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Published in: Current Cardiology Reports 2/2023

06-02-2023 | Gestational Diabetes | Women and Cardiovascular Health (N Goldberg and S Lewis, Section Editors)

Markers of Cardiovascular Risk Associated with Pregnancy

Authors: Odayme Quesada, Dawn C. Scantlebury, Joan E. Briller, Erin D. Michos, Niti R. Aggarwal

Published in: Current Cardiology Reports | Issue 2/2023

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Abstract

Purpose of Review

The purpose of the review is to summarize the unique cardiovascular disease (CVD) risk factors encountered during pregnancy and to provide the reader with a framework for acquiring a comprehensive obstetric history during the cardiovascular (CV) assessment of women.

Recent Findings

Individuals with a history of pregnancies complicated by hypertensive disorders of pregnancy (HDP), gestational diabetes (GDM), preterm delivery, low birth weight, and fetal growth restriction during pregnancy are at a higher risk of developing short- and long-term CV complications compared to those without adverse pregnancy outcomes (APOs). Women with a history of APOs can be at increased risk of CVD even after achieving normoglycemia and normal blood pressure control postpartum. Risk assessment and stratification in women must account for these APOs as recommended by the 2019 American College of Cardiology (ACC)/American Heart Association (AHA) guideline on the primary prevention of CVD. Early recognition, monitoring, and treatment of APOs are key to limiting CVD complications late in maternal life.

Summary

Recognition of APOs as female-specific cardiovascular risk factors is critical for risk stratification for women and birthing persons. Further research is needed to understand the complex interplay between genetics, environmental, behavioral, and maternal vascular health, and the association between APOs and CVD risk.
Literature
1.
go back to reference Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, Boehme AK, Buxton AE, Carson AP, Commodore-Mensah Y, Elkind MSV, Evenson KR, Eze-Nliam C, Ferguson JF, Generoso G, Ho JE, Kalani R, Khan SS, Kissela BM, Knutson KL, Levine DA, Lewis TT, Liu J, Loop MS, Ma J, Mussolino ME, Navaneethan SD, Perak AM, Poudel R, Rezk-Hanna M, Roth GA, Schroeder EB, Shah SH, Thacker EL, VanWagner LB, Virani SS, Voecks JH, Wang NY, Yaffe K, Martin SS. Heart disease and stroke statistics-2022 update: a report from the American Heart Association. Circulation. 2022;145:e153–639.CrossRefPubMed Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, Boehme AK, Buxton AE, Carson AP, Commodore-Mensah Y, Elkind MSV, Evenson KR, Eze-Nliam C, Ferguson JF, Generoso G, Ho JE, Kalani R, Khan SS, Kissela BM, Knutson KL, Levine DA, Lewis TT, Liu J, Loop MS, Ma J, Mussolino ME, Navaneethan SD, Perak AM, Poudel R, Rezk-Hanna M, Roth GA, Schroeder EB, Shah SH, Thacker EL, VanWagner LB, Virani SS, Voecks JH, Wang NY, Yaffe K, Martin SS. Heart disease and stroke statistics-2022 update: a report from the American Heart Association. Circulation. 2022;145:e153–639.CrossRefPubMed
2.
go back to reference Cushman M, Shay CM, Howard VJ, Jimenez MC, Lewey J, McSweeney JC, Newby LK, Poudel R, Reynolds HR, Rexrode KM, Sims M, Mosca LJ, American HA. Ten-year differences in women’s awareness related to coronary heart disease: results of the 2019 American Heart Association National Survey: a special report from the American Heart Association. Circulation. 2021;143:e239–48.CrossRefPubMed Cushman M, Shay CM, Howard VJ, Jimenez MC, Lewey J, McSweeney JC, Newby LK, Poudel R, Reynolds HR, Rexrode KM, Sims M, Mosca LJ, American HA. Ten-year differences in women’s awareness related to coronary heart disease: results of the 2019 American Heart Association National Survey: a special report from the American Heart Association. Circulation. 2021;143:e239–48.CrossRefPubMed
3.
go back to reference Cooney MT, Dudina AL, Graham IM. Value and limitations of existing scores for the assessment of cardiovascular risk: a review for clinicians. J Am Coll Cardiol. 2009;54:1209–27.CrossRefPubMed Cooney MT, Dudina AL, Graham IM. Value and limitations of existing scores for the assessment of cardiovascular risk: a review for clinicians. J Am Coll Cardiol. 2009;54:1209–27.CrossRefPubMed
4.
go back to reference Khot UN, Khot MB, Bajzer CT, Sapp SK, Ohman EM, Brener SJ, Ellis SG, Lincoff AM, Topol EJ. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA. 2003;290:898–904.CrossRefPubMed Khot UN, Khot MB, Bajzer CT, Sapp SK, Ohman EM, Brener SJ, Ellis SG, Lincoff AM, Topol EJ. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA. 2003;290:898–904.CrossRefPubMed
5.
go back to reference Peters SA, Huxley RR, Woodward M. Diabetes as risk factor for incident coronary heart disease in women compared with men: a systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events. Diabetologia. 2014;57:1542–51.CrossRefPubMed Peters SA, Huxley RR, Woodward M. Diabetes as risk factor for incident coronary heart disease in women compared with men: a systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events. Diabetologia. 2014;57:1542–51.CrossRefPubMed
6.
go back to reference Blumenthal RS, Buroker AB, Sq E. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease. 2019. Blumenthal RS, Buroker AB, Sq E. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease. 2019.
8.
go back to reference Sondergaard MM, Hlatky MA, Stefanick ML, Vittinghoff E, Nah G, Allison M, Gemmill A, Van Horn L, Park K, Salmoirago-Blotcher E, Sattari M, Sealy-Jefferson S, Shadyab AH, Valdiviezo C, Manson JE, Parikh NI. Association of adverse pregnancy outcomes with risk of atherosclerotic cardiovascular disease in postmenopausal women. JAMA Cardiol. 2020;5:1390–8.CrossRefPubMedPubMedCentral Sondergaard MM, Hlatky MA, Stefanick ML, Vittinghoff E, Nah G, Allison M, Gemmill A, Van Horn L, Park K, Salmoirago-Blotcher E, Sattari M, Sealy-Jefferson S, Shadyab AH, Valdiviezo C, Manson JE, Parikh NI. Association of adverse pregnancy outcomes with risk of atherosclerotic cardiovascular disease in postmenopausal women. JAMA Cardiol. 2020;5:1390–8.CrossRefPubMedPubMedCentral
9.
go back to reference Wang YX, Minguez-Alarcon L, Gaskins AJ, Wang L, Ding M, Missmer SA, Rich-Edwards JW, Manson JE, Chavarro JE. Pregnancy loss and risk of cardiovascular disease: the Nurses’ Health Study II. Eur Heart J. 2022;43:190–9.CrossRefPubMed Wang YX, Minguez-Alarcon L, Gaskins AJ, Wang L, Ding M, Missmer SA, Rich-Edwards JW, Manson JE, Chavarro JE. Pregnancy loss and risk of cardiovascular disease: the Nurses’ Health Study II. Eur Heart J. 2022;43:190–9.CrossRefPubMed
10.
go back to reference ACOG Practice Bulletin No. 212 summary: pregnancy and heart disease. Obstet Gynecol. 2019;133:1067–72.CrossRef ACOG Practice Bulletin No. 212 summary: pregnancy and heart disease. Obstet Gynecol. 2019;133:1067–72.CrossRef
11.
go back to reference Say L, Chou D, Gemmill A, Tuncalp O, Moller AB, Daniels J, Gulmezoglu AM, Temmerman M, Alkema L. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014;2:e323–33.CrossRefPubMed Say L, Chou D, Gemmill A, Tuncalp O, Moller AB, Daniels J, Gulmezoglu AM, Temmerman M, Alkema L. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014;2:e323–33.CrossRefPubMed
12.
go back to reference O’Kelly AC, Michos ED, Shufelt CL, Vermunt JV, Minissian MB, Quesada O, Smith GN, Rich-Edwards JW, Garovic VD, El Khoudary SR, Honigberg MC. Pregnancy and reproductive risk factors for cardiovascular disease in women. Circ Res. 2022;130:652–72.CrossRefPubMed O’Kelly AC, Michos ED, Shufelt CL, Vermunt JV, Minissian MB, Quesada O, Smith GN, Rich-Edwards JW, Garovic VD, El Khoudary SR, Honigberg MC. Pregnancy and reproductive risk factors for cardiovascular disease in women. Circ Res. 2022;130:652–72.CrossRefPubMed
13.
go back to reference Wu R, Wang T, Gu R, Xing D, Ye C, Chen Y, Liu X, Chen L. Hypertensive disorders of pregnancy and risk of cardiovascular disease-related morbidity and mortality: a systematic review and meta-analysis. Cardiology. 2020;145:633–47.CrossRefPubMed Wu R, Wang T, Gu R, Xing D, Ye C, Chen Y, Liu X, Chen L. Hypertensive disorders of pregnancy and risk of cardiovascular disease-related morbidity and mortality: a systematic review and meta-analysis. Cardiology. 2020;145:633–47.CrossRefPubMed
14.
go back to reference Honigberg MC, Zekavat SM, Aragam K, Klarin D, Bhatt DL, Scott NS, Peloso GM, Natarajan P. Long-term cardiovascular risk in women with hypertension during pregnancy. J Am Coll Cardiol. 2019;74:2743–54.CrossRefPubMedPubMedCentral Honigberg MC, Zekavat SM, Aragam K, Klarin D, Bhatt DL, Scott NS, Peloso GM, Natarajan P. Long-term cardiovascular risk in women with hypertension during pregnancy. J Am Coll Cardiol. 2019;74:2743–54.CrossRefPubMedPubMedCentral
15.
go back to reference Grandi SM, Filion KB, Yoon S, Ayele HT, Doyle CM, Hutcheon JA, Smith GN, Gore GC, Ray JG, Nerenberg K, Platt RW. Cardiovascular disease-related morbidity and mortality in women with a history of pregnancy complications. Circulation. 2019;139:1069–79.CrossRefPubMed Grandi SM, Filion KB, Yoon S, Ayele HT, Doyle CM, Hutcheon JA, Smith GN, Gore GC, Ray JG, Nerenberg K, Platt RW. Cardiovascular disease-related morbidity and mortality in women with a history of pregnancy complications. Circulation. 2019;139:1069–79.CrossRefPubMed
16.
go back to reference Brouwers L, van der Meiden-van Roest AJ, Savelkoul C, Vogelvang TE, Lely AT, Franx A, van Rijn BB. Recurrence of pre-eclampsia and the risk of future hypertension and cardiovascular disease: a systematic review and meta-analysis. BJOG. 2018;125:1642–54.CrossRefPubMedPubMedCentral Brouwers L, van der Meiden-van Roest AJ, Savelkoul C, Vogelvang TE, Lely AT, Franx A, van Rijn BB. Recurrence of pre-eclampsia and the risk of future hypertension and cardiovascular disease: a systematic review and meta-analysis. BJOG. 2018;125:1642–54.CrossRefPubMedPubMedCentral
17.
go back to reference •• Stuart JJ, Tanz LJ, Rimm EB, Spiegelman D, Missmer SA, Mukamal KJ, Rexrode KM, Rich-Edwards JW. Cardiovascular risk factors mediate the long-term maternal risk associated with hypertensive disorders of pregnancy. J Am Coll Cardiol. 2022;79:1901–13. Findings from this study demonstrate that established CVD risk factors arising after pregnancy explained 84% of the increased risk of CVD among women with gestational hypertension and 57% of the risk among women with preeclampsia. •• Stuart JJ, Tanz LJ, Rimm EB, Spiegelman D, Missmer SA, Mukamal KJ, Rexrode KM, Rich-Edwards JW. Cardiovascular risk factors mediate the long-term maternal risk associated with hypertensive disorders of pregnancy. J Am Coll Cardiol. 2022;79:1901–13. Findings from this study demonstrate that established CVD risk factors arising after pregnancy explained 84% of the increased risk of CVD among women with gestational hypertension and 57% of the risk among women with preeclampsia.
18.
go back to reference Yang JJ, Lee SA, Choi JY, Song M, Han S, Yoon HS, Lee Y, Oh J, Lee JK, Kang D. Subsequent risk of metabolic syndrome in women with a history of preeclampsia: data from the Health Examinees Study. J Epidemiol. 2015;25:281–8.CrossRefPubMedPubMedCentral Yang JJ, Lee SA, Choi JY, Song M, Han S, Yoon HS, Lee Y, Oh J, Lee JK, Kang D. Subsequent risk of metabolic syndrome in women with a history of preeclampsia: data from the Health Examinees Study. J Epidemiol. 2015;25:281–8.CrossRefPubMedPubMedCentral
19.
go back to reference Schliep K, Zhang Y, Tschanz J, Majersik J, Facelli J, Varner M. Hypertensive disorders of pregnancy and risk of Alzheimer’s disease, vascular dementia, and other related dementia. Innov Aging. 2021;5:650–650.CrossRefPubMedCentral Schliep K, Zhang Y, Tschanz J, Majersik J, Facelli J, Varner M. Hypertensive disorders of pregnancy and risk of Alzheimer’s disease, vascular dementia, and other related dementia. Innov Aging. 2021;5:650–650.CrossRefPubMedCentral
20.
go back to reference Benschop L, Brouwers L, Zoet GA, Meun C, Boersma E, Budde RPJ, Fauser B, de Groot CMJ, van der Schouw YT, Maas A, Velthuis BK, Linstra KM, Kavousi M, Duvekot JJ, Franx A, Steegers E, van Rijn BB, Roeters van Lennep JE and Consortium C. Early onset of coronary artery calcification in women with previous preeclampsia. Circ Cardiovasc Imaging. 2020;13:e010340. Benschop L, Brouwers L, Zoet GA, Meun C, Boersma E, Budde RPJ, Fauser B, de Groot CMJ, van der Schouw YT, Maas A, Velthuis BK, Linstra KM, Kavousi M, Duvekot JJ, Franx A, Steegers E, van Rijn BB, Roeters van Lennep JE and Consortium C. Early onset of coronary artery calcification in women with previous preeclampsia. Circ Cardiovasc Imaging. 2020;13:e010340.
21.
go back to reference McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nat Rev Dis Primers. 2019;5:47.CrossRefPubMed McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nat Rev Dis Primers. 2019;5:47.CrossRefPubMed
22.
go back to reference Casagrande SS, Linder B and Cowie CC. Prevalence of gestational diabetes and subsequent type 2 diabetes among U.S. women. Diabetes Res Clin Pract. 2018;141:200–208. Casagrande SS, Linder B and Cowie CC. Prevalence of gestational diabetes and subsequent type 2 diabetes among U.S. women. Diabetes Res Clin Pract. 2018;141:200–208.
23.
go back to reference Shah NS, Wang MC, Freaney PM, Perak AM, Carnethon MR, Kandula NR, Gunderson EP, Bullard KM, Grobman WA, O’Brien MJ, Khan SS. Trends in gestational diabetes at first live birth by race and ethnicity in the US, 2011–2019. JAMA. 2021;326:660–9.CrossRefPubMedPubMedCentral Shah NS, Wang MC, Freaney PM, Perak AM, Carnethon MR, Kandula NR, Gunderson EP, Bullard KM, Grobman WA, O’Brien MJ, Khan SS. Trends in gestational diabetes at first live birth by race and ethnicity in the US, 2011–2019. JAMA. 2021;326:660–9.CrossRefPubMedPubMedCentral
24.
go back to reference • Venkatesh KK, Lynch CD, Powe CE, Costantine MM, Thung SF, Gabbe SG, Grobman WA, Landon MB. Risk of adverse pregnancy outcomes among pregnant individuals with gestational diabetes by race and ethnicity in the United States, 2014–2020. JAMA. 2022;327:1356–67. This study demonstrated the frequency of adverse pregnancy outcomes in the US increased among pregnant individuals with gestational diabetes from 2014 to 2020 and differences by race/ethnicity persisted with highest risk of adverse pregnancy outcomes among Black mothers. • Venkatesh KK, Lynch CD, Powe CE, Costantine MM, Thung SF, Gabbe SG, Grobman WA, Landon MB. Risk of adverse pregnancy outcomes among pregnant individuals with gestational diabetes by race and ethnicity in the United States, 2014–2020. JAMA. 2022;327:1356–67. This study demonstrated the frequency of adverse pregnancy outcomes in the US increased among pregnant individuals with gestational diabetes from 2014 to 2020 and differences by race/ethnicity persisted with highest risk of adverse pregnancy outcomes among Black mothers.
25.
go back to reference Choudhury AA, Devi RV. Gestational diabetes mellitus - a metabolic and reproductive disorder. Biomed Pharmacother. 2021;143: 112183.CrossRefPubMed Choudhury AA, Devi RV. Gestational diabetes mellitus - a metabolic and reproductive disorder. Biomed Pharmacother. 2021;143: 112183.CrossRefPubMed
26.
go back to reference Vounzoulaki E, Khunti K, Abner SC, Tan BK, Davies MJ, Gillies CL. Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis. BMJ. 2020;369: m1361.CrossRefPubMedPubMedCentral Vounzoulaki E, Khunti K, Abner SC, Tan BK, Davies MJ, Gillies CL. Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis. BMJ. 2020;369: m1361.CrossRefPubMedPubMedCentral
27.
go back to reference Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 2009;373:1773–9.CrossRefPubMed Bellamy L, Casas JP, Hingorani AD, Williams D. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet. 2009;373:1773–9.CrossRefPubMed
28.
go back to reference ACOG Practice Bulletin No. 190: gestational diabetes mellitus. Obstet Gynecol. 2018;131:e49–64.CrossRef ACOG Practice Bulletin No. 190: gestational diabetes mellitus. Obstet Gynecol. 2018;131:e49–64.CrossRef
29.
go back to reference Kramer CK, Campbell S, Retnakaran R. Gestational diabetes and the risk of cardiovascular disease in women: a systematic review and meta-analysis. Diabetologia. 2019;62:905–14.CrossRefPubMed Kramer CK, Campbell S, Retnakaran R. Gestational diabetes and the risk of cardiovascular disease in women: a systematic review and meta-analysis. Diabetologia. 2019;62:905–14.CrossRefPubMed
30.
go back to reference Tobias DK, Stuart JJ, Li S, Chavarro J, Rimm EB, Rich-Edwards J, Hu FB, Manson JE, Zhang C. Association of history of gestational diabetes with long-term cardiovascular disease risk in a large prospective cohort of US women. JAMA Intern Med. 2017;177:1735–42.CrossRefPubMedPubMedCentral Tobias DK, Stuart JJ, Li S, Chavarro J, Rimm EB, Rich-Edwards J, Hu FB, Manson JE, Zhang C. Association of history of gestational diabetes with long-term cardiovascular disease risk in a large prospective cohort of US women. JAMA Intern Med. 2017;177:1735–42.CrossRefPubMedPubMedCentral
31.
go back to reference Aggarwal NR, Patel HN, Mehta LS, Sanghani RM, Lundberg GP, Lewis SJ, Mendelson MA, Wood MJ, Volgman AS, Mieres JH. Sex differences in ischemic heart disease: advances, obstacles, and next steps. Circ Cardiovasc Qual Outcomes. 2018;11: e004437.CrossRefPubMed Aggarwal NR, Patel HN, Mehta LS, Sanghani RM, Lundberg GP, Lewis SJ, Mendelson MA, Wood MJ, Volgman AS, Mieres JH. Sex differences in ischemic heart disease: advances, obstacles, and next steps. Circ Cardiovasc Qual Outcomes. 2018;11: e004437.CrossRefPubMed
32.
go back to reference •• Gunderson EP, Sun B, Catov JM, Carnethon M, Lewis CE, Allen NB, Sidney S, Wellons M, Rana JS, Hou L, Carr JJ. Gestational diabetes history and glucose tolerance after pregnancy associated with coronary artery calcium in women during midlife: the CARDIA study. Circulation. 2021;143:974–87. Findings from this study showed that history of gestation diabetes was associated with a 2-fold higher risk of midlife atherosclerotic CVD risk and that the risk was not diminished by attaining normoglycemia. Also, that there is a graded increase in risk of CAC in women associated with glucose tolerance in women without previous gestational diabetes. •• Gunderson EP, Sun B, Catov JM, Carnethon M, Lewis CE, Allen NB, Sidney S, Wellons M, Rana JS, Hou L, Carr JJ. Gestational diabetes history and glucose tolerance after pregnancy associated with coronary artery calcium in women during midlife: the CARDIA study. Circulation. 2021;143:974–87. Findings from this study showed that history of gestation diabetes was associated with a 2-fold higher risk of midlife atherosclerotic CVD risk and that the risk was not diminished by attaining normoglycemia. Also, that there is a graded increase in risk of CAC in women associated with glucose tolerance in women without previous gestational diabetes.
33.
go back to reference Minhas A, Countouris ME, Ndumele CE, Selvin E, Vaught AJ, Gandley R, Hays A, Ouyang P, Bennett WL, Catov JM, Michos ED. Abstract 12986: association of gestational diabetes with subclinical cardiovascular disease on echocardiogram and endothelial function testing. Circulation. 2021;144:A12986–A12986.CrossRef Minhas A, Countouris ME, Ndumele CE, Selvin E, Vaught AJ, Gandley R, Hays A, Ouyang P, Bennett WL, Catov JM, Michos ED. Abstract 12986: association of gestational diabetes with subclinical cardiovascular disease on echocardiogram and endothelial function testing. Circulation. 2021;144:A12986–A12986.CrossRef
34.
go back to reference Echouffo-Tcheugui JB, Guan J, Retnakaran R and Shah BR. Gestational diabetes and incident heart failure: a cohort study. Diabetes Care. 2021. Echouffo-Tcheugui JB, Guan J, Retnakaran R and Shah BR. Gestational diabetes and incident heart failure: a cohort study. Diabetes Care. 2021.
35.
go back to reference Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, Jha P, Campbell H, Walker CF, Cibulskis R, Eisele T, Liu L, Mathers C, Child Health Epidemiology Reference Group of WHO and Unicef. Global, regional, and national causes of child mortality in. a systematic analysis. Lancet. 2008;2010(375):1969–87. Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, Jha P, Campbell H, Walker CF, Cibulskis R, Eisele T, Liu L, Mathers C, Child Health Epidemiology Reference Group of WHO and Unicef. Global, regional, and national causes of child mortality in. a systematic analysis. Lancet. 2008;2010(375):1969–87.
36.
37.
go back to reference Rubens CE, Sadovsky Y, Muglia L, Gravett MG, Lackritz E and Gravett C. Prevention of preterm birth: harnessing science to address the global epidemic. Sci Transl Med. 2014;6:262sr5. Rubens CE, Sadovsky Y, Muglia L, Gravett MG, Lackritz E and Gravett C. Prevention of preterm birth: harnessing science to address the global epidemic. Sci Transl Med. 2014;6:262sr5.
38.
go back to reference Rich-Edwards JW, Klungsoyr K, Wilcox AJ, Skjaerven R. Duration of pregnancy, even at term, predicts long-term risk of coronary heart disease and stroke mortality in women: a population-based study. Am J Obstet Gynecol. 2015;213(518):e1-8. Rich-Edwards JW, Klungsoyr K, Wilcox AJ, Skjaerven R. Duration of pregnancy, even at term, predicts long-term risk of coronary heart disease and stroke mortality in women: a population-based study. Am J Obstet Gynecol. 2015;213(518):e1-8.
39.
go back to reference Tanz LJ, Stuart JJ, Williams PL, Missmer SA, Rimm EB, James-Todd TM, Rich-Edwards JW. Preterm delivery and maternal cardiovascular disease risk factors: the Nurses’ Health Study II. J Womens Health (Larchmt). 2019;28:677–85.CrossRefPubMed Tanz LJ, Stuart JJ, Williams PL, Missmer SA, Rimm EB, James-Todd TM, Rich-Edwards JW. Preterm delivery and maternal cardiovascular disease risk factors: the Nurses’ Health Study II. J Womens Health (Larchmt). 2019;28:677–85.CrossRefPubMed
40.
go back to reference Crump C, Sundquist J, Sundquist K. Preterm delivery and long-term risk of hypertension in women. JAMA Cardiol. 2022;7:65–74.CrossRefPubMed Crump C, Sundquist J, Sundquist K. Preterm delivery and long-term risk of hypertension in women. JAMA Cardiol. 2022;7:65–74.CrossRefPubMed
41.
go back to reference • Crump C, Sundquist J, Howell EA, McLaughlin MA, Stroustrup A, Sundquist K. Pre-term delivery and risk of ischemic heart disease in women. J Am Coll Cardiol. 2020;76:57–67. In this large cohort, preterm delivery was a strong independent risk factor for ischemic heart disease and persisted up to 40years after delivery. • Crump C, Sundquist J, Howell EA, McLaughlin MA, Stroustrup A, Sundquist K. Pre-term delivery and risk of ischemic heart disease in women. J Am Coll Cardiol. 2020;76:57–67. In this large cohort, preterm delivery was a strong independent risk factor for ischemic heart disease and persisted up to 40years after delivery.
42.
43.
go back to reference Crump C, Sundquist J, Sundquist K. Preterm delivery and long-term risk of stroke in women: a national cohort and cosibling study. Circulation. 2021;143:2032–44.CrossRefPubMedPubMedCentral Crump C, Sundquist J, Sundquist K. Preterm delivery and long-term risk of stroke in women: a national cohort and cosibling study. Circulation. 2021;143:2032–44.CrossRefPubMedPubMedCentral
44.
go back to reference Wu P, Gulati M, Kwok CS, Wong CW, Narain A, O’Brien S, Chew-Graham CA, Verma G, Kadam UT and Mamas MA. Preterm delivery and future risk of maternal cardiovascular disease: a systematic review and meta-analysis. J Am Heart Assoc. 2018;7. Wu P, Gulati M, Kwok CS, Wong CW, Narain A, O’Brien S, Chew-Graham CA, Verma G, Kadam UT and Mamas MA. Preterm delivery and future risk of maternal cardiovascular disease: a systematic review and meta-analysis. J Am Heart Assoc. 2018;7.
45.
go back to reference Davey Smith G, Hypponen E, Power C, Lawlor DA. Offspring birth weight and parental mortality: prospective observational study and meta-analysis. Am J Epidemiol. 2007;166:160–9.CrossRefPubMed Davey Smith G, Hypponen E, Power C, Lawlor DA. Offspring birth weight and parental mortality: prospective observational study and meta-analysis. Am J Epidemiol. 2007;166:160–9.CrossRefPubMed
46.
go back to reference Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikainen LP, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Hottenga JJ, Vilor-Tejedor N, Joshi PK, Boh ETH, Ntalla I, Pitkanen N, Mahajan A, van Leeuwen EM, Joro R, Lagou V, Nodzenski M, Diver LA, Zondervan KT, Bustamante M, Marques-Vidal P, Mercader JM, Bennett AJ, Rahmioglu N, Nyholt DR, Ma RCW, Tam CHT, Tam WH, Group CCHW, Ganesh SK, van Rooij FJ, Jones SE, Loh PR, Ruth KS, Tuke MA, Tyrrell J, Wood AR, Yaghootkar H, Scholtens DM, Paternoster L, Prokopenko I, Kovacs P, Atalay M, Willems SM, Panoutsopoulou K, Wang X, Carstensen L, Geller F, Schraut KE, Murcia M, van Beijsterveldt CE, Willemsen G, Appel EVR, Fonvig CE, Trier C, Tiesler CM, Standl M, Kutalik Z, Bonas-Guarch S, Hougaard DM, Sanchez F, Torrents D, Waage J, Hollegaard MV, de Haan HG, Rosendaal FR, Medina-Gomez C, Ring SM, Hemani G, McMahon G, Robertson NR, Groves CJ, Langenberg C, Luan J, Scott RA, Zhao JH, Mentch FD, MacKenzie SM, Reynolds RM, Early Growth Genetics C, Lowe WL, Jr., Tonjes A, Stumvoll M, Lindi V, Lakka TA, van Duijn CM, Kiess W, Korner A, Sorensen TI, Niinikoski H, Pahkala K, Raitakari OT, Zeggini E, Dedoussis GV, Teo YY, Saw SM, Melbye M, Campbell H, Wilson JF, Vrijheid M, de Geus EJ, Boomsma DI, Kadarmideen HN, Holm JC, Hansen T, Sebert S, Hattersley AT, Beilin LJ, Newnham JP, Pennell CE, Heinrich J, Adair LS, Borja JB, Mohlke KL, Eriksson JG, Widen EE, Kahonen M, Viikari JS, Lehtimaki T, Vollenweider P, Bonnelykke K, Bisgaard H, Mook-Kanamori DO, Hofman A, Rivadeneira F, Uitterlinden AG, Pisinger C, Pedersen O, Power C, Hypponen E, Wareham NJ, Hakonarson H, Davies E, Walker BR, Jaddoe VW, Jarvelin MR, Grant SF, Vaag AA, Lawlor DA, Frayling TM, Davey Smith G, Morris AP, Ong KK, Felix JF, Timpson NJ, Perry JR, Evans DM, McCarthy MI and Freathy RM. Genome-wide associations for birth weight and correlations with adult disease. Nature. 2016;538:248–252. Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikainen LP, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Hottenga JJ, Vilor-Tejedor N, Joshi PK, Boh ETH, Ntalla I, Pitkanen N, Mahajan A, van Leeuwen EM, Joro R, Lagou V, Nodzenski M, Diver LA, Zondervan KT, Bustamante M, Marques-Vidal P, Mercader JM, Bennett AJ, Rahmioglu N, Nyholt DR, Ma RCW, Tam CHT, Tam WH, Group CCHW, Ganesh SK, van Rooij FJ, Jones SE, Loh PR, Ruth KS, Tuke MA, Tyrrell J, Wood AR, Yaghootkar H, Scholtens DM, Paternoster L, Prokopenko I, Kovacs P, Atalay M, Willems SM, Panoutsopoulou K, Wang X, Carstensen L, Geller F, Schraut KE, Murcia M, van Beijsterveldt CE, Willemsen G, Appel EVR, Fonvig CE, Trier C, Tiesler CM, Standl M, Kutalik Z, Bonas-Guarch S, Hougaard DM, Sanchez F, Torrents D, Waage J, Hollegaard MV, de Haan HG, Rosendaal FR, Medina-Gomez C, Ring SM, Hemani G, McMahon G, Robertson NR, Groves CJ, Langenberg C, Luan J, Scott RA, Zhao JH, Mentch FD, MacKenzie SM, Reynolds RM, Early Growth Genetics C, Lowe WL, Jr., Tonjes A, Stumvoll M, Lindi V, Lakka TA, van Duijn CM, Kiess W, Korner A, Sorensen TI, Niinikoski H, Pahkala K, Raitakari OT, Zeggini E, Dedoussis GV, Teo YY, Saw SM, Melbye M, Campbell H, Wilson JF, Vrijheid M, de Geus EJ, Boomsma DI, Kadarmideen HN, Holm JC, Hansen T, Sebert S, Hattersley AT, Beilin LJ, Newnham JP, Pennell CE, Heinrich J, Adair LS, Borja JB, Mohlke KL, Eriksson JG, Widen EE, Kahonen M, Viikari JS, Lehtimaki T, Vollenweider P, Bonnelykke K, Bisgaard H, Mook-Kanamori DO, Hofman A, Rivadeneira F, Uitterlinden AG, Pisinger C, Pedersen O, Power C, Hypponen E, Wareham NJ, Hakonarson H, Davies E, Walker BR, Jaddoe VW, Jarvelin MR, Grant SF, Vaag AA, Lawlor DA, Frayling TM, Davey Smith G, Morris AP, Ong KK, Felix JF, Timpson NJ, Perry JR, Evans DM, McCarthy MI and Freathy RM. Genome-wide associations for birth weight and correlations with adult disease. Nature. 2016;538:248–252.
47.
go back to reference McCowan LM, Figueras F, Anderson NH. Evidence-based national guidelines for the management of suspected fetal growth restriction: comparison, consensus, and controversy. Am J Obstet Gynecol. 2018;218:S855–68.CrossRefPubMed McCowan LM, Figueras F, Anderson NH. Evidence-based national guidelines for the management of suspected fetal growth restriction: comparison, consensus, and controversy. Am J Obstet Gynecol. 2018;218:S855–68.CrossRefPubMed
48.
go back to reference Smith GD, Whitley E, Gissler M, Hemminki E. Birth dimensions of offspring, premature birth, and the mortality of mothers. Lancet. 2000;356:2066–7.CrossRefPubMed Smith GD, Whitley E, Gissler M, Hemminki E. Birth dimensions of offspring, premature birth, and the mortality of mothers. Lancet. 2000;356:2066–7.CrossRefPubMed
49.
go back to reference Stergiotou I, Bijnens B, Cruz-Lemini M, Figueras F, Gratacos E, Crispi F. Maternal subclinical vascular changes in fetal growth restriction with and without pre-eclampsia. Ultrasound Obstet Gynecol. 2015;46:706–12.CrossRefPubMed Stergiotou I, Bijnens B, Cruz-Lemini M, Figueras F, Gratacos E, Crispi F. Maternal subclinical vascular changes in fetal growth restriction with and without pre-eclampsia. Ultrasound Obstet Gynecol. 2015;46:706–12.CrossRefPubMed
50.
go back to reference Parikh NI, Cnattingius S, Mittleman MA, Ludvigsson JF, Ingelsson E. Subfertility and risk of later life maternal cardiovascular disease. Hum Reprod. 2012;27:568–75.CrossRefPubMed Parikh NI, Cnattingius S, Mittleman MA, Ludvigsson JF, Ingelsson E. Subfertility and risk of later life maternal cardiovascular disease. Hum Reprod. 2012;27:568–75.CrossRefPubMed
51.
go back to reference Lau ES, Wang D, Roberts M, Taylor CN, Murugappan G, Shadyab AH, Schnatz PF, Farland LV, Wood MJ, Scott NS, Eaton CB, Ho JE. Infertility and risk of heart failure in the Women’s Health Initiative. J Am Coll Cardiol. 2022;79:1594–603.CrossRefPubMed Lau ES, Wang D, Roberts M, Taylor CN, Murugappan G, Shadyab AH, Schnatz PF, Farland LV, Wood MJ, Scott NS, Eaton CB, Ho JE. Infertility and risk of heart failure in the Women’s Health Initiative. J Am Coll Cardiol. 2022;79:1594–603.CrossRefPubMed
52.
go back to reference Parikh NI, Jeppson RP, Berger JS, Eaton CB, Kroenke CH, LeBlanc ES, Lewis CE, Loucks EB, Parker DR, Rillamas-Sun E, Ryckman KK, Waring ME, Schenken RS, Johnson KC, Edstedt-Bonamy AK, Allison MA, Howard BV. Reproductive risk factors and coronary heart disease in the Women’s Health Initiative Observational Study. Circulation. 2016;133:2149–58.CrossRefPubMedPubMedCentral Parikh NI, Jeppson RP, Berger JS, Eaton CB, Kroenke CH, LeBlanc ES, Lewis CE, Loucks EB, Parker DR, Rillamas-Sun E, Ryckman KK, Waring ME, Schenken RS, Johnson KC, Edstedt-Bonamy AK, Allison MA, Howard BV. Reproductive risk factors and coronary heart disease in the Women’s Health Initiative Observational Study. Circulation. 2016;133:2149–58.CrossRefPubMedPubMedCentral
53.
go back to reference Cairncross ZF, Ahmed SB, Dumanski SM, Nerenberg KA, Metcalfe A. Infertility and the risk of cardiovascular disease: findings from the Study of Women’s Health Across the Nation (SWAN). CJC Open. 2021;3:400–8.CrossRefPubMed Cairncross ZF, Ahmed SB, Dumanski SM, Nerenberg KA, Metcalfe A. Infertility and the risk of cardiovascular disease: findings from the Study of Women’s Health Across the Nation (SWAN). CJC Open. 2021;3:400–8.CrossRefPubMed
54.
go back to reference Chih HJ, Elias FTS, Gaudet L, Velez MP. Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses. BMC Pregnancy Childbirth. 2021;21:449.CrossRefPubMedPubMedCentral Chih HJ, Elias FTS, Gaudet L, Velez MP. Assisted reproductive technology and hypertensive disorders of pregnancy: systematic review and meta-analyses. BMC Pregnancy Childbirth. 2021;21:449.CrossRefPubMedPubMedCentral
55.
go back to reference Dayan N, Filion KB, Okano M, Kilmartin C, Reinblatt S, Landry T, Basso O, Udell JA. Cardiovascular risk following fertility therapy: systematic review and meta-analysis. J Am Coll Cardiol. 2017;70:1203–13.CrossRefPubMed Dayan N, Filion KB, Okano M, Kilmartin C, Reinblatt S, Landry T, Basso O, Udell JA. Cardiovascular risk following fertility therapy: systematic review and meta-analysis. J Am Coll Cardiol. 2017;70:1203–13.CrossRefPubMed
56.
go back to reference Peters SA, Woodward M. Women’s reproductive factors and incident cardiovascular disease in the UK Biobank. Heart. 2018;104:1069–75.CrossRefPubMed Peters SA, Woodward M. Women’s reproductive factors and incident cardiovascular disease in the UK Biobank. Heart. 2018;104:1069–75.CrossRefPubMed
57.
go back to reference Oliver-Williams CT, Heydon EE, Smith GC, Wood AM. Miscarriage and future maternal cardiovascular disease: a systematic review and meta-analysis. Heart. 2013;99:1636–44.CrossRefPubMed Oliver-Williams CT, Heydon EE, Smith GC, Wood AM. Miscarriage and future maternal cardiovascular disease: a systematic review and meta-analysis. Heart. 2013;99:1636–44.CrossRefPubMed
58.
go back to reference Peters SA, van der Schouw YT, Wood AM, Sweeting MJ, Moons KG, Weiderpass E, Arriola L, Benetou V, Boeing H, Bonnet F, Butt ST, Clavel-Chapelon F, Drake I, Gavrila D, Key TJ, Klinaki E, Krogh V, Kuhn T, Lassale C, Masala G, Matullo G, Merritt M, Molina-Portillo E, Moreno-Iribas C, Nost TH, Olsen A, Onland-Moret NC, Overvad K, Panico S, Redondo ML, Tjonneland A, Trichopoulou A, Tumino R, Turzanski-Fortner R, Tzoulaki I, Wennberg P, Winkvist A, Thompson SG, Di Angelantonio E, Riboli E, Wareham NJ, Danesh J, Butterworth AS. Parity, breastfeeding and risk of coronary heart disease: a pan-European case-cohort study. Eur J Prev Cardiol. 2016;23:1755–65.CrossRefPubMedPubMedCentral Peters SA, van der Schouw YT, Wood AM, Sweeting MJ, Moons KG, Weiderpass E, Arriola L, Benetou V, Boeing H, Bonnet F, Butt ST, Clavel-Chapelon F, Drake I, Gavrila D, Key TJ, Klinaki E, Krogh V, Kuhn T, Lassale C, Masala G, Matullo G, Merritt M, Molina-Portillo E, Moreno-Iribas C, Nost TH, Olsen A, Onland-Moret NC, Overvad K, Panico S, Redondo ML, Tjonneland A, Trichopoulou A, Tumino R, Turzanski-Fortner R, Tzoulaki I, Wennberg P, Winkvist A, Thompson SG, Di Angelantonio E, Riboli E, Wareham NJ, Danesh J, Butterworth AS. Parity, breastfeeding and risk of coronary heart disease: a pan-European case-cohort study. Eur J Prev Cardiol. 2016;23:1755–65.CrossRefPubMedPubMedCentral
59.
go back to reference Ness RB, Harris T, Cobb J, Flegal KM, Kelsey JL, Balanger A, Stunkard AJ, D’Agostino RB. Number of pregnancies and the subsequent risk of cardiovascular disease. N Engl J Med. 1993;328:1528–33.CrossRefPubMed Ness RB, Harris T, Cobb J, Flegal KM, Kelsey JL, Balanger A, Stunkard AJ, D’Agostino RB. Number of pregnancies and the subsequent risk of cardiovascular disease. N Engl J Med. 1993;328:1528–33.CrossRefPubMed
60.
go back to reference Oliver-Williams C, Vladutiu CJ, Loehr LR, Rosamond WD, Stuebe AM. The association between parity and subsequent cardiovascular disease in women: the atherosclerosis risk in communities study. J Womens Health (Larchmt). 2019;28:721–7.CrossRefPubMed Oliver-Williams C, Vladutiu CJ, Loehr LR, Rosamond WD, Stuebe AM. The association between parity and subsequent cardiovascular disease in women: the atherosclerosis risk in communities study. J Womens Health (Larchmt). 2019;28:721–7.CrossRefPubMed
61.
go back to reference Li W, Ruan W, Lu Z, Wang D. Parity and risk of maternal cardiovascular disease: a dose-response meta-analysis of cohort studies. Eur J Prev Cardiol. 2019;26:592–602.CrossRefPubMed Li W, Ruan W, Lu Z, Wang D. Parity and risk of maternal cardiovascular disease: a dose-response meta-analysis of cohort studies. Eur J Prev Cardiol. 2019;26:592–602.CrossRefPubMed
62.
go back to reference Ogunmoroti O, Osibogun O, Kolade OB, Ying W, Sharma G, Vaidya D and Michos ED. Multiparity is associated with poorer cardiovascular health among women from the Multi-Ethnic Study of Atherosclerosis. Am J Obstet Gynecol. 2019;221:631 e1–631 e16. Ogunmoroti O, Osibogun O, Kolade OB, Ying W, Sharma G, Vaidya D and Michos ED. Multiparity is associated with poorer cardiovascular health among women from the Multi-Ethnic Study of Atherosclerosis. Am J Obstet Gynecol. 2019;221:631 e1–631 e16.
63.
go back to reference Rodriguez CP, Ogunmoroti O, Quispe R, Osibogun O, Ndumele CE, Echouffo Tcheugui J, Minhas AS, Bertoni AG, Allison MA and Michos ED. The association between multiparity and adipokine levels: the multi-ethnic study of atherosclerosis. J Womens Health (Larchmt). 2021. Rodriguez CP, Ogunmoroti O, Quispe R, Osibogun O, Ndumele CE, Echouffo Tcheugui J, Minhas AS, Bertoni AG, Allison MA and Michos ED. The association between multiparity and adipokine levels: the multi-ethnic study of atherosclerosis. J Womens Health (Larchmt). 2021.
64.
go back to reference Mazaki-Tovi S, Vaisbuch EDI, Romero R. Adipokines and pathophysiology of pregnancy complications - the role of leptin and adiponectin. Fetal Matern Med Rev. 2013;24:232–59.CrossRef Mazaki-Tovi S, Vaisbuch EDI, Romero R. Adipokines and pathophysiology of pregnancy complications - the role of leptin and adiponectin. Fetal Matern Med Rev. 2013;24:232–59.CrossRef
65.
go back to reference Ezeigwe AK, Ogunmoroti O, Minhas A, Rodriguez C, Kazzi B, Fashanu OE, Osibogun O, Kovell LC, Harrington CM, Michos ED. Abstract 9567: association between parity and markers of inflammation: the multi-ethnic study of atherosclerosis. Circulation. 2021;144:A9567–A9567.CrossRef Ezeigwe AK, Ogunmoroti O, Minhas A, Rodriguez C, Kazzi B, Fashanu OE, Osibogun O, Kovell LC, Harrington CM, Michos ED. Abstract 9567: association between parity and markers of inflammation: the multi-ethnic study of atherosclerosis. Circulation. 2021;144:A9567–A9567.CrossRef
66.
go back to reference Rosenberg N, Daviglus ML, DeVon HA, Park CG, Eldeirawi K. The association between parity and inflammation among Mexican-American women of reproductive age baries by acculturation level: results of the National Health and Nutrition Examination Survey (1999–2006). Womens Health Issues. 2017;27:485–92.CrossRefPubMedPubMedCentral Rosenberg N, Daviglus ML, DeVon HA, Park CG, Eldeirawi K. The association between parity and inflammation among Mexican-American women of reproductive age baries by acculturation level: results of the National Health and Nutrition Examination Survey (1999–2006). Womens Health Issues. 2017;27:485–92.CrossRefPubMedPubMedCentral
67.
go back to reference Kravdal O, Tverdal A, Grundy E. The association between parity, CVD mortality and CVD risk factors among Norwegian women and men. Eur J Public Health. 2020;30:1133–9.CrossRefPubMed Kravdal O, Tverdal A, Grundy E. The association between parity, CVD mortality and CVD risk factors among Norwegian women and men. Eur J Public Health. 2020;30:1133–9.CrossRefPubMed
68.
go back to reference Stuebe AM, Rich-Edwards JW. The reset hypothesis: lactation and maternal metabolism. Am J Perinatol. 2009;26:81–8.CrossRefPubMed Stuebe AM, Rich-Edwards JW. The reset hypothesis: lactation and maternal metabolism. Am J Perinatol. 2009;26:81–8.CrossRefPubMed
69.
go back to reference Tschiderer L, Seekircher L, Kunutsor SK, Peters SAE, O’Keeffe LM, Willeit P. Breastfeeding is associated with a reduced maternal cardiovascular risk: systematic review and meta-analysis involving data from 8 studies and 1 192 700 parous women. J Am Heart Assoc. 2022;11: e022746.CrossRefPubMedPubMedCentral Tschiderer L, Seekircher L, Kunutsor SK, Peters SAE, O’Keeffe LM, Willeit P. Breastfeeding is associated with a reduced maternal cardiovascular risk: systematic review and meta-analysis involving data from 8 studies and 1 192 700 parous women. J Am Heart Assoc. 2022;11: e022746.CrossRefPubMedPubMedCentral
70.
71.
go back to reference Yu J, Pudwell J, Dayan N, Smith GN. Postpartum breastfeeding and cardiovascular risk assessment in women following pregnancy complications. J Womens Health (Larchmt). 2020;29:627–35.CrossRefPubMed Yu J, Pudwell J, Dayan N, Smith GN. Postpartum breastfeeding and cardiovascular risk assessment in women following pregnancy complications. J Womens Health (Larchmt). 2020;29:627–35.CrossRefPubMed
72.
go back to reference Gunderson EP, Lewis CE, Lin Y, Sorel M, Gross M, Sidney S, Jacobs DR Jr, Shikany JM, Quesenberry CP Jr. Lactation duration and progression to diabetes in women across the childbearing years: the 30-year CARDIA study. JAMA Intern Med. 2018;178:328–37.CrossRefPubMedPubMedCentral Gunderson EP, Lewis CE, Lin Y, Sorel M, Gross M, Sidney S, Jacobs DR Jr, Shikany JM, Quesenberry CP Jr. Lactation duration and progression to diabetes in women across the childbearing years: the 30-year CARDIA study. JAMA Intern Med. 2018;178:328–37.CrossRefPubMedPubMedCentral
73.
go back to reference Feng L, Xu Q, Hu Z, Pan H. Lactation and progression to type 2 diabetes in patients with gestational diabetes mellitus: a systematic review and meta-analysis of cohort studies. J Diabetes Investig. 2018;9:1360–9.CrossRefPubMedPubMedCentral Feng L, Xu Q, Hu Z, Pan H. Lactation and progression to type 2 diabetes in patients with gestational diabetes mellitus: a systematic review and meta-analysis of cohort studies. J Diabetes Investig. 2018;9:1360–9.CrossRefPubMedPubMedCentral
74.
go back to reference Countouris ME, Schwarz EB, Rossiter BC, Althouse AD, Berlacher KL, Jeyabalan A, Catov JM. Effects of lactation on postpartum blood pressure among women with gestational hypertension and preeclampsia. Am J Obstet Gynecol. 2016;215(241):e1-8. Countouris ME, Schwarz EB, Rossiter BC, Althouse AD, Berlacher KL, Jeyabalan A, Catov JM. Effects of lactation on postpartum blood pressure among women with gestational hypertension and preeclampsia. Am J Obstet Gynecol. 2016;215(241):e1-8.
75.
go back to reference Freeman DJ, McManus F, Brown EA, Cherry L, Norrie J, Ramsay JE, Clark P, Walker ID, Sattar N and Greer IA. Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension (Dallas, Tex : 1979). 2004;44:708–14. Freeman DJ, McManus F, Brown EA, Cherry L, Norrie J, Ramsay JE, Clark P, Walker ID, Sattar N and Greer IA. Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension (Dallas, Tex : 1979). 2004;44:708–14.
76.
go back to reference Greer IA, Lyall F, Perera T, Boswell F, Macara LM. Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction? Obstet Gynecol. 1994;84:937–40.PubMed Greer IA, Lyall F, Perera T, Boswell F, Macara LM. Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction? Obstet Gynecol. 1994;84:937–40.PubMed
77.
go back to reference Gratacos E. Lipid-mediated endothelial dysfunction: a common factor to preeclampsia and chronic vascular disease. Eur J Obstet Gynecol Reprod Biol. 2000;92:63–6.CrossRefPubMed Gratacos E. Lipid-mediated endothelial dysfunction: a common factor to preeclampsia and chronic vascular disease. Eur J Obstet Gynecol Reprod Biol. 2000;92:63–6.CrossRefPubMed
78.
go back to reference Yinon Y, Kingdom JC, Odutayo A, Moineddin R, Drewlo S, Lai V, Cherney DZ, Hladunewich MA. Vascular dysfunction in women with a history of preeclampsia and intrauterine growth restriction: insights into future vascular risk. Circulation. 2010;122:1846–53.CrossRefPubMed Yinon Y, Kingdom JC, Odutayo A, Moineddin R, Drewlo S, Lai V, Cherney DZ, Hladunewich MA. Vascular dysfunction in women with a history of preeclampsia and intrauterine growth restriction: insights into future vascular risk. Circulation. 2010;122:1846–53.CrossRefPubMed
79.
go back to reference Skjaerven R, Vatten LJ, Wilcox AJ, Ronning T, Irgens LM, Lie RT. Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort. BMJ. 2005;331:877.CrossRefPubMedPubMedCentral Skjaerven R, Vatten LJ, Wilcox AJ, Ronning T, Irgens LM, Lie RT. Recurrence of pre-eclampsia across generations: exploring fetal and maternal genetic components in a population based cohort. BMJ. 2005;331:877.CrossRefPubMedPubMedCentral
80.
go back to reference Suvakov S, Cubro H, White WM, Butler Tobah YS, Weissgerber TL, Jordan KL, Zhu XY, Woollard JR, Chebib FT, Milic NM, Grande JP, Xu M, Tchkonia T, Kirkland JL, Lerman LO, Garovic VD. Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia. Biol Sex Differ. 2019;10:49.CrossRefPubMedPubMedCentral Suvakov S, Cubro H, White WM, Butler Tobah YS, Weissgerber TL, Jordan KL, Zhu XY, Woollard JR, Chebib FT, Milic NM, Grande JP, Xu M, Tchkonia T, Kirkland JL, Lerman LO, Garovic VD. Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia. Biol Sex Differ. 2019;10:49.CrossRefPubMedPubMedCentral
81.
go back to reference Suvakov S, Ghamrawi R, Cubro H, Tu H, White WM, Tobah YSB, Milic NM, Grande JP, Cunningham JM, Chebib FT, Prata L, Zhu Y, Tchkonia T, Kirkland JL, Nath KA, Milosavljevic A, Garovic VD. Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies. EBioMedicine. 2021;70: 103536.CrossRefPubMedPubMedCentral Suvakov S, Ghamrawi R, Cubro H, Tu H, White WM, Tobah YSB, Milic NM, Grande JP, Cunningham JM, Chebib FT, Prata L, Zhu Y, Tchkonia T, Kirkland JL, Nath KA, Milosavljevic A, Garovic VD. Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies. EBioMedicine. 2021;70: 103536.CrossRefPubMedPubMedCentral
82.
go back to reference Hoyert DL, Minino AM. Maternal mortality in the United States: changes in coding, publication, and data release, 2018. Natl Vital Stat Rep. 2020;69:1–18.PubMed Hoyert DL, Minino AM. Maternal mortality in the United States: changes in coding, publication, and data release, 2018. Natl Vital Stat Rep. 2020;69:1–18.PubMed
83.
go back to reference Petersen EE, Davis NL, Goodman D, Cox S, Syverson C, Seed K, Shapiro-Mendoza C, Callaghan WM, Barfield W. Racial/ethnic disparities in pregnancy-related deaths - United States, 2007–2016. MMWR Morb Mortal Wkly Rep. 2019;68:762–5.CrossRefPubMedPubMedCentral Petersen EE, Davis NL, Goodman D, Cox S, Syverson C, Seed K, Shapiro-Mendoza C, Callaghan WM, Barfield W. Racial/ethnic disparities in pregnancy-related deaths - United States, 2007–2016. MMWR Morb Mortal Wkly Rep. 2019;68:762–5.CrossRefPubMedPubMedCentral
84.
go back to reference Parikh NI, Gonzalez JM, Anderson CAM, Judd SE, Rexrode KM, Hlatky MA, Gunderson EP, Stuart JJ, Vaidya D, American Heart Association Council on E, Prevention, Council on Arteriosclerosis T, Vascular B, Council on C, Stroke N and the Stroke C. Adverse pregnancy outcomes and cardiovascular disease risk: unique opportunities for cardiovascular disease prevention in women: a scientific statement from the American Heart Association. Circulation. 2021;143:e902-e916. Parikh NI, Gonzalez JM, Anderson CAM, Judd SE, Rexrode KM, Hlatky MA, Gunderson EP, Stuart JJ, Vaidya D, American Heart Association Council on E, Prevention, Council on Arteriosclerosis T, Vascular B, Council on C, Stroke N and the Stroke C. Adverse pregnancy outcomes and cardiovascular disease risk: unique opportunities for cardiovascular disease prevention in women: a scientific statement from the American Heart Association. Circulation. 2021;143:e902-e916.
85.
go back to reference Minhas AS, Ogunwole SM, Vaught AJ, Wu P, Mamas MA, Gulati M, Zhao D, Hays AG and Michos ED. Racial disparities in cardiovascular complications with pregnancy-induced hypertension in the United States. Hypertension (Dallas, Tex : 1979). 2021;78:480–488. Minhas AS, Ogunwole SM, Vaught AJ, Wu P, Mamas MA, Gulati M, Zhao D, Hays AG and Michos ED. Racial disparities in cardiovascular complications with pregnancy-induced hypertension in the United States. Hypertension (Dallas, Tex : 1979). 2021;78:480–488.
86.
go back to reference MacDorman MF, Thoma M, Declcerq E, Howell EA. Racial and ethnic disparities in maternal mortality in the United States using enhanced vital records, 20162017. Am J Public Health. 2021;111:1673–81.CrossRefPubMed MacDorman MF, Thoma M, Declcerq E, Howell EA. Racial and ethnic disparities in maternal mortality in the United States using enhanced vital records, 20162017. Am J Public Health. 2021;111:1673–81.CrossRefPubMed
87.
go back to reference Mannoh I, Hussien M, Commodore-Mensah Y, Michos ED. Impact of social determinants of health on cardiovascular disease prevention. Curr Opin Cardiol. 2021;36:572–9.CrossRefPubMed Mannoh I, Hussien M, Commodore-Mensah Y, Michos ED. Impact of social determinants of health on cardiovascular disease prevention. Curr Opin Cardiol. 2021;36:572–9.CrossRefPubMed
88.
go back to reference Zahid S, Tanveer Ud Din M, Minhas AS, Rai D, Khan MZ, Ullah W, Van Spall HGC, Hays AG and Michos ED. Disparities in outcomes of preeclampsia hospitalizations stratified by race and median household income: insights from the U.S. National Inpatient Sample (2004–2018). J Am Coll Cardiol. 2022;79:1832–1832. Zahid S, Tanveer Ud Din M, Minhas AS, Rai D, Khan MZ, Ullah W, Van Spall HGC, Hays AG and Michos ED. Disparities in outcomes of preeclampsia hospitalizations stratified by race and median household income: insights from the U.S. National Inpatient Sample (2004–2018). J Am Coll Cardiol. 2022;79:1832–1832.
89.
go back to reference Churchwell K, Elkind MSV, Benjamin RM, Carson AP, Chang EK, Lawrence W, Mills A, Odom TM, Rodriguez CJ, Rodriguez F, Sanchez E, Sharrief AZ, Sims M, Williams O, American HA. Call to action: structural racism as a fundamental driver of health disparities: a presidential advisory from the American Heart Association. Circulation. 2020;142:e454–68.CrossRefPubMed Churchwell K, Elkind MSV, Benjamin RM, Carson AP, Chang EK, Lawrence W, Mills A, Odom TM, Rodriguez CJ, Rodriguez F, Sanchez E, Sharrief AZ, Sims M, Williams O, American HA. Call to action: structural racism as a fundamental driver of health disparities: a presidential advisory from the American Heart Association. Circulation. 2020;142:e454–68.CrossRefPubMed
90.
go back to reference Ananth CV, Friedman AM. Ischemic placental disease and risks of perinatal mortality and morbidity and neurodevelopmental outcomes. Semin Perinatol. 2014;38:151–8.CrossRefPubMed Ananth CV, Friedman AM. Ischemic placental disease and risks of perinatal mortality and morbidity and neurodevelopmental outcomes. Semin Perinatol. 2014;38:151–8.CrossRefPubMed
91.
go back to reference van Esch JJA, van Heijst AF, de Haan AFJ, van der Heijden OWH. Early-onset preeclampsia is associated with perinatal mortality and severe neonatal morbidity. J Matern Fetal Neonatal Med. 2017;30:2789–94.CrossRefPubMed van Esch JJA, van Heijst AF, de Haan AFJ, van der Heijden OWH. Early-onset preeclampsia is associated with perinatal mortality and severe neonatal morbidity. J Matern Fetal Neonatal Med. 2017;30:2789–94.CrossRefPubMed
92.
go back to reference Huang C, Li J, Qin G, Liew Z, Hu J, Laszlo KD, Tao F, Obel C, Olsen J, Yu Y. Maternal hypertensive disorder of pregnancy and offspring early-onset cardiovascular disease in childhood, adolescence, and young adulthood: a national population-based cohort study. PLoS Med. 2021;18: e1003805.CrossRefPubMedPubMedCentral Huang C, Li J, Qin G, Liew Z, Hu J, Laszlo KD, Tao F, Obel C, Olsen J, Yu Y. Maternal hypertensive disorder of pregnancy and offspring early-onset cardiovascular disease in childhood, adolescence, and young adulthood: a national population-based cohort study. PLoS Med. 2021;18: e1003805.CrossRefPubMedPubMedCentral
93.
go back to reference Andraweera PH, Lassi ZS. Cardiovascular risk factors in offspring of preeclamptic pregnancies-systematic review and meta-analysis. J Pediatr. 2019;208(104–113):e6. Andraweera PH, Lassi ZS. Cardiovascular risk factors in offspring of preeclamptic pregnancies-systematic review and meta-analysis. J Pediatr. 2019;208(104–113):e6.
94.
go back to reference Kajantie E, Osmond C and Eriksson JG. Gestational hypertension is associated with increased risk of type 2 diabetes in adult offspring: the Helsinki Birth Cohort Study. Am J Obstet Gynecol. 2017;216:281 e1–281 e7. Kajantie E, Osmond C and Eriksson JG. Gestational hypertension is associated with increased risk of type 2 diabetes in adult offspring: the Helsinki Birth Cohort Study. Am J Obstet Gynecol. 2017;216:281 e1–281 e7.
95.
go back to reference Grunnet LG, Hansen S, Hjort L, Madsen CM, Kampmann FB, Thuesen ACB, Granstromi C, Strom M, Maslova E, Frikke-Schmidt R, Damm P, Chavarro JE, Hu FB, Olsen SF, Vaag A. Adiposity, dysmetabolic traits, and earlier onset of female puberty in adolescent offspring of women with gestational diabetes mellitus: a clinical study within the Danish National Birth Cohort. Diabetes Care. 2017;40:1746–55.CrossRefPubMedPubMedCentral Grunnet LG, Hansen S, Hjort L, Madsen CM, Kampmann FB, Thuesen ACB, Granstromi C, Strom M, Maslova E, Frikke-Schmidt R, Damm P, Chavarro JE, Hu FB, Olsen SF, Vaag A. Adiposity, dysmetabolic traits, and earlier onset of female puberty in adolescent offspring of women with gestational diabetes mellitus: a clinical study within the Danish National Birth Cohort. Diabetes Care. 2017;40:1746–55.CrossRefPubMedPubMedCentral
96.
go back to reference Damm P, Houshmand-Oeregaard A, Kelstrup L, Lauenborg J, Mathiesen ER, Clausen TD. Gestational diabetes mellitus and long-term consequences for mother and offspring: a view from Denmark. Diabetologia. 2016;59:1396–9.CrossRefPubMed Damm P, Houshmand-Oeregaard A, Kelstrup L, Lauenborg J, Mathiesen ER, Clausen TD. Gestational diabetes mellitus and long-term consequences for mother and offspring: a view from Denmark. Diabetologia. 2016;59:1396–9.CrossRefPubMed
97.
go back to reference Patro Golab B, Santos S, Voerman E, Lawlor DA, Jaddoe VWV, Gaillard R, Authors MSG. Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis. Lancet Child Adolesc Health. 2018;2:812–21.CrossRefPubMed Patro Golab B, Santos S, Voerman E, Lawlor DA, Jaddoe VWV, Gaillard R, Authors MSG. Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis. Lancet Child Adolesc Health. 2018;2:812–21.CrossRefPubMed
98.
go back to reference Jowell AR, Sarma AA, Gulati M, Michos ED, Vaught AJ, Natarajan P, Powe CE, Honigberg MC. Interventions to mitigate risk of cardiovascular disease after adverse pregnancy outcomes: a review. JAMA Cardiol. 2022;7:346–55.CrossRefPubMedPubMedCentral Jowell AR, Sarma AA, Gulati M, Michos ED, Vaught AJ, Natarajan P, Powe CE, Honigberg MC. Interventions to mitigate risk of cardiovascular disease after adverse pregnancy outcomes: a review. JAMA Cardiol. 2022;7:346–55.CrossRefPubMedPubMedCentral
99.
go back to reference Ferrara A, Hedderson MM, Albright CL, Brown SD, Ehrlich SF, Caan BJ, Sternfeld B, Gordon NP, Schmittdiel JA, Gunderson EP, Mevi AA, Tsai AL, Ching J, Crites Y, Quesenberry CP Jr. A pragmatic cluster randomized clinical trial of diabetes prevention strategies for women with gestational diabetes: design and rationale of the Gestational Diabetes’ Effects on Moms (GEM) study. BMC Pregnancy Childbirth. 2014;14:21.CrossRefPubMedPubMedCentral Ferrara A, Hedderson MM, Albright CL, Brown SD, Ehrlich SF, Caan BJ, Sternfeld B, Gordon NP, Schmittdiel JA, Gunderson EP, Mevi AA, Tsai AL, Ching J, Crites Y, Quesenberry CP Jr. A pragmatic cluster randomized clinical trial of diabetes prevention strategies for women with gestational diabetes: design and rationale of the Gestational Diabetes’ Effects on Moms (GEM) study. BMC Pregnancy Childbirth. 2014;14:21.CrossRefPubMedPubMedCentral
100.
go back to reference Adedinsewo DA, Pollak AW, Phillips SD, Smith TL, Svatikova A, Hayes SN, Mulvagh SL, Norris C, Roger VL, Noseworthy PA, Yao X, Carter RE. Cardiovascular disease screening in women: leveraging artificial intelligence and digital tools. Circ Res. 2022;130:673–90.CrossRefPubMed Adedinsewo DA, Pollak AW, Phillips SD, Smith TL, Svatikova A, Hayes SN, Mulvagh SL, Norris C, Roger VL, Noseworthy PA, Yao X, Carter RE. Cardiovascular disease screening in women: leveraging artificial intelligence and digital tools. Circ Res. 2022;130:673–90.CrossRefPubMed
101.
go back to reference Aggarwal NR, Wood MJ. Sex differences in the pathophysiology, presentation, diagnosis and management of cardiac disease. 1st ed. Waltham: Elsevier; 2021. Aggarwal NR, Wood MJ. Sex differences in the pathophysiology, presentation, diagnosis and management of cardiac disease. 1st ed. Waltham: Elsevier; 2021.
Metadata
Title
Markers of Cardiovascular Risk Associated with Pregnancy
Authors
Odayme Quesada
Dawn C. Scantlebury
Joan E. Briller
Erin D. Michos
Niti R. Aggarwal
Publication date
06-02-2023
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 2/2023
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-022-01830-1

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