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13217 search results for:

Human interferon beta 

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  1. Open Access 01-12-2021 | Interferon | OriginalPaper

    Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells

    Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by the progressive destruction of pancreatic beta cells by the immune system and subsequent loss of insulin secretion. More than 50 gene variants, including several genes that …

  2. 01-07-1999 | OriginalPaper

    Recombinant Human Interferon-β-1a (Rebif®) vs Recombinant Interferon-β-1b (Betaseron®) in Healthy Volunteers

    A Pharmacodynamic and Tolerability Study

    Objectives: This study compared the pharmacodynamics and tolerability of subcutaneous 6MU (22μg) interferon (IFN)-β-la (Rebif®) and 8MU (250μg) IFN-β-1b (Betaseron®). Participants and Methods: Twelve healthy volunteers received a single injection …

  3. 01-04-2017 | OriginalPaper

    Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes

    Three hallmarks of the pancreatic islets in early human type 1 diabetes and in mouse models of the disease are overexpression of HLA class I [ 1 , 2 ], presence of markers of endoplasmic reticulum (ER) stress [ 3 – 5 ] and beta cell apoptosis [ 6 …

  4. Open Access 01-12-2017 | OriginalPaper

    Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial

  5. Open Access 01-12-2007 | OriginalPaper

    Differential inhibition of human cytomegalovirus (HCMV) by toll-like receptor ligands mediated by interferon-beta in human foreskin fibroblasts and cervical tissue

    Human cytomegalovirus (HCMV) can be acquired sexually and is shed from the genital tract. Cross-sectional studies in women show that changes in genital tract microbial flora affect HCMV infection and/or shedding. Since genital microbial flora may …

  6. 01-03-2005 | OriginalPaper

    Human interferon beta, nimustine hydrochloride, and radiation therapy in the treatment of newly diagnosed malignant astrocytomas

    Previous investigators have reported encouraging results for malignant gliomas treated using a combination of human interferon beta (IFN-β) with nimustine hydrochloride (ACNU) and radiation therapy (termed IAR therapy). This study was undertaken …

  7. 01-07-2005 | OriginalPaper

    Differential effects of interferon alpha-2b and beta on the signaling pathways in human liver cancer cells

  8. 01-06-2000 | OriginalPaper

    Efficacy of Post Operative Adjuvant Therapy with Human Interferon Beta, MCNU and Radiation (IMR) for Malignant Glioma: Comparison Among Three Protocols

     In order to develop ultimate adjuvant therapy for malignant gliomas, we analysed 77 patients with malignant gliomas (29 anaplastic astrocytomas (AAs) and 48 glioblastoma multiformes (GMs)) treated by three protocols of IMR therapy (human

  9. Open Access 01-12-2012 | OriginalPaper

    MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up

    In a previous study in the Spanish multiple sclerosis (MS) population, our group found that the MHC2TA +1614 genotype frequency was very different when MS patients with human herpesvirus 6 (HHV-6) were compared with MS patients without this virus …

  10. Open Access 01-12-2005 | OriginalPaper

    Synergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gamma

    Human cytomegalovirus (HCMV) is a ubiquitous beta-herpesvirus that affects 60–80% of the human population [ 1 ]. The lytic replication cycle of HCMV is a temporally regulated cascade of events that is initiated when the virus binds to host cell …

  11. 14-03-2024 | Multiple Sclerosis in Childhood | News | Article

    Highly effective therapies should be first-line treatment for pediatric MS

    The most common HET agents given were natalizumab (42.6%) and fingolimod (33.3%), while MET most frequently consisted of interferon (63.5%), glatiramer acetate (13.7%), or dimethyl fumarate (13.0%).

  12. Open Access 10-05-2024 | Human interferon beta | Online First

    Long-term clinical outcomes in patients with CIS treated with interferon beta-1b: results from the 15-year follow up of the BENEFIT trial

    Multiple sclerosis (MS) treatment intervention with immunomodulating therapy at early disease stage improves short term clinical outcomes. The objective of this study is to describe the long-term outcomes and healthcare utilization of patients …

  13. 01-05-2024 | Human interferon beta | News

    Interferon-beta-1b

    Thrombotic microangiopathy
  14. 01-03-2024 | Human interferon beta | News

    Interferon-beta-1

    Thrombotic microangiopathy
  15. Open Access 01-12-2024 | Natalizumab | ReviewPaper

    Cost-utility and cost-effectiveness analysis of disease-modifying drugs of relapsing–remitting multiple sclerosis: a systematic review

    MS is a chronic demyelinating disorder of the central nervous system that is clasified as an immune-mediated inflammatory disease [ 1 , 2 ]. The clinical course and severity of the disease are variable, but the most common symptoms of the disease …

  16. Open Access 01-04-2022 | Erythropoietin | OriginalPaper

    Recombinant human erythropoietin and interferon-β-1b protect against 3-nitropropionic acid-induced neurotoxicity in rats: possible role of JAK/STAT signaling pathway

    3-Nitropropionic acid (3-NP) model serves as a beneficial tool to evaluate the effect of novel treatments for Huntington’s disease (HD). The aim of the present study was to demonstrate the neuroprotective effect of recombinant human erythropoietin …

  17. 01-03-2024 | Multiple Sclerosis | News

    Multiple drugs

    Lack of efficacy, Off label use and methicillin-resistant Staphylococcus aureus meningitis.
  18. Open Access 01-12-2024 | Human Immunodeficiency Virus | OriginalPaper

    The association between single-nucleotide polymorphisms within type 1 interferon pathway genes and human immunodeficiency virus type 1 viral load in antiretroviral-naïve participants

    Disease progression among antiretroviral treatment (ART) naïve people living with HIV (PLWH) differs substantially [ 1 ], with both viral and host genetic factors (and their interaction) known to play an important role [ 2 – 4 ]. Human leukocyte …

  19. 20-03-2024 | Events

    Abstracts

  20. 05-04-2024 | Hepatocellular Carcinoma | Events

    Abstracts

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