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Neurology Intracranial Space-Occupying Lesion

Intracranial Space-Occupying Lesion

Empty sella syndrome: an update

Empty sella is generally an incidental radiological finding, but when endocrine, neurological, ophthalmological, or psychiatric symptoms occur empty sella syndrome must be promptly diagnosed.

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Editor's Choice

Primary vitreoretinal lymphoma mimics fungal endophthalmitis

PVRL is a life-threatening neoplasm. It can be mistaken for non-infectious uveitis, as it often presents with vitritis that responds to corticosteroids, but this case shows that it can also mimic infectious uveitis.

Intracranial pressure crisis

All patients with severe brain injury resulting in cerebral edema, space-occupying lesions, or hydrocephalus are at risk for ICP crisis. Get the latest information on critical care management and neuromonitoring.

Emerging therapies for brain metastases

Therapies designed to penetrate the blood-brain barrier and target key drivers like EGFR, ALK, HER2, and BRAF have revolutionized treatment of brain metastases from non-small-cell lung cancer, breast cancer, and melanoma.

Advances in primary CNS lymphoma

Diagnosis of PCNSL can be challenging, but genomic cfDNA testing on CSF has emerged as a new tool. The disease is now often curable in patients younger than 65 years, with several promising clinical trials ongoing for older patients.

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Keynote webinar | Spotlight on sleep in brain health

  • Webinar | 02-05-2024 | 17:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.

Dr. Rolf Fronczek
Dr. Renata Riha
Dr. Sven Rupprecht
Developed by: Springer Medicine
Watch now

Case Studies

Primary vitreoretinal lymphoma mimics fungal endophthalmitis

PVRL is a life-threatening neoplasm. It can be mistaken for non-infectious uveitis, as it often presents with vitritis that responds to corticosteroids, but this case shows that it can also mimic infectious uveitis.

Brain abscesses from nocardiosis in an immunocompetent patient

Nocardia infection primarily affects immunocompromised patients and brain abscess is rare. But N. beijingensis is an emerging pathogen in immunocompetent individuals and abscess formation appears to be a common manifestation.

Thunderclap headache due to ADEM

Thunderclap headache as a first clinical manifestation of acute disseminated encephalomyelitis has not been described before, and significant intracranial hypertension in ADEM is rarely reported. This unusual case combines both.

Episode 4: Stem cell therapy for PD

A new era for managing Parkinson’s disease?

STEM-PD, the first in-human safety trial of stem cell therapy for Parkinson’s disease, began this year and marks a huge step forward for this type of treatment.

We talk to Prof. Malin Parmar about why stem cell therapy is such a good option for patients with Parkinson’s disease and get an update on the current status of the trial.

Dr. Malin Parmar
Listen now

Current Reviews

Association of retinol binding protein and the risk of idiopathic intracranial hypertension: a systematic review and meta-analysis

Idiopathic Intracranial Hypertension (IIH), also known as pseudotumor cerebri, is a neurological disorder characterized by increased intracranial pressure (ICP) without a known cause. It predominantly affects young women of childbearing age and is …

Emerging nanoplatforms towards microenvironment-responsive glioma therapy

Gliomas are aggressive intracranial tumors of the central nervous system with a poor prognosis, high risk of recurrence, and low survival rates. Radiation, surgery, and chemotherapy are traditional cancer therapies. It is very challenging to …

Association of tumor treating fields (TTFields) therapy with overall survival in newly diagnosed glioblastoma

Glioblastoma (GBM) is a rare and aggressive primary central nervous system tumor with high morbidity and mortality. Standard treatments include surgery, radiotherapy (RT), and temozolomide (TMZ) chemotherapy, but these options are often …

Efgartigimod treatment for therapy-refractory autoimmune encephalitis with coexistent NMDAR and LGI1 antibodies: a case report and literature review

The Fc receptor (FcRn) inhibitors can ameliorate autoimmune conditions such as myasthenia gravis through a rapid and specific clearance of serum IgG levels, and they also have potential for future use in a wider variety of antibody-mediated …

Further Reading

Clinical characteristics and outcomes in leptomeningeal disease with or without brain metastasis: insights from an explorative data analysis of the Charité LMD registry

Leptomeningeal disease (LMD) also known as leptomeningeal metastasis (LMM) involves the spread of cancer cells into the leptomeninges and/or cerebrospinal fluid (CSF). It is generally considered a late-stage complication of metastatic malignancies …

Mental health status and associated factors of caregivers of patients with malignant brain tumors

Caregivers of patients with cancer play a crucial role in patient care and symptom management, yet the associated demands can significantly impact their health and quality of life (QOL). Studies indicate that these caregivers’ mental health tends …

A hybrid [18F]fluoropivalate PET-multiparametric MRI to detect and characterise brain tumour metastases based on a permissive environment for monocarboxylate transport

The incidence of Intracranial Metastatic Disease (IMD) continues to increase in part due to improvements in systemic therapy resulting in durable control of extra-cranial disease (ECD). Contrast-enhanced Magnetic Resonance Imaging (CE-MRI) is the …

Between-hospital variation in biopsy indication for patients with newly diagnosed glioblastoma in the Dutch Quality Registry for Neurosurgery

The standard treatment for patients with glioblastoma consists of maximal safe resection followed by adjuvant concurrent chemo-radiotherapy [ 1 ]. Cytoreductive surgical resection is the treatment of choice in most glioblastoma cases, as it has …

Related topics

Primary vitreoretinal lymphoma mimics fungal endophthalmitis

PVRL is a life-threatening neoplasm. It can be mistaken for non-infectious uveitis, as it often presents with vitritis that responds to corticosteroids, but this case shows that it can also mimic infectious uveitis.

Read more

Empty sella syndrome: an update

Empty sella is generally an incidental radiological finding, but when endocrine, neurological, ophthalmological, or psychiatric symptoms occur empty sella syndrome must be promptly diagnosed.

Read more