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BMC Cancer

Issue 1/2010

Content (697 Articles)

Open Access Research article

Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study

Monique M Cherrier, Paul R Borghesani, Amy L Shelton, Celestia S Higano

Open Access Research article

A multicentric observational trial of pegylated liposomal doxorubicin for metastatic breast cancer

Jens Huober, Werner Fett, Arnd Nusch, Michael Neise, Marcus Schmidt, Arthur Wischnik, Steffen Gerhardt, Thomas Goehler, Hans-Joachim Lück, Andreas Rost

Open Access Research article

Residual γH2AX foci as an indication of lethal DNA lesions

Judit P Banáth, Dmitry Klokov, Susan H MacPhail, C Adriana Banuelos, Peggy L Olive

Open Access Research article

Tocotrienols are good adjuvants for developing cancer vaccines

Sitti Rahma Abdul Hafid, Ammu Kutty Radhakrishnan, Kalanithi Nesaretnam

Open Access Research article

Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors

Deidi Strickland Bergestuen, Jørgen Gravning, Kristina Hermann Haugaa, Laura G Sahakyan, Svend Aakhus, Espen Thiis-Evensen, Erik Øie, Pål Aukrust, Håvard Attramadal, Thor Edvardsen

Open Access Research article

Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase

Elina Mattila, Heidi Marttila, Niko Sahlberg, Pekka Kohonen, Siri Tähtinen, Pasi Halonen, Merja Perälä, Johanna Ivaska

Open Access Research article

Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer

Oscar Fernández-Guinea, Alejandro Andicoechea, Luis O González, Salomé González-Reyes, Antonio M Merino, Luis C Hernández, Alfonso López-Muñiz, Paz García-Pravia, Francisco J Vizoso

Open Access Research article

Immunohistochemical analysis of oxidative stress and DNA repair proteins in normal mammary and breast cancer tissues

Carol D Curtis, Daniel L Thorngren, Ann M Nardulli

Open Access Research article

Chemosensitization of cancer cells by siRNA using targeted nanogel delivery

Erin B Dickerson, William H Blackburn, Michael H Smith, Laura B Kapa, L Andrew Lyon, John F McDonald

Open Access Research article

XIAP is not required for human tumor cell survival in the absence of an exogenous death signal

John Sensintaffar, Fiona L Scott, Robert Peach, Jeffrey H Hager

Open Access Research article

Bone invading NSCLC cells produce IL-7: mice model and human histologic data

Ilaria Roato, Davide Caldo, Laura Godio, Lucia D'Amico, Paolo Giannoni, Emanuela Morello, Rodolfo Quarto, Luigi Molfetta, Paolo Buracco, Antonio Mussa, Riccardo Ferracini

Open Access Research article

Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts

Daniel M Appledorn, Kim-Hien T Dao, Sandra O'Reilly, Veronica M Maher, J Justin McCormick

Open Access Research article

Feasibility of brief psychological distress screening by a community-based telephone helpline for cancer patients and carers

Anna L Hawkes, Karen L Hughes, Sandy D Hutchison, Suzanne K Chambers

Open Access Research article

Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: Comparison of the CGH profiles between cancer cell lines and primary cancer tissues

Katumi Tsuji, Shigeto Kawauchi, Soichiro Saito, Tomoko Furuya, Kenzo Ikemoto, Motonao Nakao, Shigeru Yamamoto, Masaaki Oka, Takashi Hirano, Kohsuke Sasaki

Open Access Research article

Cystatin E/M suppresses legumain activity and invasion of human melanoma

Jon J Briggs, Mads H Haugen, Harald T Johansen, Adam I Riker, Magnus Abrahamson, Øystein Fodstad, Gunhild M Mælandsmo, Rigmor Solberg

Open Access Research article

Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate

Gonzalo Rodríguez-Berriguete, Benito Fraile, Fermín R de Bethencourt, Angela Prieto-Folgado, Nahikari Bartolome, Claudia Nuñez, Bruna Prati, Pilar Martínez-Onsurbe, Gabriel Olmedilla, Ricardo Paniagua, Mar Royuela

Open Access Research article

Detection of HPV DNA in esophageal cancer specimens from different regions and ethnic groups: a descriptive study

Xueqian Wang, Xiuyun Tian, Fangfang Liu, Yiqiang Zhao, Min Sun, Dafang Chen, Changdong Lu, Zhong Wang, Xiaotian Shi, Qingying Zhang, Donghong Zhang, Zhongying Shen, Feng Li, Curtis C Harris, Hong Cai, Yang Ke

Open Access Research article

Grp78 promotes the invasion of hepatocellular carcinoma

Rongjian Su, Zhen Li, Hongdan Li, Huijuan Song, Cuifen Bao, Jia Wei, Liufang Cheng

Open Access Research article

Identification of S100A8-correlated genes for prediction of disease progression in non-muscle invasive bladder cancer

Seon-Kyu Kim, Eun-Jung Kim, Sun-Hee Leem, Yun-Sok Ha, Yong-June Kim, Wun-Jae Kim

Open Access Research article

Chordoma: clinical characteristics, management and prognosis of a case series of 25 patients

Virginia Ferraresi, Carmen Nuzzo, Carmine Zoccali, Ferdinando Marandino, Antonello Vidiri, Nicola Salducca, Massimo Zeuli, Diana Giannarelli, Francesco Cognetti, Roberto Biagini

Open Access Research article

Simultaneous CXCL12 and ESR1 CpG island hypermethylation correlates with poor prognosis in sporadic breast cancer

Edneia AS Ramos, Anamaria A Camargo, Karin Braun, Renata Slowik, Iglenir J Cavalli, Enilze MSF Ribeiro, Fábio de O Pedrosa, Emanuel M de Souza, Fabrício F Costa, Giseli Klassen

Open Access Study protocol

A multilevel study of the determinants of area-level inequalities in colorectal cancer survival

Peter D Baade, Gavin Turrell, Joanne F Aitken

Open Access Research article

Metastatic lymph node in gastric cancer; Is it a real distant metastasis?

Do Hyoung Lim, Hyeong Su Kim, Young Suk Park, Jeeyun Lee, Se Hoon Park, Ho Yeong Lim, Sang Hoon Ji, Min Jae Park, Seong Yoon Yi, Ji Yeong An, Tae Sung Sohn, Jae Hyoung Noh, Jae Moon Bae, Sung Kim, Cheol Keun Park, Won Ki Kang

Open Access Research article

Cost-effectiveness analysis of pemetrexed versus docetaxel in the second-line treatment of non-small cell lung cancer in Spain: results for the non-squamous histology population

Yumi Asukai, Amparo Valladares, Carlos Camps, Eifiona Wood, Kaisa Taipale, Jorge Arellano, Alejo Cassinello, José Antonio Sacristán, Tatiana Dilla

Open Access Research article

MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol

Yu Ren, Xuan Zhou, Mei Mei, Xu-Bo Yuan, Lei Han, Guang-Xiu Wang, Zhi-Fan Jia, Peng Xu, Pei-Yu Pu, Chun-Sheng Kang

Open Access Research article

Trastuzumab with either docetaxel or vinorelbine as first-line treatment for patients with HER2-positive advanced breast cancer: a retrospective comparison

Stefania Redana, Michela Donadio, Franco Nolè, Maria Elena Jacomuzzi, Alessandra Beano, Rossella Martinello, Anna Sapino, Giuseppe Viale, Massimo Aglietta, Filippo Montemurro

Open Access Research article

Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model

Jacob E Koskimaki, Emmanouil D Karagiannis, Benjamin C Tang, Hans Hammers, D Neil Watkins, Roberto Pili, Aleksander S Popel

Open Access Research article

BCNU for recurrent glioblastoma multiforme: efficacy, toxicity and prognostic factors

Thomas Reithmeier, Erika Graf, Tobias Piroth, Michael Trippel, Marcus O Pinsker, Guido Nikkhah

Open Access Research article

Endometrial cancer in Puerto Rico: incidence, mortality and survival (1992-2003)

Ana Patricia Ortiz, Javier Pérez, Yomayra Otero-Domínguez, Omar García-Rodríguez, Sheyla Garced-Tirado, Frances Escalera-Maldonado, Sadja Gaud-Quintana, Elvis Santiago-Rodríguez, Katherine Svensson, José L Vergara-Arroyo, Karen Ortiz, Mariela Torres, Guillermo Tortolero-Luna, Nayda Figueroa-Vallés

Open Access Research article

Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation

Yanyuan Wu, Monica Alvarez, Dennis J Slamon, Phillip Koeffler, Jaydutt V Vadgama

Open Access Research article

Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cells

Liduan Zheng, Guosong Jiang, Hong Mei, Jiarui Pu, Jihua Dong, Xiaohua Hou, Qiangsong Tong

Open Access Research article

Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent

Deborah A Altomare, Susanna M Rybak, Jianming Pei, Jacob V Maizel, Mitchell Cheung, Joseph R Testa, Kuslima Shogen

Open Access Research article

Mammographic density and markers of socioeconomic status: a cross-sectional study

Zoe Aitken, Kate Walker, Bernardine H Stegeman, Petra A Wark, Sue M Moss, Valerie A McCormack, Isabel dos Santos Silva

Open Access Research article

A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole

Zaida Garcia-Casado, Angel Guerrero-Zotano, Antonio Llombart-Cussac, Ana Calatrava, Antonio Fernandez-Serra, Amparo Ruiz-Simon, Joaquin Gavila, Miguel A Climent, Sergio Almenar, Jose Cervera-Deval, Josefina Campos, Carlos Vazquez Albaladejo, Antonio Llombart-Bosch, Vicente Guillem, Jose A Lopez-Guerrero

Open Access Research article

Molecular risk assessment of BIG 1-98 participants by expression profiling using RNA from archival tissue

Janine Antonov, Vlad Popovici, Mauro Delorenzi, Pratyaksha Wirapati, Anna Baltzer, Andrea Oberli, Beat Thürlimann, Anita Giobbie-Hurder, Giuseppe Viale, Hans Jörg Altermatt, Stefan Aebi, Rolf Jaggi

Open Access Research article

Argonaute proteins: potential biomarkers for human colon cancer

Lan Li, Chaohui Yu, Hengjun Gao, Youming Li

Open Access Research article

Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer

Amy M Lum, Bruce B Wang, Gabriele B Beck-Engeser, Lauri Li, Namitha Channa, Matthias Wabl

Open Access Research article

Cellular processes of v-Src transformation revealed by gene profiling of primary cells - Implications for human cancer

Bart M Maślikowski, Benjamin D Néel, Ying Wu, Lizhen Wang, Natalie A Rodrigues, Germain Gillet, Pierre-André Bédard

Open Access Research article

TrkB is highly expressed in NSCLC and mediates BDNF-induced the activation of Pyk2 signaling and the invasion of A549 cells

Siyang Zhang, Dawei Guo, Wenting Luo, Qingfu Zhang, Ying Zhang, Chunyan Li, Yao Lu, Zeshi Cui, Xueshan Qiu

Open Access Research article

Methylation status of individual CpG sites within Alu elements in the human genome and Alu hypomethylation in gastric carcinomas

Shengyan Xiang, Zhaojun Liu, Baozhen Zhang, Jing Zhou, Bu-Dong Zhu, Jiafu Ji, Dajun Deng

Open Access Research article

Prognostic stratification of patients with advanced renal cell carcinoma treated with sunitinib: comparison with the Memorial Sloan-Kettering prognostic factors model

Aristotelis Bamias, Alexandra Karadimou, Sofia Lampaki, George Lainakis, Lia Malettou, Eleni Timotheadou, Kostas Papazisis, Charalambos Andreadis, Loukas Kontovinis, Ioannis Anastasiou, Kostas Stravodimos, Ioannis Xanthakis, Andreas Skolarikos, Christos Christodoulou, Kostas Syrigos, Christos Papandreou, Evangelia Razi, Urania Dafni, George Fountzilas, Meletios A Dimopoulos

Open Access Research article

4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest

Ching-Yu Yen, Chien-Chih Chiu, Fang-Rong Chang, Jeff Yi-Fu Chen, Chi-Ching Hwang, You-Cheng Hseu, Hsin-Ling Yang, Alan Yueh-Luen Lee, Ming-Tz Tsai, Zong-Lun Guo, Yu-Shan Cheng, Yin-Chang Liu, Yu-Hsuan Lan, Yu-Ching Chang, Ying-Chin Ko, Hsueh-Wei Chang, Yang-Chang Wu

Open Access Research article

Novel genetic variants in miR-191 gene and familial ovarian cancer

Jie Shen, Richard DiCioccio, Kunle Odunsi, Shashikant B Lele, Hua Zhao

Open Access Technical advance

Promoter methylation analysis of O6-methylguanine-DNA methyltransferase in glioblastoma: detection by locked nucleic acid based quantitative PCR using an imprinted gene (SNURF) as a reference

Luca Morandi, Enrico Franceschi, Dario de Biase, Gianluca Marucci, Alicia Tosoni, Mario Ermani, Annalisa Pession, Giovanni Tallini, Alba Brandes

Open Access Case report

Hemorrhage of brain metastasis from non-small cell lung cancer post gefitinib therapy: two case reports and review of the literature

Dan-Fang Yan, Sen-Xiang Yan, Jing-Song Yang, Yi-Xiang J Wang, Xiao-Li Sun, Xin-Biao Liao, Jun-Qing Liu

Open Access Research article

Association of nutritional status and serum albumin levels with development of toxicity in patients with advanced non-small cell lung cancer treated with paclitaxel-cisplatin chemotherapy: a prospective study

Oscar Arrieta, Rosa M Michel Ortega, Geraldine Villanueva-Rodríguez, Maria G Serna-Thomé, Diana Flores-Estrada, Consuelo Diaz-Romero, Cindy M Rodríguez, Luis Martínez, Karla Sánchez-Lara

Open Access Research article

Effect of troglitazone on tumor growth and pulmonary metastasis development of the mouse osteosarcoma cell line LM8

Junichi Aizawa, Kenshi Sakayama, Setsuya Kamei, Teruki Kidani, Haruyasu Yamamoto, Yoshiaki Norimatsu, Hiroshi Masuno

Open Access Research article

German cancer statistics 2004

Jörg Haberland, Joachim Bertz, Ute Wolf, Thomas Ziese, Bärbel-Maria Kurth

Open Access Research article

Hybrid capture vs. PCR screening of cervical human papilloma virus infections. Cytological and histological associations in 1270 women

Sotirios Tsiodras, John Georgoulakis, Aikaterini Chranioti, Zanis Voulgaris, Amanda Psyrri, Angeliki Tsivilika, John Panayiotides, Petros Karakitsos

Open Access Research article

In vitro and in vivo characterization of highly purified Human Mesothelioma derived cells

Alice Melotti, Antonio Daga, Daniela Marubbi, Annalisa Zunino, Luciano Mutti, Giorgio Corte

Open Access Research article

Identification of hypoxanthine as a urine marker for non-Hodgkin lymphoma by low-mass-ion profiling

Byong Chul Yoo, Sun-Young Kong, Sang-Geun Jang, Kyung-Hee Kim, Sun-A Ahn, Weon-Seo Park, Sohee Park, Tak Yun, Hyeon-Seok Eom

Open Access Research article

Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2 homodimers in a clinic-based cohort of patients with metastatic breast cancer

Masakazu Toi, Jeff Sperinde, Weidong Huang, Shigehira Saji, John Winslow, Xueguang Jin, Yuping Tan, Shinji Ohno, Seigo Nakamura, Hiroji Iwata, Norikazu Masuda, Kenjiro Aogi, Satoshi Morita, Christos Petropoulos, Michael Bates

Open Access Research article

Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment

Sergey V Tokalov, Nasreddin D Abolmaali

Open Access Research article

Stabilization of mismatch repair gene PMS2 by glycogen synthase kinase 3β is implicated in the treatment of cervical carcinoma

Yuan Zhang, Yi Min Shu, Shu Fang Wang, Bang Hong Da, Ze Hua Wang, Hua Bin Li

Open Access Research article

Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) overexpression in pancreatic ductal adenocarcinoma correlates with poor survival

David F Schaeffer, Daniel R Owen, Howard J Lim, Andrew K Buczkowski, Stephen W Chung, Charles H Scudamore, David G Huntsman, Sylvia SW Ng, David A Owen

Open Access Research article

Activated CD4+T cells enhance radiation effect through the cooperation of interferon-γ and TNF-α

Yixiang Wang, Soroosh Radfar, Hung T Khong

Open Access Research article

Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysis

Enio Ferreira, Helenice Gobbi, Bruna S Saraiva, Geovanni D Cassali

Open Access Case report

Bladder metastases of appendiceal mucinous adenocarcinoma: a case presentation

Gianluigi Taverna, Matteo Corinti, Piergiuseppe Colombo, Fabio Grizzi, Mauro Severo, Alessando Piccinelli, Guido Giusti, Alessio Benetti, Paolo A Zucali, Pierpaolo Graziotti

Open Access Research article

Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients

Massimo Mascolo, Maria Luisa Vecchione, Gennaro Ilardi, Massimiliano Scalvenzi, Guido Molea, Maria Di Benedetto, Loredana Nugnes, Maria Siano, Gaetano De Rosa, Stefania Staibano

Open Access Research article

E2F5 status significantly improves malignancy diagnosis of epithelial ovarian cancer

Narasimhan Kothandaraman, Vladimir B Bajic, Pang NK Brendan, Chan Y Huak, Peh B Keow, Khalil Razvi, Manuel Salto-Tellez, Mahesh Choolani

Open Access Research article

Expression of survivin detected by immunohistochemistry in the cytoplasm and in the nucleus is associated with prognosis of leiomyosarcoma and synovial sarcoma patients

Helge Taubert, Chris Heidenreich, Hans-Jürgen Holzhausen, Antje Schulz, Matthias Bache, Matthias Kappler, Alexander W Eckert, Peter Würl, Ingo Melcher, Kathrin Hauptmann, Steffen Hauptmann, Klaus-Dieter Schaser

Open Access Research article

CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors

Cristina Patru, Luciana Romao, Pascale Varlet, Laure Coulombel, Eric Raponi, Josette Cadusseau, François Renault-Mihara, Cécile Thirant, Nadine Leonard, Alain Berhneim, Maria Mihalescu-Maingot, Jacques Haiech, Ivan Bièche, Vivaldo Moura-Neto, Catherine Daumas-Duport, Marie-Pierre Junier, Hervé Chneiweiss

Open Access Research article

Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice

Chiyo Doi, Noboru Egashira, Atsushi Kawabata, Dharmendra Kumar Maurya, Naomi Ohta, Deepthi Uppalapati, Rie Ayuzawa, Lara Pickel, Yuka Isayama, Deryl Troyer, Susumu Takekoshi, Masaaki Tamura

Open Access Research article

Pluripotency-associated genes in human nasopharyngeal carcinoma CNE-2 cells are reactivated by a unique epigenetic sub-microenvironment

Jun-Xia Cao, Yu-Xin Cui, Zi-Jie Long, Zhong-Min Dai, Ji-Yan Lin, Yi Liang, Fei-Meng Zheng, Yi-Xin Zeng, Quentin Liu

Open Access Research article

The 4q27 locus and prostate cancer risk

Elizabeth A Tindall, Hoa N Hoang, Melissa C Southey, Dallas R English, John L Hopper, Graham G Giles, Gianluca Severi, Vanessa M Hayes

Open Access Research article

Immunoscreening of the extracellular proteome of colorectal cancer cells

Susanne Klein-Scory, Salwa Kübler, Hanna Diehl, Christina Eilert-Micus, Anke Reinacher-Schick, Kai Stühler, Bettina Warscheid, Helmut E Meyer, Wolff Schmiegel, Irmgard Schwarte-Waldhoff

Open Access Research article

Microarray analysis of DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays

Yi Qing, Xue-Qin Yang, Zhao-Yang Zhong, Xin Lei, Jia-Yin Xie, Meng-Xia Li, De-Bing Xiang, Zeng-Peng Li, Zhen-Zhou Yang, Ge Wang, Dong Wang

Open Access Research article

Lipophilic aroylhydrazone chelator HNTMB and its multiple effects on ovarian cancer cells

Kyu Kwang Kim, Thilo S Lange, Rakesh K Singh, Laurent Brard

Open Access Research article

Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines

Siina Junnila, Arto Kokkola, Marja-Liisa Karjalainen-Lindsberg, Pauli Puolakkainen, Outi Monni

Open Access Research article

Trends in the incidence and survival of multiple myeloma in South East England 1985-2004

Christine Renshaw, Nicolas Ketley, Henrik Møller, Elizabeth A Davies

Open Access Research article

Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer

Vera N Senchenko, Ekaterina A Anedchenko, Tatiana T Kondratieva, George S Krasnov, Alexei A Dmitriev, Veronika I Zabarovska, Tatiana V Pavlova, Vladimir I Kashuba, Michael I Lerman, Eugene R Zabarovsky

Open Access Research article

HAX-1 overexpression, splicing and cellular localization in tumors

Alicja Trebinska, Alina Rembiszewska, Karolina Ciosek, Konrad Ptaszynski, Sebastian Rowinski, Jolanta Kupryjanczyk, Janusz A Siedlecki, Ewa A Grzybowska

Open Access Research article

Gene expression profiles of lung adenocarcinoma linked to histopathological grading and survival but not to EGF-R status: a microarray study

Jens Neumann, Friedrich Feuerhake, Gian Kayser, Thorsten Wiech, Konrad Aumann, Bernward Passlick, Paul Fisch, Martin Werner, Axel zur Hausen

Open Access Research article

Selective regain of egfr gene copies in CD44+/CD24-/lowbreast cancer cellular model MDA-MB-468

Konstantin Agelopoulos, Burkhard Greve, Hartmut Schmidt, Heike Pospisil, Stefan Kurtz, Kai Bartkowiak, Antje Andreas, Marek Wieczorek, Eberhard Korsching, Horst Buerger, Burkhard Brandt

Open Access Research article

Expression of ZIC family genes in meningiomas and other brain tumors

Jun Aruga, Yayoi Nozaki, Minoru Hatayama, Yuri S Odaka, Naoki Yokota

Open Access Research article

Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?

Mark M Aloysius, Abed M Zaitoun, Timothy E Bates, Mohammad Ilyas, Dumitru Constantin-Teodosiu, Brian J Rowlands, Dileep N Lobo

Open Access Research article

Maternal consumption of canola oil suppressed mammary gland tumorigenesis in C3(1) TAg mice offspring

Gabriela Ion, Juliana A Akinsete, W Elaine Hardman

Open Access Research article

Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases

Martin Grimm, Martin Gasser, Marco Bueter, Johanna Strehl, Johann Wang, Ekaterina Nichiporuk, Detlef Meyer, Christoph T Germer, Ana M Waaga-Gasser, Andreas Thalheimer

Open Access Research article

Functional significance of the hepaCAM gene in bladder cancer

Yunfeng He, Xiaohou Wu, Chunli Luo, Lie Wang, Jie Lin

Open Access Research article

Parenteral nutrition support for patients with pancreatic cancer. Results of a phase II study

Uwe Pelzer, Dirk Arnold, Mehmet Goevercin, Jens Stieler, Bernd Doerken, Hanno Riess, Helmut Oettle

Open Access Research article

Pancreatic adenocarcinoma exerts systemic effects on the peripheral blood myeloid and plasmacytoid dendritic cells: an indicator of disease severity?

Vegard Tjomsland, Per Sandström, Anna Spångeus, Davorka Messmer, Johan Emilsson, Ursula Falkmer, Sture Falkmer, Karl-Eric Magnusson, Kurt Borch, Marie Larsson

Open Access Research article

Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore

Hui Wan Chua, Daniel Ng, Serena Choo, San San Lum, Huihua Li, Li Ying Soh, Kanaga Sabapathy, Adeline Seow

Open Access Research article

Targeting HOX and PBX transcription factors in ovarian cancer

Richard Morgan, Lynn Plowright, Kevin J Harrington, Agnieszka Michael, Hardev S Pandha

Open Access Research article

Favourable ten-year overall survival in a Caucasian population with high probability of hereditary breast cancer

Laura Cortesi, Cristina Masini, Claudia Cirilli, Veronica Medici, Isabella Marchi, Giovanna Cavazzini, Giuseppe Pasini, Daniela Turchetti, Massimo Federico

Open Access Research article

Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines

Marie-Claude Amoureux, Béma Coulibaly, Olivier Chinot, Anderson Loundou, Philippe Metellus, Geneviève Rougon, Dominique Figarella-Branger

Open Access Research article

Multimodal therapy for synergic inhibition of tumour cell invasion and tumour-induced angiogenesis

Pamela Zengel, Diana Ramp, Brigitte Mack, Stefan Zahler, Alexander Berghaus, Bernd Muehlenweg, Olivier Gires, Suna Schmitz

Open Access Research article

Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer

Manuela Eppenberger, Inti Zlobec, Daniel Baumhoer, Luigi Terracciano, Alessandro Lugli

Open Access Research article

Alterations of the extracellular matrix in ovarian cancer studied by Second Harmonic Generation imaging microscopy

Oleg Nadiarnykh, Ronald B LaComb, Molly A Brewer, Paul J Campagnola

Open Access Research article

The investigation of Mitogen-Activated Protein kinase Phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging

Cheng-Jeng Tai, Alexander TH Wu, Jeng-Feng Chiou, Hsun-Jin Jan, Hon-Jian Wei, Chung-Huei Hsu, Che-Tong Lin, Wen-Ta Chiu, Cheng-Wen Wu, Horng-Mo Lee, Win-Ping Deng

Open Access Study protocol

Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma

Claudia Blattmann, Susanne Oertel, Daniela Schulz-Ertner, Stefan Rieken, Sabine Haufe, Volker Ewerbeck, Andreas Unterberg, Irini Karapanagiotou-Schenkel, Stephanie E Combs, Anna Nikoghosyan, Marc Bischof, Oliver Jäkel, Peter Huber, Andreas E Kulozik, Jürgen Debus

Open Access Research article

Quantitative methylation profiling in tumor and matched morphologically normal tissues from breast cancer patients

Ilse Van der Auwera, Catherine Bovie, Cecilia Svensson, Xuan B Trinh, Ridha Limame, Peter van Dam, Steven J van Laere, Eric A van Marck, Luc Y Dirix, Peter B Vermeulen

Open Access Research article

Genetic and epigenetic silencing of the beclin 1gene in sporadic breast tumors

Zidong Li, Bo Chen, Yiqing Wu, Feng Jin, Yongjing Xia, Xiangjun Liu

Open Access Research article

Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study

Adam Naguib, Panagiota N Mitrou, Laura J Gay, James C Cooke, Robert N Luben, Richard Y Ball, Alison McTaggart, Mark J Arends, Sheila A Rodwell

Open Access Research article

Inter-country and ethnic variation in colorectal cancer survival: Comparisons between a Philippine population, Filipino-Americans and Caucasians

Maria Theresa Redaniel, Adriano Laudico, Maria Rica Mirasol-Lumague, Adam Gondos, Gemma Uy, Hermann Brenner

Open Access Research article

A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes

Debora Fumagalli, Patrick G Gavin, Yusuke Taniyama, Seung-Il Kim, Hyun-Joo Choi, Soonmyung Paik, Katherine L Pogue-Geile

Open Access Research article

Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation

Wen-Shan Liu, Chung-Han Hsin, Ying-Hsiang Chou, Jung-Tung Liu, Ming-Fang Wu, Szu-Wen Tseng, Jong-Kang Lee, Hsien-Chun Tseng, Tzu-Hwei Wang, Mao-Chang Su, Huei Lee

Open Access Research article

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

Anna Martirosyan, James W Clendening, Carolyn A Goard, Linda Z Penn

Open Access Research article

Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors

Sally Järvelä, Immo Rantala, Alejandra Rodriguez, Heini Kallio, Seppo Parkkila, Vuokko L Kinnula, Ylermi Soini, Hannu Haapasalo

Open Access Research article

Long-term survival of cancer patients compared to heart failure and stroke: A systematic review

Vasileios Askoxylakis, Christian Thieke, Sven T Pleger, Patrick Most, Judith Tanner, Katja Lindel, Hugo A Katus, Jürgen Debus, Marc Bischof

Open Access Technical advance

In situ protein expression in tumour spheres: development of an immunostaining protocol for confocal microscopy

Louis-Bastien Weiswald, Jean-Marc Guinebretière, Sophie Richon, Dominique Bellet, Bruno Saubaméa, Virginie Dangles-Marie

Open Access Research article

Effects of clusterin over-expression on metastatic progression and therapy in breast cancer

Louise Flanagan, Lorna Whyte, Namita Chatterjee, Martin Tenniswood

Open Access Research article

The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence

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Differential profiling of breast cancer plasma proteome by isotope-coded affinity tagging method reveals biotinidase as a breast cancer biomarker

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Birth length and weight as predictors of breast cancer prognosis

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CD133 expression in chemo-resistant Ewing sarcoma cells

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The percentage of CD133+ cells in human colorectal cancer cell lines is influenced by Mycoplasma hyorhinis infection

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Increased expression of urokinase plasminogen activator and its cognate receptor in human seminomas

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Open Access Study protocol

The lung cancer exercise training study: a randomized trial of aerobic training, resistance training, or both in postsurgical lung cancer patients: rationale and design

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Spontaneous feline mammary intraepithelial lesions as a model for human estrogen receptor- and progesterone receptor-negative breast lesions

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Anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liver

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The spectrum of resistance in SR/CR mice: the critical role of chemoattraction in the cancer/leukocyte interaction

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Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?

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Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer

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Lack of relationship between TIMP-1 tumour cell immunoreactivity, treatment efficacy and prognosis in patients with advanced epithelial ovarian cancer

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High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology

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Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway

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Breast cancer histology and receptor status characterization in Asian Indian and Pakistani women in the U.S. - a SEER analysis

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Interference with Activator Protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells

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Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent

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Open Access Technical advance

A new method to detect loss of heterozygosity using cohort heterozygosity comparisons

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Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma

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Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays

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Open Access Research article

Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy

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Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy

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Comparative proteomic analysis of plasma membrane proteins between human osteosarcoma and normal osteoblastic cell lines

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A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma

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Aqueous Cinnamon Extract (ACE-c) from the bark of Cinnamomum cassiacauses apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential

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Estrogen regulation of TRPM8 expression in breast cancer cells

Dechen Chodon, Arnaud Guilbert, Isabelle Dhennin-Duthille, Mathieu Gautier, Marie-Sophie Telliez, Henri Sevestre, Halima Ouadid-Ahidouch

Open Access Research article

Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine

Krishnan Rathinasamy, Bhavya Jindal, Jayant Asthana, Parminder Singh, Petety V Balaji, Dulal Panda

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Explaining disparities in colorectal cancer screening among five Asian ethnic groups: A population-based study in California

Annette E Maxwell, Catherine M Crespi, Cynthia M Antonio, Peiyun Lu

Open Access Research article

Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma

Gerald N DeLorenze, Lucie McCoy, Ai-Lin Tsai, Charles P Quesenberry Jr, Terri Rice, Dora Il'yasova, Margaret Wrensch

Open Access Research article

Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells

Xue-Rong Miao, Xiao-Fei Gao, Jing-Xiang Wu, Zhi-Jie Lu, Zhang-Xiang Huang, Xiao-Qing Li, Cheng He, Wei-Feng Yu

Open Access Research article

Hypermethylated 14-3-3-σ and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis

Mercedes Zurita, Pedro C Lara, Rosario del Moral, Blanca Torres, José Luis Linares-Fernández, Sandra Ríos Arrabal, Joaquina Martínez-Galán, Francisco Javier Oliver, José Mariano Ruiz de Almodóvar

Open Access Research article

Residual hepatocellular carcinoma after oxaliplatin treatment has increased metastatic potential in a nude mouse model and is attenuated by Songyou Yin

Wei Xiong, Zheng-Gang Ren, Shuang-Jian Qiu, Hui-Chuan Sun, Lu Wang, Bin-Bin Liu, Qi-Song Li, Wei Zhang, Xiao-Dong Zhu, Liang Liu, Wen-Quan Wang, Zhao-You Tang

Open Access Research article

The number and microlocalization of tumor-associated immune cells are associated with patient's survival time in non-small cell lung cancer

Fuqiang Dai, Lunxu Liu, Guowei Che, Nanbin Yu, Qiang Pu, Shangfu Zhang, Junliang Ma, Lin Ma, Zongbing You

Open Access Research article

Association between EGF +61 G/A and glioma risk in a Chinese population

Shujie Wang, Yao Zhao, Zhenchao Ruan, Hongyan Chen, Weiwei Fan, Juxiang Chen, Qihan Wu, Ji Qian, Tianbao Zhang, Yan Huang, Daru Lu

Open Access Research article

A genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer

Jean-Philippe Meyniel, Paul H Cottu, Charles Decraene, Marc-Henri Stern, Jérôme Couturier, Ingrid Lebigot, André Nicolas, Nina Weber, Virginie Fourchotte, Séverine Alran, Audrey Rapinat, David Gentien, Sergio Roman-Roman, Laurent Mignot, Xavier Sastre-Garau

Open Access Research article

Protein expression profile and prevalence pattern of the molecular classes of breast cancer - a Saudi population based study

Dalal M Al Tamimi, Mohamed A Shawarby, Ayesha Ahmed, Ammar K Hassan, Amal A AlOdaini

Open Access Research article

Is lymphadenectomy a prognostic marker in endometrioid adenocarcinoma of the human endometrium?

Nina Bassarak, Thomas Blankenstein, Ansgar Brüning, Darius Dian, Florian Bergauer, Klaus Friese, Ioannis Mylonas

Open Access Research article

Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4

Patricia A Cronin, Jiang H Wang, H Paul Redmond

Open Access Research article

Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features

Pei Woon Ang, Marie Loh, Natalia Liem, Pei Li Lim, Fabienne Grieu, Aparna Vaithilingam, Cameron Platell, Wei Peng Yong, Barry Iacopetta, Richie Soong

Open Access Research article

Use of ER/PR/HER2 subtypes in conjunction with the 2007 St Gallen Consensus Statement for early breast cancer

Katrina Bauer, Carol Parise, Vincent Caggiano

Open Access Research article

The aberrant asynchronous replication — characterizing lymphocytes of cancer patients — is erased following stem cell transplantation

Arnon Nagler, Samuel Cytron, Maya Mashevich, Avital Korenstein-Ilan, Lydia Avivi

Open Access Research article

Improved survival for non-Hodgkin lymphoma patients in New South Wales, Australia

Xue Q Yu, Wendy H Chen, Dianne L O'Connell

Open Access Research article

Pretreatment malnutrition and quality of life - association with prolonged length of hospital stay among patients with gynecological cancer: a cohort study

Brenda Laky, Monika Janda, Srinivas Kondalsamy-Chennakesavan, Geoffrey Cleghorn, Andreas Obermair

Open Access Research article

Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes

Zhihui Wang, Claes G Trope, Vivi Ann Flørenes, Zhenhe Suo, Jahn M Nesland, Ruth Holm

Open Access Research article

Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers

William N Rom, Judith D Goldberg, Doreen Addrizzo-Harris, Heather N Watson, Michael Khilkin, Alissa K Greenberg, David P Naidich, Bernard Crawford, Ellen Eylers, Daorong Liu, Eng M Tan

Open Access Research article

Methylenetetrahydrofolate reductase C677T polymorphism in patients with gastric and colorectal cancer in a Korean population

Lian-Hua Cui, Min-Ho Shin, Sun-Seog Kweon, Hee Nam Kim, Hye-Rim Song, Jin-Mei Piao, Jin-Su Choi, Hyun Jeong Shim, Jun Eul Hwang, Hyeong-Rok Kim, Young-Kyu Park, Soo-Hyun Kim

Open Access Research article

Expression signatures of TP53 mutations in serous ovarian cancers

Marcus Q Bernardini, Tsukasa Baba, Paula S Lee, Jason C Barnett, Gregory P Sfakianos, Angeles Alvarez Secord, Susan K Murphy, Edwin Iversen, Jeffrey R Marks, Andrew Berchuck

Open Access Research article

Identification of valid reference genes for gene expression studies of human stomach cancer by reverse transcription-qPCR

Hyun-Wook Rho, Byoung-Chan Lee, Eun-Seok Choi, Il-Ju Choi, Yeon-Su Lee, Sung-Ho Goh

Open Access Research article

Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-κB

Ida Grotterød, Gunhild M Mælandsmo, Kjetil Boye

Open Access Technical advance

Development of an enzyme-linked immunosorbent assay for the detection of human calretinin in plasma and serum of mesothelioma patients

Irina Raiko, Ingrid Sander, Daniel G Weber, Monika Raulf-Heimsoth, Adrian Gillissen, Jens Kollmeier, Arnaud Scherpereel, Thomas Brüning, Georg Johnen

Open Access Research article

Canine classical seminoma: a specific malignant type with human classifications is highly correlated with tumor angiogenesis

Jong-Hyuk Kim, Chi-Ho Yu, Ji-Young Yhee, Keum-Soon Im, Na-Hyun Kim, Jung-Hyang Sur

Open Access Research article

Estradiol suppresses tissue androgens and prostate cancer growth in castration resistant prostate cancer

Bruce Montgomery, Peter S Nelson, Robert Vessella, Tom Kalhorn, David Hess, Eva Corey

Open Access Research article

Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin

Ai-Li Shiau, Min-Li Teo, Shin-Yao Chen, Chrong-Reen Wang, Jeng-Long Hsieh, Meng-Ya Chang, Chih-Jui Chang, Julie Chao, Lee Chao, Chao-Liang Wu, Che-Hsin Lee

Open Access Case report

Primary myxofibrosarcoma of the parotid: case report

Xu Li, Xin Chen, Zhao-Hui Shi, Yang Chen, Jing Ye, Li Qiao, Jian-Hua Qiu

Open Access Research article

CDO1 Promoter Methylation is a Biomarker for Outcome Prediction of Anthracycline Treated, Estrogen Receptor-Positive, Lymph Node-Positive Breast Cancer Patients

Dimo Dietrich, Manuel Krispin, Jörn Dietrich, Anne Fassbender, Jörn Lewin, Nadia Harbeck, Manfred Schmitt, Serenella Eppenberger-Castori, Vincent Vuaroqueaux, Frédérique Spyratos, John A Foekens, Ralf Lesche, John WM Martens

Open Access Research article

Pim1 promotes human prostate cancer cell tumorigenicity and c-MYC transcriptional activity

Jongchan Kim, Meejeon Roh, Sarki A Abdulkadir

Open Access Research article

Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop

Mattias K Andersson, Melker Göransson, Anita Olofsson, Carola Andersson, Pierre Åman

Open Access Research article

Overexpression of S100A4 in human cancer cell lines resistant to methotrexate

Nuria Mencía, Elisabet Selga, Isabel Rico, M Cristina de Almagro, Xenia Villalobos, Sara Ramirez, Jaume Adan, Jose L Hernández, Véronique Noé, Carlos J Ciudad

Open Access Research article

Putative tumour-suppressor gene DAB2is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma

Joanna H Tong, David C Ng, Shuk L Chau, Ken K So, Patrick P Leung, Tin L Lee, Raymond W Lung, Michael W Chan, Anthony W Chan, Kwok W Lo, Ka F To

Open Access Research article

Prognostic relevance of ALT-associated markers in liposarcoma: a comparative analysis

Lorenza Venturini, Rosita Motta, Alessandro Gronchi, MariaGrazia Daidone, Nadia Zaffaroni

Open Access Research article

Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates

Alessandra Estrela-Lima, Márcio SS Araújo, João M Costa-Neto, Andréa Teixeira-Carvalho, Stella M Barrouin-Melo, Sergio V Cardoso, Olindo A Martins-Filho, Rogéria Serakides, Geovanni D Cassali

Open Access Research article

Carmustine and methotrexate in combination after whole brain radiation therapy in breast cancer patients presenting with brain metastases: a retrospective study

William Jacot, Marie-Cécile Gerlotto-Borne, Simon Thezenas, Stéphane Pouderoux, Sylvain Poujol, Mahdi About, Gilles Romieu

Open Access Research article

Micronutrients attenuate progression of prostate cancer by elevating the endogenous inhibitor of angiogenesis, Platelet Factor-4

David Cervi, Brian Pak, Natalie A Venier, Linda M Sugar, Robert K Nam, Neil E Fleshner, Laurence H Klotz, Vasundara Venkateswaran

Open Access Research article

Human Papilloma Virus prevalence and type-specific relative contribution in invasive cervical cancer specimens from Italy

Luciano Mariani, Núria Monfulleda, Laia Alemany, Enrico Vizza, Ferdinando Marandino, Amina Vocaturo, Maria Benevolo, Beatriz Quirós, Belén Lloveras, Jo Ellen Klaustermeier, Wim Quint, Silvia de Sanjosé, Fs Xavier Bosch

Open Access Research article

Fractal dimension of chromatin is an independent prognostic factor for survival in melanoma

Valcinir Bedin, Randall L Adam, Bianca CS de Sá, Gilles Landman, Konradin Metze

Open Access Research article

Induction of cytotoxic T lymphocytes primed with Tumor RNA-loaded Dendritic Cells in esophageal squamous cell carcinoma: preliminary step for DC vaccine design

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Open Access Research article

High-throughput miRNA profiling of human melanoma blood samples

Petra Leidinger, Andreas Keller, Anne Borries, Jörg Reichrath, Knuth Rass, Sven U Jager, Hans-Peter Lenhof, Eckart Meese

Open Access Research article

The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D cultures

Silva Krause, Maricel V Maffini, Ana M Soto, Carlos Sonnenschein

Open Access Case report

Malignant fibrous histiocytoma of the distal femur after an arthroscopic anterior cruciate ligament reconstruction: A case report and a review of the literature

Turgay Efe, Thomas J Heyse, Markus D Schofer, Susanne Fuchs-Winkelmann, Peter Rexin, Jan Schmitt

Open Access Research article

Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivotumor growth

Pedro Andreu-Pérez, Javier Hernandez-Losa, Teresa Moliné, Rosa Gil, Judit Grueso, Anna Pujol, Javier Cortés, Matias A Avila, Juan A Recio

Open Access Research article

Cancer risk assessment of ethyl carbamate in alcoholic beverages from Brazil with special consideration to the spirits cachaça and tiquira

Dirk W Lachenmeier, Maria CP Lima, Ian CC Nóbrega, José AP Pereira, Florence Kerr-Corrêa, Fotis Kanteres, Jürgen Rehm

Open Access Research article

The optimal number of lymph nodes examined in stage II colorectal cancer and its impact of on outcomes

Hok Kwok Choi, Wai Lun Law, Jensen TC Poon

Open Access Research article

Differential expression of centrosomal proteins at different stages of human glioma

Joon-Khim Loh, Ann-Shung Lieu, Chia-Hua Chou, Fang-Yi Lin, Chia-Hung Wu, Sheng-Long Howng, Chung-Ching Chio, Yi-Ren Hong

Open Access Research article

Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells

Xiang Wu, Yu Zhu, Huiqin Yan, Boning Liu, Ying Li, Qinghua Zhou, Ke Xu

Open Access Research article

Increased expression of MMP9 is correlated with poor prognosis of nasopharyngeal carcinoma

Zhen Liu, Lixia Li, Zhixiong Yang, Weiren Luo, Xin Li, Huiling Yang, Kaitai Yao, Bin Wu, Weiyi Fang

Open Access Research article

hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis

Jillian de Wilde, Jan M Kooter, Renée M Overmeer, Debbie Claassen-Kramer, Chris JLM Meijer, Peter JF Snijders, Renske DM Steenbergen

Open Access Study protocol

Physical Activity during Cancer Treatment (PACT) Study: design of a randomised clinical trial

Miranda J Velthuis, Anne M May, Ria AG Koppejan-Rensenbrink, Brigitte CM Gijsen, Eric van Breda, G Ardine de Wit, Carin D Schröder, Evelyn M Monninkhof, Eline Lindeman, Elsken van der Wall, Petra HM Peeters

Open Access Research article

Periostin is up-regulated in high grade and high stage prostate cancer

Verena Tischler, Florian R Fritzsche, Peter J Wild, Carsten Stephan, Hans-Helge Seifert, Marc-Oliver Riener, Thomas Hermanns, Ashkan Mortezavi, Josefine Gerhardt, Peter Schraml, Klaus Jung, Holger Moch, Alex Soltermann, Glen Kristiansen

Open Access Research article

Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study

Hoirun Nisa, Suminori Kono, Guang Yin, Kengo Toyomura, Jun Nagano, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Takafumi Maekawa, Yohichi Yasunami, Kenji Takenaka, Hitoshi Ichimiya, Reiji Terasaka

Open Access Technical advance

Soluble Fas might serve as a diagnostic tool for gastric adenocarcinoma

Samaneh Boroumand-Noughabi, Hamid Reza Sima, Kamran Ghaffarzadehgan, Mostafa Jafarzadeh, Hamid Reza Raziee, Hanieh Hosseinnezhad, Omeed Moaven, Mohammad Taghi Rajabi-Mashhadi, Amir Abbas Azarian, Mojtaba Mashhadinejad, Jalil Tavakkol-Afshari

Open Access Research article

Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo

Phan LCHB Tran, Soo-A Kim, Hong Seok Choi, Jung-Hoon Yoon, Sang-Gun Ahn

Open Access Research article

CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women

Koushik Chatterjee, Collet Dandara, Margaret Hoffman, Anna-Lise Williamson

Open Access Research article

Hopefulness predicts resilience after hereditary colorectal cancer genetic testing: a prospective outcome trajectories study

Samuel MY Ho, Judy WC Ho, George A Bonanno, Annie TW Chu, Emily MS Chan

Open Access Research article

Centrosome clustering and cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors

Javier del Rey, Esther Prat, Immaculada Ponsa, Josep Lloreta, Antoni Gelabert, Ferran Algaba, Jordi Camps, Rosa Miró

Open Access Research article

Incidence of chemotherapy-induced amenorrhea associated with epirubicin, docetaxel and navelbine in younger breast cancer patients

Wen-Bin Zhou, Hong Yin, Xiao-An Liu, Xiao-Ming Zha, Lin Chen, Jun-Cheng Dai, Ai-di Tao, Ling Chen, Jing-Jing Ma, Li-Jun Ling, Shui Wang

Open Access Research article

Quercetin abrogates chemoresistance in melanoma cells by modulating ΔNp73

Thilakavathy Thangasamy, Sivanandane Sittadjody, Geoffrey C Mitchell, Erin E Mendoza, Vijayababu M Radhakrishnan, Kirsten H Limesand, Randy Burd

Open Access Research article

Combined effects of IL-8 and CXCR2gene polymorphisms on breast cancer susceptibility and aggressiveness

Kaouther Snoussi, Wijden Mahfoudh, Noureddine Bouaouina, Meriem Fekih, Hedi Khairi, Ahmed N Helal, Lotfi Chouchane

Open Access Research article

Anaemia and thrombocytopenia in patients with prostate cancer and bone metastases

Carsten Nieder, Ellinor Haukland, Adam Pawinski, Astrid Dalhaug

Open Access Research article

Lung cancer risk in never-smokers: a population-based case-control study of epidemiologic risk factors

Darren R Brenner, Rayjean J Hung, Ming-Sound Tsao, Frances A Shepherd, Michael R Johnston, Steven Narod, Warren Rubenstein, John R McLaughlin

Open Access Research article

Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines

Qiwei Yang, Yufeng Tian, Kelly R Ostler, Alexandre Chlenski, Lisa J Guerrero, Helen R Salwen, Lucy A Godley, Susan L Cohn

Open Access Research article

ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors

Heléne Gustavsson, Tajana Tešan, Karin Jennbacken, Kouji Kuno, Jan-Erik Damber, Karin Welén

Open Access Research article

Identification of galectin-7 as a potential biomarker for esophageal squamous cell carcinoma by proteomic analysis

Xi Zhu, Ming Ding, Mei-Lan Yu, Ming-Xiang Feng, Li-Jie Tan, Fu-Kun Zhao

Open Access Research article

Inferring predominant pathways in cellular models of breast cancer using limited sample proteomic profiling

Yogesh M Kulkarni, Vivian Suarez, David J Klinke II

Open Access Research article

Inoculated mammary carcinoma-associated fibroblasts: contribution to hormone independent tumor growth

Victoria T Fabris, Ana Sahores, Silvia I Vanzulli, Lucas Colombo, Alfredo A Molinolo, Claudia Lanari, Caroline A Lamb

Open Access Research article

Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation

Jessica McCready, Jessica D Sims, Doug Chan, Daniel G Jay

Open Access Research article

Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung

Tatyana Kalinina, Cenap Güngör, Sabrina Thieltges, Maren Möller-Krull, Eva Maria Murga Penas, Daniel Wicklein, Thomas Streichert, Udo Schumacher, Viacheslav Kalinin, Ronald Simon, Benjamin Otto, Judith Dierlamm, Heidi Schwarzenbach, Katharina E Effenberger, Maximilian Bockhorn, Jakob R Izbicki, Emre F Yekebas

Open Access Research article

Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray

Elin Möllerström, Anikó Kovács, Kristina Lövgren, Szilard Nemes, Ulla Delle, Anna Danielsson, Toshima Parris, Donal J Brennan, Karin Jirström, Per Karlsson, Khalil Helou

Open Access Research article

Promoter- and cell-specific epigenetic regulation of CD44, Cyclin D2, GLIPR1 and PTEN by Methyl-CpG binding proteins and histone modifications

Imke Müller, Frank Wischnewski, Klaus Pantel, Heidi Schwarzenbach

Open Access Research article

The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts

Hichame Id Boufker, Laurence Lagneaux, Mehdi Najar, Martine Piccart, Ghanem Ghanem, Jean-Jacques Body, Fabrice Journé

Open Access Research article

SNAI2/Slug promotes growth and invasion in human gliomas

Hong Wei Yang, Lata G Menon, Peter M Black, Rona S Carroll, Mark D Johnson

Open Access Research article

Expression of growth factor receptors and targeting of EGFR in cholangiocarcinoma cell lines

Ling Xu, Martin Hausmann, Wolfgang Dietmaier, Silvia Kellermeier, Theresa Pesch, Manuela Stieber-Gunckel, Elisabeth Lippert, Frank Klebl, Gerhard Rogler

Open Access Research article

Adherence to cancer screening guidelines across Canadian provinces: an observational study

Erin C Strumpf, Zhijin Chai, Srikanth Kadiyala

Open Access Research article

Health-related quality of life in glioma patients in China

Jin-xiang Cheng, Bo-lin Liu, Xiang Zhang, Wei Lin, Yong-qiang Zhang, Wei-ping Liu, Jian-ning Zhang, Hong Lin, Rui Wang, Hong Yin

Open Access Research article

14-3-3epsiloncontributes to tumour suppression in laryngeal carcinoma by affecting apoptosis and invasion

Xing-Hua Che, Hong Chen, Zhen-Ming Xu, Chao Shang, Kai-Lai Sun, Wei-Neng Fu

Open Access Research article

Necrosis related HIF-1α expression predicts prognosis in patients with endometrioid endometrial carcinoma

Laura MS Seeber, Nicole Horrée, Petra van der Groep, Elsken van der Wall, René HM Verheijen, Paul J van Diest

Open Access Research article

Peri-operative chemotherapy for the treatment of resectable liver metastases from colorectal cancer: A systematic review and meta-analysis of randomized trials

Martina Wieser, Stefan Sauerland, Dirk Arnold, Wolff Schmiegel, Anke Reinacher-Schick

Open Access Research article

Self-reported history of Pap-smear in HIV-positive women in Northern Italy: a cross-sectional study

Luigino Dal Maso, Silvia Franceschi, Mauro Lise, Priscilla Sassoli de' Bianchi, Jerry Polesel, Florio Ghinelli, Fabio Falcini, Alba C Finarelli

Open Access Research article

Lineage analysis of early and advanced tubular adenocarcinomas of the stomach: continuous or discontinuous?

Takahisa Nakayama, Zhi-Qiang Ling, Ken-ichi Mukaisho, Takanori Hattori, Hiroyuki Sugihara

Open Access Research article

Irradiation-induced telomerase activity and gastric cancer risk: a case-control analysis in a Chinese Han population

Xianli He, Qing Qiao, Naijian Ge, Jing Nan, Shuqun Shen, Zizhong Wang, Yefa Yang, Guoqiang Bao

Open Access Research article

Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer

Jennifer Gjerde, Jürgen Geisler, Steinar Lundgren, Dagfinn Ekse, Jan Erik Varhaug, Gunnar Mellgren, Vidar M Steen, Ernst A Lien

Open Access Research article

Altered time structure of neuro-endocrine-immune system function in lung cancer patients

Gianluigi Mazzoccoli, Gianluigi Vendemiale, Angelo De Cata, Stefano Carughi, Roberto Tarquini

Open Access Research article

Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer

Lorna W Harries, John RB Perry, Paul McCullagh, Malcolm Crundwell

Open Access Research article

Activation of endogenous p53 by combined p19Arf gene transfer and nutlin-3 drug treatment modalities in the murine cell lines B16 and C6

Christian A Merkel, Rafael B da Silva Soares, Anna Carolina V de Carvalho, Daniela B Zanatta, Marcio C Bajgelman, Paula Fratini, Eugenia Costanzi-Strauss, Bryan E Strauss

Open Access Research article

Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma

Antal Csepregi, Matthias PA Ebert, Christoph Röcken, Regine Schneider-Stock, Juliane Hoffmann, Hans-Ulrich Schulz, Albert Roessner, Peter Malfertheiner

Open Access Research article

Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells

Lili Jiang, Qin Huang, Siyang Zhang, Qingfu Zhang, Jihong Chang, Xueshan Qiu, Enhua Wang

Open Access Research article

Robust multi-tissue gene panel for cancer detection

Joseph Irgon, C Chris Huang, Yi Zhang, Dmitri Talantov, Gyan Bhanot, Sándor Szalma

Open Access Research article

Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapy

Mariusz Koda, Luiza Kanczuga-Koda, Mariola Sulkowska, Eva Surmacz, Stanislaw Sulkowski

Open Access Research article

Clinical outcomes and prognostic factors in patients with breast diffuse large B cell lymphoma; Consortium for Improving Survival of Lymphoma (CISL) study

Ho-Young Yhim, Hye Jin Kang, Yoon Hee Choi, Seok Jin Kim, Won Seog Kim, Yee Soo Chae, Jin Seok Kim, Chul Won Choi, Sung Yong Oh, Hyeon Seok Eom, Jeong-A Kim, Jae Hoon Lee, Jong-Ho Won, Hyeok Shim, Je-Jung Lee, Hwa Jung Sung, Hyo Jung Kim, Dae Ho Lee, Cheolwon Suh, Jae-Yong Kwak

Open Access Case report

Ectopic primary type A thymoma located in two thoracic vertebras: a case report

Ferdinando Marandino, Carmine Zoccali, Nicola Salducca, Mirella Marino, Paolo Visca

Open Access Research article

Tumour necrosis factor-alpha expression in tumour islets confers a survival advantage in non-small cell lung cancer

Chandra M Ohri, Aarti Shikotra, Ruth H Green, David A Waller, Peter Bradding

Open Access Case report

Early invasive vulvar squamous cell carcinoma arising in a woman with vulvar pemphigus vulgaris and systemic lupus erythematosus

Giuseppe Bifulco, Vincenzo D Mandato, Roberto Piccoli, Pierluigi Giampaolino, Chiara Mignogna, Michele D Mignogna, Luigi Costagliola, Carmine Nappi

Open Access Research article

Targeting surface nucleolin with a multivalent pseudopeptide delays development of spontaneous melanoma in RET transgenic mice

Diala El Khoury, Damien Destouches, Renée Lengagne, Bernard Krust, Yamina Hamma-Kourbali, Marylène Garcette, Sandra Niro, Masashi Kato, Jean-Paul Briand, José Courty, Ara G Hovanessian, Armelle Prévost-Blondel

Open Access Research article

Identification of viral infections in the prostate and evaluation of their association with cancer

Margarita L Martinez-Fierro, Robin J Leach, Lauro S Gomez-Guerra, Raquel Garza-Guajardo, Teresa Johnson-Pais, Joke Beuten, Idelma B Morales-Rodriguez, Mario A Hernandez-Ordoñez, German Calderon-Cardenas, Rocio Ortiz-Lopez, Ana M Rivas-Estilla, Jesus Ancer-Rodriguez, Augusto Rojas-Martinez

Open Access Research article

Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells

Luc Friboulet, Claire Gourzones, Sai Wah Tsao, Yannis Morel, Carine Paturel, Stéphane Témam, Catherine Uzan, Pierre Busson

Open Access Research article

Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cells

Nitin Koul, Vivek Sharma, Deobrat Dixit, Sadashib Ghosh, Ellora Sen

Open Access Research article

Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells

Jørn Henriksen, Marianne Stabell, Leonardo A Meza-Zepeda, Silje AU Lauvrak, Moustapha Kassem, Ola Myklebost

Open Access Research article

The CS1 segment of fibronectin is involved in human OSCC pathogenesis by mediating OSCC cell spreading, migration, and invasion

Pachiyappan Kamarajan, Angeles Garcia-Pardo, Nisha J D'Silva, Yvonne L Kapila

Open Access Research article

EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosis

Ranju Ralhan, Jun Cao, Terence Lim, Christina MacMillan, Jeremy L Freeman, Paul G Walfish

Open Access Research article

Does delay in diagnosing colorectal cancer in symptomatic patients affect tumor stage and survival? A population-based observational study

Jochim S Terhaar sive Droste, Frank A Oort, René WM van der Hulst, Veerle MH Coupé, Mike E Craanen, Gerrit A Meijer, Linde M Morsink, Otto Visser, Roy LJ van Wanrooij, Chris JJ Mulder

Open Access Research article

Serum CD26 is related to histopathological polyp traits and behaves as a marker for colorectal cancer and advanced adenomas

Loretta De Chiara, Ana M Rodríguez-Piñeiro, Francisco J Rodríguez-Berrocal, Oscar J Cordero, David Martínez-Ares, María Páez de la Cadena

Open Access Research article

8q24 sequence variants in relation to prostate cancer risk among men of African descent: A case-control study

Marnita L Benford, Tiva T VanCleave, Nicole A Lavender, Rick A Kittles, LaCreis R Kidd

Open Access Research article

Elevated MED28 expression predicts poor outcome in women with breast cancer

Nam K Yoon, Erin L Maresh, Yahya Elshimali, Ai Li, Steve Horvath, David B Seligson, David Chia, Lee Goodglick

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An 8-gene qRT-PCR-based gene expression score that has prognostic value in early breast cancer

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Cardiotoxicity of anthracycline agents for the treatment of cancer: Systematic review and meta-analysis of randomised controlled trials

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Open Access Case report

Pituitary hCG production and cerebral tuberculosis mimicking disease progression during chemotherapy for an advanced ovarian germ cell tumour

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Takehiko Shiraishi, Jonhard Eysturskarð, Peter E Nielsen

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Open Access Study protocol

Enhancing return-to-work in cancer patients, development of an intervention and design of a randomised controlled trial

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Characterization of the apoptotic response of human leukemia cells to organosulfur compounds

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Open Access Case report

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Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells

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Stimulation of angiogenesis resulting from cooperation between macrophages and MDA-MB-231 breast cancer cells: proposed molecular mechanism and effect of tetrathiomolybdate

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Tumor suppressor genes are frequently methylated in lymph node metastases of breast cancers

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Physical activity interventions to improve daily walking activity in cancer survivors

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SLUG/SNAI2 and Tumor Necrosis Factor Generate Breast Cells With CD44+/CD24- Phenotype

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TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients

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Restoration of radiation therapy-induced salivary gland dysfunction in mice by post therapy IGF-1 administration

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Survivin gene silencing sensitizes prostate cancer cells to selenium growth inhibition

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Impact of adjuvant chemotherapy for gliomatosis cerebri

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LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells

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Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy

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Ming Yan, Qin Xu, Ping Zhang, Xiao-jian Zhou, Zhi-yuan Zhang, Wan-tao Chen

Open Access Case report

Imatinib induced severe skin reactions and neutropenia in a patient with gastrointestinal stromal tumor

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Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts

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Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response

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Open Access Study protocol

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Open Access Study protocol

Study Protocol: A randomized controlled trial of patient navigation-activation to reduce cancer health disparities

Samantha Hendren, Jennifer J Griggs, Ronald M Epstein, Sharon Humiston, Sally Rousseau, Pascal Jean-Pierre, Jennifer Carroll, Amanat M Yosha, Starlene Loader, Kevin Fiscella

Open Access Research article

N-terminal and C-terminal heparin-binding domain polypeptides derived from fibronectin reduce adhesion and invasion of liver cancer cells

Nan-Hong Tang, Yan-Lin Chen, Xiao-Qian Wang, Xiu-Jin Li, Yong Wu, Qi-Lian Zou, Yuan-Zhong Chen

Open Access Research article

Expression pattern of matrix metalloproteinases in human gynecological cancer cell lines

Andrea Schröpfer, Ulrike Kammerer, Michaela Kapp, Johannes Dietl, Sonja Feix, Jelena Anacker

Open Access Research article

Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm

Manuela Cervelli, Gabriella Bellavia, Emiliano Fratini, Roberto Amendola, Fabio Polticelli, Marco Barba, Rodolfo Federico, Fabrizio Signore, Giacomo Gucciardo, Rosalba Grillo, Patrick M Woster, Robert A Casero Jr, Paolo Mariottini

Open Access Research article

Efficacy of c-Met inhibitor for advanced prostate cancer

William H Tu, Chunfang Zhu, Curtis Clark, James G Christensen, Zijie Sun

Open Access Research article

Triple negativity and young age as prognostic factors in lymph node-negative invasive ductal carcinoma of 1 cm or less

Ji Hyun Kwon, Yu Jung Kim, Keun-Wook Lee, Do-Youn Oh, So Yeon Park, Jee Hyun Kim, Eui Kyu Chie, Sung-Won Kim, Seock-Ah Im, In-Ah Kim, Tae-You Kim, In Ae Park, Dong-Young Noh, Yung-Jue Bang, Sung Whan Ha

Open Access Research article

The role of concurrent chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma among endemic population: a meta-analysis of the phase iii randomized trials

Li Zhang, Chong Zhao, Bijesh Ghimire, Ming-Huang Hong, Qing Liu, Yang Zhang, Ying Guo, Yi-Jun Huang, Zhong-Zhen Guan

Open Access Research article

Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11

Emmalena Gregory-Bryson, Elizabeth Bartlett, Matti Kiupel, Schantel Hayes, Vilma Yuzbasiyan-Gurkan

Open Access Research article

The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells

Catrin Schult, Meike Dahlhaus, Sabine Ruck, Mandy Sawitzky, Francesca Amoroso, Sandra Lange, Daniela Etro, Aenne Glass, Georg Fuellen, Sonja Boldt, Olaf Wolkenhauer, Luca Maria Neri, Mathias Freund, Christian Junghanss

Open Access Research article

Allelotyping identification of genomic alterations in rectal chromosomally unstable tumors without preoperative treatment

Benoît Romain, Agnès Neuville, Nicolas Meyer, Cécile Brigand, Serge Rohr, Anne Schneider, Marie-Pierre Gaub, Dominique Guenot

Open Access Research article

Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis

Mark E Reeves, Scott W Baldwin, Melissa L Baldwin, Shin-Tai Chen, Jeremy M Moretz, Robert J Aragon, Xinmin Li, Donna D Strong, Subburaman Mohan, Yousef G Amaar

Open Access Research article

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

Daniele Campa, Anika Hüsing, James D McKay, Olga Sinilnikova, Ulla Vogel, Anne Tjønneland, Kim Overvad, Jakob Stegger, Françoise Clavel-Chapelon, Nathalie Chabbert-Buffet, Guy Fagherazzi, Antonia Trichopoulou, Dimosthenis Zylis, Erifili Oustoglou, Sabine Rohrmann, Birgit Teucher, Eva Fisher, Heiner Boeing, Giovanna Masala, Vittorio Krogh, Carlotta Sacerdote, Salvatore Panico, Rosario Tumino, N Charlotte Onland-Moret, Carla H van Gils, H Bas Bueno-de-Mesquita, Eiliv Lund, María Dolores Chirlaque, Núria Sala, José Ramon Quirós, Eva Ardanaz, Pilar Amiano, Esther Molina-Montes, Göran Hallmans, Per Lenner, Ruth C Travis, Timothy J Key, Nick Wareham, Kay-Tee Khaw, Sabina Rinaldi, Nadia Slimani, Veronique Chajes, Afshan Siddiq, Elio Riboli, Rudolf Kaaks, Federico Canzian

Open Access Research article

Comparison of thymidine phosphorylase expression and prognostic factors in gallbladder and bile duct cancer

Hye Sung Won, Myung Ah Lee, Eun-Seon Chung, Dong-Goo Kim, Young Kyoung You, Tae Ho Hong, In-Seok Lee

Open Access Research article

Dose escalation study of an anti-thrombocytopenic agent in patients with chemotherapy induced thrombocytopenia

Robert D Levin, MaryAnn Daehler, James F Grutsch, John L Hall, Digant Gupta, Christopher G Lis

Open Access Research article

Raloxifene inhibits tumor growth and lymph node metastasis in a xenograft model of metastatic mammary cancer

Masa-Aki Shibata, Junji Morimoto, Eiko Shibata, Hitomi Kurose, Kanako Akamatsu, Zhong-Lian Li, Moriaki Kusakabe, Masahide Ohmichi, Yoshinori Otsuki

Open Access Research article

"Poker" association of weekly alternating 5-fluorouracil, irinotecan, bevacizumab and oxaliplatin (FIr-B/FOx) in first line treatment of metastatic colorectal cancer: a phase II study

Gemma Bruera, Alessandra Santomaggio, Katia Cannita, Paola Lanfiuti Baldi, Marianna Tudini, Federica De Galitiis, Maria Mancini, Paolo Marchetti, Adelmo Antonucci, Corrado Ficorella, Enrico Ricevuto

Open Access Debate

Pancreatic cancer and depression: myth and truth

Martina Mayr, Roland M Schmid

Open Access Research article

Alternative splicing and nonsense-mediated decay regulate telomerase reverse transcriptase (TERT) expression during virus-induced lymphomagenesis in vivo

Souheila Amor, Sylvie Remy, Ginette Dambrine, Yves Le Vern, Denis Rasschaert, Sylvie Laurent

Open Access Study protocol

Transperineal prostate brachytherapy, using I-125 seed with or without adjuvant androgen deprivation, in patients with intermediate-risk prostate cancer: study protocol for a phase III, multicenter, randomized, controlled trial

Kenta Miki, Takayoshi Kiba, Hiroshi Sasaki, Masahito Kido, Manabu Aoki, Hiroyuki Takahashi, Keiko Miyakoda, Takushi Dokiya, Hidetoshi Yamanaka, Masanori Fukushima, Shin Egawa

Open Access Research article

Comparative survival analysis of breast cancer microarray studies identifies important prognostic genetic pathways

Jeffrey C Miecznikowski, Dan Wang, Song Liu, Lara Sucheston, David Gold

Open Access Research article

The PstI/RsaI and DraI polymorphisms of CYP2E1and head and neck cancer risk: a meta-analysis based on 21 case-control studies

Kefu Tang, Yang Li, Zhao Zhang, Yunmin Gu, Yuyu Xiong, Guoyin Feng, Lin He, Shengying Qin

Open Access Research article

Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma

Yun-Sook Kim, Jin Hwan Do, Sumi Bae, Dong-Han Bae, Woong Shick Ahn

Open Access Research article

Epigenetic inactivation of the NORE1gene correlates with malignant progression of colorectal tumors

Chang Kyun Lee, Jin-Hee Lee, Min-Goo Lee, Seong-In Jeong, Tae-Kyu Ha, Min-Ju Kang, Byung-Kyu Ryu, Young Hwangbo, Jae-Jun Shim, Jae Young Jang, Kil Yeon Lee, Hyo Jong Kim, Sung-Gil Chi

Open Access Research article

Chemokine-mediated distribution of dendritic cell subsets in renal cell carcinoma

Peter Middel, Sven Brauneck, Werner Meyer, Heinz-Joachim Radzun

Open Access Case report

Oligodendroglioma of the ciliary body: a unique case report and the review of literature

Qing Guo, Jie Hao, Shou bin Sun, Shou ping Xu, Qian Yang, Qi liang Guo, Guo dong Cui

Open Access Research article

Herbal compound "Songyou Yin" reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice

Xiu-Yan Huang, Zi-Li Huang, Lu Wang, Yong-Hua Xu, Xin-Yu Huang, Kai-Xing Ai, Qi Zheng, Zhao-You Tang

Open Access Research article

Comparison of darbepoetin alfa dosed weekly (QW) vs. extended dosing schedule (EDS) in the treatment of anemia in patients receiving multicycle chemotherapy in a randomized, phase 2, open-label trial

Lee Schwartzberg, Ronald Burkes, Barry Mirtsching, Timothy Rearden, Peter Silberstein, Lorrin Yee, Amy Inamoto, Tom Lillie

Open Access Research article

Prognostic factors for outcomes after whole-brain irradiation of brain metastases from relatively radioresistant tumors: a retrospective analysis

Thekla Meyners, Christine Heisterkamp, Jan-Dirk Kueter, Theo Veninga, Lukas JA Stalpers, Steven E Schild, Dirk Rades

Open Access Research article

Retrospective analyses of cisplatin-based doublet combination chemotherapy in patients with advanced gastric cancer

Do Hyoung Lim, Se Hoon Park, Keon Woo Park, Jung Hun Kang, Sung Yong Oh, In Gyu Hwang, Jung Mi Kwon, Sang-Cheol Lee, Hui-Young Lee, Hyeong Su Kim, Ho Yeong Lim, Won Ki Kang

Open Access Research article

NF-κB targeting by way of IKK inhibition sensitizes lung cancer cells to adenovirus delivery of TRAIL

Cigdem Aydin, Ahter D Sanlioglu, Atil Bisgin, Burcak Yoldas, Levent Dertsiz, Bahri Karacay, Thomas S Griffith, Salih Sanlioglu

Open Access Research article

Statistical techniques to construct assays for identifying likely responders to a treatment under evaluation from cell line genomic data

Erich P Huang, Jane Fridlyand, Nicholas Lewin-Koh, Peng Yue, Xiaoyan Shi, David Dornan, Bart Burington

Open Access Research article

Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin

Manuela Pinheiro, Terje Ahlquist, Stine A Danielsen, Guro E Lind, Isabel Veiga, Carla Pinto, Vera Costa, Luís Afonso, Olga Sousa, Maria Fragoso, Lúcio Santos, Rui Henrique, Paula Lopes, Carlos Lopes, Ragnhild A Lothe, Manuel R Teixeira

Open Access Research article

Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients

Mariya Y Radeva, Franziska Jahns, Anne Wilhelm, Michael Glei, Utz Settmacher, Karl Otto Greulich, Henning Mothes

Open Access Research article

Modified Gompertz equation for electrotherapy murine tumor growth kinetics: predictions and new hypotheses

Luis E Bergues Cabrales, Juan J Godina Nava, Andrés Ramírez Aguilera, Javier A González Joa, Héctor M Camué Ciria, Maraelys Morales González, Miriam Fariñas Salas, Manuel Verdecia Jarque, Tamara Rubio González, Miguel A O'Farril Mateus, Soraida C Acosta Brooks, Fabiola Suárez Palencia, Lisset Ortiz Zamora, María C Céspedes Quevedo, Sarah Edward Seringe, Vladimir Crombet Cuitié, Idelisa Bergues Cabrales, Gustavo Sierra González

Open Access Research article

Therapy with un-engineered naïve rat umbilical cord matrix stem cells markedly inhibits growth of murine lung adenocarcinoma

Dharmendra K Maurya, Chiyo Doi, Atsushi Kawabata, Marla M Pyle, Clay King, Zhihong Wu, Deryl Troyer, Masaaki Tamura

Open Access Research article

Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions

Li Xie, Xi Chen, Lifeng Wang, Xiaoping Qian, Tingting Wang, Jia Wei, Lixia Yu, Yitao Ding, Chenyu Zhang, Baorui Liu

Open Access Research article

Preferences for active and aggressive intervention among patients with advanced cancer

Vincent Maida, Jonathan Peck, Marguerite Ennis, Navjot Brar, Alexandria R Maida

Open Access Research article

Resveratrol represses YKL-40 expression in human glioma U87 cells

Wei Zhang, Koji Murao, Xiang Zhang, Kensuke Matsumoto, Suwarni Diah, Masaki Okada, Keisuke Miyake, Nobuyuki Kawai, Zhou Fei, Takashi Tamiya

Open Access Research article

Assessment of depression and anxiety in adult cancer outpatients: a cross-sectional study

Nauman A Jadoon, Waqar Munir, Mohammad A Shahzad, Zeshan S Choudhry

Open Access Research article

Gene expression analysis of cell death induction by Taurolidine in different malignant cell lines

Ansgar M Chromik, Stephan A Hahn, Adrien Daigeler, Annegret Flier, Daniel Bulut, Christina May, Kamran Harati, Jan Roschinsky, Dominique Sülberg, Dirk Weyhe, Ulrich Mittelkötter, Waldemar Uhl

Open Access Research article

Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts

Johanna Tuomela, Tove J Grönroos, Maija P Valta, Jouko Sandholm, Aleksi Schrey, Jani Seppänen, Päivi Marjamäki, Sarita Forsback, Ilpo Kinnunen, Olof Solin, Heikki Minn, Pirkko L Härkönen

Open Access Research article

Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancers

Zhaomin Li, Zizheng Dong, David Myer, Michele Yip-Schneider, Jianguo Liu, Ping Cui, C Max Schmidt, Jian-Ting Zhang

Open Access Research article

Prioritizing genes associated with prostate cancer development

Ivan P Gorlov, Kanishka Sircar, Hongya Zhao, Sankar N Maity, Nora M Navone, Olga Y Gorlova, Patricia Troncoso, Curtis A Pettaway, Jin Young Byun, Christopher J Logothetis

Open Access Research article

SHOX2 DNA Methylation is a Biomarker for the diagnosis of lung cancer based on bronchial aspirates

Bernd Schmidt, Volker Liebenberg, Dimo Dietrich, Thomas Schlegel, Christoph Kneip, Anke Seegebarth, Nadja Flemming, Stefanie Seemann, Jürgen Distler, Jörn Lewin, Reimo Tetzner, Sabine Weickmann, Ulrike Wille, Triantafillos Liloglou, Olaide Raji, Martin Walshaw, Michael Fleischhacker, Christian Witt, John K Field

Open Access Research article

Antiproliferative and pro-apoptotic effects afforded by novel Src-kinase inhibitors in human neuroblastoma cells

Michele Navarra, Marilena Celano, Jessica Maiuolo, Silvia Schenone, Maurizio Botta, Adriano Angelucci, Placido Bramanti, Diego Russo

Open Access Research article

The influence of nativity and neighborhoods on breast cancer stage at diagnosis and survival among California Hispanic women

Theresa HM Keegan, Thu Quach, Sarah Shema, Sally L Glaser, Scarlett L Gomez

Open Access Research article

Improved prognostic classification of breast cancer defined by antagonistic activation patterns of immune response pathway modules

Andrew E Teschendorff, Sergio Gomez, Alex Arenas, Dorraya El-Ashry, Marcus Schmidt, Mathias Gehrmann, Carlos Caldas

Open Access Research article

HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression

Jacqueline Kessler, Antje Hahnel, Henri Wichmann, Swetlana Rot, Matthias Kappler, Matthias Bache, Dirk Vordermark

Open Access Study protocol

Randomised trial of proton vs. carbon ion radiation therapy in patients with low and intermediate grade chondrosarcoma of the skull base, clinical phase III study

Anna V Nikoghosyan, Geraldine Rauch, Marc W Münter, Alexandra D Jensen, Stephanie E Combs, Meinhard Kieser, Jürgen Debus

Open Access Study protocol

Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study

Anna V Nikoghosyan, Irini Karapanagiotou-Schenkel, Marc W Münter, Alexandra D Jensen, Stephanie E Combs, Jürgen Debus

Open Access Research article

High number of CD45RO+ tumor infiltrating lymphocytes is an independent prognostic factor in non-metastasized (stage I-IIA) esophageal adenocarcinoma

Sandra Rauser, Rupert Langer, Sebastian Tschernitz, Peter Gais, Uta Jütting, Marcus Feith, Heinz Höfler, Axel Walch

Open Access Research article

Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

Feng-Hou Gao, Xiao-Hui Hu, Wei Li, Hua Liu, Yan-Jie Zhang, Zhu-Ying Guo, Mang-Hua Xu, Shi-Ting Wang, Bin Jiang, Feng Liu, Ying-Zheng Zhao, Yong Fang, Fang-Yuan Chen, Ying-Li Wu

Open Access Research article

Plexin-B1 silencing inhibits ovarian cancer cell migration and invasion

Shuangmei Ye, Xing Hao, Ting Zhou, Mingfu Wu, Juncheng Wei, Yongjun Wang, Li Zhou, Xuefeng Jiang, Li Ji, Yin Chen, Lanying You, Yiqun Zhang, Gang Xu, Jianfeng Zhou, Ding Ma, Shixuan Wang

Open Access Debate

CCC meets ICU: Redefining the role of critical care of cancer patients

Michael von Bergwelt-Baildon, Michael J Hallek, Alexander A Shimabukuro-Vornhagen, Matthias Kochanek

Open Access Research article

Polymorphisms in regulatory regions of Cyclooxygenase-2 gene and breast cancer risk in Brazilians: a case-control study

Diogo N Piranda, Juliana S Festa-Vasconcellos, Laura M Amaral, Anke Bergmann, Rosane Vianna-Jorge

Open Access Research article

Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma

Mehdi H Shahi, Mohammad Afzal, Subrata Sinha, Charles G Eberhart, Juan A Rey, Xing Fan, Javier S Castresana

Open Access Study protocol

Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: The MARCIE Trial

Stephanie E Combs, Lutz Edler, Iris Burkholder, Stefan Rieken, Daniel Habermehl, Oliver Jäkel, Thomas Haberer, Andreas Unterberg, Wolfgang Wick, Jürgen Debus, Renate Haselmann

Open Access Research article

Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells

Chao-Jie Wang, Johannes Stratmann, Zong-Guang Zhou, Xiao-Feng Sun

Open Access Research article

TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma

Shumin Wang, Xue Xiao, Xiaoying Zhou, Tingting Huang, Chunping Du, Nana Yu, Yingxi Mo, Longde Lin, Jinyan Zhang, Ning Ma, Mariko Murata, Guangwu Huang, Zhe Zhang

Open Access Research article

Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles

Robert Klopfleisch, Dido Lenze, Michael Hummel, Achim D Gruber

Open Access Research article

Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma

Beth A Tamburini, Tzu L Phang, Susan P Fosmire, Milcah C Scott, Susan C Trapp, Megan M Duckett, Sally R Robinson, Jill E Slansky, Leslie C Sharkey, Gary R Cutter, John W Wojcieszyn, Donald Bellgrau, Robert M Gemmill, Lawrence E Hunter, Jaime F Modiano

Open Access Correspondence

Eastern asian expert panel opinion: designing clinical trials of molecular targeted therapy for hepatocellular carcinoma

Winnie Yeo, Pei-Jer Chen, Junji Furuse, Kwang-Hyub Han, Chiun Hsu, Ho-Yeong Lim, Hanlim Moon, Shukui Qin, Ee-Min Yeoh, Sheng-Long Ye

Open Access Research article

Topoisomerase II alpha expression and the benefit of adjuvant chemotherapy for postoperative patients with non-small cell lung cancer

Shi Yan, Jiao Shun-Chang, Chen Li, Li Jie, Lv Ya-Li, Wang Ling-Xiong

Open Access Research article

Population-based study of ovarian cancer in Côte d'Or: prognostic factors and trends in relative survival rates over the last 20 years

Zeinab Hamidou, Sylvain Causeret, Tienhan S Dabakuyo, Julie Gentil, Laurent Arnould, Patrick Roignot, Thierry Altwegg, Marie-Laure Poillot, Franck Bonnetain, Patrick Arveux

Open Access Research article

Neck dissection and post-operative chemotherapy with dimethyl triazeno imidazole carboxamide and cisplatin protocol are useful for oral mucosal melanoma

Xi Yang, Guo-xin Ren, Chen-ping Zhang, Guo-yu Zhou, Yong-jie Hu, Wen-jun Yang, Wei Guo, Jiang Li, Lai-ping Zhong

Open Access Study protocol

Design of the Quality of Life in Motion (QLIM) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of a combined physical exercise and psychosocial training program to improve physical fitness in children with cancer

Katja I Braam, Elisabeth M van Dijk, Margreet A Veening, Marc B Bierings, Johannes HM Merks, Martha A Grootenhuis, Mai JM Chinapaw, Gerben Sinnema, Tim Takken, Jaap Huisman, Gertjan JL Kaspers, Eline van Dulmen-den Broeder

Open Access Research article

Racial differences in treatment and survival in older patients with diffuse large B-cell lymphoma (DLBCL)

Robert Griffiths, Michelle Gleeson, Kevin Knopf, Mark Danese

Open Access Research article

COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer

Sharon A Glynn, Robyn L Prueitt, Lisa A Ridnour, Brenda J Boersma, Tiffany M Dorsey, David A Wink, Julie E Goodman, Harris G Yfantis, Dong H Lee, Stefan Ambs

Open Access Research article

Tumour auto-antibody screening: performance of protein microarrays using SEREX derived antigens

René Stempfer, Parvez Syed, Klemens Vierlinger, Rudolf Pichler, Eckart Meese, Petra Leidinger, Nicole Ludwig, Albert Kriegner, Christa Nöhammer, Andreas Weinhäusel

Open Access Research article

Merging transcriptomics and metabolomics - advances in breast cancer profiling

Eldrid Borgan, Beathe Sitter, Ole Christian Lingjærde, Hilde Johnsen, Steinar Lundgren, Tone F Bathen, Therese Sørlie, Anne-Lise Børresen-Dale, Ingrid S Gribbestad

Open Access Debate

Exclusive and adjuvant radiotherapy in breast cancer patients with synchronous metastases

Romuald Le Scodan, David Ali, Denise Stevens

Open Access Research article

Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

Ymera Pignochino, Ivana Sarotto, Caterina Peraldo-Neia, Junia Y Penachioni, Giuliana Cavalloni, Giorgia Migliardi, Laura Casorzo, Giovanna Chiorino, Mauro Risio, Alberto Bardelli, Massimo Aglietta, Francesco Leone

Open Access Research article

p21WAF1/CIP1 gene transcriptional activation exerts cell growth inhibition and enhances chemosensitivity to cisplatin in lung carcinoma cell

Junxia Wei, Jiang Zhao, Min Long, Yuan Han, Xi Wang, Fang Lin, Jihong Ren, Ting He, Huizhong Zhang

Open Access Research article

A randomized phase III study of the docetaxel/carboplatin combination versus docetaxel single-agent as second line treatment for patients with advanced/metastatic Non-Small Cell Lung Cancer

Athanasios G Pallis, Sophia Agelaki, Athina Agelidou, Ioannis Varthalitis, Kostas Syrigos, Nikolaos Kentepozidis, Georgia Pavlakou, Athanasios Kotsakis, Emmanouel Kontopodis, Vassilis Georgoulias

Open Access Research article

Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen

Velasco Cimica, Melissa E Smith, Zhikai Zhang, Deepti Mathur, Sridhar Mani, Ganjam V Kalpana

Open Access Research article

A panel of kallikrein markers can predict outcome of prostate biopsy following clinical work-up: an independent validation study from the European Randomized Study of Prostate Cancer screening, France

Amine Benchikh, Caroline Savage, Angel Cronin, Gilles Salama, Arnauld Villers, Hans Lilja, Andrew Vickers

Open Access Research article

Polymorphisms in genes involved in the estrogen pathway and mammographic density

Isabelle Dumas, Caroline Diorio

Open Access Case report

Should helical tomotherapy replace brachytherapy for cervical cancer? Case report

Chen-Hsi Hsieh, Ming-Chow Wei, Yao-Peng Hsu, Ngot-Swan Chong, Yu-Jen Chen, Sheng-Mou Hsiao, Yen-Ping Hsieh, Li-Ying Wang, Pei-Wei Shueng

Open Access Research article

Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells

Michela Carlet, Kristina Janjetovic, Johannes Rainer, Stefan Schmidt, Renate Panzer-Grümayer, Georg Mann, Martina Prelog, Bernhard Meister, Christian Ploner, Reinhard Kofler

Open Access Research article

Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer

Elton Rexhepaj, Karin Jirstrom, Darran P O'Connor, Sallyann L O'Brien, Goran Landberg, Michael J Duffy, Donal J Brennan, William M Gallagher

Open Access Research article

Evaluation of FTIR Spectroscopy as a diagnostic tool for lung cancer using sputum

Paul D Lewis, Keir E Lewis, Robin Ghosal, Sion Bayliss, Amanda J Lloyd, John Wills, Ruth Godfrey, Philip Kloer, Luis AJ Mur

Open Access Research article

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

Dusan Djokovic, Alexandre Trindade, Joana Gigante, Marina Badenes, Lilliana Silva, Ren Liu, Xiuqing Li, Ming Gong, Valery Krasnoperov, Parkash S Gill, Antonio Duarte

Open Access Research article

The use of chemotherapy regimens carrying a moderate or high risk of febrile neutropenia and the corresponding management of febrile neutropenia: an expert survey in breast cancer and non-Hodgkin's lymphoma

Laetitia Gerlier, Mark Lamotte, Ahmad Awada, André Bosly, Greet Bries, Véronique Cocquyt, Christian Focan, Stéphanie Henry, Yassine Lalami, Jean-Pascal Machiels, Jeroen Mebis, Nicole Straetmans, Didier Verhoeven, Luc Somers

Open Access Research article

Characteristic odour in the blood reveals ovarian carcinoma

György Horvath, Håkan Andersson, Gunnar Paulsson

Open Access Research article

If it is in the marrow, is it also in the blood? An analysis of 1,000 paired samples from patients with B-cell non-Hodgkin lymphoma

Patrizia Mancuso, Angelica Calleri, Pierluigi Antoniotti, Jessica Quarna, Giancarlo Pruneri, Francesco Bertolini

Open Access Case report

Low-grade extraskeletal osteosarcoma of the chest wall: case report and review of literature

Renaud Sabatier, Corinne Bouvier, Gonzague de Pinieux, Anthony Sarran, Isabelle Brenot-Rossi, Florence Pedeutour, Bruno Chetaille, Patrice Viens, Pierre-Jean Weiller, François Bertucci

Open Access Research article

Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts

Anne Sofie Brems-Eskildsen, Karsten Zieger, Helle Toldbod, Cherie Holcomb, Russell Higuchi, Francisco Mansilla, Pia P Munksgaard, Michael Borre, Torben F Ørntoft, Lars Dyrskjøt

Open Access Research article

Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells

Hari Raghu, Prasanna Kumar Sodadasu, Rama Rao Malla, Christopher S Gondi, Norman Estes, Jasti S Rao

Open Access Research article

Weight change during chemotherapy changes the prognosis in non metastatic breast cancer for the worse

Emilie Thivat, Sophie Thérondel, Olivier Lapirot, Catherine Abrial, Pierre Gimbergues, Emilie Gadéa, Eloïse Planchat, Fabrice Kwiatkowski, Marie A Mouret-Reynier, Philippe Chollet, Xavier Durando

Open Access Research article

Mutually exclusive expression of DLX2 and DLX5/6 is associated with the metastatic potential of the human breast cancer cell line MDA-MB-231

Monica Morini, Simonetta Astigiano, Yorick Gitton, Laura Emionite, Valentina Mirisola, Giovanni Levi, Ottavia Barbieri

Open Access Research article

Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study

Donghong Zhang, Qingying Zhang, Li Zhou, Leijun Huo, Yi Zhang, Zhongying Shen, Yi Zhu

Open Access Study protocol

Treatment of locally advanced carcinomas of head and neck with intensity-modulated radiation therapy (IMRT) in combination with cetuximab and chemotherapy: the REACH protocol

Gregor Habl, Alexandra D Jensen, Karin Potthoff, Matthias Uhl, Holger Hof, Jacek Hajda, Christian Simon, Jürgen Debus, Robert Krempien, Marc W Münter

Open Access Research article

Phosphorylated Smad2 in Advanced Stage Gastric Carcinoma

Osamu Shinto, Masakazu Yashiro, Takahiro Toyokawa, Takafumi Nishii, Ryoji Kaizaki, Taro Matsuzaki, Satoru Noda, Naoshi Kubo, Hiroaki Tanaka, Yosuke Doi, Masaichi Ohira, Kazuya Muguruma, Tetsuji Sawada, Kosei Hirakawa

Open Access Research article

Long-term survival of women with basal-like ductal carcinoma in situ of the breast: a population-based cohort study

Wenjing Zhou, Karin Jirström, Christine Johansson, Rose-Marie Amini, Carl Blomqvist, Olorunsola Agbaje, Fredrik Wärnberg

Open Access Research article

BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

Henne Holstege, Hugo M Horlings, Arno Velds, Anita Langerød, Anne-Lise Børresen-Dale, Marc J van de Vijver, Petra M Nederlof, Jos Jonkers

Open Access Research article

14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in Head and Neck cancer cells

Muzafar A Macha, Ajay Matta, SS Chauhan, KW Michael Siu, Ranju Ralhan

Open Access Research article

Recurrence and mortality according to Estrogen Receptor status for breast cancer patients undergoing conservative surgery. Ipsilateral breast tumour recurrence dynamics provides clues for tumour biology within the residual breast

Romano Demicheli, Ilaria Ardoino, Patrizia Boracchi, Danila Coradini, Roberto Agresti, Cristina Ferraris, Massimiliano Gennaro, William JM Hrushesky, Elia Biganzoli

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Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene

Francesca Pellicano, Rachel E Thomson, Gareth J Inman, Tomoko Iwata

Open Access Research article

Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer

Shioto Suzuki, Yoh Dobashi, Yayoi Hatakeyama, Ryosuke Tajiri, Takashi Fujimura, Carl H Heldin, Akishi Ooi

Open Access Research article

KRAS analysis in colorectal carcinoma: Analytical aspects of Pyrosequencing and allele-specific PCR in clinical practice

Magnus Sundström, Karolina Edlund, Monica Lindell, Bengt Glimelius, Helgi Birgisson, Patrick Micke, Johan Botling

Open Access Research article

Boron neutron capture therapy induces apoptosis of glioma cells through Bcl-2/Bax

Peng Wang, Haining Zhen, Xinbiao Jiang, Wei Zhang, Xin Cheng, Geng Guo, Xinggang Mao, Xiang Zhang

Open Access Research article

Specific genomic aberrations in primary colorectal cancer are associated with liver metastases

Sjoerd C Bruin, Christiaan Klijn, Gerrit-Jan Liefers, Linde M Braaf, Simon A Joosse, Eric H van Beers, Victor J Verwaal, Hans Morreau, Lodewyk F Wessels, Marie-Louise F van Velthuysen, Rob AEM Tollenaar, Laura J van't Veer

Open Access Research article

The Brustkrebs-Studien.de website for breast cancer patients: User acceptance of a German internet portal offering information on the disease and treatment options, and a clinical trials matching service

Markus Wallwiener, Christian W Wallwiener, Sara Y Brucker, Andreas D Hartkopf, Tanja N Fehm, Julia K Kansy

Open Access Research article

The invasive lobular carcinoma as a prototype luminal A breast cancer: A retrospective cohort study

So-Youn Jung, Junsoo Jeong, Seung-Ho Shin, Youngmee Kwon, Eun-A Kim, Kyoung Lan Ko, Kyung Hwan Shin, Keun Seok Lee, In Hae Park, Seeyoun Lee, Seok Won Kim, Han-Sung Kang, Jungsil Ro

Open Access Research article

Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis

Salomé González-Reyes, Laura Marín, Lucía González, Luis O González, José M del Casar, Maria L Lamelas, José M González-Quintana, Francisco J Vizoso

Open Access Research article

Assessment of a six gene panel for the molecular detection of circulating tumor cells in the blood of female cancer patients

Eva Obermayr, Fatima Sanchez-Cabo, Muy-Kheng M Tea, Christian F Singer, Michael Krainer, Michael B Fischer, Jalid Sehouli, Alexander Reinthaller, Reinhard Horvat, Georg Heinze, Dan Tong, Robert Zeillinger

Open Access Research article

Impact of maximum Standardized Uptake Value (SUVmax) evaluated by 18-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG-PET/CT) on survival for patients with advanced renal cell carcinoma: a preliminary report

Kazuhiro Namura, Ryogo Minamimoto, Masahiro Yao, Kazuhide Makiyama, Takayuki Murakami, Futoshi Sano, Narihiko Hayashi, Ukihide Tateishi, Hanako Ishigaki, Takeshi Kishida, Takeshi Miura, Kazuki Kobayashi, Sumio Noguchi, Tomio Inoue, Yoshinobu Kubota, Noboru Nakaigawa

Open Access Research article

Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition

Christina Hackl, Sven A Lang, Christian Moser, Akira Mori, Stefan Fichtner-Feigl, Claus Hellerbrand, Wolfgang Dietmeier, Hans J Schlitt, Edward K Geissler, Oliver Stoeltzing

Open Access Research article

1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer

Kathy Vanderlaag, Yunpeng Su, Arthur E Frankel, Robert C Burghardt, Rola Barhoumi, Gayathri Chadalapaka, Indira Jutooru, Stephen Safe

Open Access Research article

Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis

Carolyn M Hutter, Martha L Slattery, David J Duggan, Jill Muehling, Karen Curtin, Li Hsu, Shirley AA Beresford, Aleksandar Rajkovic, Gloria E Sarto, James R Marshall, Nazik Hammad, Robert Wallace, Karen W Makar, Ross L Prentice, Bette J Caan, John D Potter, Ulrike Peters

Open Access Research article

Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progressioan

Mikhail G Dozmorov, Joseph T Azzarello, Jonathan D Wren, Kar-Ming Fung, Qing Yang, Jeffrey S Davis, Robert E Hurst, Daniel J Culkin, Trevor M Penning, Hsueh-Kung Lin

Open Access Research article

Ethnic and socioeconomic trends in breast cancer incidence in New Zealand

Ruth Cunningham, Caroline Shaw, Tony Blakely, June Atkinson, Diana Sarfati

Open Access Research article

Impact of hormonal treatment duration in combination with radiotherapy for locally advanced prostate cancer: Meta-analysis of randomized trials

Federica Cuppone, Emilio Bria, Diana Giannarelli, Vanja Vaccaro, Michele Milella, Cecilia Nisticò, Enzo Maria Ruggeri, Isabella Sperduti, Sergio Bracarda, Paola Pinnarò, Gaetano Lanzetta, Paola Muti, Francesco Cognetti, Paolo Carlini

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Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures

Joseph R Cohen, Daniel Z Resnick, Pawel Niewiadomski, Hongmei Dong, Linda M Liau, James A Waschek

Open Access Research article

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

Uffe H Olesen, Jakob G Petersen, Antje Garten, Wieland Kiess, Jun Yoshino, Shin-Ichiro Imai, Mette K Christensen, Peter Fristrup, Annemette V Thougaard, Fredrik Björkling, Peter B Jensen, Søren J Nielsen, Maxwell Sehested

Open Access Research article

Characterization of ductal and lobular breast carcinomas using novel prolactin receptor isoform specific antibodies

Erika Ginsburg, Stefanie Alexander, Sarah Lieber, Sarah Tarplin, Luwanda Jenkins, Linda Pang, Christopher D Heger, Paul Goldsmith, Barbara K Vonderhaar

Open Access Study protocol

Potential drug interactions and duplicate prescriptions among ambulatory cancer patients: a prevalence study using an advanced screening method

Roelof WF van Leeuwen, Eleonora L Swart, Frits A Boom, Martin S Schuitenmaker, Jacqueline G Hugtenburg

Open Access Research article

Differential expression of anterior gradient gene AGR2 in prostate cancer

Erin L Maresh, Vei Mah, Mohammad Alavi, Steve Horvath, Lora Bagryanova, Emily S Liebeskind, Laura A Knutzen, Yong Zhou, David Chia, Alvin Y Liu, Lee Goodglick

Open Access Research article

Initial partial response and stable disease according to RECIST indicate similar survival for chemotherapeutical patients with advanced non-small cell lung cancer

Lijie He, Yuee Teng, Bo Jin, Mingfang Zhao, Ping Yu, Xuejun Hu, Jingdong Zhang, Songbai Li, Yaling Gao, Yunpeng Liu

Open Access Research article

Gene expression of PMP22 is an independent prognostic factor for disease-free and overall survival in breast cancer patients

Dan Tong, Georg Heinze, Dietmar Pils, Andrea Wolf, Christian F Singer, Nicole Concin, Gerda Hofstetter, Ingrid Schiebel, Margaretha Rudas, Robert Zeillinger

Open Access Research article

VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment

Steven G Patten, Una Adamcic, Kristen Lacombe, Kanwal Minhas, Karolina Skowronski, Brenda L Coomber

Open Access Research article

Induction of cell cycle arrest at G1 and S phases and cAMP-dependent differentiation in C6 glioma by low concentration of cycloheximide

Xijun Liu, Jin-Ming Yang, Samuel S Zhang, Xin-Yuan Liu, David X Liu

Open Access Research article

Malignant transformation of oral leukoplakia: a retrospective cohort study of 218 Chinese patients

Wei Liu, Yu-Feng Wang, Hai-Wei Zhou, Peng Shi, Zeng-Tong Zhou, Guo-Yao Tang

Open Access Research article

Expression of BMI-1 and Mel-18 in breast tissue - a diagnostic marker in patients with breast cancer

Margit LH Riis, Torben Lüders, Anne-Jorunn Nesbakken, Hilde S Vollan, Vessela Kristensen, Ida RK Bukholm

Open Access Research article

The Colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information

Wendy L Allen, Puthen V Jithesh, Gavin R Oliver, Irina Proutski, Daniel B Longley, Heinz-Josef Lenz, Vitali Proutski, Paul Harkin, Patrick G Johnston

Open Access Research article

Tumor location and patient characteristics of colon and rectal adenocarcinomas in relation to survival and TNM classes

Kari Hemminki, Irene Santi, Marianne Weires, Hauke Thomsen, Jan Sundquist, Justo Lorenzo Bermejo

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Evaluation of Best Supportive Care and Systemic Chemotherapy as Treatment Stratified according to the retrospective Peritoneal Surface Disease Severity Score (PSDSS) for Peritoneal Carcinomatosis of Colorectal Origin

Joerg OW Pelz, Terence C Chua, Jesus Esquivel, Alexander Stojadinovic, Joerg Doerfer, David L Morris, Uwe Maeder, Christoph-Thomas Germer, Alexander G Kerscher

Open Access Research article

Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: a case control study

Jun Maeda, Masahiko Higashiyama, Akira Imaizumi, Tomio Nakayama, Hiroshi Yamamoto, Takashi Daimon, Minoru Yamakado, Fumio Imamura, Ken Kodama

Open Access Technical advance

Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX®Colon Cancer Assay

Kim M Clark-Langone, Chithra Sangli, Jayadevi Krishnakumar, Drew Watson

Open Access Research article

Preoperative dexamethasone reduces postoperative pain, nausea and vomiting following mastectomy for breast cancer

Jorge Gómez-Hernández, Alba Lorena Orozco-Alatorre, Marisela Domínguez-Contreras, Antonio Oceguera-Villanueva, Salvador Gómez-Romo, Andrea Socorro Alvarez Villaseñor, Clotilde Fuentes-Orozco, Alejandro González-Ojeda

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Meta-analysis of quantitative diffusion-weighted MR imaging in the differential diagnosis of breast lesions

Xin Chen, Wen-ling Li, Yi-li Zhang, Qian Wu, You-min Guo, Zhi-lan Bai

Open Access Research article

Circulating endothelial cells are an early predictor in renal cell carcinoma for tumor response to sunitinib

Viktor Gruenwald, Gernot Beutel, Susanne Schuch-Jantsch, Christoph Reuter, Philipp Ivanyi, Arnold Ganser, Marion Haubitz

Open Access Case report

Toxic risk of stereotactic body radiotherapy and concurrent helical tomotherapy followed by erlotinib for non-small-cell lung cancer treatment - case report

Chen-Hsi Hsieh, Hou-Tai Chang, Shih-Chiang Lin, Yu-Jen Chen, Li-Ying Wang, Yen-Ping Hsieh, Chien-An Chen, Ngot-Swan Chong, Shoei Long Lin, Chun-Yi Chen, Pei-Wei Shueng

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Separate and combined analysis of successive dependent outcomes after breast-conservation surgery: recurrence, metastases, second cancer and death

Virginie Rondeau, Simone Mathoulin-Pélissier, Lucie Tanneau, Annie J Sasco, Gaétan MacGrogan, Marc Debled

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine