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Immunity & Ageing
Published in: Immunity & Ageing 1/2021

Open Access 01-12-2021 | Alzheimer's Disease | Review

A description of the relationship in healthy longevity and aging-related disease: from gene to protein

Authors: Xiaolin Ni, Zhaoping Wang, Danni Gao, Huiping Yuan, Liang Sun, Xiaoquan Zhu, Qi Zhou, Ze Yang

Published in: Immunity & Ageing | Issue 1/2021

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Abstract

Human longevity is a complex phenotype influenced by both genetic and environmental factors. It is also known to be associated with various types of age-related diseases, such as Alzheimer’s disease (AD) and cardiovascular disease (CVD). The central dogma of molecular biology demonstrates the conversion of DNA to RNA to the encoded protein. These proteins interact to form complex cell signaling pathways, which perform various biological functions. With prolonged exposure to the environment, the in vivo homeostasis adapts to the changes, and finally, humans adopt the phenotype of longevity or aging-related diseases. In this review, we focus on two different states: longevity and aging-related diseases, including CVD and AD, to discuss the relationship between genetic characteristics, including gene variation, the level of gene expression, regulation of gene expression, the level of protein expression, both genetic and environmental influences and homeostasis based on these phenotypes shown in organisms.
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Metadata
Title
A description of the relationship in healthy longevity and aging-related disease: from gene to protein
Authors
Xiaolin Ni
Zhaoping Wang
Danni Gao
Huiping Yuan
Liang Sun
Xiaoquan Zhu
Qi Zhou
Ze Yang
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Immunity & Ageing / Issue 1/2021
Electronic ISSN: 1742-4933
DOI
https://doi.org/10.1186/s12979-021-00241-0

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