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Cardiac Glycoside 

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  1. Open Access 01-12-2019 | Cardiac Glycoside | ReviewPaper

    New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin

    Traditional Chinese Medicine (TCM) is a medical practice with more than 2500 years of history in China. It has recently been recognized as a new type of chemotherapy adjuvant that can improve the efficacy of chemotherapy and ameliorate the side …

  2. 01-05-2007 | ReviewPaper

    Endogenous and Exogenous Cardiac Glycosides and their Mechanisms of Action

    Cardiac glycosides have been used for decades to treat congestive heart failure. The recent identification of cardiotonic steroids such as ouabain, digoxin, marinobufagenin, and telocinobufagin in blood plasma, adrenal glands, and hypothalamus of …

  3. 01-07-2017 | OriginalPaper

    The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway

    Carcinoma of the colon is a common malignant tumor of the gastrointestinal tract. Globally, it is the third most common cancer, the fourth most common cause of cancer death, and the second most common cancer in terms of the number of individuals …

  4. 01-04-2016 | OriginalPaper

    Use of cardiac glycosides and risk of glioma

    Cardiac glycosides induce apoptotic effects on glioma cells, but whether cardiac glycosides protect against risk for glioma is unknown. We therefore explored the relation between glycoside use and glioma risk using a large and validated database.

  5. 01-10-2005 | BriefCommunication

    Cardiac Glycosides: William Withering (1741–1799)

  6. 01-08-2013 | ReviewPaper

    Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials

    Cardiac glycosides have a long history in the treatment of cardiac disease. However, several preclinical studies as well as two phase I studies have shown that cardenolides may also possess anticancer effects. The mechanisms of these anticancer …

  7. Open Access 01-07-2012 | Abstract

    The role of cardiac glycosides in influencing breast cancer cell proliferation

    Cardiac Glycosides (CGs) are commonly used to treat congestive heart failure. CGs inhibit the Sodium Potassium ATPase (Na+/K+ ATPase) pump. Interestingly, CGs have been suggested to inhibit proliferation and migration of breast cancer cells. A …

  8. 01-12-2008 | OriginalPaper

    Role of Cardiac Glycosides in Regulation of the Growth of Retinal Tissue Explants

    We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10–12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal …

  9. Open Access 01-12-2014 | OriginalPaper

    Cardiac glycosides use and the risk of lung cancer: a nested case–control study

    Cardiac glycosides (CGs) are natural steroids, derived from digitalis, that share a chemical structure with estrogens and are therefore considered phytoestrogens. The CG family includes digoxin, digitoxin and lanatoside C which remain important …

  10. 01-03-2011 | OriginalPaper

    Mechanism of Cardioprotective Effect of Adenocine and Non-Glycoside Cardiotonic Drugs during Experimental Chronic Cardiac Insufficiency

    The therapeutic action of adenocine during cardiac insufficiency (heart failure) caused by ischemic (stenosis) or reperfusion (removal of ligature) injury to the myocardium prevents depletion of ATP, the major energy source for myocytes in the …

  11. 01-08-2014 | OriginalPaper

    Cardiac glycosides and the risk of breast cancer in women with chronic heart failure and supraventricular arrhythmia

    The aim of this study is to determine whether the use of cardiac glycosides (CGs), drugs used in the treatment of congestive heart failure (CHF) and supra-ventricular arrhythmia, is associated with an increased risk of breast cancer. A cohort of …

  12. 01-03-2011 | OriginalPaper

    The alpha-synuclein 5′untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen

    Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson’s disease (PD). Dopaminergic neurons exhibit elevated iron levels that can accelerate toxic SNCA fibril …

  13. 01-12-2005 | OriginalPaper

    Successful treatment of oleander intoxication (cardiac glycosides) with digoxin-specific Fab antibody fragments in a 7-year-old child

    Case report and review of literature

    A 7-year-old girl presented six hours after ingestion of a yellow oleander seed (Thevetia peruviana) with severe emesis, change in colour vision and complete heart block. Initial treatment with phenytoin and isoprenalin infusion led to …

  14. 01-03-2006 | OriginalPaper

    Sodium/potasium ATPase (Na+, K+-ATPase) and ouabain/related cardiac glycosides: a new paradigm for development of anti- breast cancer drugs?

    Prolonged exposure to 17β-estradiol (E2) is a key etiological factor for human breast cancer. The biological effects and carcinogenic effects of E2 are mediated via estrogen receptors (ERs), ERα and ERβ. Anti-estrogens, e.g. tamoxifen, and …

  15. 01-01-2002 | OriginalPaper

    Subcellular and Molecular Mechanisms of the Effects of Cardiac Glycosides and Angiotensin-Converting Enzyme Inhibitors on Contractile Function and Energy Conversion in Myocardial Myofibrils under Normal Conditions and during Acute Cardiac Insufficiency

    Experiments on skinned and hybrid myocardial fibers isolated from normal dogs and animals subjected to 120-min occlusion of the anterior interventricular branch of the coronary artery showed that in contrast to cardiac glycosides …

  16. 01-04-2006 | OriginalPaper

    Submolecular mechanisms underlying in vitro and in vivo effect of cardiac glycosides on contractile activity of myocardial myofibrils during heart failure

    The development of severe heart failure associated with toxicoallergic myocarditis is accompanied by profound structural and conformational changes in the outer domain of actin (major protein in a thin filament of cardiomyocyte sarcomere). These …

  17. 22-12-2023 | Intoxication | Online First

    Accidental fatal poisoning in a child due to ingestion of Nerium oleander leaf

    Nerium oleander is an ornamental plant that belongs to the family Apocynaceae. It contains a cardiac glycoside named oleandrin, which is present in all parts of the oleander plant. Suicidal and medication-related deaths due to Nerium oleander …

  18. 10-10-2023 | Digoxin | OriginalPaper

    Population Pharmacokinetics of Digoxin in Nonagenarian Patients: Optimization of the Dosing Regimen

    Digoxin is a cardiac glycoside widely prescribed for congestive heart failure (CHF) and atrial fibrillation (AF) [ 1 ]. Due to its narrow therapeutic range (0.8–2.0 ng/mL), strong toxicity, and side effects, which may appear even with recommended …

  19. 01-08-2006 | Abstract

    Amiodarone/β-adrenoceptor antagonists/cardiac glycosides

    Torsade de pointes: 3 case reports
  20. Open Access 01-12-2024 | Ciprofloxacin | OriginalPaper

    Phytochemical characterization, antimicrobial and antioxidant activities of Terminalia catappa methanol and aqueous extracts

    Herbal medicine has been acknowledged as a reservoir of bioactive phytochemicals that can be employed to address and avert diverse human health predicaments, whether chronic or acute. The manifestation of its ethno-pharmacological advantages has …

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