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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2024

Open Access 11-03-2024 | Migraine | Review

The glymphatic system in migraine and other headaches

Authors: Maria Grazia Vittorini, Aysenur Sahin, Antonin Trojan, Sevil Yusifli, Tamta Alashvili, Gonçalo V. Bonifácio, Ketevan Paposhvili, Viktoria Tischler, Christian Lampl, Simona Sacco, on behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS)

Published in: The Journal of Headache and Pain | Issue 1/2024

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Abstract

Glymphatic system is an emerging pathway of removing metabolic waste products and toxic solutes from the brain tissue. It is made of a network of perivascular spaces, filled in cerebrospinal and interstitial fluid, encompassing penetrating and pial vessels and communicating with the subarachnoid space. It is separated from vessels by the blood brain barrier and from brain tissue by the endfeet of the astrocytes rich in aquaporin 4, a membrane protein which controls the water flow along the perivascular space. Animal models and magnetic resonance (MR) studies allowed to characterize the glymphatic system function and determine how its impairment could lead to numerous neurological disorders (e.g. Alzheimer’s disease, stroke, sleep disturbances, migraine, idiopathic normal pressure hydrocephalus). This review aims to summarize the role of the glymphatic system in the pathophysiology of migraine in order to provide new ways of approaching to this disease and to its therapy.
Literature
1.
Edvinsson L, Villalón CM, MaassenVanDenBrink A (2012) Basic mechanisms of migraine and its acute treatment. Pharmacol Ther 136(3):319–333PubMedCrossRef
2.
Yuan Z, Li W, Tang H, Mei Y, Qiu D, Zhang M et al (2023) Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI. Ann Clin Transl Neurol 10(7):1160–1169PubMedPubMedCentralCrossRef
3.
Ashina M, Katsarava Z, Do TP, Buse DC, Pozo-Rosich P, Özge A et al (2021) Migraine: epidemiology and systems of care. Lancet 397(10283):1485–1495PubMedCrossRef
4.
Steiner TJ, Stovner LJ (2023) Global epidemiology of migraine and its implications for public health and health policy. Nat Rev Neurol 19(2):109–117PubMedCrossRef
5.
Liu X, Wu G, Tang N, Li L, Liu C, Wang F, Ke S (2021) Glymphatic drainage blocking aggravates brain edema, neuroinflammation via modulating TNF-α, IL-10, and AQP4 after intracerebral hemorrhage in rats. Front Cell Neurosci 15:784154PubMedPubMedCentralCrossRef
6.
(2018) Headache Classification Committee of the International Headache Society (IHS) the international classification of headache disorders, 3rd edition. Cephalalgia 38(1):1–211
7.
Bhatt S, Nagappa AN, Patil CR (2020) Role of oxidative stress in depression. Drug Discov Today 25:1270–1276PubMedCrossRef
8.
Kepp O, Galluzzi L, Zitvogel L, Kroemer G (2010) Pyroptosis-A cell death modality of its kind? Eur J Immunol 40:627–630PubMedCrossRef
9.
Rainville JR, Hode GE (2019) Inflaming sex differences in mood disorders. Neuropsychopharmacology 44:184–199PubMedCrossRef
10.
Xue JH, Yanamoto H, Nakajo Y, Tohnai N, Nakano Y, Hori T, Iihara K, Miyamoto S (2009) Induced spreading depression evokes cell division of astrocytes in the subpial zone, generating neural precursor-like cells and new immature neurons in the adult cerebral cortex. Stroke 40:e606-613PubMedCrossRef
11.
Sukhotinsky I, Dilekoz E, Wang Y, Qin T, Eikermann-Haerter K, Waeber C, Ayata C (2011) Chronic daily cortical spreading depressions suppress spreading depression susceptibility. Cephalalgia 31:1601–1608PubMedCrossRef
12.
Gu S, Li Y, Jiang Y, Huang JH, Wang F (2022) Glymphatic dysfunction induced oxidative stress and neuro-inflammation in major depression disorders. Antioxidants (Basel) 11(11):2296PubMedCrossRef
13.
Zhang XC, Kainz V, Burstein R, Levy D (2011) Tumor necrosis factoralpha induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Pain 152:140–149PubMedCrossRef
14.
He W, Long T, Pan Q, Zhang S, Zhang Y, Zhang D, Qin G, Chen L et al (2019) Microglial NLRP3 inflammasome activation mediates IL-1beta release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model. J Neuroinflammation 16:78PubMedPubMedCentralCrossRef
15.
Thuraiaiyah J, Erritzoe-Jervild M, Al-Khazali HM, Schytz HW, Younis S (2022) The role of cytokines in migraine: a systematic review. Cephalalgia 42(14):1565–1588PubMedCrossRef
16.
Spekker E, Tanaka M, Szabo A, Vecsei L (2021) Neurogenic inflammation: the participant in migraine and recent advancements in translational research. Biomedicines 10(1):76PubMedPubMedCentralCrossRef
17.
18.
Goadsby PJ, Edvinsson L, Ekman R (1990) Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 28(2):183–187PubMedCrossRef
19.
20.
21.
22.
23.
Schain AJ, Melo-Carrillo A, Strassman AM, Burstein R (2017) Cortical spreading depression closes paravascular space and impairs glymphatic flow: implications for migraine headache. J Neurosci 37:2904–2915PubMedPubMedCentralCrossRef
24.
Ciurea AV, Mohan AG, Covache-Busuioc RA, Costin HP, Saceleanu VM (2023) The Brain’s glymphatic system: drawing new perspectives in neuroscience. Brain Sci 13:1005PubMedPubMedCentralCrossRef
25.
Ellis S (2006) Structure and function of the lymphatic system: an overview. Br J Community Nurs 11:S4–S6PubMedCrossRef
26.
27.
Mathiisen TM, Lehre KP, Danbolt NC, Ottersen OP (2010) The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction. Glia 58(9):1094–1103PubMedCrossRef
28.
Rennels M, Gregory TF, Blaumanis OR, Fujimoto K, Grady PA (1985) Evidence for a ‘paravascular’ fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res 326(1):47–63PubMedCrossRef
29.
30.
Aldred AR, Brack CM, Schreiber G (1995) The cerebral expression of plasma protein genes in different species. Comp Biochem Physiol B Biochem Mol Biol 111:1–15PubMedCrossRef
31.
Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA et al (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amy- loid b. Sci Transl Med 4:147ra111PubMedPubMedCentralCrossRef
32.
Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E (2015) Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol 11:457–470PubMedPubMedCentralCrossRef
33.
34.
Gouveia-Freitas K, Bastos-Leite AJ (2021) Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology. Neuroradiology 63:1581–1597PubMedPubMedCentralCrossRef
35.
Kassem NA, Deane R, Segal MB, Preston JE (2006) Role of transthyretin in thyroxine transfer from cerebrospinal fluid to brain and choroid plexus. Am J Physiol Regul Integr Comp Physiol 291:R1310–R1315PubMedCrossRef
36.
37.
38.
Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T et al (2022) The glymphatic system: current understanding and modeling. iScience 29:104987ADSCrossRef
39.
Zhang Y, Song J, He XZ, Xiong J, Xue R, Ge GH et al (2020) Quantitative determination of glymphatic flow using spectrophotofluorometry. Neurosci Bull 36(12):1524–1537PubMedPubMedCentralCrossRef
40.
Dai JK, Wang SX, Shan D, Niu HC, Lei H (2018) Super-resolution track-density imaging reveals fine anatomical features in tree shrew primary visual cortex and hippocampus. Neurosci Bull 34:438–448PubMedCrossRef
41.
Kress BT, Iliff JJ, Xia MS, Wang MH, Wei HLS, Zeppenfeld D et al (2014) Impairment of paravascular clearance pathways in the aging brain. Ann Neurol 76:845–861PubMedPubMedCentralCrossRef
42.
Pizzo ME, Wolak DJ, Kumar NN, Brunette E, Brunnquell CL, Hannocks MJ et al (2018) Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery. J Physiol 596:445–475PubMedCrossRef
43.
Wei F, Song J, Zhang C, Lin J, Xue R, Shan LD et al (2019) Chronic stress impairs the aquaporin-4-mediated glymphatic transport through glucocorticoid signaling. Psychopharmacology 236(4):1367–1384PubMedCrossRef
44.
Wei F, Zhang C, Xue R, Shan L, Gong S, Wang G et al (2017) The pathway of subarachnoid CSF moving into the spinal parenchyma and the role of astrocytic aquaporin-4 in this process. Life Sci 182:29–40PubMedCrossRef
45.
46.
47.
Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M et al (2013) Brainwide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest 123:1299–1309PubMedPubMedCentralCrossRef
48.
49.
50.
Kaur J, Davoodi-Bojd E, Fahmy LM, Zhang L, Ding G, Hu J et al (2020) Magnetic resonance imaging and modeling of the glymphatic system. Diagnostics (Basel) 10(6):344PubMedCrossRef
51.
de Leon MJ, Li Y, Okamura N, Tsui WH, Saint-Louis LA, Glodzik L et al (2017) Cerebrospinal fluid clearance in Alzheimer disease measured with dynamic PET. J Nucl Med 58:1471–1476PubMedPubMedCentralCrossRef
52.
53.
Plog BA, Mestre H, Olveda GE, Sweeney AM, Kenney HM, Cove A et al (2018) Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain. JCI Insight 3(23):e126138PubMedPubMedCentralCrossRef
54.
Li X, Lin Z, Liu C, Bai R, Wu D, Yang J (2023) Glymphatic imaging in pediatrics. J Magn Reson Imaging
55.
Sepehrband F, Barisano G, Sheikh-Bahaei N, Cabeen RP, Choupan J, Law M, Toga AW (2019) Image processing approaches to enhance perivascular space visibility and quantification using MRI. Sci Rep 9(1):12351ADSPubMedPubMedCentralCrossRef
56.
Boespflug EL, Schwartz DL, Lahna D, Pollock J, Iliff JJ, Kaye JA, Rooney W, Silbert LC (2018) MR imaging-based multimodal autoidentification of perivascular spaces (mMAPS): automated morphologic segmentation of enlarged perivascular spaces at clinical field strength. Radiology 286(2):632–642PubMedCrossRef
57.
Potter GM, Chappell FM, Morris Z, Wardlaw JM (2015) Cerebral perivascular spaces visible on magnetic resonance imaging: development of a qualitative rating scale and its observer reliability. Cerebrovasc Dis 39(3–4):224–231PubMedPubMedCentralCrossRef
58.
59.
Dubost F, Adams H, Bortsova G et al (2019) 3D regression neural network for the quantification of enlarged perivascular spaces in brain MRI. Med Image Anal 51:89–100PubMedCrossRef
60.
Drenthen GS, Elschot EP, van der Knaap N, Uher D, Voorter PHM, Backes WH et al (2023) Imaging interstitial fluid with MRI: a narrative review on the associations of altered interstitial fluid with vascular and neurodegenerative abnormalities. J Magn Reson Imaging
61.
Steward CE, Venkatraman VK, Lui E, Malpas CB, Ellis KA, Cyarto EV et al (2021) Assessment of the DTI-ALPS parameter along the perivascular space in older adults at risk of dementia. J Neuroimaging 31:569–578PubMedCrossRef
62.
Othersen JB, Maize JC, Woolson RF, Budisavljevic MN (2007) Nephrogenic systemic fibrosis after exposure to gadolinium in patients with renal failure. Nephrol Dial Transplant 22:3179–3185PubMedCrossRef
63.
Li L, Gao FQ, Zhang B, Luo BN, Yang ZY, Zhao J (2008) Overdosage of intrathecal gadolinium and neurological response. Clin Radiol 63:1063–1068PubMedCrossRef
64.
Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Mestre H, Lee H et al (2020) Perivascular spaces in the brain: anatomy, physiology and pathology. Nat Rev Neurol 16:137–153PubMedCrossRef
65.
Ohashi T, Naganawa S, Iwata S, Kuno K (2021) Age-related changes in the distribution of intravenously administered gadolinium-based contrast agents leaked into the cerebrospinal fluid in patients with suspected endolymphatic hydrops. Jpn J Radiol 39:433–441PubMedCrossRef
66.
Taoka T, Ito R, Nakamichi R, Nakane T, Sakai M, Ichikawa K et al (2022) Diffusion-weighted image analysis along the perivascular space (DWI–ALPS) for evaluating interstitial fluid status: age dependence in normal subjects. Jpn J Radiol 40:894–902PubMedPubMedCentralCrossRef
67.
van Veluw SJ, Biessels GJ, Bouvy WH, Spliet WG, Zwanenburg JJ, Luijten PR et al (2016) Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces. J Cereb Blood Flow Metab 36(3):576–580PubMedCrossRef
68.
Cai K, Tain R, Das S, Damen FC, Sui Y, Valyi-Nagy T, Elliott MA, Zhou XJ (2015) The feasibility of quantitative MRI of perivascular spaces at 7T. J Neurosci Methods 256:151–156PubMedPubMedCentralCrossRef
69.
Barisano G, Law M, Custer RM, Toga AW, Sepehrband F (2021) Perivascular space imaging at ultrahigh field MR imaging. Magn Reson Imaging Clin N Am 29(1):67–75PubMedCrossRef
70.
Huang W, Zhang Y, Zhou Y, Zong J, Qiu T, Hu L et al (2023) Glymphatic dysfunction in migraine mice model. Neuroscience 15(528):64–74CrossRef
71.
Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, Kasischke KA, Nedergaard M (2007) Cortical spreading depression causes and coincides with tissue hypoxia. Nat Neurosci 10:754–762PubMedCrossRef
72.
Tomita M, Tomita Y, Unekawa M, Toriumi H, Suzuki N (2011) Oscillating neuro-capillary coupling during cortical spreading depression as observed by tracking of FITC-labeled RBCs in single capillaries. Neuroimage 56:1001–1010PubMedCrossRef
73.
Molchanova S, Kӧӧbi P, Oja SS, Saransaari P (2004) Interstitial concentrations of amino acids in the rat striatum during global forebrain ischemia and potassium-evoked spreading depression. Neurochem Res 29:1519–1527PubMedCrossRef
74.
Schock SC, Munyao N, Yakubchyk Y, Sabourin LA, Hakim AM, Ventureyra EC, Thompson CS (2007) Cortical spreading depression releases ATP into the extracellular space and purinergic receptor activation contributes to the induction of ischemic tolerance. Brain Res 1168:129–138PubMedCrossRef
75.
Vyskocil F, Kritz N, Bures J (1972) Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats. Brain Res 39:255–259PubMedCrossRef
76.
77.
Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R (2010) Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci 30:8807–8814PubMedPubMedCentralCrossRef
78.
Zhang X, Levy D, Kainz V, Noseda R, Jakubowski M, Burstein R (2011) Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol 69:855–865PubMedPubMedCentralCrossRef
79.
Toriello M, Gonzalez-Quintanilla V, Perez-Pereda S, Fontanillas N, Pascual J (2021) The potential role of the glymphatic system in headache disorders. Pain Med 22(12):3098–3100PubMedCrossRef
80.
Lee DA, Lee HJ, Park KM (2022) Normal glymphatic system function in patients with migraine: a pilot study. Headache 62:718–725PubMedCrossRef
81.
Zhang X, Wang W, Bai X, Zhang X, Yuan Z, Jiao B (2023) Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space. J Headache Pain 24(1):147PubMedPubMedCentralCrossRef
82.
Zhang D, Huang X, Mao C, Chen Y, Miao Z, Liu C et al (2021) Assessment of normalized cerebral blood flow and its connectivity with migraines without aura during interictal periods by arterial spin labeling. J Headache Pain 22(1):72–43PubMedPubMedCentralCrossRef
83.
Michels L, Villanueva J, O’Gorman R, Muthuraman M, Koirala N, Büchler R et al (2019) Interictal hyperperfusion in the higher visual cortex in patients with episodic migraine. Headache 59(10):1808–1820PubMedCrossRef
84.
De Benedittis G (1987) Headache lateralization and functional cerebral asymmetry: a task-related EEG power spectrum analysis. J Neurosurg Sci 31(3):109–119PubMed
85.
Amin FM, Hougaard A, Magon S, Sprenger T, Wolfram F, Rostrup E et al (2018) Altered thalamic connectivity during spontaneous attacks of migraine without aura: a resting-state fMRI study. Cephalalgia 38(7):1237–1244PubMedCrossRef
86.
Bathel A, Schweizer L, Stude P, Glaubitz B, Wulms N, Delice S et al (2018) Increased thalamic glutamate/glutamine levels in migraineurs. J Headache Pain 19(1):55PubMedPubMedCentralCrossRef
87.
Wu CH, Chang FC, Wang YF, Lirng JF, Wu HM et al (2023) Impaired glymphatic and meningeal lymphatic functions in patients with chronic migraine. Ann Neurol
88.
Zhang W, Zhou Y, Wang J, Gong X, Chen Z, Zhang X et al (2021) Glymphatic clearance function in patients with cerebral small vessel disease. Neuroimage 238:118257PubMedCrossRef
89.
Kruit M, van Buchem M, Launer L, Terwindt G, Ferrari M (2010) Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: the population-based MRI CAMERA study. Cephalalgia 30(2):129–136PubMedPubMedCentralCrossRef
90.
Hamedani AG, Rose KM, Peterlin BL, Mosley TH, Coker LH, Jack CR et al (2013) Migraine and white matter hyperintensities: the ARIC MRI study. Neurology 81(15):1308–1313PubMedPubMedCentralCrossRef
91.
Bashir A, Lipton RB, Ashina S, Ashina M (2013) Migraine and structural changes in the brain: a systematic review and meta-analysis. Neurology 81(14):1260–1268PubMedPubMedCentralCrossRef
92.
Blair GW, Thrippleton MJ, Shi Y, Hamilton I, Stringer M, Chappell F et al (2020) Intracranial hemodynamic relationships in patients with cerebral small vessel disease. Neurology 94(21):e2258–e2269PubMedPubMedCentralCrossRef
93.
94.
Ornello R, Bruno F, Frattale I, Curcio G, Pistoia F, Splendiani A, Sacco S (2023) White matter hyperintensities in migraine are not mediated by a dysfunction of the glymphatic system—a diffusion tensor imaging magnetic resonance imaging study. Headache 63:1128–1134PubMedCrossRef
95.
Christensen J, Yamakawa GR, Shultz SR, Mychasiuk R (2021) Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties. Prog Neurobiol 198:101917PubMedCrossRef
96.
Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M et al (2013) Sleep drives metabolite clearance from the adult brain. Science 342:373–377ADSPubMedCrossRef
97.
Vgontzas A, Pavlović JM (2018) Sleep disorders and migraine: review of literature and potential pathophysiology mechanisms. Headache 58(7):1030–1039PubMedPubMedCentralCrossRef
98.
99.
100.
101.
Taoka T, Masutani Y, Kawai H, Nakane T, Matsuoka K, Yasuno F et al (2017) Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases. Jpn J Radiol 35(4):172–178PubMedCrossRef
102.
Shen T, Yue Y, Ba F, He T, Tang X, Hu X et al (2022) Diffusion along perivascular spaces as marker for impairment of glymphatic system in Parkinson’s disease. NPJ Parkinsons Dis 8(1):174PubMedPubMedCentralCrossRef
103.
Hablitz LM, Vinitsky HS, Sun Q, Stæger FF, Sigurdsson B, Mortensen KN, Lilius TO, Nedergaard M (2019) Increased glymphatic influx is correlatedwith high EEG delta power and low heart rate inmice under anesthesia. Sci Adv 5(2):eaav5447ADSPubMedPubMedCentralCrossRef
104.
Nicholson P, Kedra A, Shotar E, Bonnin S, Boch AL, Shor N (2021) Idiopathic intracranial hypertension: glymphedema of the brain. J Neuro-Ophthalmol 41:93–97CrossRef
105.
Bidot S, Saindane AM, Peragallo JH, Bruce BB, Newman NJ, Biousse V (2015) Brain imaging in idiopathic intracranial hypertension. J Neuroophthalmol 35:400–411PubMedCrossRef
106.
Maralani PJ, Hassanlou M, Torres C, Chakraborty S, Kingstone M, Patel V et al (2012) Accuracy of brain imaging in the diagnosis of idiopathic intracranial hypertension. Clin Radiol 67:656–663PubMedCrossRef
107.
Lenck S, Vallee F, Labeyrie MA, Touitou V, Saint-Maurice JP, Guillonnet A et al (2017) Stenting of the lateral sinus in idiopathic intracranial hypertension according to the type of stenosis. Neurosurgery 80:393–400PubMedCrossRef
108.
De Simone R, Ranieri A, Montella S, Erro R, Fiorillo C, Bonavita V (2011) Sinus venous stenosis-associated IIHWOP is a powerful risk factor for progression and refractoriness of pain in primary headache patients: a review of supporting evidences. Neurol Sci 32(suppl 1):S169–S171PubMedCrossRef
109.
Mamikoglu B, Algın O, Mengü G, Erdogan-Küçükdaglı F, Kessler A (2023) Transverse sinus pathologies, vestibular migraine and intracranial hypertension without papilledema. Am J Otolaryngol 44;103931
110.
Piantino J, Lim MM, Newgard CD, Iliff J (2019) Linking traumatic brain injury, sleep disruption and post-traumatic headache: a potential role for glymphatic pathway dysfunction. Curr Pain Headache Rep 23:62PubMedCrossRef
Metadata
Title
The glymphatic system in migraine and other headaches
Authors
Maria Grazia Vittorini
Aysenur Sahin
Antonin Trojan
Sevil Yusifli
Tamta Alashvili
Gonçalo V. Bonifácio
Ketevan Paposhvili
Viktoria Tischler
Christian Lampl
Simona Sacco
on behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS)
Publication date
11-03-2024
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2024
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-024-01741-2

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