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Tackling the psychological burden of diabetes

Explore the interplay between diabetes and mental health conditions, the consequences and implications for clinical practice, and the role of endocrinologists in recognizing and managing psychological difficulties.

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Editor's Choice

Type 1 diabetes, aging, and frailty: an underexplored intersection

The life expectancy of people with type 1 diabetes has improved, but type 1 diabetes may accelerate aging and contribute to the development of frailty. Explore the underlying mechanisms, frailty assessment, and prevention strategies.

Orforglipron may offer superior efficacy over oral semaglutide

The novel oral GLP-1 receptor agonist orforglipron shows noninferior and potentially superior glycemic control versus oral semaglutide in type 2 diabetes, but with more gastrointestinal adverse events.

Cardiorenal and metabolic dimensions of cardiomyopathies

Metabolic and renal dysfunctions can influence the disease trajectory, treatment response, and prognosis of cardiomyopathies. A holistic and multidisciplinary approach is key to identifying the appropriate therapies.

SGLT2 inhibitors improve outcomes over DPP4 inhibitors in type 2 diabetes with liver cirrhosis

SGLT2 inhibitors are linked to lower kidney, cardiovascular, and hepatic risks than DPP-4 inhibitors in patients with type 2 diabetes and liver cirrhosis.

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Keynote webinar | Spotlight on the insulin toolkit for type 2 diabetes

Insulin remains key to the management of type 2 diabetes, but its role continues to evolve with the arrival of once-weekly regimens presenting new opportunities and challenges. How can once-weekly insulin therapy be implemented to optimize patient care?

Dr. Alice Cheng
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Raising the standard: ensuring patient safety through minimum requirements for CGM performance

Prof. Chantal Mathieu highlights how the absence of rigorous performance standards for continuous glucose monitors in Europe contributes to wide variability in device accuracy, raising important concerns about patient safety.

Supported by:
  • Abbott Diabetes Care
Prof. Chantal Mathieu
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Video

Case Studies

Insulin edema in slowly progressive type 1 diabetes

A unusual case of bilateral lower-leg edema that developed in an older woman with SPIDDM shortly after she started basal–bolus insulin therapy with insulin aspart and insulin degludec. 

Post-bariatric hypoglycemia in a patient with heart failure

A man who achieved diabetes remission after gastric bypass presented with hypoglycemic episodes and endogenous hyperinsulinemia. Hypoglycemia resolved and fasting tests normalized when sacubitril/valsartan was discontinued due to worsening renal function.

Misdiagnosis of diabetic ketoacidosis

A woman with abdominal pain was diagnosed with ureteral stones, but her pain persisted despite stent placement. A prior diagnosis of type 2 diabetes led to diabetic ketoacidosis being identified as the cause of the pain. 

Episode 19: GLP-1 medicines - past, present, and future

From diabetes to obesity and beyond

In 2005 the US FDA approved the first GLP-1 medicine for type 2 diabetes, marking the start of a remarkable journey that goes beyond the stimulation of insulin secretion.

Prof. Daniel Drucker gives us a fascinating insight into the early work on GLP-1 and discusses how these medicines are impacting the lives of people with diabetes and obesity. He covers what's known about how they work, treatment duration, side effects, and the role of bariatric surgery, plus what's in the pipeline in terms of drug development and the indications that GLP-1 medicines may be used to treat in the future.

Prof. Daniel Drucker
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Podcast

Current Reviews

Impact of adjunctive melatonin in periodontal therapy on glycated hemoglobin levels in patients with type 2 diabetes and periodontal disease: a systematic review and meta-analysis

Background Melatonin has demonstrated anti-inflammatory, antioxidant, and immunomodulatory properties, making it a potential adjunct in periodontal therapy. However, its systemic metabolic effects, particularly on glycemic control in patients with …

RSSDI guidelines for management of type 2 diabetes mellitus in older adults

The Research Society for the Study of Diabetes in India (RSSDI) Guidelines for the Management of Diabetes in Older Adults provide evidence-based, India-specific recommendations addressing the growing challenge of type 2 diabetes mellitus (T2DM) in …

MicroRNAs in type 2 diabetes mellitus and its cardiovascular complications: mechanistic insights and translational potential

Diabetes mellitus (DM) is a multifactorial disease driven by genetic and environmental factors, with type 2 diabetes mellitus (T2DM) constituting the majority of cases. A major cause of morbidity and mortality in diabetic patients is …

Atypical diabetes subtypes in Black African populations

Atypical diabetes subtypes and presentations are disproportionately prevalent in populations of African and Asian ancestry. This review discusses the epidemiology, clinical presentation, aetiopathogenesis and management of four atypical diabetes …

Keynote series | Spotlight on managing health in obesity

Obesity is a major contributor to cardiorenal metabolic disease, but its impact extends throughout the body. Understand how obesity can affect other organ systems and impact treatment, and whether weight-loss measures improve outcomes.

Prof. Eva L. Feldman
Prof. Jonette Keri
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Video

CME & eLearning

Real-world application of CGM technology (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Refine the application of CGM technology in primary care to enhance the management of type 2 diabetes. Benefit from key updates and experiential learning using CGM devices, and practice your clinical decision-making skills with real cases, vodcasts, and interactive infographics.

Independent Medical Education Grant:
  • Abbott

Paediatric endocrinology (Link opens in a new window)

Treating children with hormone disorders is complex and requires tailored management. To help you provide the most effective care, we deliver news, cases and expert reviews covering adrenal, thyroid, pituitary, growth, and puberty disorders, obesity, and diabetes.

Independent Medical Education Grant:
  • Merck Healthcare KGaA, Darmstadt, Germany

Further Reading

Systematic analysis of loss-of-function variants across MODY genes demonstrates gene-specific effects and expands the spectrum of INS variants causing MODY

Accurate interpretation of genetic variants in MODY genes is critical for diagnosis but remains a challenge in clinical practice. Variant classification remains challenging due to uncertainty regarding functional impact, the complexity of disease …

Different clinical autoimmune polyglandular syndrome phenotypes among patients with thyroid diseases

Autoimmune thyroid diseases (AITDs), primarily Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), represent the most prevalent organ-specific autoimmune disorders (ADs) in Western countries [ 1 – 3 ]. The prevalence of HT-related hypothyroidism …

Blood pressure and blood lipids reduction, but not glycemic changes, predict cognitive improvements after exercise training in people with type 2 diabetes: an exploratory analysis in a clinical trial

Type 2 Diabetes Mellitus (T2DM) accelerates cognitive decline rates [ 1 ], diminishes several cognitive domains [ 2 ], and increases dementia incidence [ 1 ], with declines in brain health affecting the patient's quality of life, disease …

Efficacy and Safety of Once-Weekly IcoSema Versus Once-Daily IDegLira in People with Type 2 Diabetes: Systematic Literature Review and Network Meta-analysis

  • Open Access
  • Insulins
  • Original Research

Many people with type 2 diabetes (T2D) on insulin therapy require treatment intensification or early combination approaches, as recognised by current treatment guidelines, including the 2022 American Diabetes Association (ADA)/European Association …

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Image Credits
Mental health conditions concept illustration/© Dragon Claws / Stock.adobe.com, Older man in wheelchair with an insulin pump/© Halfpoint / Stock.adobe.com (symbolic image with model), Man taking a pill/© golfcphoto / iStock / Getty Images Plus (symbolic image with model), Wooden heart and kidneys/© (M) Hiroshi Watanabe / Photodisc / Getty, Close-up of yellow pills/© Ladanifer / iStock / Getty Images Plus, Insulin injection needles / pens /© digicomphoto / iStock / Getty Images Plus, Woman prepares self-injection pen/© Jon Challicom / Getty Images (symbolic image with model), Paper kidneys with pills on pink background/© Pixel-Shot / stock.adobe.com, One red and several untreated wooden figures in front of a doctor holding a stethoscope/© Nadzeya Haroshka / iStock / Getty Images Plus, Woman monitoring glucose level with sensor and an app on her phone while training at swimming pool/© (M) Goffkein, stock.adobe.com (symbolic image with model), Woman with leg edema/© Toa55 / iStock / Getty Images Plus (symbolic image with model), Man taking a pill/© sebra / stock.adobe.com (symbolic image with model), Woman with abdominal pain/© Srisakorn / iStock / Getty Images Plus (symbolic image with model), Medicine Matters Podcast promo image/© Springer Medizin GmbH, Spotlight on obesity series 4x3 image/© smartboy10 / Getty Images / iStock, Real-world application of CGM technology to improve diabetes management in primary care/© Springer Healthcare IME, medwireNewsFocus: Pediatric endocrinology teaser, Doctor and pregnant woman at hospital/© Syda Productions / stock.adobe.com (symbolic image with models), Woman holding her baby/© Amorn Suriyan / iStock / Getty Images Plus (symbolic image with models), Pregnant woman at a medical appointment/© Phushutter / stock.adobe.com (symbolic image with models), Pregnant woman testing her blood glucose levels/© A&J Fotos / Getty Images / iStock (symbolic image with model), Woman in bed with her eyes shut/© alfa27 / stock.adobe.com (symbolic image with model), Man receiving vaccination/© anon / stock.adobe.com (symbolic image with models), Digital health concept image/© DSN_1 / stock.adobe.com, Woman at medical appointment/© Lacheev / iStock / Getty Images Plus (symbolic image with models), Foods to support a healthy digestive system/© fcafotodigital / e+ / Getty Images, 3D render of stairs leading to flying paper plane/© bpawesome / iStock / Getty Images Plus