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BMC Cancer
Published in: BMC Cancer 1/2010

Open Access 01-12-2010 | Case report

Extramammary Paget's disease with the appearance of a nodule: a case report

Authors: Xia Wang, Wenlin Yang, Jian Yang

Published in: BMC Cancer | Issue 1/2010

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Abstract

Background

Extramammary Paget's disease (EMPD) remains a rare condition with only a limited number of cases reported in the literature. EMPD is mainly composed of intraepidermal Paget cells, and possesses variable clinical behaviors and histological appearances, leading to difficulty in the diagnosis of this disease.

Case presentation

We here report a case of primary EMPD with the appearance of a nodule on the background of erythema. Histological assessment showed Paget cell infiltration throughout the epidermis with dermal spread. Using immunohistochemistry, the expressions of CK7, CK19, CK20, GCDFP-15, CEA, S-100 protein and bcl-2 were examined to elucidate the cellular differentiation of the carcinoma.

Conclusion

According to the histological assessment, this case was diagnosed as primary EMPD with carcinoma cells invading into the dermis, but without lymph node infiltration.
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Metadata
Title
Extramammary Paget's disease with the appearance of a nodule: a case report
Authors
Xia Wang
Wenlin Yang
Jian Yang
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2010
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-10-405

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