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Clinical Phytoscience

Issue 1/2021

Content (96 Articles)

Acute, sub-acute, sub-chronic and chronic toxicity studies of four important Nigerian ethnomedicinal plants in rats

  • Open Access
  • Original contribution

Abdullah M. Tauheed, Mohammed Mamman, Abubakar Ahmed, Na’imatu A. Sani, Mohammed M. Suleiman, Mohammed H. Sulaiman, Emmanuel O. Balogun

Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies

Emmanuel Sina Akintimehin, Kayode Olayele Karigidi, Tope Samuel Omogunwa, Foluso Olutope Adetuyi

Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats

  • Open Access
  • Original contribution

Efosa Godwin Ewere, Ngozi Paulinus Okolie, Erhunmwunsee Dalton Avan, Patience Edet Umoh

Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs

Earnest Oghenesuvwe Erhirhie, Chidozie Ikegbune, Anthony Ifeanyi Okeke, Chukwunonso Chukwudike Onwuzuligbo, Ngozi Ukamaka Madubuogwu, Uche Maryann Chukwudulue, Onyinye Blessing Okonkwo

Antiglycation potential of Indigoferin a, Indigoferin B and Indigoferin C natural products from Indigofera heterantha Brandis

  • Open Access
  • Short communication

Ayesha Khan, Ajmal Khan, Manzoor Ahmad, Mumtaz Ali, Umar Farooq, Farhan Ahmad Khan, Syed Majid Bukhari

Dichloromethane extract of Potentilla fulgens wall. Ex. Sims ameliorates alloxan-induced oxidative stress and inflammatory responses in mice

  • Open Access
  • Original contribution

Valrielyn Saio, Donkupar Syiem, Ramesh Sharma, Careen Liza Pakyntein

Evaluation of anti-arthritic and anti-inflammatory activities of Martynia annua L. Ethanolic extract

  • Open Access
  • Arthritis
  • Original contribution

Suruj Kaushik, Parag Jain, Trilochan Satapathy, Prerna Purabiya, Amit Roy

Overview on pharmacovigilance of nephrotoxic herbal medicines used worldwide

Noufissa Touiti, Tarik Sqalli Houssaini, Sanae Achour

Anxiolytic-like effect of Urena lobata (L.) in swiss albino mice

  • Open Access
  • Alkaloids
  • Original contribution

Muhammad Torequl Islam, Thoufiqul Alam Riaz, Seyed Abdulmajid Ayatollahi, Javad Sharifi-Rad

Composition and biological assays of the leaf essential oil of Asparagus flagellaris (Kunth) Bak

Oluwakayode O. Odeja, Michael Gabriel Ibok, Ejike O. Okpala

Phytochemical screening and anticancer activity of the aerial parts extract of Xanthium strumarium L. on HepG2 cancer cell line

  • Open Access
  • Alkaloids
  • Original contribution

Hai Trieu Ly, Trieu Minh Truong, Thi Thu Huong Nguyen, Hoang Dung Nguyen, Yuxia Zhao, Van Minh Le

Phytodentistry in Africa: prospects for head and neck cancers

Henry A. Adeola, Saheed Sabiu, Raphael T. Aruleba, Tayo A. Adekiya, Anthonio O. Adefuye, Ogheneochuko J. Adefuye, Babatunji E. Oyinloye

Sorghum halepense (L.) Pers rhizomes inhibitory potential against diabetes and free radicals

Muhammad Abdur Rehman Shah, Rahmat Ali Khan, Mushtaq Ahmed

Evaluation of antipsoriatic activity of gel containing Pongamia pinnata extract on Imiquimod-induced psoriasis

Kamlesh Wadher, Shital Dabre, Anjali Gaidhane, Sagar Trivedi, Milind Umekar

Benefits of Stryphnodendron adstringens when associated with hydrogel on wound healing in diabetic rats

Patricia de Souza de Aguiar, Áurea Pandolfo Correa, Flavia Tasmin Techera Antunes, Alexandre Falcão de Barros Ferraz, Suele Biehals Vencato, Gabriela Jouglard Vasques Amado, Elenir Wiiland, Dione Silva Corrêa, Ivana Grivicich, Alessandra Hubner de Souza

Proteolytic enzyme arbitrated antagonization of helminthiasis by Cinnamomum cappara leaf extract in Pheretima posthuma

  • Open Access
  • Helminths
  • Original contribution

Kayeen Vadakkan, Meena K Cheruvathur, Anu S Chulliparambil, Famy Francis, Anu P Abimannue

Phytowaste as nutraceuticals in boosting public health

  • Open Access
  • Review

Chinyere S. Dike, Chinna N. Orish, Chukwuemeka R. Nwokocha, Francis D. Sikoki, Bolaji B. Babatunde, Chiara Frazzoli, Orish E. Orisakwe

Serotonergic and noradrenergic response of ethanol extract; opioidergic response of ethyl acetate extract of Dicranopteris linearis L. leaf

Mohammad Mustakim Billah, Ayreen Sonia Chowdhury, Kashfia Nawrin, Saqline Mostaq, Md. Abu Rayhan, Razwanur Rahman Tushar

Bioactive constituents with antibacterial, resistance modulation, anti-biofilm formation and efflux pump inhibition properties from Aidia genipiflora stem bark

  • Open Access
  • Verapamil
  • Original contribution

Daniel Anokwah, Evelyn Asante-Kwatia, Abraham Y. Mensah, Cynthia Amaning Danquah, Benjamin K. Harley, Isaac Kingsley Amponsah, Lukas Oberer

The potential of herbal extracts to inhibit SARS-CoV-2: a pilot study

Michela Luisa De Pellegrin, Anette Rohrhofer, Philipp Schuster, Barbara Schmidt, Philipp Peterburs, André Gessner

Cardioprotective effect of Malva verticillata against doxorubicin -induced toxicity in rats

  • Open Access
  • Alkaloids
  • Original contribution

Doa’a Anwar Ibrahim, Mohammad Abdualqodous Almutawakel, Rowida Al-Badani

Plant active products and emerging interventions in water potabilisation: disinfection and multi-drug resistant pathogen treatment

  • Open Access
  • Review

Adeyemi O. Adeeyo, Joshua N. Edokpayi, Mercy A. Alabi, Titus A. M. Msagati, John O. Odiyo

The protective effect of Rubus fruticosus L. on blood composition in cyclophosphamide treated male rats

  • Open Access
  • Original contribution

Naser Mirazi, Ida Shahabi Baher, Zahra Izadi, Abdolkarim Hosseini

Phytochemistry and pharmacological studies of Plumbago zeylanica L.: a medicinal plant review

  • Open Access
  • Review

Babita Shukla, Sumedha Saxena, Shazia Usmani, Poonam Kushwaha

Effects of BNO 1016 on ciliary transport velocity and cell culture surface liquid height of sinonasal epithelial cultures

  • Open Access
  • Original contribution

Alan D. Workman, Ivy W. Maina, Vasiliki Triantafillou, Neil N. Patel, Charles C. L. Tong, Edward C. Kuan, David W. Kennedy, James N. Palmer, Nithin D. Adappa, Noam A. Cohen

In-vitro cytotoxic and anti-Vibrio cholerae activities of alcoholic extracts of Desmodium triflorum (L.) whole plant and Terminalia citrina (Roxb.) fruits

Rubaba Karim, Mst Marium Begum, Yeasmin Jui, Tanjina Islam, Masum Billah, Yeasir Arafat, Mehnaz Karim, Ashfia Fatima Khan, Md. Sohanur Rahman

Phytochemical constituent and antimicrobial properties of guava extracts of east Hararghe of Oromia, Ethiopia

  • Open Access
  • Alkaloids
  • Original contribution

Dereje A. Oncho, Meseret C. Ejigu, Olyad E. Urgessa

Phytotherapeutic potential of bi-herbal extract of cinnamon and turmeric: in vivo antidiabetic studies

R. Sivaranjani, T. John Zachariah, N. K. Leela

Toxicity study and anti-trypanosomal activities of aqueous and methanol whole plant extracts of Brillantaisia owariensis on Trypanosoma brucei-induced infection in BALB/c mice

  • Open Access
  • Original contribution

Nafisa Garba Ayawa, Suleiman Babatunde Ramon-Yusuf, Yunusa Adamu Wada, Sonnie Joshua Oniye, Dalhatu Mukhtari Shehu

Hepatoprotective activity against acetaminophen-induced liver dysfunction and GC-MS profiling of a brown algae Sargassum ilicifolium

Khan Hira, Hafiza Farhat, Nida Sohail, Madeeha Ansari, Jehan Ara, Syed Ehteshamul-Haque

Attenuation of glycation and biochemical aberrations in fructose‐loaded rats by polyphenol‐rich ethyl acetate fraction of Parkia biglobosa (jacq.) Benth. (Mimosaceae) leaves

  • Open Access
  • Original contribution

Christian Chiazor Chibuogwu, Rita Onyekachukwu Asomadu, Innocent Uzochukwu Okagu, Chinelo C Nkwocha, Ben Chibuzo Amadi

Effect of Aegle marmelos on the growth of brushite crystals

  • Open Access
  • Original contribution

G. Anushya, R. Mahesh, T. H. Freeda, R. Ramachandran, G. Raju

Antimicrobial, antioxidant, anti-inflammatory and cytotoxic study of extracts of Guibourtia tessmanii (harms) J. Léonard from Gabon

  • Open Access
  • Original contribution

Cédric Sima Obiang, Rick Léonid Ngoua Meye Misso, Guy Roger Ndong Atome, Rany Berty Mbeng Obame, Joseph Privat Ondo, Louis Clément Obame Engonga, Edouard Nsi Emvo

Correction to: Attenuation of glycation and biochemical aberrations in fructose-loaded rats by polyphenol-rich ethyl acetate fraction of Parkia biglobosa (jacq.) Benth. (Mimosaceae) leaves

  • Open Access
  • Correction

Christian Chiazor Chibuogwu, Rita Onyekachukwu Asomadu, Innocent Uzochukwu Okagu, Chinelo C. Nkwocha, Ben Chibuzo Amadi

Protective role of Pandanus tectorius Parkinson ex Du Roi in diabetes, hyperlipidemia, liver and kidney dysfunction in alloxan diabetic rats

Saima Sundus, Khan Hira, Nida Sohail, Habiba, Amna Tariq, Jehan Ara, Viqar Sultana, Syed Ehteshamul-Haque

Antioxidant property, anti-inflammatory and analgesic effects of aqueous extracts of two onion bulbs varieties (Allium cepa L.)

  • Open Access
  • Edema
  • Original contribution

Mang Yannick Dimitry, Panyo’o Akdowa Emmanuel, Djiogue Manejo Josiane Edith, Abdou Bouba Armand, Njintang Yanou Nicolas

Diosgenin and galactomannans, natural products in the pharmaceutical sciences

Mohamad Hesam Shahrajabian, Wenli Sun, Diorge Jonatas Marmitt, Qi Cheng

Anti-proliferative, antioxidant effects of methanol extract of Calotropis procera leaf on lung cancer cells (H1299) and its ameliorative effect on expression of CD146 on blood cells

Ayobami Matthew Olajuyin, Adefunke Kafayat Olajuyin, Ziqi Wang, Xingru Zhao, Zhiwei Xu, Quncheng Zhang, Xiaoju Zhang

Phytochemistry and therapeutic potential of black pepper [Piper nigrum (L.)] essential oil and piperine: a review

  • Open Access
  • Review

Kaliyaperumal Ashokkumar, Muthusamy Murugan, M. K. Dhanya, Arjun Pandian, Thomas D. Warkentin

Ethno-medicinal, phytochemistry, and pharmacological importance of Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae): a useful medicinal plant of sub-Saharan Africa

Olumide Samuel Fadahunsi, Peter Ifeoluwa Adegbola, Olubukola Sinbad Olorunnisola, Temitayo Idris Subair, David Oluwasegun Adepoju, Ayodeji Zabdiel Abijo

Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

  • Open Access
  • Metformin
  • Original contribution

Olubanke O. Ogunlana, Babatunde O. Adetuyi, Miracle Rotimi, lohor Esalomi, Alaba Adeyemi, Julie Akinyele, Oluseyi E. Ogunlana, Oluwatosin A. Adetuyi, Oluwaseun A. Adebisi, Edward K. Opata, Roua S. Baty, Gaber El-Saber Batiha

Acute and sub-acute toxicity profile of crude extract and fractions of Gymnema sylvestre

  • Open Access
  • Alkaloids
  • Original contribution

Rofiyat Omolara Raji, Hadiza Lami Muhammad, Abdulkadir Abubakar, Sophia Shekwoyan Maikai, Habibat Feyishara Raji

Root extracts of Anacardium occidentale reduce hyperglycemia and oxidative stress in vitro

  • Open Access
  • Insulins
  • Original contribution

TM Archana, K Soumya, Jesna James, Sudheesh Sudhakaran

Flavonoids, alkaloids and saponins: are these plant-derived compounds an alternative to the treatment of rheumatoid arthritis? A literature review

Luis Ângelo Macedo Santiago, Roberval Nascimento Moraes Neto, Ana Caroline Santos Ataíde, Dâmaris Cristina Sousa Carvalho Fonseca, Enio Fernandes Aragão Soares, Joicy Cortez de Sá Sousa, Renata Mondego-Oliveira, Rachel Melo Ribeiro, Maria do Socorro de Sousa Cartágenes, Lídio Gonçalves Lima-Neto, Rafael Cardoso Carvalho, Eduardo Martins de Sousa

Phytotoxicity, cytotoxicity and chemical composition of Spondias mombin Linn. Stem bark

  • Open Access
  • Original contribution

Kissinger Obaogie Orumwensodia, Patrick Ojeifo Uadia, Muhammed Iqbal Choudhary

Active status on phytochemistry and pharmacology of Pergularia daemia Forsk. (Trellis-vine): a review

  • Open Access
  • Review

Devanesan Arul Ananth, Garlapati Deviram, Vijayaraghavan Mahalakshmi, V. Ratna Bharathi

Preliminary toxicology profile of Dennettia tripetala (Pepper Fruit) methanolic leaves extract

  • Open Access
  • Original contribution

Joseph Chukwufumnanya Mordi, Patrick Chukwuyenum Ichipi-Ifukor, Godfery Rume Kweki, Rita Ngozi Ichipi-Ifukor, John Chukwuma Oyem, Uche Dennis-Eboh

Safety and influence of a novel extract of fenugreek on healthy young women: a randomized, double-blinded, placebo-controlled study

Aman Khanna, Jestin Thomas, Febi John, Balu Maliakel, I. M. Krishnakumar

Cure and prevention of cardiovascular diseases: herbs for heart

Suman Ray, Mahesh Kumar Saini

Cardiovascular benefits of Momordica charantia in cholesterol-fed Wistar rats

Silvanus Olu Innih, Ikechi Gerald Eze, Kingsley Omage

Toxicological evaluation of the dried hydroethanolic extract of Amaranthus spinosus L. roots in Artemia salina larvae and Sprague Dawley rats

  • Open Access
  • Original contribution

Kokou Atchou, Povi Lawson-Evi, Aboudoulatif Diallo, Kwashie Eklu-Gadegbeku

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

  • Open Access
  • Original contribution

Chahrazed Benzaid, Lazhari Tichati, Fouzia Trea, Mahmoud Rouabhia, Kheireddine Ouali

Toxicological screening and evaluation of anti-allergic and anti-hyperglycemic potential of Sonneratia caseolaris (L.) Engl. fruits

  • Open Access
  • Original contribution

Shrabanti Dev, Rabindra Nath Acharyya, Sheuly Akter, Md. Abdullah Al Bari, Kaniz Asma, Hemayet Hossain, Kishore Kumar Sarkar, Nripendra Nath Biswas, Asish Kumar Das

Correction to: An exploratory analysis on the toxicity & safety profile of Polyherbal combination of curcumin, quercetin and rutin

  • Open Access
  • Correction

Reshu Tiwari, Mohammed Haris Siddiqui, Tarique Mahmood, Alvina Farooqui, Paramdeep Bagga, Farogh Ahsan, Arshiya Shamim

Antiproliferative effect of extracts and fractions of the root of Terminalia avicennioides (Combretaceae) Guill and Perr. on HepG2 and Vero cell lines

  • Open Access
  • Original contribution

Hadiza Aliyu-Amoo, Hamza Ibrahim Isa, Emmanuel Mfotie Njoya, Lyndy Joy McGaw

Impact of Althaea Officinalis extract in patients with atopic eczema: a double-blind randomized controlled trial

Negar Khalighi, Farahzad Jabbari-Azad, Maral Barzegar-Amini, Jalil Tavakkol-Afshari, Pouran Layegh, Roshanak Salari

Safety assessment of bio-synthesized iodine-doped silver nanoparticle wound ointment in experimental rats

  • Open Access
  • Original contribution

Oluwatosin Kudirat Shittu, Olawale Issac Oluyomi, Theresa Yebo Gara

Inhibition of phospholipase A2, platelet aggregation and egg albumin induced rat paw oedema as anti-inflammatory effect of Peltophorun pterocarpus stem-bark

Osmund Chukwuma Enechi, Emmanuel Sunday Okeke, Ogochukwu Emmanuel Awoh, Charles Obinwanne Okoye, Chinaza Kyrian Odo

Sida acuta Burm.f. leaves ethanol extract ameliorates haematological and biochemical alterations induced by Plasmodium berghei ANKA-65 in mice

  • Open Access
  • Malaria
  • Original contribution

Osmond Chukwuma Enechi, Christian Chijioke Amah, Innocent Uzochukwu Okagu, Pamela Chidinma Ononiwu, Alice Chinwendu Nweke, Theophilus Chukwudi Ugwuanyi, Emmanuel Arinzechukwu Ajibo, Anthonia Chiamaka Nweze, Blessing Chiamaka Chukwurah

Evaluation of clinical trials of the plants, which have ethnobotanical uses for skin disorders in Turkey: a review

Zinar Alan, Halil Özgüldü, Meryem Sedef Erdal, Ayşenur Yaman Bucak, A. Yağız Üresin, Emine Akalın

Antioxidant and immunomodulatory effect of AKSS16-LIV01 – a multi herbal formulation against ethanol induced liver dysfunction in mice

Soumendra Darbar, Srimoyee Saha, Kausikisankar Pramanik, Atiskumar Chattopadhyay

Evaluation of bioactivity and phytochemical screening of endophytic fungi isolated from Ceriops decandra (Griff.) W. Theob, a mangrove plant in Bangladesh

  • Open Access
  • Original contribution

Mita Munshi, Md. Hossain Sohrab, Mst. Nadira Begum, Sattyajit Roy Rony, Md. Adnan Karim, Farhana Afroz, Md. Nazmul Hasan

Baccharis trimera aqueous extract modulates inflammation and nociception in mice

Natiely Silveira de Almeida, Alexandre de Barros Falcão Ferraz, Claudia Pedron, Dione Silva Correa, Luciene Bruno Vieira, Flavia Tasmim Techera Antunes, Alessandra Hubner de Souza

Pleurotus tuber-regium inclusion in diet ameliorates dyslipidaemia in obese-type 2 diabetic rats

  • Open Access
  • Obesity
  • Original contribution

Akindele Oluwatosin Adeyi, Folasade Ajoke Adams, Clementina Oyinkansola Adenipekun

Evaluation of cerebroprotective effect of Ricinus communis leaves against ischemia reperfusion injury in rats

Nesar Ahmad, Anuradha Mishra, Farogh Ahsan, Zafar Khan

Phenolic rich-extracts from Nauclea latifolia fruit restored Lead acetate-induced liver and kidney damaged in Wistar rats

  • Open Access
  • Original contribution

Musa Bola Busari, Rabiat Unekwu Hamzah, Hadiza Lami Muhammad, Ruqayyah Shehu Yusuf, Fatima Mohammad Madaki, Jamiu Olabanji Adeniyi, Yunusa Olatunji Ibrahim, Eustace Bonghan Berinyuy

Differential expression of gluconeogenic enzymes in early- and late-stage diabetes: the effect of Citrullus colocynthis (L.) Schrad. Seed extract on hyperglycemia and hyperlipidemia in Wistar-Albino rats model

Arezoo Afshari, Fouzieh Salimi, Azin Nowrouzi, Masoumeh Babaie Khalili, Salar Bakhtiyari, Gholamreza Hassanzadeh, Maryam Shabani, Ali Ahadi, Masoumeh Farhadiannezhad

Hypoglycaemic activity of Smilax canellifolia Mill. rhizomes: a bioassay-guided isolation and identification of synergistic compounds

Davia A. Peddie, Sophia J. Bryan, Sheena Francis, Ruby L. Alexander-Lindo

Toxicological studies of aqueous and ethanol leaf extract of Spondias purpurea (red plum) in rats

  • Open Access
  • Original contribution

T. Y. Gara, A. I. Daniel, F. M. Muhammad, H. H. Ndayako

Comparative studies on the hypoglycemic and antioxidant activities of Vernonia amygdalina delile and Baccharoides tenoreana olive in alloxan-induced hyperglycemic rats

Samuel Chijioke Attama, Patrick Emeka Aba, Chinwe Uchechukwu Asuzu, Isaac Uzoma Asuzu

Plantain based dough meal: nutritional property, antioxidant activity and dyslipidemia ameliorating potential in high-fat induced rats

Timilehin David Oluwajuyitan, Oluwole Steve Ijarotimi, Tayo Nathaniel Fagbemi

Anti-diuretic and anti-glycemic properties of Jatropha gossypiifolia L. leave extract on wistar rats

Benjamin Ogunma Gabriel, Mac Donald Idu

Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts

Julius Kevin Cura, Antonio Basilio, Ma. Cristina De Las Llagas

Anti-diabetic effect of Stachytarpheta jamaicensis on low dose streptozotocin-induced diabetic rats fed on a high-fat diet

Mac Donald Idu, Owen – Obaseki Edehia, Benjamin Ogunma Gabriel

Correction to: Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts

Julius Kevin Cura, Antonio Basilio, Ma. Cristina De Las Llagas