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BMC Medical Research Methodology

Issue 1/2018

Content (180 Articles)

Evaluating screening approaches for hepatocellular carcinoma in a cohort of HCV related cirrhosis patients from the Veteran’s Affairs Health Care System

  • Open Access
  • Research article

Nabihah Tayob, Peter Richardson, Donna L. White, Xiaoying Yu, Jessica A. Davila, Fasiha Kanwal, Ziding Feng, Hashem B. El-Serag

A systematic comparison of recurrent event models for application to composite endpoints

  • Open Access
  • Technical advance

Ann-Kathrin Ozga, Meinhard Kieser, Geraldine Rauch

Effects of pre-notification, invitation length, questionnaire length and reminder on participation rate: a quasi-randomised controlled trial

  • Open Access
  • Research article

Marie Koitsalu, Martin Eklund, Jan Adolfsson, Henrik Grönberg, Yvonne Brandberg

A comparison of estimators from self-controlled case series, case-crossover design, and sequence symmetry analysis for pharmacoepidemiological studies

  • Open Access
  • Research article

Yoshinori Takeuchi, Tomohiro Shinozaki, Yutaka Matsuyama

What kind of systematic review should I conduct? A proposed typology and guidance for systematic reviewers in the medical and health sciences

  • Open Access
  • Correspondence

Zachary Munn, Cindy Stern, Edoardo Aromataris, Craig Lockwood, Zoe Jordan

Structure formats of randomised controlled trial abstracts: a cross-sectional analysis of their current usage and association with methodology reporting

  • Open Access
  • Research article

Fang Hua, Tanya Walsh, Anne-Marie Glenny, Helen Worthington

Comparison of nuisance parameters in pediatric versus adult randomized trials: a meta-epidemiologic empirical evaluation

  • Open Access
  • Research article

Ben Vandermeer, Ingeborg van der Tweel, Marijke C. Jansen-van der Weide, Stephanie S. Weinreich, Despina G. Contopoulos-Ioannidis, Dirk Bassler, Ricardo M. Fernandes, Lisa Askie, Haroon Saloojee, Paola Baiardi, Susan S. Ellenberg, Johanna H. van der Lee

A multiple imputation method based on weighted quantile regression models for longitudinal censored biomarker data with missing values at early visits

  • Open Access
  • Research article

MinJae Lee, Mohammad H. Rahbar, Matthew Brown, Lianne Gensler, Michael Weisman, Laura Diekman, John D. Reveille

A systematic review of comparisons between protocols or registrations and full reports in primary biomedical research

  • Open Access
  • Research article

Guowei Li, Luciana P. F. Abbade, Ikunna Nwosu, Yanling Jin, Alvin Leenus, Muhammad Maaz, Mei Wang, Meha Bhatt, Laura Zielinski, Nitika Sanger, Bianca Bantoto, Candice Luo, Ieta Shams, Hamnah Shahid, Yaping Chang, Guangwen Sun, Lawrence Mbuagbaw, Zainab Samaan, Mitchell A. H. Levine, Jonathan D. Adachi, Lehana Thabane

Reporting of heterogeneity of treatment effect in cohort studies: a review of the literature

  • Open Access
  • Research article

Meryl Dahan, Caroline Scemama, Raphael Porcher, David J. Biau

Development and validation of self-reported line drawings of the modified Beighton score for the assessment of generalised joint hypermobility

  • Open Access
  • Research article

Dale J. Cooper, Brigitte E. Scammell, Mark E. Batt, Debbie Palmer

Getting messier with TIDieR: embracing context and complexity in intervention reporting

  • Open Access
  • Debate

Sarah Cotterill, Sarah Knowles, Anne-Marie Martindale, Rebecca Elvey, Susan Howard, Nia Coupe, Paul Wilson, Michael Spence

Does different information disclosure on placebo control affect blinding and trial outcomes? A case study of participant information leaflets of randomized placebo-controlled trials of acupuncture

  • Open Access
  • Research article

Soyeon Cheon, Hi-Joon Park, Younbyoung Chae, Hyangsook Lee

Assessing the effect of a partly unobserved, exogenous, binary time-dependent covariate on survival probabilities using generalised pseudo-values

  • Open Access
  • Technical advance

Ulrike Pötschger, Harald Heinzl, Maria Grazia Valsecchi, Martina Mittlböck

Studying medical communication with video vignettes: a randomized study on how variations in video-vignette introduction format and camera focus influence analogue patients’ engagement

  • Open Access
  • Research article

Leonie N. C. Visser, Nadine Bol, Marij A. Hillen, Mathilde G. E. Verdam, Hanneke C. J. M. de Haes, Julia C. M. van Weert, Ellen M. A. Smets

Defeat and entrapment: more than meets the eye? Applying network analysis to estimate dimensions of highly correlated constructs

  • Open Access
  • Research article

Thomas Forkmann, Tobias Teismann, Jana-Sophie Stenzel, Heide Glaesmer, Derek de Beurs

Correction to: On the use of the outcome variable “small for gestational age” when gestational age is a potential mediator: a maternal asthma perspective

  • Open Access
  • Correction

Geneviève Lefebvre, Mariia Samoilenko

Factor structure and psychometric properties of the english version of the trier inventory for chronic stress (TICS-E)

  • Open Access
  • Research article

Katja Petrowski, Sören Kliem, Michael Sadler, Alicia E. Meuret, Thomas Ritz, Elmar Brähler

Using an onset-anchored Bayesian hierarchical model to improve predictions for amyotrophic lateral sclerosis disease progression

  • Open Access
  • Research article

Alex G. Karanevich, Jeffrey M. Statland, Byron J. Gajewski, Jianghua He

Value of information methods to design a clinical trial in a small population to optimise a health economic utility function

  • Open Access
  • Research article

Michael Pearce, Siew Wan Hee, Jason Madan, Martin Posch, Simon Day, Frank Miller, Sarah Zohar, Nigel Stallard

Correction to: Multiple Score Comparison: a network meta-analysis approach to comparison and external validation of prognostic scores

  • Open Access
  • Correction

Sarah R. Haile, Beniamino Guerra, Joan B. Soriano, Milo A. Puhan

The management of children with bronchiolitis in the Australasian hospital setting: development of a clinical practice guideline

  • Open Access
  • Research article

Sharon O’Brien, Sally Wilson, Fenella J. Gill, Elizabeth Cotterell, Meredith L Borland, Edward Oakley, Stuart R Dalziel

Advantages of a multi-state approach in surgical research: how intermediate events and risk factor profile affect the prognosis of a patient with locally advanced rectal cancer

  • Open Access
  • Research article

G. Manzini, T. J. Ettrich, M. Kremer, M. Kornmann, D. Henne-Bruns, D. A. Eikema, P. Schlattmann, L. C. de Wreede

DeepSurv: personalized treatment recommender system using a Cox proportional hazards deep neural network

  • Open Access
  • Research article

Jared L. Katzman, Uri Shaham, Alexander Cloninger, Jonathan Bates, Tingting Jiang, Yuval Kluger

Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review

  • Open Access
  • Research article

Christopher J. Weir, Isabella Butcher, Valentina Assi, Stephanie C. Lewis, Gordon D. Murray, Peter Langhorne, Marian C. Brady

Pragmatism in practice: lessons learned during screening and enrollment for a randomised controlled trial in rural northern Ethiopia

  • Open Access
  • Research article

Meseret Molla, Henok Negussie, Moses Ngari, Esther Kivaya, Patricia Njuguna, Fikre Enqueselassie, James A. Berkley, Gail Davey

An application of restricted mean survival time in a competing risks setting: comparing time to ART initiation by injection drug use

  • Open Access
  • Research article

Keri L. Calkins, Chelsea E. Canan, Richard D. Moore, Catherine R. Lesko, Bryan Lau

Methodological and clinical implications of a three-in-one Russian doll design for tracking health trajectories and improving health and function through innovative exercise treatments in adults with disability

  • Open Access
  • Study protocol

James H. Rimmer, Cassandra Herman, Brooks Wingo, Kevin Fontaine, Tapan Mehta

Psychometric properties and population norms of the positive mental health instrument in a representative multi-ethnic Asian population

  • Open Access
  • Research article

Janhavi Ajit Vaingankar, Mythily Subramaniam, Linda Wei Lin Tan, Edimansyah Abdin, Wei Yen Lim, Hwee Lin Wee, Siow Ann Chong, Rob Martinus van Dam

Quality assessment of systematic reviews on total hip or knee arthroplasty using mod-AMSTAR

  • Open Access
  • Research article

Xinyu Wu, Huan Sun, Xiaoqin Zhou, Ji Wang, Jing Li

Using bundle embeddings to predict daily cortisol levels in human subjects

  • Open Access
  • Research article

Roelof B. Toonen, Klaas J. Wardenaar, Elisabeth H. Bos, Sonja L. van Ockenburg, Peter de Jonge

Sample size determination for mediation analysis of longitudinal data

  • Open Access
  • Research article

Haitao Pan, Suyu Liu, Danmin Miao, Ying Yuan

Correction to: joint models for longitudinal and time-to-event data: a review of reporting quality with a view to meta-analysis

  • Open Access
  • Correction

Maria Sudell, Ruwanthi Kolamunnage-Dona, Catrin Tudur-Smith

Writing a discussion section: how to integrate substantive and statistical expertise

  • Open Access
  • Debate

Michael Höfler, John Venz, Sebastian Trautmann, Robert Miller

Nature and reporting characteristics of UK health technology assessment systematic reviews

  • Open Access
  • Research article

Christopher Carroll, Eva Kaltenthaler

Colliding ideals – an interview study of how intervention researchers address adherence and adaptations in replication studies

  • Open Access
  • Research article

Ulrica von Thiele Schwarz, Ulrika Förberg, Knut Sundell, Henna Hasson

Comparison of methodological quality rating of systematic reviews on neuropathic pain using AMSTAR and R-AMSTAR

  • Open Access
  • Research article

Svjetlana Dosenovic, Antonia Jelicic Kadic, Katarina Vucic, Nikolina Markovina, Dawid Pieper, Livia Puljak

Measuring colorectal cancer incidence: the performance of an algorithm using administrative health data

  • Open Access
  • Research article

Mamadou Diop, Erin C. Strumpf, Geetanjali D. Datta

Validating the use of veterans affairs tobacco health factors for assessing change in smoking status: accuracy, availability, and approach

  • Open Access
  • Research article

Anne C. Melzer, Erika A. Pinsker, Barbara Clothier, Siamak Noorbaloochi, Diana J. Burgess, Elisheva R. Danan, Steven S. Fu

Informative graphing of continuous safety variables relative to normal reference limits

  • Open Access
  • Research article

Christopher D. Breder

Simulation-based power calculations for planning a two-stage individual participant data meta-analysis

  • Open Access
  • Research article

Joie Ensor, Danielle L. Burke, Kym I. E. Snell, Karla Hemming, Richard D. Riley

Influence of blinding on treatment effect size estimate in randomized controlled trials of oral health interventions

  • Open Access
  • Research article

Humam Saltaji, Susan Armijo-Olivo, Greta G. Cummings, Maryam Amin, Bruno R. da Costa, Carlos Flores-Mir

Validation of verbal autopsy methods using hospital medical records: a case study in Vietnam

  • Open Access
  • Research article

Hong Thi Tran, Hoa Phuong Nguyen, Sue M. Walker, Peter S. Hill, Chalapati Rao

Methods to systematically review and meta-analyse observational studies: a systematic scoping review of recommendations

  • Open Access
  • Research article

Monika Mueller, Maddalena D’Addario, Matthias Egger, Myriam Cevallos, Olaf Dekkers, Catrina Mugglin, Pippa Scott

The appropriateness of Bland-Altman’s approximate confidence intervals for limits of agreement

  • Open Access
  • Research article

Gwowen Shieh

List randomization for eliciting HIV status and sexual behaviors in rural KwaZulu-Natal, South Africa: a randomized experiment using known true values for validation

  • Open Access
  • Research article

Noah Haber, Guy Harling, Jessica Cohen, Tinofa Mutevedzi, Frank Tanser, Dickman Gareta, Kobus Herbst, Deenan Pillay, Till Bärnighausen, Günther Fink

A realist approach to eliciting the initial programme theory of the antiretroviral treatment adherence club intervention in the Western Cape Province, South Africa

  • Open Access
  • Research article

Ferdinand C. Mukumbang, Bruno Marchal, Sara Van Belle, Brian van Wyk

Analysis of randomised trials with long-term follow-up

  • Open Access
  • Debate

Robert D. Herbert, Jessica Kasza, Kari Bø

Bias due to censoring of deaths when calculating extra length of stay for patients acquiring a hospital infection

  • Open Access
  • Research article

Shahina Rahman, Maja von Cube, Martin Schumacher, Martin Wolkewitz

joineRML: a joint model and software package for time-to-event and multivariate longitudinal outcomes

  • Open Access
  • Software

Graeme L. Hickey, Pete Philipson, Andrea Jorgensen, Ruwanthi Kolamunnage-Dona

Rapid response in health technology assessment: a Delphi study for a Brazilian guideline

  • Open Access
  • Research article

Marcus Tolentino Silva, Everton Nunes da Silva, Jorge Otávio Maia Barreto

Effectiveness of motivational interviewing, health education and brief advice in a population of smokers who are not ready to quit

  • Open Access
  • Research article

Majid Bani-Yaghoub, Abdellatif Elhomani, Delwyn Catley

Cost-effectiveness of diagnostic and therapeutic interventions for chronic hepatitis C: a systematic review of model-based analyses

  • Open Access
  • Research article

Rodolfo Castro, Louise Crathorne, Hugo Perazzo, Julio Silva, Chris Cooper, Jo Varley-Campbell, Daniel Savignon Marinho, Marcela Haasova, Valdilea G. Veloso, Rob Anderson, Chris Hyde

Outlier classification performance of risk adjustment methods when profiling multiple providers

  • Open Access
  • Research article

Timo B. Brakenhoff, Kit C. B. Roes, Karel G. M. Moons, Rolf H. H. Groenwold

Factors associated with missed assessments in a 2-year longitudinal study of acute respiratory distress syndrome survivors

  • Open Access
  • Research article

Sara E. Heins, Amy W. Wozniak, Elizabeth Colantuoni, Kristin A. Sepulveda, Pedro A. Mendez-Tellez, Cheryl Dennison-Himmelfarb, Dale M. Needham, Victor D. Dinglas

How is AMSTAR applied by authors – a call for better reporting

  • Open Access
  • Research article

Dawid Pieper, Nadja Koensgen, Jessica Breuing, Long Ge, Uta Wegewitz

Access to primary care for socio-economically disadvantaged older people in rural areas: exploring realist theory using structural equation modelling in a linked dataset

  • Open Access
  • Research article

John A. Ford, Andy Jones, Geoff Wong, Allan Clark, Tom Porter, Nick Steel

Modelling memory decay after injuries using household survey data from Khartoum State, Sudan

  • Open Access
  • Research article

Ivar Heuch, Safa Abdalla, Sally El Tayeb

Comparison of response rates on invitation mode of a web-based survey on influenza vaccine adverse events among healthcare workers: a pilot study

  • Open Access
  • Research article

Xiaochen Tai, Alanna M. Smith, Allison J. McGeer, Eve Dubé, Dorothy Linn Holness, Kevin Katz, Linda McGillis Hall, Shelly A. McNeil, Jeff Powis, Brenda L. Coleman

Modelling attrition and nonparticipation in a longitudinal study of prostate cancer

  • Open Access
  • Research article

Samantha Spiers, Evrim Oral, Elizabeth T. H. Fontham, Edward S. Peters, James L. Mohler, Jeannette T. Bensen, Christine S. Brennan

Instrumental variable analysis in the context of dichotomous outcome and exposure with a numerical experiment in pharmacoepidemiology

  • Open Access
  • Research article

Babagnidé François Koladjo, Sylvie Escolano, Pascale Tubert-Bitter

A preference-based item response theory model to measure health: concept and mathematics of the multi-attribute preference response model

  • Open Access
  • Research article

Catharina G. M. Groothuis-Oudshoorn, Edwin R. van den Heuvel, Paul F. M. Krabbe

Comparing performance between log-binomial and robust Poisson regression models for estimating risk ratios under model misspecification

  • Open Access
  • Research article

Wansu Chen, Lei Qian, Jiaxiao Shi, Meredith Franklin

Evaluation of surrogate measures of insulin sensitivity - correlation with gold standard is not enough

  • Open Access
  • Debate

Anna Rudvik, Marianne Månsson

Estimation of delay to diagnosis and incidence in HIV using indirect evidence of infection dates

  • Open Access
  • Research article

Oliver T. Stirrup, David T. Dunn

The use of single armed observational data to closing the gap in otherwise disconnected evidence networks: a network meta-analysis in multiple myeloma

  • Open Access
  • Research article

Susanne Schmitz, Áine Maguire, James Morris, Kai Ruggeri, Elisa Haller, Isla Kuhn, Joy Leahy, Natalia Homer, Ayesha Khan, Jack Bowden, Vanessa Buchanan, Michael O’Dwyer, Gordon Cook, Cathal Walsh

Estimating causal effects of time-dependent exposures on a binary endpoint in a high-dimensional setting

  • Open Access
  • Research article

Vahé Asvatourian, Clélia Coutzac, Nathalie Chaput, Caroline Robert, Stefan Michiels, Emilie Lanoy

Community Assessment of COPD Health Care (COACH) study: a clinical audit on primary care performance variability in COPD care

  • Open Access
  • Research article

María Abad-Arranz, Ana Moran-Rodríguez, Enrique Mascarós Balaguer, Carmen Quintana Velasco, Laura Abad Polo, Sara Núñez Palomo, Jaime Gonzálvez Rey, Ana María Fernández Vargas, Antonio Hidalgo Requena, Jose Manuel Helguera Quevedo, Marina García Pardo, Jose Luis Lopez-Campos, Jose Luis Lopez-Campos, Ana Morán Rodríguez, Enrique Mascarós Balaguer, María Abad Arranz, Ana M. Fernández Vargas, Antonio Hidalgo Requena, José Manuel Helguera Quevedo, Sara Núñez Palomo, Ana María Fernández Vargas, Beatriz Elorza Maza, Cristina Pulido Vázquez, Eloy de Haro Muñoz, Enrique Pérez Ortiz, Fernando López Verde, Francisco José Guirado Hidalgo, Irene Martínez Ríos, Jose María Lopez López, Juan Antonio Lara González, Juan Carlos Navarro González, Manolo Del Rey Pérez, Manuel Resa Alcalá, Ramon Nicolas Franco Reins, Raúl Rabaneda Bueno, José Galván Espinosa, José Miguel Cerón, Antonio Núñez Montenegro, Eugenio Contreras, Andra Crisán, Bárbara Quevedo Benyto, Beatriz Sanchís Yago, Carmen Quintana Velasco, Clara Cañardo Alastuey, Clara Lanuzzelli Barroso, Clara López Mas, Daniel Rubio Castro, Laura Abad Polo, Marina García Pardo, Arancha Rojo Calderón, Carmen Toca Incera, Esperanza Rueda Alonso, Helena Bermejo Ruiz, Juan Carlos López Caro, Luis Sainz de Rozas Arpide, María Jesús Fernández Lerones, Jaime Gonzálvez Rey, Gabriel Romero de Ávila Cabezón, Carlos Chapela Villa, Ruth Otero González, Jose Ramón Parada Jorgal, Irene Valle González, Maite Espantoso Romero, Susana Friande Pereira, Alejandra Montero Costa, Alicia Jorge Formariz, Ana Isabel Hernández Regalado, Ana Maria Rey López, Ángel Alonso Val, Ángel Luis Laguna, Ángel Quijada Monso, Ángeles Casado Aguado, Beata Bordzynska Michalska, Beatriz Orozco Carratalá, Beatriz Solans Aisa, Carmen Mateo Pascual, Carmen Vieira Pascual, Cristina Alvarez Alonso, Cristina García Lombardia, David González Gallardo, Dolores Morata Perelló, Eleonora Valinoti, Elisabet Astorga García, Encarnación Santos Montealegre, Enrique Rodríguez de Mingo, Francisco Sánchez Martín, Gloria Viñas Fernández, Guillermina López Fernández, Itziar Valero Infantes, Jaime Marín Cañada, José Luis Martínez Carrasco, José Ramón Sánchez Picón, Juan Carlos Moreno Fernández, Juan Miguel Pinar Manzanet, Julia Caballer Rodilla, Juncal Martínez Irazusta, Leticia Pérez Esteban, Luis Toledano Rubio, Maria Belén García Benito, Maria Belén Ortega Trompeta, María Cruz Díez Pérez, María Dolores Tuñón Leiva, María José Lougedo Calderón, María Sol Lorenzo Borda, Margarita Jimeno Rodríguez, Maria Carmen Lobón Agúndez, Maria Dolores García Granado, Marta Ruesga Estébanez, Mercedes Adriaá Sanz, Mercedes Capitán Caldas, Mercedes Marinas Barba, Miguel Ángel Delgado  Nicolás, Miriam Sánchez Herraínz, Mirian Sánchez Herráiz, María Belén Martinez Urroz, María del Pino Calderín Morales, Montserrat Uriel Martínez, Norma Doria Carlín, Nuria de la Peña Antón, Paloma López-Hermosa Seseña, Pilar Aranda Arias, Pilar Blanco García, Raquel García Arriola, Raquel Martínez Bernardos, Raquel Sanjurjo Navarro, Raúl de Simón Gutiérrez, Sergio Heras Criado, Sonia Carmon aGranados, Teresa Gómez Rodríguez, Teresa Troyano Rivas

Correction for retest effects across repeated measures of cognitive functioning: a longitudinal cohort study of postoperative delirium

  • Open Access
  • Research article

Annie M. Racine, Yun Gou, Tamara G. Fong, Edward R. Marcantonio, Eva M. Schmitt, Thomas G. Travison, Sharon K. Inouye, Richard N. Jones

Meta-analysis of binary outcomes via generalized linear mixed models: a simulation study

  • Open Access
  • Research article

Ilyas Bakbergenuly, Elena Kulinskaya

Animal experimental research design in critical care

  • Open Access
  • Research article

Justin S. Merkow, Janine M. Hoerauf, Angela F. Moss, Jason Brainard, Lena M. Mayes, Ana Fernandez-Bustamante, Susan K. Mikulich-Gilbertson, Karsten Bartels

Towards integrated surveillance of zoonoses: spatiotemporal joint modeling of rodent population data and human tularemia cases in Finland

  • Open Access
  • Research article

C. Rotejanaprasert, A. Lawson, H. Rossow, J. Sane, O. Huitu, H. Henttonen, V. J. Del Rio Vilas

Development and validation of a MEDLINE search filter/hedge for degenerative cervical myelopathy

  • Open Access
  • Research article

Benjamin M. Davies, Samuel Goh, Keonwoo Yi, Isla Kuhn, Mark R. N. Kotter

Reference effect measures for quantifying, comparing and visualizing variation from random and fixed effects in non-normal multilevel models, with applications to site variation in medical procedure use and outcomes

  • Open Access
  • Research article

Thomas J. Glorioso, Gary K. Grunwald, P. Michael Ho, Thomas M. Maddox

The “RCT augmentation”: a novel simulation method to add patient heterogeneity into phase III trials

  • Open Access
  • Technical advance

Helene Karcher, Shuai Fu, Jie Meng, Mikkel Zöllner Ankarfeldt, Orestis Efthimiou, Mark Belger, Josep Maria Haro, Lucien Abenhaim, Clementine Nordon

The importance of including aliases in data linkage with vulnerable populations

  • Open Access
  • Research article

Holly Tibble, Hsei Di Law, Matthew J. Spittal, Rosemary Karmel, Rohan Borschmann, Katie Hail-Jares, Laura A. Thomas, Stuart A. Kinner

Creation of a new clinical framework – why women choose mastectomy versus breast conserving therapy

  • Open Access
  • Research article

Jeffrey Gu, Gary Groot

Is recession bad for your mental health? The answer could be complex: evidence from the 2008 crisis in Spain

  • Open Access
  • Research article

Joaquín Moncho, Pamela Pereyra-Zamora, Nayara Tamayo-Fonseca, Manuel Giron, Manuel Gómez-Beneyto, Andreu Nolasco

Simulation shows undesirable results for competing risks analysis with time-dependent covariates for clinical outcomes

  • Open Access
  • Research article

Inga Poguntke, Martin Schumacher, Jan Beyersmann, Martin Wolkewitz

Self-reported measures in health research for people with intellectual disabilities: an inclusive pilot study on suitability and reliability

  • Open Access
  • Research article

Kristel Vlot-van Anrooij, Hilde Tobi, Thessa I. M. Hilgenkamp, Geraline L. Leusink, Jenneken Naaldenberg

Bonferroni-Holm and permutation tests to compare health data: methodological and applicative issues

  • Open Access
  • Research article

Massimiliano Giacalone, Zirilli Agata, Paolo Carmelo Cozzucoli, Angela Alibrandi

A dynamic Bayesian Markov model for health economic evaluations of interventions in infectious disease

  • Open Access
  • Research article

Katrin Haeussler, Ardo van den Hout, Gianluca Baio

Prediction models for clustered data with informative priors for the random effects: a simulation study

  • Open Access
  • Research article

Haifang Ni, Rolf H. H. Groenwold, Mirjam Nielen, Irene Klugkist

Self-selection in a population-based cohort study: impact on health service use and survival for bowel and lung cancer assessed using data linkage

  • Open Access
  • Research article

Nicola Creighton, Stuart Purdie, Matthew Soeberg, Richard Walton, Deborah Baker, Jane Young

Defining the process to literature searching in systematic reviews: a literature review of guidance and supporting studies

  • Open Access
  • Debate

Chris Cooper, Andrew Booth, Jo Varley-Campbell, Nicky Britten, Ruth Garside

The effect of a voucher incentive on a survey response rate in the clinical setting: a quasi-randomized controlled trial

  • Open Access
  • Research article

Dawid Pieper, Nina Kotte, Peggy Ober

Multiple imputation for patient reported outcome measures in randomised controlled trials: advantages and disadvantages of imputing at the item, subscale or composite score level

  • Open Access
  • Research article

Ines Rombach, Alastair M. Gray, Crispin Jenkinson, David W. Murray, Oliver Rivero-Arias

How can we get Iraq- and Afghanistan-deployed US Veterans to participate in health-related research? Findings from a national focus group study

  • Open Access
  • Research article

Alyson J. Littman, Gala True, Emily Ashmore, Tracy Wellens, Nicholas L. Smith

Does pattern mixture modelling reduce bias due to informative attrition compared to fitting a mixed effects model to the available cases or data imputed using multiple imputation?: a simulation study

  • Open Access
  • Research article

Catherine A. Welch, Séverine Sabia, Eric Brunner, Mika Kivimäki, Martin J. Shipley

Heckman imputation models for binary or continuous MNAR outcomes and MAR predictors

  • Open Access
  • Research article

Jacques-Emmanuel Galimard, Sylvie Chevret, Emmanuel Curis, Matthieu Resche-Rigon

Pure intervention effect or effect in routine health care - blinded or non-blinded randomized controlled trial

  • Open Access
  • Debate

Antti Malmivaara

Harmonization of delirium severity instruments: a comparison of the DRS-R-98, MDAS, and CAM-S using item response theory

  • Open Access
  • Research article

Alden L. Gross, Doug Tommet, Madeline D’Aquila, Eva Schmitt, Edward R. Marcantonio, Benjamin Helfand, Sharon K. Inouye, Richard N. Jones, Sharon K. Inouye, Richard N. Jones, Tamara Fong, Tammy Hshieh, Edward R. Marcantonio, Annie Racine, Eva M. Schmitt, Dena Schulman-Green, Patricia A. Tabloski, Thomas Travison, Tatiana Abrantes, Brett Armstrong, Sylvia Bertrand, Angelee Butters, Madeline D’Aquila, Jacqueline Gallagher, Jennifer Kettell, Jacqueline Nee, Katelyn Parisi, Margaret Vella, Guoquan Xu, Lauren Weiner, Yun Gou, Douglas Tommet, Charles H. Brown, Sevdenur Cizginer, Diane Clark, Joseph H. Flaherty, Anne Gleason, Ann M. Kolanowski, Karen J. Neufeld, Margaret G. O’Connor, Margaret A. Pisani, Thomas Robinson, Joe Verghese, Heidi Wald, Sharon M. Gordon

Estimation of an inter-rater intra-class correlation coefficient that overcomes common assumption violations in the assessment of health measurement scales

  • Open Access
  • Research article

Carly A. Bobak, Paul J. Barr, A. James O’Malley

The Ottawa SAH search algorithms: protocol for a multi- centre validation study of primary subarachnoid hemorrhage prediction models using health administrative data (the SAHepi prediction study protocol)

  • Open Access
  • Study protocol

S. W. English, L. McIntyre, V. Saigle, M. Chassé, D. A. Fergusson, A. F. Turgeon, F. Lauzier, D. Griesdale, A. Garland, R. Zarychanski, A. Algird, C. van Walraven

A randomized comparison of three data collection models for the measurement of parent experiences with diabetes outpatient care

  • Open Access
  • Research article

Oyvind Bjertnaes, Hilde Hestad Iversen, Torild Skrivarhaug

Quality of randomized controlled trials of new generation antidepressants and antipsychotics identified in the China National Knowledge Infrastructure (CNKI): a literature and telephone interview study

  • Open Access
  • Research article

Zheng Tong, Fangzhou Li, Yusuke Ogawa, Norio Watanabe, Toshi A. Furukawa

Primary versus secondary source of data in observational studies and heterogeneity in meta-analyses of drug effects: a survey of major medical journals

  • Open Access
  • Research article

Guillermo Prada-Ramallal, Fatima Roque, Maria Teresa Herdeiro, Bahi Takkouche, Adolfo Figueiras

Comparing survival functions with interval-censored data in the presence of an intermediate clinical event

  • Open Access
  • Research article

Sohee Kim, Jinheum Kim, Chung Mo Nam

A descriptive analysis of non-Cochrane child-relevant systematic reviews published in 2014

  • Open Access
  • Research article

Michelle Gates, Sarah A Elliott, Cydney Johnson, Denise Thomson, Katrina Williams, Ricardo M Fernandes, Lisa Hartling

Sense and sensibility: on the diagnostic value of control chart rules for detection of shifts in time series data

  • Open Access
  • Research article

Jacob Anhøj, Tore Wentzel-Larsen

Assessment of research waste part 2: wrong study populations- an exemplar of baseline vitamin D status of participants in trials of vitamin D supplementation

  • Open Access
  • Research article

Mark J. Bolland, Andrew Grey, Alison Avenell

A transdisciplinary team approach to scoping reviews: the case of pediatric polypharmacy

  • Open Access
  • Research article

Paul M Bakaki, Jennifer Staley, Rujia Liu, Neal Dawson, Negar Golchin, Alexis Horace, Hannah Johnson, Jennifer Waldron, Almut Winterstein, Lawrence C Kleinman, Shari D Bolen

Assessment of research waste part 1: an exemplar from examining study design, surrogate and clinical endpoints in studies of calcium intake and vitamin D supplementation

  • Open Access
  • Research article

Mark J. Bolland, Alison Avenell, Andrew Grey

Risks and rewards of using prepaid vs. postpaid incentive checks on a survey of physicians

  • Open Access
  • Research article

Kristine Wiant, Emily Geisen, Darryl Creel, Gordon Willis, Andrew Freedman, Janet de Moor, Carrie Klabunde

Appropriate statistical methods for analysing partially nested randomised controlled trials with continuous outcomes: a simulation study

  • Open Access
  • Research article

Jane Candlish, M. Dawn Teare, Munyaradzi Dimairo, Laura Flight, Laura Mandefield, Stephen J. Walters

Development and validation of a search filter to identify equity-focused studies: reducing the number needed to screen

  • Open Access
  • Research article

Stephanie L Prady, Eleonora P Uphoff, Madeleine Power, Su Golder

Correction to: multiple imputation for patient reported outcome measures in randomised controlled trials: advantages and disadvantages of imputing at the item, subscale or composite score level

  • Open Access
  • Correction

Ines Rombach, Alastair M Gray, Crispin Jenkinson, David W Murray, Oliver Rivero-Arias

The Shiny Balancer - software and imbalance criteria for optimally balanced treatment allocation in small RCTs and cRCTs

  • Open Access
  • Software

Thomas Grischott

Systematic review of the psychometric properties of instruments to measure sexual desire

  • Open Access
  • Research article

Denisse Cartagena-Ramos, Miguel Fuentealba-Torres, Flávio Rebustini, Ana Carolina Andrade Biaggi Leite, Willyane de Andrade Alvarenga, Ricardo Alexandre Arcêncio, Rosana Aparecida Spadoti Dantas, Lucila Castanheira Nascimento

A comparison of metrics and performance characteristics of different search strategies for article retrieval for a systematic review of the global epidemiology of kidney and urinary diseases

  • Open Access
  • Research article

Boris Bikbov, Norberto Perico, Giuseppe Remuzzi, Boris Bikbov, Claudia Cella, Monica Cortinovis, William Couser, Patricia Veronica Espindola Estevez, Flavio Gaspari, Felipe Antonio Rodriguez de Leon, Catherine Michaud, Valeria Miglioli, Christopher Murray, Mohsen Nagavi, Bishnu Pahari, Norberto Perico, Esteban Porrini, Giuseppe Remuzzi, Andrea Alejandra Panozo Rivero, Bernadette Thomas, Marcello Tonelli, Karen Courville de Vaccaro, Theo Vos, Natasha Wiebe, Sara Wulf

Can men be trusted in population-based surveys to report couples’ medical care for infertility?

  • Open Access
  • Research article

Soraya Belgherbi, Elise de La Rochebrochard

Odds ratios from logistic, geometric, Poisson, and negative binomial regression models

  • Open Access
  • Research article

Christopher J. Sroka, Haikady N. Nagaraja

A new approach for sample size calculation in cost-effectiveness studies based on value of information

  • Open Access
  • Technical advance

Clément Bader, Sébastien Cossin, Aline Maillard, Antoine Bénard

Engaging military couples in marital research: does requesting referrals from service members to recruit their spouses introduce sample bias?

  • Open Access
  • Research article

Hope Seib McMaster, Valerie A. Stander, Christianna S. Williams, Kelly A. Woodall, Christopher A. O’Malley, Lauren M. Bauer, Evelyn P. Davila, Carlos Carballo, Jackie Pflieger, Cynthia LeardMann, Sabrina Richardson, Evelyn Sun

A systematic survey shows that reporting and handling of missing outcome data in networks of interventions is poor

  • Open Access
  • Research article

Loukia M. Spineli, Juan J. Yepes-Nuñez, Holger J. Schünemann

Synthesising conceptual frameworks for patient and public involvement in research – a critical appraisal of a meta-narrative review

  • Open Access
  • Research article

David Evans, Noreen Hopewell-Kelly, Michele Kok, Jo White

Application of the dyadic data analysis in behavioral medicine research: marital satisfaction and anxiety in infertile couples

  • Open Access
  • Research article

Saman Maroufizadeh, Mostafa Hosseini, Abbas Rahimi Foroushani, Reza Omani-Samani, Payam Amini

Mediation analysis with a time-to-event outcome: a review of use and reporting in healthcare research

  • Open Access
  • Research article

Lauren Lapointe-Shaw, Zachary Bouck, Nicholas A. Howell, Theis Lange, Ani Orchanian-Cheff, Peter C. Austin, Noah M. Ivers, Donald A. Redelmeier, Chaim M. Bell

Application of a new dietary pattern analysis method in nutritional epidemiology

  • Open Access
  • Research article

Fengqing Zhang, Tinashe M. Tapera, Jiangtao Gou

Examiners’ influence on the measured active and passive extension deficit in finger joints affected by Dupuytren disease

  • Open Access
  • Research article

Jesper Nordenskjöld, Stina Brodén, Isam Atroshi

A systematic review of the clinical application of data-driven population segmentation analysis

  • Open Access
  • Research article

Shi Yan, Yu Heng Kwan, Chuen Seng Tan, Julian Thumboo, Lian Leng Low

Development and reliability assessment of a new quality appraisal tool for cross-sectional studies using biomarker data (BIOCROSS)

  • Open Access
  • Research article

Jan Wirsching, Sophie Graßmann, Fabian Eichelmann, Laura Malin Harms, Matthew Schenk, Eva Barth, Alide Berndzen, Moses Olalekan, Leen Sarmini, Hedwig Zuberer, Krasimira Aleksandrova

Exploring the impact of public health teams on alcohol premises licensing in England and Scotland (ExILEnS): procotol for a mixed methods natural experiment evaluation

  • Open Access
  • Study protocol

Niamh Fitzgerald, Matt Egan, Frank de Vocht, Colin Angus, James Nicholls, Niamh Shortt, Tim Nichols, Nason Maani Hessari, Cheryl McQuire, Richard Purves, Nathan Critchlow, Andrea Mohan, Laura Mahon, Colin Sumpter, Linda Bauld

Barriers in general practitioners’ dementia diagnostics among people with a migration background in Germany (BaDeMi) - study protocol for a cross-sectional survey

  • Open Access
  • Study protocol

Judith Tillmann, Rieke Schnakenberg, Marie-Therese Puth, Klaus Weckbecker, Johannes Just, Eva Münster

Human papillomavirus infection: protocol for a randomised controlled trial of imiquimod cream (5%) versus podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in the treatment and prevention of recurrence of anogenital warts (HIPvac trial)

  • Open Access
  • Study protocol

Macey L. Murray, Jade Meadows, Caroline J. Doré, Andrew J. Copas, Lewis J. Haddow, Charles Lacey, Mark Jit, Kate Soldan, Kate Bennett, Michelle Tetlow, Mayura Nathan, Richard Gilson

Putting family into family-based obesity prevention: enhancing participant engagement through a novel integrated knowledge translation strategy

  • Open Access
  • Research article

Kathryn Walton, Tory Ambrose, Angela Annis, David WL. Ma, Jess Haines

Subgroups of lifestyle patterns among hypertension patients: a latent-class analysis

  • Open Access
  • Research article

Jalileh Ghanbari, Asghar Mohammadpoorasl, Leila Jahangiry, Mahdieh Abbasalizad Farhangi, Jamileh Amirzadeh, Koen Ponnet

Hypothesis testing in Bayesian network meta-analysis

  • Open Access
  • Technical advance

Lorenz Uhlmann, Katrin Jensen, Meinhard Kieser

Multistate recursively imputed survival trees for time-to-event data analysis: an application to AIDS and mortality post-HIV infection data

  • Open Access
  • Research article

Leili Tapak, Michael R. Kosorok, Majid Sadeghifar, Omid Hamidi

Bubble effect: including internet search engines in systematic reviews introduces selection bias and impedes scientific reproducibility

  • Open Access
  • Debate

Marko Ćurković, Andro Košec

Are we on the cusp of a fourth research paradigm? Predicting the future for a new approach to methods-use in medical and health services research

  • Open Access
  • Debate

Frances Rapport, Jeffrey Braithwaite

Methodological development of tools to measure how women are treated during facility-based childbirth in four countries: labor observation and community survey

  • Open Access
  • Research article

Meghan A. Bohren, Joshua P. Vogel, Bukola Fawole, Ernest T. Maya, Thae Maung Maung, Mamadou Diouldé Baldé, Agnes A. Oyeniran, Modupe Ogunlade, Kwame Adu-Bonsaffoh, Nwe Oo Mon, Boubacar Alpha Diallo, Abou Bangoura, Richard Adanu, Sihem Landoulsi, A. Metin Gülmezoglu, Özge Tunçalp

Improving the normalization of complex interventions: part 1 - development of the NoMAD instrument for assessing implementation work based on normalization process theory (NPT)

  • Open Access
  • Research article

Tim Rapley, Melissa Girling, Frances S. Mair, Elizabeth Murray, Shaun Treweek, Elaine McColl, Ian Nicholas Steen, Carl R. May, Tracy L. Finch

Development of standard clinical endpoints for use in dengue interventional trials: introduction and methodology

  • Open Access
  • Research article

Thomas Jaenisch, Kim Hendrickx, Martin Erpicum, Liane Agulto, Kay M. Tomashek, Walla Dempsey, João Bosco Siqueira, Morgan A. Marks, Michael P. Fay, Catherine Laughlin, Maina L’Azou, Yee-Sin Leo, Federico Narvaez, Remy Teyssou, Stephen J. Thomas, Hasitha Tissera, Derek Wallace, Annelies Wilder-Smith, Duane J. Gubler, M. Cristina Cassetti

Improving the normalization of complex interventions: part 2 - validation of the NoMAD instrument for assessing implementation work based on normalization process theory (NPT)

  • Open Access
  • Research article

Tracy L. Finch, Melissa Girling, Carl R. May, Frances S. Mair, Elizabeth Murray, Shaun Treweek, Elaine McColl, Ian Nicholas Steen, Clare Cook, Christopher R. Vernazza, Nicola Mackintosh, Samridh Sharma, Gaery Barbery, Jimmy Steele, Tim Rapley

The impact of status and social context on health service co-design: an example from a collaborative improvement initiative in UK primary care

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  • Research article

Ian Litchfield, Louise Bentham, Ann Hill, Richard J. McManus, Richard Lilford, Sheila Greenfield

CDSS-RM: a clinical decision support system reference model

  • Open Access
  • Debate

Dimitrios Zikos, Nailya DeLellis

Joint modeling of multivariate longitudinal data and survival data in several observational studies of Huntington’s disease

  • Open Access
  • Research article

Jeffrey D. Long, James A. Mills

Assessing the effect of risk factors on rates of obstetric transfusion over time using two methodological approaches

  • Open Access
  • Research article

Edward Jegasothy, Jillian Patterson, Deborah Randall, Tanya A. Nippita, Judy M. Simpson, David O. Irving, Jane B. Ford

A qualitative approach to guide choices for designing a diary study

  • Open Access
  • Research article

Karin A. M. Janssens, Elisabeth H. Bos, Judith G. M. Rosmalen, Marieke C. Wichers, Harriëtte Riese

Reliability in evaluator-based tests: using simulation-constructed models to determine contextually relevant agreement thresholds

  • Open Access
  • Research article

Dylan T. Beckler, Zachary C. Thumser, Jonathon S. Schofield, Paul D. Marasco

Parametric assumptions equate to hidden observations: comparing the efficiency of nonparametric and parametric models for estimating time to AIDS or death in a cohort of HIV-positive women

  • Open Access
  • Research article

Jacqueline E. Rudolph, Stephen R. Cole, Jessie K. Edwards

Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach

  • Open Access
  • Debate

Zachary Munn, Micah D. J. Peters, Cindy Stern, Catalin Tufanaru, Alexa McArthur, Edoardo Aromataris

Retinal vascular tortuosity assessment: inter-intra expert analysis and correlation with computational measurements

  • Open Access
  • Research article

Lucía Ramos, Jorge Novo, José Rouco, Stephanie Romeo, María D. Álvarez, Marcos Ortega

Prognostic models for intracerebral hemorrhage: systematic review and meta-analysis

  • Open Access
  • Research article

Tiago Gregório, Sara Pipa, Pedro Cavaleiro, Gabriel Atanásio, Inês Albuquerque, Paulo Castro Chaves, Luís Azevedo

The challenges of recruiting cancer patient/caregiver dyads: informing randomized controlled trials

  • Open Access
  • Research article

Leila Heckel, Kate M. Gunn, Patricia M. Livingston

The patient experience with treatment and self-management (PETS) questionnaire: translation and cultural adaption of the Norwegian version

  • Open Access
  • Research article

Anne Marie Lunde Husebø, Ingvild Margreta Morken, Kristina Sundt Eriksen, Oda Karin Nordfonn

Characterising and justifying sample size sufficiency in interview-based studies: systematic analysis of qualitative health research over a 15-year period

  • Open Access
  • Research article

Konstantina Vasileiou, Julie Barnett, Susan Thorpe, Terry Young

Which ICD-9-CM codes should be used for bronchiolitis research?

  • Open Access
  • Research article

Paul Walsh, Stephen J. Rothenberg

Variable participation of knowledge users in cancer health services research: results of a multiple case study

  • Open Access
  • Research article

Mary Ann O’Brien, Andrea Carson, Lisa Barbera, Melissa C. Brouwers, Craig C. Earle, Ian D. Graham, Nicole Mittmann, Eva Grunfeld

Retention strategies in longitudinal cohort studies: a systematic review and meta-analysis

  • Open Access
  • Research article

Samantha Teague, George J. Youssef, Jacqui A. Macdonald, Emma Sciberras, Adrian Shatte, Matthew Fuller-Tyszkiewicz, Chris Greenwood, Jennifer McIntosh, Craig A. Olsson, Delyse Hutchinson, Sharyn Bant, Sophie Barker, Anna Booth, Tanja Capic, Laura Di Manno, Alisha Gulenc, Genevieve Le Bas, Primrose Letcher, Claire Ann Lubotzky, Jessica Opie, Melissa O’Shea, Evelyn Tan, Jo Williams

Using the Beta distribution in group-based trajectory models

  • Open Access
  • Technical advance

Jonathan Elmer, Bobby L. Jones, Daniel S. Nagin

Periodic reflections: a method of guided discussions for documenting implementation phenomena

  • Open Access
  • Research article

Erin P. Finley, Alexis K. Huynh, Melissa M. Farmer, Bevanne Bean-Mayberry, Tannaz Moin, Sabine M. Oishi, Jessica L. Moreau, Karen E. Dyer, Holly Jordan Lanham, Luci Leykum, Alison B. Hamilton

Exploring reporting quality of systematic reviews and Meta-analyses on nursing interventions in patients with Alzheimer’s disease before and after PRISMA introduction

  • Open Access
  • Research article

Xiao Sun, Xiaobin Zhou, Yan Yu, Haihua Liu

The interaction of personal, contextual, and study characteristics and their effect on recruitment and participation of pregnant women in research: a qualitative study in Lebanon

  • Open Access
  • Research article

Jennifer J. Ayoub, May Abiad, Michele R. Forman, Lara Nasreddine, Nahla Hwalla, Ghina Ghazeeri, Anwar Nassar, Khalid Yunis, Saadeddine Itani, Al Anoud Al Thani, Mariam Alabdulmalik, Amira Mahmoud Hassan, Hiba Bawadi, Gladys Honein-AbouHaidar, Farah Naja

Sample size calculation in multi-centre clinical trials

  • Open Access
  • Research article

Markus Harden, Tim Friede

Improving the quality of reporting of systematic reviews of dose-response meta-analyses: a cross-sectional survey

  • Open Access
  • Research article

Chang Xu, Tong-Zu Liu, Peng-Li Jia, Yu Liu, Ling Li, Liang-Liang Cheng, Xin Sun

Protocol for the development of a core outcome set for pelvic girdle pain, including methods for measuring the outcomes: the PGP-COS study

  • Open Access
  • Study protocol

Francesca Wuytack, Annelie Gutke, Britt Stuge, Siv Mørkved, Christina Olsson, Hilde Stendal Robinson, Nina K. Vøllestad, Birgitta Öberg, Lena Nilsson Wikmar, Juan Jose Saldaña Mena, Valerie Smith

Lasso regularization for left-censored Gaussian outcome and high-dimensional predictors

  • Open Access
  • Research article

Perrine Soret, Marta Avalos, Linda Wittkop, Daniel Commenges, Rodolphe Thiébaut

Methods for evaluating adverse drug event preventability in emergency department patients

  • Open Access
  • Research article

Stephanie A. Woo, Amber Cragg, Maeve E. Wickham, David Peddie, Ellen Balka, Frank Scheuermeyer, Diane Villanyi, Corinne M. Hohl

Quantity and quality of nucleic acids extracted from archival formalin fixed paraffin embedded prostate biopsies

  • Open Access
  • Research article

Jessica Carlsson, Sabina Davidsson, Jonna Fridfeldt, Francesca Giunchi, Valentina Fiano, Chiara Grasso, Renata Zelic, Lorenzo Richiardi, Ove Andrén, Andreas Pettersson, Michelangelo Fiorentino, Olof Akre

Methods for trustworthy nutritional recommendations NutriRECS (Nutritional Recommendations and accessible Evidence summaries Composed of Systematic reviews): a protocol

  • Open Access
  • Study protocol

Bradley C. Johnston, Pablo Alonso-Coello, Malgorzata M. Bala, Dena Zeraatkar, Montserrat Rabassa, Claudia Valli, Catherine Marshall, Regina El Dib, Robin W. M. Vernooij, Per O. Vandvik, Gordon H. Guyatt

Determinants of the willingness to participate in biobanking among Malaysian stakeholders in the Klang Valley

  • Open Access
  • Research article

Latifah Amin, Hasrizul Hashim, Zurina Mahadi, Khaidzir Ismail

Norm values and psychometric properties of the brief symptom inventory-18 regarding individuals between the ages of 60 and 95

  • Open Access
  • Research article

Katja Petrowski, Bjarne Schmalbach, Melanie Jagla, Gabriele Helga Franke, Elmar Brähler

Impact of linkage quality on inferences drawn from analyses using data with high rates of linkage errors in rural Tanzania

  • Open Access
  • Research article

Christopher T. Rentsch, Katie Harron, Mark Urassa, Jim Todd, Georges Reniers, Basia Zaba

Use of predicted vital status to improve survival analysis of multidrug-resistant tuberculosis cohorts

  • Open Access
  • Research article

Meredith B. Brooks, Salmaan Keshavjee, Irina Gelmanova, Nataliya A. Zemlyanaya, Carole D. Mitnick, Justin Manjourides

Participatory action research, mixed methods, and research teams: learning from philosophically juxtaposed methodologies for optimal research outcomes

  • Open Access
  • Research article

Marguerite C. Sendall, Laura K. McCosker, Alison Brodie, Melissa Hill, Phil Crane

A comparison of multiple imputation methods for missing data in longitudinal studies

  • Open Access
  • Research article

Md Hamidul Huque, John B. Carlin, Julie A. Simpson, Katherine J. Lee

Discrepancies in endpoints between clinical trial protocols and clinical trial registration in randomized trials in oncology

  • Open Access
  • Research article

Victoria J. Serpas, Kanwal P. Raghav, Daniel M. Halperin, James Yao, Michael J. Overman

Analysis of self-report and biochemically verified tobacco abstinence outcomes with missing data: a sensitivity analysis using two-stage imputation

  • Open Access
  • Research article

Yiwen Zhang, Xianghua Luo, Chap T. Le, Jasjit S. Ahluwalia, Janet L. Thomas

Study filters for non-randomized studies of interventions consistently lacked sensitivity upon external validation

  • Open Access
  • Research article

Elke Hausner, Maria-Inti Metzendorf, Bernd Richter, Fabian Lotz, Siw Waffenschmidt

A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies

  • Open Access
  • Research article

Niansheng Tang, Songjian Wang, Gen Ye

Strategies and challenges associated with recruiting retirement village communities and residents into a group exercise intervention

  • Open Access
  • Research article

Rachel L. Duckham, Jamie L. Tait, Caryl A. Nowson, Kerrie M. Sanders, Dennis R. Taaffe, Keith D. Hill, Robin M. Daly

Adjustment for unmeasured confounding through informative priors for the confounder-outcome relation

  • Open Access
  • Research article

Rolf H. H. Groenwold, Inbal Shofty, Milica Miočević, Maarten van Smeden, Irene Klugkist

Evaluation of the quality and value of data sources for postmarket surveillance of the safety of cough and cold medications in children

  • Open Access
  • Research article

Jody L. Green, Kate M. Reynolds, William Banner, G. Randall Bond, Ralph E. Kauffman, Robert B. Palmer, Ian M. Paul, Richard C. Dart

Validity of the International Physical Activity Questionnaire (IPAQ) for assessing moderate-to-vigorous physical activity and sedentary behaviour of older adults in the United Kingdom

  • Open Access
  • Research article

Claire Cleland, Sara Ferguson, Geraint Ellis, Ruth F. Hunter

Factors associated with retention in a smoking cessation trial for persons with a mental illness: a descriptive study

  • Open Access
  • Research article

Alexandra P. Metse, Nur Ashikin Noor Hizam, John Wiggers, Paula Wye, Jenny A. Bowman

Mechanisms, contexts and points of contention: operationalizing realist-informed research for complex health interventions

  • Open Access
  • Research article

James Shaw, Carolyn Steele Gray, G. Ross Baker, Jean-Louis Denis, Mylaine Breton, Jennifer Gutberg, Gaya Embuldeniya, Peter Carswell, Annette Dunham, Ann McKillop, Timothy Kenealy, Nicolette Sheridan, Walter Wodchis

Machine learning methodologies versus cardiovascular risk scores, in predicting disease risk

  • Open Access
  • Research article

Alexandros C. Dimopoulos, Mara Nikolaidou, Francisco Félix Caballero, Worrawat Engchuan, Albert Sanchez-Niubo, Holger Arndt, José Luis Ayuso-Mateos, Josep Maria Haro, Somnath Chatterji, Ekavi N. Georgousopoulou, Christos Pitsavos, Demosthenes B. Panagiotakos

The generation of consensus guidelines for carrying out process evaluations in rehabilitation research

  • Open Access
  • Research article

P. Masterson-Algar, C. R. Burton, J. Rycroft-Malone

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