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6133 search results for:

Alkaloids 

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  1. Open Access 01-12-2024 | Alkaloids | Letter

    A strategy to pioneer key agent(s) in Cephalotaxus alkaloids against pan-cancer via filtering methodology based on integrated pharmacology

  2. Open Access 01-12-2024 | Lung Cancer | OriginalPaper

    Mechanisms predictive of Tibetan Medicine Sophora moorcroftiana alkaloids for treatment of lung cancer based on the network pharmacology and molecular docking

    Lung cancer (LC), as an exceedingly significant public health problem in developing and developed countries, has a high incidence and mortality rate, and it is one of the most common malignant tumors in clinical practice [ 1 ]. In recent years, the …

  3. 29-07-2023 | Alkaloids | BriefCommunication

    Cordythiazole A, the first member of thiazole alkaloids from Chinese cordyceps, with α-glucosidase inhibitory activity

    Chinese cordyceps, also known as Dong-Chong-Xia-Cao, is widely recognized as a famous precious tonic herb, and used as traditional Chinese medicine for centuries. It is mainly used for regulating the immune system and improving functions of the …

  4. Open Access 01-12-2022 | Alkaloids | ReviewPaper

    Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

    Regulated cell death (RCD) is a critical and active process that is controlled by specific signal transduction pathways and can be regulated by genetic signals or drug interventions. Meanwhile, RCD is closely related to the occurrence and therapy …

  5. Open Access 01-12-2022 | Alkaloids | Erratum

    Correction: Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

    The original article [ 1 ] mistakenly omitted co-corresponding authorship of co-author, Gu Zhan. This has since been restored.

  6. Open Access 01-12-2023 | Fosinopril | OriginalPaper

    The alkaloids of Corydalis hendersonii Hemsl. contribute to the cardioprotective effect against ischemic injury in mice by attenuating cardiomyocyte apoptosis via p38 MAPK signaling pathway

    Ischemic heart disease (IHD), caused by the imbalance between coronary blood flow and myocardial demand due to changes in the coronary circulation, has a high incidence and fatality rate [ 1 , 2 ]. Although the drug development and treatment …

  7. 23-01-2023 | Alkaloids | BriefCommunication

    Two new β-carboline alkaloids from the roots of Anemone altaica

    The genus Anemone (Ranunculaceae) consists of about 150 species worldwide, which are primarily distributed in the temperate regions of the Northern Hemisphere [ 1 , 2 ]. There are about 50 species found in China, which are distributed in most …

  8. 12-01-2023 | Alkaloids | OriginalPaper

    Ergot alkaloids in sclerotia collected in Japan: synthetic profiles and induction of apoptosis by Clavine-type compounds

    The genus Claviceps (Clavicipitaceae) is famous for producing ergot alkaloids (EAs) in sclerotia. EAs can cause ergotism, resulting in convulsions and necrosis when ingested, making these compounds a serious concern for food safety. Agroclavine …

  9. 01-03-2022 | Alkaloids | News

    Medicines Safety Update and PI changes for administration of vinca alkaloids

  10. 25-10-2022 | Alkaloids | OriginalPaper

    Seasonal variation of alkaloids and polyphenol in Ephedra sinica cultivated in Japan and controlling factors

    We investigated the seasonal variation of alkaloids (ephedrine and pseudoephedrine), total polyphenol, and sugar contents in Ephedra sinica cultivated in Japan and elucidated the controlling factors for the variation. In 2018, alkaloids and …

  11. 01-06-2022 | Alkaloids | ReviewPaper

    Effects of ayahuasca and its alkaloids on substance use disorders: an updated (2016–2020) systematic review of preclinical and human studies

    Ayahuasca is a hallucinogenic/psychedelic traditionally used for ritual and therapeutic purposes. One such therapeutic use is related to Substance Use Disorders (SUDs). A previous systematic review of preclinical and human studies published until …

  12. 01-12-2021 | Alkaloids

    Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment

    Malignant tumor has become one of the major diseases that seriously endangers human health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely associated with patient prognosis. Tumor growth and progression are …

  13. Open Access 01-12-2021 | Colchicine | OriginalPaper

    Effects of Stephania hainanensis alkaloids on MSU-induced acute gouty arthritis in mice

    Gout is an inherited disorder of purine metabolism that causes hyperuricemia and inflammatory arthritis, and it is very common worldwide [ 1 ]. Gouty patients usually suffer from unbearable pain and joint swelling, which seriously affect the normal …

  14. Open Access 01-12-2022 | Colchicine | ReviewPaper

    Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

    Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect …

  15. Open Access 01-12-2021 | Alkaloids | OriginalPaper

    Corydalis saxicola Bunting total alkaloids attenuate paclitaxel-induced peripheral neuropathy through PKCε/p38 MAPK/TRPV1 signaling pathway

    Paclitaxel, extracted from Taxus brevifolia Nutt., is widely used to treat solid tumors, such as breast cancer, lung cancer, ovarian cancer [ 1 ]. It exerts anticancer effects by increasing the stability of tubulin polymer and inhibiting the …

  16. Open Access 01-12-2021 | Alkaloids | ReviewPaper

    Flavonoids, alkaloids and saponins: are these plant-derived compounds an alternative to the treatment of rheumatoid arthritis? A literature review

    Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by synovial inflammation leading to progressive joint erosion and, eventually, joint deformities. RA treatment includes anti-inflammatories, corticosteroids, synthetic …

  17. Open Access 01-09-2021 | Alkaloids | OriginalPaper

    Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish

    Alkaloids are a structurally complex group of natural products that have a diverse range of biological activities and significant therapeutic applications. In this study, we examined the acute, anxiolytic-like effects of nicotinic acetylcholine …

  18. 25-05-2022 | Alkaloids | OriginalPaper

    Bioactivity inspired C19-diterpenoid alkaloids for overcoming multidrug-resistant cancer

    The pharmacological activities of C19-diterpenoid alkaloids are related to their basic skeletons (e.g., aconitine-type or lycoctonine-type). Also, few studies have been reported on the chemosensitizing effects of diterpenoid alkaloids.

  19. 01-12-2020 | Pharmacokinetics

    Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug–drug interactions

    Herbal medicines are gaining popularity for the treatment of chronic and complex diseases as it works by hitting multiple molecular targets to modulate different signaling pathways [ 1 – 3 ]. Major advances have been made regarding their activities …

  20. 01-07-2020 | Alkaloids | OriginalPaper

    Identification of five mitragyna alkaloids in blood and tissues using liquid chromatography-quadrupole/time-of-flight mass spectrometry

    Kratom ( Mitragyna speciosa ) is a psychoactive botanical substance that presents a variety of analytical challenges [ 1 ]. Mitragyna alkaloids can produce dose-dependent effects. Stimulant-like effects predominate at a low dose, while higher …

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