Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2010

Open Access 01-12-2010 | Case report

Ectopic primary type A thymoma located in two thoracic vertebras: a case report

Authors: Ferdinando Marandino, Carmine Zoccali, Nicola Salducca, Mirella Marino, Paolo Visca

Published in: BMC Cancer | Issue 1/2010

Login to get access

Abstract

Background

The thymus arises in the ventral portion of the third and fourth pharyngeal pouch. It descends into the anterior mediastinum at 6th week of gestation. Any errors occurring during this process can cause dissemination of aberrant nodules that are responsible for most atypical thymomas.

Case Presentation

The authors report a unusual case of type-A thymoma located in D10 and D11 vertebral bodies.
The histology showed a uniform growth of short, spindle shaped, mitotically inactive cells. A few small, normal lymphocytes were seen scattered or in small groups. The immunohistochemical investigation for neuroectodermal, neuroendocrine, vascular and muscular markers were negative. It also confirmed the presence of CD3+, CD5+ T lymphocytes and the absence of immature T-lymphocyte markers.

Conclusions

The case described shows a thymic hystogenesis for spindle cell tumours. To our knowledge no other cases of vertebral thymomas have been described in international literature.
Appendix
Available only for authorised users
Literature
1.
Tan A, Holdener GP, Hecht A, et al: Malignant thymoma in an ectopic thymus: CT appearance. J Comput Assist Tomogr. 1991, 15: 842-4. 10.1097/00004728-199109000-00024.CrossRefPubMed
2.
MacLean G, Guberman A, Giulivi A: Late pseudo-exacerbation of myasthenia gravis due to ectopic thymoma invading lower cranial nerves. Can J Neurol Sci. 1990, 17: 46-8.PubMed
3.
Moran CA, Suster S, Fishback NF, et al: Primary intrapulmonary thymoma. A clinicopathologic and immunohistochemical study of eight cases. Am J Surg Pathol. 1995, 19: 304-12. 10.1097/00000478-199503000-00008.CrossRefPubMed
4.
Attanoos RL, Galateau-Salle F, Gibbs AR, et al: Primary thymic epithelial tumours of the pleura mimicking malignant mesothelioma. Histopathology. 2002, 41: 42-9. 10.1046/j.1365-2559.2002.01422.x.CrossRefPubMed
5.
Kanzaki M, Oyama K, Ikeda T, et al: Non invasive thymoma in the middle mediastinum. Ann Thorac Surg. 2004, 77: 2209-10. 10.1016/S0003-4975(03)01392-4.CrossRefPubMed
6.
Duwe BV, Sterman DH, Musani AI: Tumours of the mediastinum. Chest. 2005, 128: 2893-909. 10.1378/chest.128.4.2893.CrossRefPubMed
7.
Chilosi M, Facchettti F, Dei Tos AP, et al: Bcl-2 expression in pleural and extrapleural solitary fibrous tumours. J Pathol. 1997, 181: 362-7. 10.1002/(SICI)1096-9896(199704)181:4<362::AID-PATH764>3.0.CO;2-Y.CrossRefPubMed
8.
WHO Classification of Tumours: Parthology and Genetics of Tumours of soft tissue and bone. Edited by: Fletcher CDM, Unni K, Mertens K. 2002, Lyon
9.
Chilosi M, Castelli P, Martignoni G, et al: Neoplastic epithelial cells in a subset of human thymomas express the B cell-associated CD20 antigen. Am J Surg Pathol. 1992, 16: 988-97. 10.1097/00000478-199210000-00010.CrossRefPubMed
10.
Alexiev BA, Drachenberg CB, Burke AP: Thymomas: a cytological and immunohistochemical study, with emphasis on lymphoid and neuroendocrine markers. Diagn Pathol. 2007, 11 (2): 13-10.1186/1746-1596-2-13.CrossRef
11.
Pan CC, Chen WY, Chiang H: Spindle cell and mixed spindle/lymphocytic thymomas: an integrated clinicopathologic and immunohistochemical study of 81 cases. Am J Surg Pathol. 2001, 25: 111-20. 10.1097/00000478-200101000-00013.CrossRefPubMed
12.
Müller-Hermelink HK, Marino M, Palestro G, et al: Immunohistological evidences of cortical and medullary differentiation in thymoma. Virchows Arch A Pathol Anat Histopathol. 1985, 408: 143-61. 10.1007/BF00707978.CrossRefPubMed
Metadata
Title
Ectopic primary type A thymoma located in two thoracic vertebras: a case report
Authors
Ferdinando Marandino
Carmine Zoccali
Nicola Salducca
Mirella Marino
Paolo Visca
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2010
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-10-322

Other articles of this Issue 1/2010

BMC Cancer 1/2010 Go to the issue

Research article

Expression of CIAPIN1 in human colorectal cancer and its correlation with prognosis

Research article

Decreased Hsp90 expression in infiltrative lobular carcinoma: an immunohistochemical study

Research article

Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response

Research article

CDO1 Promoter Methylation is a Biomarker for Outcome Prediction of Anthracycline Treated, Estrogen Receptor-Positive, Lymph Node-Positive Breast Cancer Patients

Research article

Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts

Research article

The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits