leila Janani, Seyed Abbas Motevalian

Methods for the inclusion of real-world evidence in network meta-analysis

David A. Jenkins, Humaira Hussein, Reynaldo Martina, Pascale Dequen-O’Byrne, Keith R. Abrams, Sylwia Bujkiewicz

Joint modelling of multivariate longitudinal clinical laboratory safety outcomes, concomitant medication and clinical adverse events: application to artemisinin-based treatment during pregnancy clinical trial

  • Open Access
  • Research

Noel Patson, Mavuto Mukaka, Umberto D’Alessandro, Gertrude Chapotera, Victor Mwapasa, Don Mathanga, Lawrence Kazembe, Miriam K. Laufer, Tobias Chirwa

What do stroke survivors’ value about participating in research and what are the most important research problems related to stroke or transient ischemic attack (TIA)? A survey

Ishanka Weerasekara, Jasmine Baye, Meredith Burke, Gary Crowfoot, Gillian Mason, Rachael Peak, Dawn Simpson, Frederick Rohan Walker, Michael Nilsson, Michael Pollack, Coralie English

Determining diagnosis date of diabetes using structured electronic health record (EHR) data: the SEARCH for diabetes in youth study

  • Open Access
  • Research

Kristin M. Lenoir, Lynne E. Wagenknecht, Jasmin Divers, Ramon Casanova, Dana Dabelea, Sharon Saydah, Catherine Pihoker, Angela D. Liese, Debra Standiford, Richard Hamman, Brian J. Wells

Employing multiple synchronous outcome samples per subject to improve study efficiency

  • Open Access
  • Software

Roger P. A’Hern

Are morbidity and mortality estimates from randomized controlled trials externally valid? A comparison of outcomes among infants enrolled into an RCT or a cohort study in Botswana

Neil Thivalapill, Shahin Lockman, Kathleen Powis, Rebecca Zash, Jean Leidner, Gbolahan Ajibola, Mompati Mmalane, Joseph Makhema, Roger L. Shapiro

Predictive P-score for treatment ranking in Bayesian network meta-analysis

  • Open Access
  • Research

Kristine J. Rosenberger, Rui Duan, Yong Chen, Lifeng Lin

A novel weighting method to remove bias from within-subject exposure dependency in case-crossover studies

Kiyoshi Kubota, Thu-Lan Kelly, Tsugumichi Sato, Nicole Pratt, Elizabeth Roughead, Takuhiro Yamaguchi

Analysis of COVID-19 data using neutrosophic Kruskal Wallis H test

Rehan Ahmad Khan Sherwani, Huma Shakeel, Wajiha Batool Awan, Maham Faheem, Muhammad Aslam

Random survival forests for dynamic predictions of a time-to-event outcome using a longitudinal biomarker

Kaci L Pickett, Krithika Suresh, Kristen R Campbell, Scott Davis, Elizabeth Juarez-Colunga

GoodReports: developing a website to help health researchers find and use reporting guidelines

  • Open Access
  • Research

Caroline Struthers, James Harwood, Jennifer Anne de Beyer, Paula Dhiman, Patricia Logullo, Michael Schlüssel

Statistical reanalysis of vascular event outcomes in primary and secondary vascular prevention trials

Lisa J. Woodhouse, Alan A. Montgomery, Jonathan Mant, Barry R. Davis, Ale Algra, Jean-Louis Mas, Jan A. Staessen, Lutgarde Thijs, Andrew Tonkin, Adrienne Kirby, Stuart J. Pocock, John Chalmers, Graeme J. Hankey, J. David Spence, Peter Sandercock, Hans-Christoph Diener, Shinichiro Uchiyama, Nikola Sprigg, Philip M. Bath

coreSCD: multi-stakeholder consensus on core outcomes for sickle cell disease clinical trials

  • Open Access
  • Research article

Ellen Tambor, Matoya Robinson, Lewis Hsu, Hsing-Yuan Chang, Jennifer Al Naber

Response rate of patient reported outcomes: the delivery method matters

Olaf M. Neve, Peter Paul G. van Benthem, Anne M. Stiggelbout, Erik F. Hensen

Bayesian additional evidence for decision making under small sample uncertainty

  • Open Access
  • Research

Arjun Sondhi, Brian Segal, Jeremy Snider, Olivier Humblet, Margaret McCusker

Methodological challenges and solution strategies during implementation of a midwife-led multicenter randomized controlled trial (RCT) in maternity hospitals

  • Open Access
  • Research

Sabine Striebich, Elke Mattern, Theresa Oganowski, Rainhild Schäfers, Gertrud Ayerle

Methodological quality for systematic reviews of adverse events with surgical interventions: a cross-sectional survey

  • Open Access
  • Research

Xiaoqin Zhou, Linji Li, Lifeng Lin, Ke Ju, Joey S. W. Kwong, Chang Xu

Prevalence of evidence of inconsistency and its association with network structural characteristics in 201 published networks of interventions

  • Open Access
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Areti Angeliki Veroniki, Sofia Tsokani, Ian R. White, Guido Schwarzer, Gerta Rücker, Dimitris Mavridis, Julian P. T. Higgins, Georgia Salanti

Evaluating complex interventions in context: systematic, meta-narrative review of case study approaches

  • Open Access
  • Research article

Sara Paparini, Chrysanthi Papoutsi, Jamie Murdoch, Judith Green, Mark Petticrew, Trisha Greenhalgh, Sara E. Shaw

Mediation analysis methods used in observational research: a scoping review and recommendations

  • Open Access
  • Research

Judith J. M. Rijnhart, Sophia J. Lamp, Matthew J. Valente, David P. MacKinnon, Jos W. R. Twisk, Martijn W. Heymans

Pre-statistical harmonization of behavioral instruments across eight surveys and trials

Diefei Chen, Eric Jutkowitz, Skylar L. Iosepovici, John C. Lin, Alden L. Gross

Understanding the groups of care transition strategies used by U.S. hospitals: an application of factor analytic and latent class methods

  • Open Access
  • Care
  • Research

Glen Mays, Jing Li, Jessica Miller Clouser, Gaixin Du, Arnold Stromberg, Brian Jack, Huong Q. Nguyen, Mark V. Williams

Inspection plan for COVID-19 patients for Weibull distribution using repetitive sampling under indeterminacy

G. Srinivasa Rao, Muhammad Aslam

Satisfaction and experience with colorectal cancer screening: a systematic review of validated patient reported outcome measures

A. Selva, C. Selva, Y. Álvarez-Pérez, N. Torà, P. López, R. Terraza-Núñez, V. Rodríguez, I. Solà, Andrea Burón, Francesc Macià, Salvador Machlab, Carles Pericay, Teresa Puig

Methods to support evidence-informed decision-making in the midst of COVID-19: creation and evolution of a rapid review service from the National Collaborating Centre for Methods and Tools

Sarah E. Neil-Sztramko, Emily Belita, Robyn L. Traynor, Emily Clark, Leah Hagerman, Maureen Dobbins

Spatial data analysis of malnutrition among children under-five years in Ethiopia

Haile Mekonnen Fenta, Temesgen Zewotir, Essey Kebede Muluneh

Incentive delivery timing and follow-up survey completion in a prospective cohort study of injured children: a randomized experiment comparing prepaid and postpaid incentives

  • Open Access
  • Research

Morgan M. Millar, Lenora M. Olson, John M. VanBuren, Rachel Richards, Murray M. Pollack, Richard Holubkov, Robert A. Berg, Joseph A. Carcillo, Patrick S. McQuillen, Kathleen L. Meert, Peter M. Mourani, Randall S. Burd

A narrative review on the validity of electronic health record-based research in epidemiology

  • Open Access
  • Review

Milena A. Gianfrancesco, Neal D. Goldstein

Independence estimators for re-randomisation trials in multi-episode settings: a simulation study

  • Open Access
  • Research

Brennan C. Kahan, Ian R. White, Sandra Eldridge, Richard Hooper

Predictors for participation in DNA self-sampling of childhood cancer survivors in Switzerland

  • Open Access
  • Research

Nicolas Waespe, Sven Strebel, Denis Marino, Veneranda Mattiello, Fanny Muet, Tiago Nava, Christina Schindera, Fabien N. Belle, Luzius Mader, Adrian Spoerri, Claudia E. Kuehni, Marc Ansari

Low methodological quality of systematic reviews on acupuncture: a cross-sectional study

Leonard Ho, Fiona Y. T. Ke, Charlene H. L. Wong, Irene X. Y. Wu, Andy K. L. Cheung, Chen Mao, Vincent C. H. Chung

Standardizing registry data to the OMOP Common Data Model: experience from three pulmonary hypertension databases

Patricia Biedermann, Rose Ong, Alexander Davydov, Alexandra Orlova, Philip Solovyev, Hong Sun, Graham Wetherill, Monika Brand, Eva-Maria Didden

Analysis of multivariate longitudinal substance use outcomes using multivariate mixed cumulative logit model

  • Open Access
  • Research

Xiaolei Lin, Robin Mermelstein, Donald Hedeker

Reporting of methods to prepare, pilot and perform data extraction in systematic reviews: analysis of a sample of 152 Cochrane and non-Cochrane reviews

  • Open Access
  • Research

Roland Brian Büchter, Alina Weise, Dawid Pieper

Major adverse cardiovascular event definitions used in observational analysis of administrative databases: a systematic review

Elliott Bosco, Leon Hsueh, Kevin W. McConeghy, Stefan Gravenstein, Elie Saade

Improving retention of community-recruited participants in HIV prevention research through Saturday household visits; findings from the HPTN 071 (PopART) study in South Africa

N. F. Bell-Mandla, R. Sloot, G. Maarman, S. Griffith, A. Moore, S. Floyd, R. Hayes, S. Fidler, H. Ayles, P. Bock

Frequency and characteristics of promissory conference abstracts, i.e. abstracts without results, accepted at Cochrane Colloquia 1994-2020

  • Open Access
  • Research

Darko Novak, Livia Puljak

Visualizing adverse events in clinical trials using correspondence analysis with R-package visae

Márcio A. Diniz, Gillian Gresham, Sungjin Kim, Michael Luu, N. Lynn Henry, Mourad Tighiouart, Greg Yothers, Patricia A. Ganz, André Rogatko

A simulation study for evaluating the performance of clustering measures in multilevel logistic regression

Nicholas Siame Adam, Halima S. Twabi, Samuel O.M. Manda

General characteristics and reasons for the discontinuation of drug clinical trials in mainland China

  • Open Access
  • Research article

Ben-nian Huo, Mao-lin Ai, Yun-tao Jia, Yao Liu, Yang Wang, Nan-ge Yin, Lin Song

Effects of personalized invitation letters on research participation among general practitioners: a randomized trial

  • Open Access
  • Research

Patrick Hennrich, Christine Arnold, Michel Wensing

Appraising clinical applicability of studies: mapping and synthesis of current frameworks, and proposal of the FrACAS framework and VICORT checklist

  • Open Access
  • Research

Quoc Dinh Nguyen, Erica M. Moodie, Philippe Desmarais, Robert Goulden, Marie-France Forget, Eric Peters, Sahar Saeed, Mark R. Keezer, Christina Wolfson

Predicting clinical events using Bayesian multivariate linear mixed models with application to scleroderma

Ji Soo Kim, Ami A. Shah, Laura K. Hummers, Scott L. Zeger

Advancing data science in drug development through an innovative computational framework for data sharing and statistical analysis

Ann-Marie Mallon, Dieter A. Häring, Frank Dahlke, Piet Aarden, Soroosh Afyouni, Daniel Delbarre, Khaled El Emam, Habib Ganjgahi, Stephen Gardiner, Chun Hei Kwok, Dominique M. West, Ewan Straiton, Sibylle Haemmerle, Adam Huffman, Tom Hofmann, Luke J. Kelly, Peter Krusche, Marie-Claude Laramee, Karine Lheritier, Greg Ligozio, Aimee Readie, Luis Santos, Thomas E. Nichols, Janice Branson, Chris Holmes

Methodological aspects for accelerometer-based assessment of physical activity in heart failure and health

Fabian Schwendinger, Jonathan Wagner, Denis Infanger, Arno Schmidt-Trucksäss, Raphael Knaier

Methodological implications of adapting and applying a web-based questionnaire on health problems to adolescent football players

  • Open Access
  • Research

Solveig E. Hausken-Sutter, Astrid Schubring, Stefan Grau, Klara Boije af Gennäs, Natalie Barker-Ruchti

Estimating the natural indirect effect and the mediation proportion via the product method

  • Open Access
  • Research

Chao Cheng, Donna Spiegelman, Fan Li

On clinical trial fragility due to patients lost to follow up

  • Open Access
  • CABG
  • Research

Benjamin R. Baer, Stephen E. Fremes, Mario Gaudino, Mary Charlson, Martin T. Wells

Impact of the COVID-19 pandemic on publication dynamics and non-COVID-19 research production

Marc Raynaud, Valentin Goutaudier, Kevin Louis, Solaf Al-Awadhi, Quentin Dubourg, Agathe Truchot, Romain Brousse, Nouredine Saleh, Alessia Giarraputo, Charlotte Debiais, Zeynep Demir, Anaïs Certain, Francine Tacafred, Esteban Cortes-Garcia, Safia Yanes, Jessy Dagobert, Sofia Naser, Blaise Robin, Élodie Bailly, Xavier Jouven, Peter P. Reese, Alexandre Loupy

Oversampling and replacement strategies in propensity score matching: a critical review focused on small sample size in clinical settings

  • Open Access
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Daniele Bottigliengo, Ileana Baldi, Corrado Lanera, Giulia Lorenzoni, Jonida Bejko, Tomaso Bottio, Vincenzo Tarzia, Massimiliano Carrozzini, Gino Gerosa, Paola Berchialla, Dario Gregori

Evaluating the performance of propensity score matching based approaches in individual patient data meta-analysis

  • Open Access
  • Research article

Fatema Tuj Johara, Andrea Benedetti, Robert Platt, Dick Menzies, Piret Viiklepp, Simon Schaaf, Edward Chan

Instrumental variable estimation for a time-varying treatment and a time-to-event outcome via structural nested cumulative failure time models

Joy Shi, Sonja A. Swanson, Peter Kraft, Bernard Rosner, Immaculata De Vivo, Miguel A. Hernán

Does pre-notification increase questionnaire response rates: a randomised controlled trial nested within a systematic review

  • Open Access
  • Research

Benjamin Woolf, Phil Edwards

Predicting the natural history of metabolic syndrome with a Markov-system dynamic model: a novel approach

Abbas Rezaianzadeh, Esmaeil Khedmati Morasae, Davood Khalili, Mozhgan Seif, Ehsan Bahramali, Fereidoun Azizi, Pezhman Bagheri

Similarities, reliability and gaps in assessing the quality of conduct of systematic reviews using AMSTAR-2 and ROBIS: systematic survey of nutrition reviews

Mateusz J. Swierz, Dawid Storman, Joanna Zajac, Magdalena Koperny, Paulina Weglarz, Wojciech Staskiewicz, Magdalena Gorecka, Anna Skuza, Adam Wach, Klaudia Kaluzinska, Justyna Bochenek-Cibor, Bradley C. Johnston, Malgorzata M. Bala

Development of a dynamic interactive web tool to enhance understanding of multi-state model analyses: MSMplus

  • Open Access
  • Software

Nikolaos Skourlis, Michael J. Crowther, Therese M-L. Andersson, Paul C. Lambert

Comparing current and emerging practice models for the extrapolation of survival data: a simulation study and case-study

  • Open Access
  • Research

Benjamin Kearns, Matt D. Stevenson, Kostas Triantafyllopoulos, Andrea Manca

Exploring the impact of ineligibility on individuals expressing interest in a trial aimed at improving daily functioning regarding perceptions of self, research and likelihood of future participation

Christopher P. Dwyer, Helen McAneney, Fionnuala M. Rogers, Robert Joyce, Sinéad M. Hynes

Does advance contact with research participants increase response to questionnaires: an updated systematic review and meta-analysis

  • Open Access
  • Research

Benjamin Woolf, Phil Edwards

Time-varying associations between an exposure history and a subsequent health outcome: a landmark approach to identify critical windows

  • Open Access
  • Technical advance

Maude Wagner, Francine Grodstein, Karen Leffondre, Cécilia Samieri, Cécile Proust-Lima

Predicting COVID-19 mortality risk in Toronto, Canada: a comparison of tree-based and regression-based machine learning methods

Cindy Feng, George Kephart, Elizabeth Juarez-Colunga

Modular literature review: a novel systematic search and review method to support priority setting in health policy and practice

  • Open Access
  • Research

Annariina M. Koivu, Patricia J. Hunter, Pieta Näsänen-Gilmore, Yvonne Muthiani, Jaana Isojärvi, Pia Pörtfors, Ulla Ashorn, Per Ashorn

A latent-class heteroskedastic hurdle trajectory model: patterns of adherence in obstructive sleep apnea patients on CPAP therapy

Niek G. P. Den Teuling, Edwin R. van den Heuvel, Mark S. Aloia, Steffen C. Pauws

Concordance rate of a four-quadrant plot for repeated measurements

  • Open Access
  • Research

Mayu Hiraishi, Kensuke Tanioka, Toshio Shimokawa

New adaptive lasso approaches for variable selection in automated pharmacovigilance signal detection

Émeline Courtois, Pascale Tubert-Bitter, Ismaïl Ahmed

Impact of vaccine prioritization strategies on mitigating COVID-19: an agent-based simulation study using an urban region in the United States

Hanisha Tatapudi, Rachita Das, Tapas K. Das

Feasibility of a hybrid clinical trial for respiratory virus detection in toddlers during the influenza season

Soledad Muñoz-Ramírez, Begoña Escribano-López, Vallivana Rodrigo-Casares, Carlos Vergara-Hernández, Desamparados Gil-Mary, Ignacio Sorribes-Monrabal, María Garcés-Sánchez, María-Jesús Muñoz-Del-Barrio, Ana-María Albors-Fernández, María-Isabel Úbeda-Sansano, María-Victoria Planelles-Cantarino, Ester-María Largo-blanco, Eva Suárez-Vicent, Javier García-Rubio, Patricia Bruijning-Verhagen, Alejandro Orrico-Sánchez, Javier Díez-Domingo

Ethnographic research as an evolving method for supporting healthcare improvement skills: a scoping review

  • Open Access
  • Research

Georgia B. Black, Sandra van Os, Samantha Machen, Naomi J. Fulop

Communicating incidental and reportable findings from research MRIs: considering factors beyond the findings in an underrepresented pediatric population

  • Open Access
  • Research

Kiley B. Vander Wyst, Micah L. Olson, Smita S. Bailey, Ana Martinez Valencia, Armando Peña, Jeffrey Miller, Mitchell Shub, Lee Seabrooke, Janiel Pimentel, Kiri Olsen, Robert B. Rosenberg, Gabriel Q. Shaibi

Correction to: Applying a novel approach to scoping review incorporating artificial intelligence: mapping the natural history of gonorrhoea

Jane Whelan, Mohammad Ghoniem, Nicolas Médoc, Mike Apicella, Ekkehard Beck

Analysis of zero inflated dichotomous variables from a Bayesian perspective: application to occupational health

  • Open Access
  • Research

David Moriña, Pedro Puig, Albert Navarro

An adaptive gBOIN design with shrinkage boundaries for phase I dose-finding trials

  • Open Access
  • Article

Rongji Mu, Zongliang Hu, Guoying Xu, Haitao Pan

Moving beyond the classic difference-in-differences model: a simulation study comparing statistical methods for estimating effectiveness of state-level policies

Beth Ann Griffin, Megan S. Schuler, Elizabeth A. Stuart, Stephen Patrick, Elizabeth McNeer, Rosanna Smart, David Powell, Bradley D. Stein, Terry L. Schell, Rosalie Liccardo Pacula

Improving postal survey response using behavioural science: a nested randomised control trial

Emily McBride, Hiromi Mase, Robert S. Kerrison, Laura A. V. Marlow, Jo Waller

The automation of relevant trial registration screening for systematic review updates: an evaluation study on a large dataset of ClinicalTrials.gov registrations

  • Open Access
  • Research

Didi Surian, Florence T. Bourgeois, Adam G. Dunn

Impact of limited sample size and follow-up on single event survival extrapolation for health technology assessment: a simulation study

  • Open Access
  • Research

Jaclyn M. Beca, Kelvin K. W. Chan, David M. J. Naimark, Petros Pechlivanoglou

Modelling of longitudinal data to predict cardiovascular disease risk: a methodological review

  • Open Access
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David Stevens, Deirdre A. Lane, Stephanie L. Harrison, Gregory Y. H. Lip, Ruwanthi Kolamunnage-Dona

The roles of predictors in cardiovascular risk models - a question of modeling culture?

  • Open Access
  • Research

Christine Wallisch, Asan Agibetov, Daniela Dunkler, Maria Haller, Matthias Samwald, Georg Dorffner, Georg Heinze

Guidance for using artificial intelligence for title and abstract screening while conducting knowledge syntheses

Candyce Hamel, Mona Hersi, Shannon E. Kelly, Andrea C. Tricco, Sharon Straus, George Wells, Ba’ Pham, Brian Hutton

Early experience with an opt-in research register - Scottish Health Research Register (SHARE): a multi-method evaluation of participant recruitment performance

  • Open Access
  • Research article

Wen Shi, Shobna Vasishta, Louise Dow, Daniella Cavellini, Colin Palmer, Brian McKinstry, Frank Sullivan

Bayesian spatio-temporal distributed lag modeling for delayed climatic effects on sparse malaria incidence data

Chawarat Rotejanaprasert, Nattwut Ekapirat, Prayuth Sudathip, Richard J. Maude

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