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Osteonecrosis 

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  1. Open Access 01-12-2024 | OriginalPaper

    Epidemiological investigation and diagnostic analysis of osteonecrosis of the femoral head in three northeastern provinces of China

    Osteonecrosis of the femoral head (ONFH) involves a series of pathological changes, such as the death of bone marrow components and bone cells, subchondral fracture, and articular surface collapse, resulting in hip pain and dysfunction owing to …

  2. Open Access 01-12-2024 | OriginalPaper

    YTHDF2-Mediated m6A methylation inhibition by miR27a as a protective mechanism against hormonal osteonecrosis in BMSCs

    Necrosis of the femoral head is a pathological condition with multiple causes that substantially impacts quality of life [ 1 ]. In the USA and Europe, 2–10% of hip replacements are attributed to this condition, while in Asia, this figure is 60% [ 2 …]. Among nontraumatic cases, steroid-induced necrosis of the femoral head (SNFH) has the highest incidence and is steadily increasing [

  3. Open Access 01-12-2024 | Osteonecrosis of the Femoral Head | OriginalPaper

    Non-traumatic osteonecrosis of the femoral head induced by steroid and alcohol exposure is associated with intestinal flora alterations and metabolomic profiles

    Osteonecrosis of the femoral head (ONFH) is a severe medical condition that primarily affects young to middle-aged adults [ 1 ]. In its advanced stages, ONFH can lead to femoral head collapse, necessitating total hip arthroplasty (THA) [ 2 , 3 ].

  4. 06-05-2024 | Osteonecrosis of the Femoral Head | Online First

    Long-term outcomes of the mayo conservative hip system in patients aged 30 years or less with osteonecrosis of the femoral head: mean follow-up of more than 10 years

    Osteonecrosis of the femoral head (ONFH) is a disabling pathology that primarily affects younger adult patients. In cases of extensive necrosis, total hip arthroplasty (THA) is necessary even in younger patients when joint-preserving procedures …

  5. Open Access 01-12-2024 | Osteonecrosis of the Femoral Head | OriginalPaper

    Exosomes derived from M2 macrophages prevent steroid-induced osteonecrosis of the femoral head by modulating inflammation, promoting bone formation and inhibiting bone resorption

    Inflammatory reactions are involved in the development of steroid-induced osteonecrosis of the femoral head(ONFH). Studies have explored the therapeutic efficacy of inhibiting inflammatory reactions in steroid-induced ONFH and revealed that …

  6. 01-05-2024 | Osteonecrosis | Online First

    Prone position magnetic resonance imaging for the mandibular bone: enhancing image quality to perform texture analysis for medication-related osteonecrosis of the jaw and carcinoma of the lower gingiva

  7. Open Access 01-12-2024 | Osteonecrosis of the Femoral Head | OriginalPaper

    m6A methylation modification and immune infiltration analysis in osteonecrosis of the femoral head

    Osteonecrosis of the femoral head (ONFH) is a elaborate hip disease characterized by collapse of femoral head and osteoarthritis. RNA N6-methyladenosine (m6A) plays a crucial role in a lot of biological processes within eukaryotic cells. However …

  8. Open Access 01-12-2024 | Shingles | OriginalPaper

    Infection may play an important role in the pathogenesis of alveolar osteonecrosis following facial herpes zoster: a case report and literature review

    Herpes zoster (HZ) is one of the most common skin diseases caused by viruses, and up to one-third of humans may be affected during their lives [ 1 ]. Facial HZ develops when varicella-zoster virus (VZV) affects the trigeminal nerve [ 2 ]. Herpetic …

  9. 02-01-2024 | Osteonecrosis of the Femoral Head | OriginalPaper

    Is there still an indication for the Birmingham Hip Resurfacing in femoral head osteonecrosis?

    Osteonecrosis of the femoral head (ONFH) is a progressive hip disease that is commonly encountered in orthopaedic clinics [ 1 ]. It is associated with bone marrow cell death and complex bone resorption [ 2 ], and it affects more than 20 million …

  10. Open Access 01-12-2024 | Osteonecrosis of the Femoral Head | OriginalPaper

    The small screw-apex distance is potentially associated with femoral head osteonecrosis in adults with femoral neck fractures treated by closed reduction and percutaneous 3 parallel cannulated screws

    Femoral neck fractures (FNFs) are among the most common fractures in elderly individuals, accounting for approximately 50% of all hip fractures [ 1 ]. These fractures pose a serious threat to the health and quality of life of patients [ 2 – 4 ].

  11. 08-04-2024 | Osteonecrosis of the Femoral Head | Online First

    Corticosteroid-associated osteonecrosis of the femoral head in an 87-year-old patient following treatment for COVID-19-associated pneumonia: A case report

    Coronavirus disease 2019 is known to cause severe acute respiratory syndrome, and serious cases need to be treated with corticosteroids. Herein, we report an 87-year-old woman who developed bilateral osteonecrosis of the femoral head after …

  12. 01-04-2024 | Osteonecrosis | ReviewPaper

    Medication-related osteonecrosis of the jaw: evolving research for multimodality medical management

    Medication-related osteonecrosis of the jaw (MRONJ) is defined as the presence of exposed dental bone for a duration exceeding 8 weeks that can be probed through either an intraoral or extraoral fistula in patients with a history of treatment with …

  13. 02-03-2024 | Osteonecrosis of the Femoral Head | Online First

    Subtracting–adding strategy for necrotic lesion segmentation in osteonecrosis of the femoral head

    Osteonecrosis of the femoral head (ONFH) is a refractory orthopaedic disease that mainly affects middle-aged population [ 1 ]. 80% of affected patients will progressively suffer from a collapse of the femoral head if left untreated [ 2 ]. Various …

  14. 06-03-2024 | Photodynamic Therapy | Online First

    Role of Photodynamic Therapy in Osteonecrosis and Osteoradionecrosis of the Jaws: A Systematic Review

    The term "osteonecrosis" is referred to devitalized bone and aetiology ascribed to various reasons. Osteoradionecrosis (ORN) is a condition where patients present with exposed bone due to a non-healing wound more than 3 to 6 months, with a history …

  15. Open Access 20-02-2024 | Hip-TEP | OriginalPaper

    Evaluation of the long-term patient-reported outcomes after hip arthroplasty or joint preserving with Sugioka femoral osteotomy in patients with femoral head osteonecrosis

    Osteonecrosis of the femoral head (ONFH), a serious disease encountered in younger patients, is a devastating condition with multifactorial aetiology. If left untreated, femoral head collapse often occurs and progresses to secondary osteoarthritis …

  16. Open Access 01-12-2024 | Osteonecrosis of the Femoral Head | OriginalPaper

    Correlation of serum and local CXCL13 levels with disease severity in patients with non-traumatic osteonecrosis of femoral head

    Osteonecrosis of the femoral head (ONFH) represents a challenging condition that can result in incapacitating hip pain and limitations on physical activity, particularly among young adults [ 1 ]. The pathophysiology of non-traumatic ONFH (NT-ONFH) …

  17. Open Access 01-12-2024 | Hip-TEP | OriginalPaper

    Total hip arthroplasty after failed transtrochanteric rotational osteotomy for osteonecrosis of the femoral head: analysis of three-dimensional morphological features

    One of the surgical treatments for osteonecrosis of the femoral head (ONFH), which frequently occurs in adolescence [ 1 , 2 ], is transtrochanteric rotational osteotomy (TRO) [ 3 – 8 ]. In this procedure, the femoral head is rotated anteriorly or …

  18. 25-03-2024 | Osteonecrosis | Online First

    Ozone infiltration as an adjunctive treatment to piezoelectric surgery in the management of medication-related osteonecrosis of the jaws: case series of 29 patients

    Medication-related osteonecrosis of the jaw (MRONJ) is a serious side effect of certain pharmacological agents that are used in the treatment of osteoporosis and oncological purposes [ 1 – 5 ]. According to a recent review from Cochrane database …

  19. Open Access 01-12-2024 | Bisphosphonate | OriginalPaper

    Oral health, dental treatment, and medication related osteonecrosis of the jaw in multiple myeloma – a longitudinal cohort study

    Multiple myeloma (MM) is a malignant haematological disease originating from the lymphatic B cell system in the bone marrow. The global incidence of myeloma is 160,000 cases/year, with a mortality rate of 106,000 people/year. Mean survival in MM …

  20. Open Access 29-02-2024 | Osteonecrosis | Online First

    Surgical and conservative treatment outcomes of medication-related osteonecrosis of the jaw located at tori: a retrospective study

    Medication-related osteonecrosis of the jaw (MRONJ) is a severe side effect of antiresorptive (AR) medication. AR medication includes bisphosphonates and denosumab and is used in low doses for patients with osteoporosis and as an adjuvant or in …

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