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Primary vitreoretinal lymphoma mimics fungal endophthalmitis

PVRL is a life-threatening neoplasm. It can be mistaken for non-infectious uveitis, as it often presents with vitritis that responds to corticosteroids, but this case shows that it can also mimic infectious uveitis.

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Editor's Choice

Emerging therapies for brain metastases

Therapies designed to penetrate the blood-brain barrier and target key drivers like EGFR, ALK, HER2, and BRAF have revolutionized treatment of brain metastases from non-small-cell lung cancer, breast cancer, and melanoma.

Advances in primary CNS lymphoma

Diagnosis of PCNSL can be challenging, but genomic cfDNA testing on CSF has emerged as a new tool. The disease is now often curable in patients younger than 65 years, with several promising clinical trials ongoing for older patients.

Updated guidelines for chemotherapy in glioma

Evidence-based guidelines from the Congress of Neurological Surgeons on the role of chemotherapy in patients with newly diagnosed WHO grade II diffuse glioma. Explore the latest recommendations.

CAR T-cell therapy for CNS lymphoma

Neurotoxicity concerns have led to people with CNS lymphomas being excluded from pivotal trials of CAR T-cell therapies. But data from recent studies show promising efficacy and manageable toxicity.

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Keynote webinar | Spotlight on sleep in brain health

  • Webinar | 02-05-2024 | 17:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.

Dr. Rolf Fronczek
Dr. Renata Riha
Dr. Sven Rupprecht
Developed by: Springer Medicine
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Case Studies

Primary vitreoretinal lymphoma mimics fungal endophthalmitis

PVRL is a life-threatening neoplasm. It can be mistaken for non-infectious uveitis, as it often presents with vitritis that responds to corticosteroids, but this case shows that it can also mimic infectious uveitis.

Novel CSF biomarkers for PCNSL

Diagnosis of primary diffuse large B-cell lymphoma of the CNS is challenging and often delayed. In these three cases with varied clinical presentations and radiological findings, diagnosis was suggested by novel CSF biomarkers.

Post-surgical spontaneous paroxysmal hypothermia

Three cases demonstrating that SPH (in which recurrent core temperature is less than 35°) is not unusual in patients undergoing surgery for hypothalamic lesions.

Episode 4: Stem cell therapy for PD

A new era for managing Parkinson’s disease?

STEM-PD, the first in-human safety trial of stem cell therapy for Parkinson’s disease, began this year and marks a huge step forward for this type of treatment.

We talk to Prof. Malin Parmar about why stem cell therapy is such a good option for patients with Parkinson’s disease and get an update on the current status of the trial.

Dr. Malin Parmar
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Current Reviews

Emerging nanoplatforms towards microenvironment-responsive glioma therapy

Gliomas are aggressive intracranial tumors of the central nervous system with a poor prognosis, high risk of recurrence, and low survival rates. Radiation, surgery, and chemotherapy are traditional cancer therapies. It is very challenging to …

Association of tumor treating fields (TTFields) therapy with overall survival in newly diagnosed glioblastoma

Glioblastoma (GBM) is a rare and aggressive primary central nervous system tumor with high morbidity and mortality. Standard treatments include surgery, radiotherapy (RT), and temozolomide (TMZ) chemotherapy, but these options are often …

Efgartigimod treatment for therapy-refractory autoimmune encephalitis with coexistent NMDAR and LGI1 antibodies: a case report and literature review

The Fc receptor (FcRn) inhibitors can ameliorate autoimmune conditions such as myasthenia gravis through a rapid and specific clearance of serum IgG levels, and they also have potential for future use in a wider variety of antibody-mediated …

It’s all downstream from here: RTK/Raf/MEK/ERK pathway resistance mechanisms in glioblastoma

IDH wild-type glioblastoma (GBM) is the most common and lethal primary brain tumour, primarily due to challenges in achieving gross total resection and the presence of highly invasive cells that contribute to resistance to standard of care …

Further Reading

Between-hospital variation in biopsy indication for patients with newly diagnosed glioblastoma in the Dutch Quality Registry for Neurosurgery

The standard treatment for patients with glioblastoma consists of maximal safe resection followed by adjuvant concurrent chemo-radiotherapy [ 1 ]. Cytoreductive surgical resection is the treatment of choice in most glioblastoma cases, as it has …

Treatment practices and survival outcomes for IDH-wildtype glioblastoma patients according to MGMT promoter methylation status: insights from the U.S. National Cancer Database

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with an annual incidence of approximately 2 per 100,000 population [ 1 ]. First line treatment includes maximal safe surgical debulking followed by a combination of …

Freiburg Neuropathology Case Conference: Progressive Optic Nerve Lesion Over a 16-Year Period

A 60-years-old female patient, first presented in 2008 with a transient visual impairment of the left eye and pathological visually evoked potentials. Magnetic resonance imaging (MRI) revealed a unilateral, concentric, enhancing lesion encasing …

Sonodynamic therapy with a single neoadjuvant, diffuse delivery of low-intensity ultrasound with 5-ALA in treatment naïve glioblastoma results in tumor-specific cytotoxic edema and increased apoptosis

High-grade gliomas are the most common primary brain tumors in adults, the most malignant type being glioblastoma [ 1 ]. With maximal safe resection and combined radio- and chemotherapy, median overall survival for newly diagnosed glioblastoma is …