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8224 search results for:

Indomethacin 

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  1. 16-04-2024 | Metamizole | Online First

    Neuroendocrine modulation by metamizole and indomethacin: investigating the impact on neuronal markers and GnRH release

    The management of neural damage poses a dual challenge, as it typically requires both immediate symptom relief and a broader objective of slowing disease progression. The self-repair capacity of the nervous system, which is compromised due to …

  2. 06-03-2024 | Atropine | OriginalPaper

    Cholecystokinin-Induced Duodenogastric Bile Reflux Increases the Severity of Indomethacin-Induced Gastric Antral Ulcers in Re-fed Mice

    Although nonsteroidal anti-inflammatory drugs (NSAIDs) often cause gastric ulcers in the pre-pyloric (antral) area in humans [ 1 – 4 ], in experimental animals, NSAIDs, when administered after a prolonged fast, selectively produce gastric lesions …

  3. 01-12-2024 | Indomethacin | OriginalPaper

    Efficacy of rectal indomethacin in prevention of post-operative hyperamylasemia following pancreatoduodenectomy: a randomized controlled trial

    Post-operative pancreatic fistula (POPF) continues to remain the Achilles heel of pancreatoduodenectomy (PD). Recent evidence suggests that postoperative hyperamylasemia (POH) may be a key predictor of POPF [ 1 , 2 ]. The presence of POH has also …

  4. Open Access 01-12-2024 | Indomethacin | OriginalPaper

    Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations

    The histological definition of gastric ulcerative disease is mucous membrane injury that affects of the stomach superficial or deeper muscularis mucosa [ 1 , 2 ]. The epidemiological data has unveiled remarkable rates of incidence and prevalence …

  5. 17-01-2023 | Pharmacokinetics | OriginalPaper

    Development of an Intrauterine Device Releasing Both Indomethacin and Levonorgestrel During the First Months of Use: Pharmacokinetic Characterization in Healthy Women

    Long-acting reversible contraceptives (LARCs) are the most effective methods of reversible contraception [ 1 ]. This effectiveness is in part attributable to the fact that LARC methods are not compliance-dependent; pregnancy rates with …

  6. 26-08-2023 | Atropine | OriginalPaper

    Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT3 and Dopamine D2 Receptors in Mice

    Although the importance of peptic ulcer disease has diminished since the 1990s due to the advent of potent antisecretory medications and the ability to eradicate H. pylori , peptic ulcer disease remains a major health problem and cause of …

  7. 25-04-2023 | Patent Ductus Arteriosus | OriginalPaper

    Neonatal acute kidney injury during indomethacin therapy: does it predict ductal closure?

    Preterm newborns are at risk for persistent patency of the ductus arteriosus (DA), a fetal vascular structure that allows blood from the placenta to bypass the uninflated fetal lungs. Functional closure of the DA occurs within the first 48 h in …

  8. 01-11-2021 | Indomethacin

    Indomethacin-Induced Headache: Causing the Problem You Are Trying to Solve

    The practice of headache medicine requires providers to be well versed in the potential side effects of medications. We walk a fine line in allegiance to the “primum non nocere” of the Hippocratic oath when managing high frequency and disabling …

  9. Open Access 01-12-2021 | Xerophthalmia | OriginalPaper

    Controversy of indomethacin eye drops in the treatment of rheumatoid arthritis-induced corneal ulceration: a case report

    Perforation of the cornea is a rare finding in patients with rheumatoid arthritis (RA) [ 1 , 2 ]. This paper reports the case of perforated corneal ulceration in a patient with RA that had been treated for 3 weeks with topical indomethacin prior to …

  10. 01-06-2023 | OriginalPaper

    Desmopressin Plus Tolterodine vs Desmopressin Plus Indomethacin for Refractory Pediatric Enuresis: An Open-label Randomized Controlled Trial

  11. 01-04-2022 | Migraine

    Indomethacin for refractory COVID or post-COVID headache: a retrospective study

    Corona Virus Disease (COVID-19) is a disease caused by the newly identified human coronavirus (HCoV) named Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) [ 1 , 2 ]. It has been a global pandemic since March 2020. Although it affects …

  12. Open Access 01-12-2020 | Pancreatitis | Erratum

    Correction to: Rectal indomethacin alone versus indomethacin and prophylactic pancreatic stent placement for preventing pancreatitis after ERCP: study protocol for a randomized controlled trial

    An amendment to this paper has been published and can be accessed via the original article.

  13. 01-08-2021 | Premature Rupture of Membranes | Letter

    Antenatal Indomethacin Use Altering the Initial Presentation of Type 4A Bartter Syndrome

  14. 01-10-2020 | Herpes Virus | News

    Indomethacin

    Encephalopathy, hemiparesis and aphasia
  15. 01-01-2022 | Indomethacin | OriginalPaper

    Protective Effect of Luminal Uric Acid Against Indomethacin-Induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota

    Uric acid (UA) is the end product of purine nucleotides in humans [ 1 ]. There are approximately 1200 mg of UA in the human body, and about 700 mg of UA is synthesized per day and excreted [ 2 ]. Previously, only the urinary excretion of UA had …

  16. 04-05-2022 | Indomethacin | OriginalPaper

    Cell-free probiotic supernatant (CFS) treatment alleviates indomethacin-induced enterocolopathy in BALB/c mice by down-modulating inflammatory response and oxidative stress: potential alternative targeted treatment

    Probiotics and their metabolites appear to be a promising approach that targets both the intestinal inflammation and dysbiosis in bowel diseases. In this context, the emergence of the probiotic cell-free supernatant (CFS) has attracted more …

  17. 01-10-2021 | Cluster Headache | OriginalPaper

    A retrospective observation on 105 patients with chronic cluster headache receiving indomethacin

    Cluster headache (CH) is a primary headache, classified into 2 subforms: episodic (ECH) and chronic (CCH). The chronic form is defined by a lack of remission or remissions lasting less than 1 month in ICHD-3 Beta version (2013), less than 3 months …

  18. Open Access 01-12-2019 | Patent Ductus Arteriosus | OriginalPaper

    Base excess and hematocrit predict response to indomethacin in very low birth weight infants with patent ductus arteriosus

    Management of hemodynamically significant patent ductus arteriosus (HSPDA) in VLBW (< 1500 g) infants remains a challenge. Increasingly, the decision to treat any given infant rests on a risk-benefit analysis, balancing the known risks of HSPDA …

  19. 01-08-2020 | Famotidine | OriginalPaper

    LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) exerts anti-ulcer effects via 5-hydroxytryptamine receptor 7 activation on indomethacin-induced gastric ulcers in rats

    Gastric ulcer (GU) is a tissue loss with specific margins that passes through the muscularis mucosa in the stomach and duodenum mucosa in response to the harmful effects of acid and pepsin. Helicobacter pylori (HP) infection, aspirin, and the use …

  20. Open Access 01-12-2019 | Indomethacin | OriginalPaper

    Therapeutic effects of hydro-alcoholic extract of Achillea wilhelmsii C. Koch on indomethacin-induced gastric ulcer in rats: a proteomic and metabolomic approach

    Gastric ulcer is a benign lesion on the mucosal epithelium which is considered the most prevalent gastrointestinal disorder affecting 5% of the population worldwide. However, its management has turned into a major challenge in recent years [ 1 , 2 …

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