Issue 1/2011
Content (161 Articles)
Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6
Beate Fuchs, Markus Rupp, Hossein A Ghofrani, Ralph T Schermuly, Werner Seeger, Friedrich Grimminger, Thomas Gudermann, Alexander Dietrich, Norbert Weissmann
Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats
Lunyin Yu, Charles A Hales
β-thymosins and interstitial lung disease: study of a scleroderma cohort with a one-year follow-up
Maria De Santis, Rosanna Inzitari, Silvia L Bosello, Giusy Peluso, Chiara Fanali, Federica Iavarone, Gaetano Zizzo, Mario Bocci, Tiziana Cabras, Irene Messana, Leo Fuso, Francesco Varone, Gabriella Pagliari, Massimo Castagnola, Gianfranco Ferraccioli
Mometasone and desloratadine additive effect on eosinophil survival and cytokine secretion from epithelial cells
Joaquim Mullol, Francisco de Borja Callejas, Maria Asunción Martínez-Antón, Eva Méndez-Arancibia, Isam Alobid, Laura Pujols, Antonio Valero, Cesar Picado, Jordi Roca-Ferrer
Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension
Marie Billaud, Diana Dahan, Roger Marthan, Jean-Pierre Savineau, Christelle Guibert
KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome
Tomohiro Kondo, Noboru Hattori, Nobuhisa Ishikawa, Hiroshi Murai, Yoshinori Haruta, Nobuyuki Hirohashi, Koichi Tanigawa, Nobuoki Kohno
Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD
Lisette IZ Kunz, Thérèse S Lapperre, Jiska B Snoeck-Stroband, Simona E Budulac, Wim Timens, Simone van Wijngaarden, Jasmijn A Schrumpf, Klaus F Rabe, Dirkje S Postma, Peter J Sterk, Pieter S Hiemstra
Matrix metalloproteinase-9 predicts pulmonary status declines in α1-antitrypsin deficiency
Theodore A Omachi, Mark D Eisner, Alexis Rames, Lada Markovtsova, Paul D Blanc
Disaturated-phosphatidylcholine and Surfactant protein-B turnover in human acute lung injury and in control patients
Manuela Simonato, Aldo Baritussio, Carlo Ori, Luca Vedovelli, Sandra Rossi, Lorenza Dalla Massara, Sabina Rizzi, Virgilio P Carnielli, Paola E Cogo
Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study
Massimo Miniati, Simonetta Monti, Giuseppina Basta, Franca Cocci, Edo Fornai, Matteo Bottai
Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps
Eric D Bateman, Tim W Harrison, Santiago Quirce, Helen K Reddel, Roland Buhl, Marc Humbert, Christine R Jenkins, Stefan Peterson, Ollie Östlund, Paul M O'Byrne, Malcolm R Sears, Göran S Eriksson
Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation
Jake K Nikota, Fernando M Botelho, Carla MT Bauer, Manel Jordana, Anthony J Coyle, Alison A Humbles, Martin R Stampfli
Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis
Rosanna Di Paola, Elena Talero, Maria Galuppo, Emanuela Mazzon, Placido Bramanti, Virginia Motilva, Salvatore Cuzzocrea
Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells
Yumiko Ishikawa, Kazuyuki Kobayashi, Masatsugu Yamamoto, Kyosuke Nakata, Tetsuya Takagawa, Yasuhiro Funada, Yoshikazu Kotani, Hajime Karasuyama, Masaru Yoshida, Yoshihiro Nishimura
CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease
Ying Chang, Jessica Nadigel, Nicholas Boulais, Jean Bourbeau, François Maltais, David H Eidelman, Qutayba Hamid
Differentiated transplant derived airway epithelial cell cytokine secretion is not regulated by cyclosporine
Timothy Floreth, Eric Stern, Yingli Tu, Randi Stern, Edward R Garrity Jr, Sangeeta M Bhorade, Steven R White
Tenascin-C and alpha-smooth muscle actin positive cells are increased in the large airways in patients with COPD
Magnus Löfdahl, Riitta Kaarteenaho, Elisa Lappi-Blanco, Göran Tornling, Magnus C Sköld
Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review
Marie Westwood, Jean Bourbeau, Paul W Jones, Annamaria Cerulli, Gorana Capkun-Niggli, Gill Worthy
Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: a review
Dongmei Wu, Dongwon Lee, Yong Kiel Sung
High blood pressure, antihypertensive medication and lung function in a general adult population
Eva Schnabel, Stefan Karrasch, Holger Schulz, Sven Gläser, Christa Meisinger, Margit Heier, Annette Peters, H-Erich Wichmann, Jürgen Behr, Rudolf M Huber, Joachim Heinrich
Peripheral endothelial dysfunction is associated with gas exchange inefficiency in smokers
Sven Gläser, Anne Obst, Christian F Opitz, Marcus Dörr, Stephan B Felix, Klaus Empen, Henry Völzke, Ralf Ewert, Christoph Schäper, Beate Koch
Pro-inflammatory endothelial cell dysfunction is associated with intersectin-1s down-regulation
Sunit Singla, Dan Predescu, Cristina Bardita, Minhua Wang, Jian Zhang, Robert A Balk, Sanda Predescu
A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression
ZhenHua Ni, JiHong Tang, ZhuYing Cai, Wei Yang, Lei Zhang, Qingge Chen, Long Zhang, XiongBiao Wang
Prevention of bronchial hyperreactivity in a rat model of precapillary pulmonary hypertension
Walid Habre, Gergely Albu, Tibor Z Janosi, Fabienne Fontao, Britta S von Ungern-Sternberg, Maurice Beghetti, Ferenc Petak
Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells
Dae Yong Kim, Eun Young Kwon, Gwan Ui Hong, Yun Song Lee, Seung-Hyo Lee, Jai Youl Ro
Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease
Paul W Jones, Stephen I Rennard, Alvar Agusti, Pascal Chanez, Helgo Magnussen, Leonardo Fabbri, James F Donohue, Eric D Bateman, Nicholas J Gross, Rosa Lamarca, Cynthia Caracta, Esther Garcia Gil
Transcriptional landscape of bone marrow-derived very small embryonic-like stem cells during hypoxia
Sina A Gharib, Abdelnaby Khalyfa, Magdalena J Kucia, Ehab A Dayyat, Jinkwan Kim, Heather B Clair, David Gozal
Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches
Didier Renard, Michael Looby, Benjamin Kramer, David Lawrence, David Morris, Donald R Stanski
Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats
Bhola K Dahal, Djuro Kosanovic, Christina Kaulen, Teodora Cornitescu, Rajkumar Savai, Julia Hoffmann, Irwin Reiss, Hossein A Ghofrani, Norbert Weissmann, Wolfgang M Kuebler, Werner Seeger, Friedrich Grimminger, Ralph T Schermuly
Decreased respiratory system compliance on the sixth day of mechanical ventilation is a predictor of death in patients with established acute lung injury
Eric J Seeley, Daniel F McAuley, Mark Eisner, Michael Miletin, HanJing Zhuo, Michael A Matthay, Richard H Kallet
Genome-wide analysis of the mouse lung transcriptome reveals novel molecular gene interaction networks and cell-specific expression signatures
Rudi Alberts, Lu Lu, Robert W Williams, Klaus Schughart
Pulmonary arterial dysfunction in insulin resistant obese Zucker rats
Javier Moral-Sanz, Carmen Menendez, Laura Moreno, Enrique Moreno, Angel Cogolludo, Francisco Perez-Vizcaino
Ingraft chimerism in lung transplantation - a study in a porcine model of obliterative bronchiolitis
Outi E Päiväniemi, Petra Musilova, Peter M Raivio, Paula K Maasilta, Hanni S Alho, Jiri Rubes, Kristiina Aittomäki, Ulla-Stina Salminen
Genetic variation in TIMP1 but not MMPs predict excess FEV1 decline in two general population-based cohorts
CC van Diemen, DS Postma, M Siedlinski, A Blokstra, HA Smit, HM Boezen
IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides
Suzanne Zuyderduyn, Dennis K Ninaber, Jasmijn A Schrumpf, Marianne AJA van Sterkenburg, Renate M Verhoosel, Frans A Prins, Sandra van Wetering, Klaus F Rabe, Pieter S Hiemstra
GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells
Nils Nickel, Danny Jonigk, Tibor Kempf, Clemens L Bockmeyer, Lavinia Maegel, Johanna Rische, Florian Laenger, Ulrich Lehmann, Clemens Sauer, Mark Greer, Tobias Welte, Marius M Hoeper, Heiko A Golpon
Effect of recombinant IL-10 on cultured fetal rat alveolar type II cells exposed to 65%-hyperoxia
Hyeon-Soo Lee, Chun-Ki Kim
Is sirolimus a therapeutic option for patients with progressive pulmonary lymphangioleiomyomatosis?
Claus Neurohr, Anna L Hoffmann, Patrick Huppmann, Vivian A Herrera, Franziska Ihle, Stefan Leuschner, Werner von Wulffen, Tobias Meis, Carlos Baezner, Hanno Leuchte, Rainer Baumgartner, Gregor Zimmermann, Juergen Behr
Health status in the TORCH study of COPD: treatment efficacy and other determinants of change
Paul W Jones, Julie A Anderson, Peter MA Calverley, Bartolome R Celli, Gary T Ferguson, Christine Jenkins, Julie C Yates, Jørgen Vestbo, Michael D Spencer
Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury
Fang Zhou, Shigemitsu Onizawa, Atsushi Nagai, Kazutetsu Aoshiba
AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice
Sébastien Hulo, Hélène Tiesset, Steve Lancel, Jean J Louis Edmé, Benoit Viollet, Annie Sobaszek, Rémi Nevière
Exhaled breath condensate pH as a biomarker of COPD severity in ex-smokers
Andriana I Papaioannou, Stelios Loukides, Markos Minas, Konstantina Kontogianni, Petros Bakakos, Konstantinos I Gourgoulianis, Manos Alchanatis, Spyros Papiris, Konstantinos Kostikas
CD39+Regulatory T cells suppress generation and differentiation of Th17 cells in human malignant pleural effusion via a LAP-dependent mechanism
Zhi-Jian Ye, Qiong Zhou, Jian-Chu Zhang, Xiao Li, Cong Wu, Shou-Ming Qin, Jian-Bao Xin, Huan-Zhong Shi
Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus Enterotoxin B in mice
Wouter Huvenne, Ellen A Lanckacker, Olga Krysko, Ken R Bracke, Tine Demoor, Peter W Hellings, Guy G Brusselle, Guy F Joos, Claus Bachert, Tania Maes
The effect of cathepsin K deficiency on airway development and TGF-β1 degradation
Dongwei Zhang, Nelson Leung, Ekkehard Weber, Paul Saftig, Dieter Brömme
Ultrastructural changes of the intracellular surfactant pool in a rat model of lung transplantation-related events
Lars Knudsen, Hazibullah Waizy, Heinz Fehrenbach, Joachim Richter, Thorsten Wahlers, Thorsten Wittwer, Matthias Ochs
Exhaled nitric oxide and clinical phenotypes of childhood asthma
Bruno Mahut, Séverine Peyrard, Christophe Delclaux
Expansion of CD4+CD25+helper T cells without regulatory function in smoking and COPD
Ester Roos-Engstrand, Jamshid Pourazar, Annelie F Behndig, Anders Bucht, Anders Blomberg
Immunohistochemical detection and regulation of α5nicotinic acetylcholine receptor (nAChR) subunits by FoxA2 during mouse lung organogenesis
Jason L Porter, Benjamin R Bukey, Alex J Geyer, Charles P Willnauer, Paul R Reynolds
Cigarette smoke induces β2-integrin-dependent neutrophil migration across human endothelium
Saskia A Overbeek, Saskia Braber, Paul A J Henricks, Marije Kleinjan, Vera M Kamp, Niki A Georgiou, Johan Garssen, Aletta D Kraneveld, Gert Folkerts
Fibrocytes and the tissue niche in lung repair
Annika Andersson-Sjöland, Kristian Nihlberg, Leif Eriksson, Leif Bjermer, Gunilla Westergren-Thorsson
A promoter SNP rs4073T>A in the common allele of the interleukin 8 gene is associated with the development of idiopathic pulmonary fibrosis via the IL-8 protein enhancing mode
Mi-Hyun Ahn, Byung-Lae Park, Shin-Hwa Lee, Sung-Woo Park, Jong-Sook Park, Do-Jin Kim, An-Soo Jang, Jai-Soung Park, Hwa-Kyun Shin, Soo-Taek Uh, Yang-Ki Kim, Young Whan Kim, Sung Koo Han, Ki-Suck Jung, Kye Young Lee, Sung Hwan Jeong, Jeong Woong Park, Byoung Whui Choi, In Won Park, Man Pyo Chung, Hyoung Doo Shin, Jin Woo Song, Dong Soon Kim, Choon-Sik Park, Young-Soo Shim
Increase of nitrosative stress in patients with eosinophilic pneumonia
Kanako Furukawa, Hisatoshi Sugiura, Kazuto Matsunaga, Tomohiro Ichikawa, Akira Koarai, Tsunahiko Hirano, Satoru Yanagisawa, Yoshiaki Minakata, Keiichiro Akamatsu, Masae Kanda, Manabu Nishigai, Masakazu Ichinose
Diagnostic utility of C-reactive Protein combined with brain natriuretic peptide in acute pulmonary edema: a cross sectional study
Kosaku Komiya, Hiroshi Ishii, Shinji Teramoto, Osamu Takahashi, Nobuoki Eshima, Ou Yamaguchi, Noriyuki Ebi, Junji Murakami, Hidehiko Yamamoto, Jun-ichi Kadota
Physiologic and molecular consequences of endothelial Bmpr2 mutation
Susan Majka, Moira Hagen, Thomas Blackwell, Julie Harral, Jennifer A Johnson, Robert Gendron, Helene Paradis, Daniel Crona, James E Loyd, Eva Nozik-Grayck, Kurt R Stenmark, James West
Expression analysis of asthma candidate genes during human and murine lung development
Erik Melén, Alvin T Kho, Sunita Sharma, Roger Gaedigk, J Steven Leeder, Thomas J Mariani, Vincent J Carey, Scott T Weiss, Kelan G Tantisira
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension
Djuro Kosanovic, Baktybek Kojonazarov, Himal Luitel, Bhola K Dahal, Akylbek Sydykov, Teodora Cornitescu, Wiebke Janssen, Ralf P Brandes, Neil Davie, Hossein A Ghofrani, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Ralph T Schermuly
Elemental analysis of lung tissue particles and intracellular iron content of alveolar macrophages in pulmonary alveolar proteinosis
Yasuo Shimizu, Shinichi Matsuzaki, Kunio Dobashi, Noriko Yanagitani, Takahiro Satoh, Masashi Koka, Akihito Yokoyama, Takeru Ohkubo, Yasuyuki Ishii, Tomihiro Kamiya, Masatomo Mori
Low-molecular-weight heparin reduces hyperoxia-augmented ventilator-induced lung injury via serine/threonine kinase-protein kinase B
Li-Fu Li, Cheng-Ta Yang, Chung-Chi Huang, Yung-Yang Liu, Kuo-Chin Kao, Horng-Chyuan Lin
Real time analysis of β2-adrenoceptor-mediated signaling kinetics in Human Primary Airway Smooth Muscle Cells reveals both ligand and dose dependent differences
Charlotte K Billington, Ian P Hall
Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsiveness
Nancy T Mendonça, Jennifer Kenyon, Adam S LaPrad, Sohera N Syeda, George T O'Connor, Kenneth R Lutchen
Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation
Koustav Ganguly, Swapna Upadhyay, Martin Irmler, Shinji Takenaka, Katrin Pukelsheim, Johannes Beckers, Martin Hrabé De Angelis, Eckard Hamelmann, Tobias Stoeger, Holger Schulz
Influence of degree of specific allergic sensitivity on severity of rhinitis and asthma in Chinese allergic patients
Jing Li, Ying Huang, Xiaoping Lin, Deyu Zhao, Guolin Tan, Jinzhun Wu, Changqing Zhao, Jing Zhao, Michael D Spangfort, Nanshan Zhong
Weight and metabolic effects of cpap in obstructive sleep apnea patients with obesity
Jose M Garcia, Hossein Sharafkhaneh, Max Hirshkowitz, Rania Elkhatib, Amir Sharafkhaneh
In vivo imaging of the airway wall in asthma: fibered confocal fluorescence microscopy in relation to histology and lung function
Ching Yong Yick, Jan H von der Thüsen, Elisabeth H Bel, Peter J Sterk, Peter W Kunst
Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system
Meixia Gao, Anju Singh, Kristin Macri, Curt Reynolds, Vandana Singhal, Shyam Biswal, Ernst W Spannhake
The prevalence of alpha-1 antitrypsin deficiency in Ireland
Tomás P Carroll, Catherine A O'Connor, Olwen Floyd, Joseph McPartlin, Dermot P Kelleher, Geraldine O'Brien, Borislav D Dimitrov, Valerie B Morris, Clifford C Taggart, Noel G McElvaney
The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial
Hiroyuki Taniguchi, Yasuhiro Kondoh, Masahito Ebina, Arata Azuma, Takashi Ogura, Yoshio Taguchi, Moritaka Suga, Hiroki Takahashi, Koichiro Nakata, Atsuhiko Sato, Yukihiko Sugiyama, Shoji Kudoh, Toshihiro Nukiwa
Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease
Shigeo Kawase, Noboru Hattori, Nobuhisa Ishikawa, Yasushi Horimasu, Kazunori Fujitaka, Osamu Furonaka, Takeshi Isobe, Seigo Miyoshi, Hironobu Hamada, Takashi Yamane, Akihito Yokoyama, Nobuoki Kohno
Hepcidin expression in human airway epithelial cells is regulated by interferon-γ
Marie D Frazier, Lisa B Mamo, Andrew J Ghio, Jennifer L Turi
Low bone mineral density in men with chronic obstructive pulmonary disease
James M Duckers, Bronwen AJ Evans, William D Fraser, Michael D Stone, Charlotte E Bolton, Dennis J Shale
The emphysematous lung is abnormally sensitive to TRAIL-mediated apoptosis
Mathieu C Morissette, Julie Parent, Julie Milot
Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
Joel Mermis, Haihua Gu, Bing Xue, Fang Li, Ossama Tawfik, Shilpa Buch, Sonja Bartolome, Amy O'Brien-Ladner, Navneet K Dhillon
Hemodynamic and clinical onset in patients with hereditary pulmonary arterial hypertension and BMPR2 mutations
Nicole Pfarr, Justyna Szamalek-Hoegel, Christine Fischer, Katrin Hinderhofer, Christian Nagel, Nicola Ehlken, Henning Tiede, Horst Olschewski, Frank Reichenberger, Ardeschir HA Ghofrani, Werner Seeger, Ekkehard Grünig
Nasal lavage natural killer cell function is suppressed in smokers after live attenuated influenza virus
Katherine M Horvath, Margaret Herbst, Haibo Zhou, Hongtao Zhang, Terry L Noah, Ilona Jaspers
Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis
Gloria-Beatriz Machado, Albanita V de Oliveira, Alessandra M Saliba, Carolina D Mallet de Lima, José HR Suassuna, Maria-Cristina Plotkowski
Angiogenesis gene expression in murine endothelial cells during post-pneumonectomy lung growth
Miao Lin, Kenji Chamoto, Barry C Gibney, Grace S Lee, Dinee Collings-Simpson, Jan Houdek, Moritz A Konerding, Akira Tsuda, Steven J Mentzer
Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened pro-inflammatory response in the lungs of preterm lambs
Fatoumata B Sow, Jack M Gallup, Subramaniam Krishnan, Andriani C Patera, JoAnn Suzich, Mark R Ackermann
Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice
Eun Sun Kim, Yun Sil Chang, Soo Jin Choi, Jin Kyu Kim, Hey Soo Yoo, So Yoon Ahn, Dong Kyung Sung, Soo Yoon Kim, Ye Rim Park, Won Soon Park
Endothelial-like cells in chronic thromboembolic pulmonary hypertension: crosstalk with myofibroblast-like cells
Seiichiro Sakao, Hiroyuki Hao, Nobuhiro Tanabe, Yasunori Kasahara, Katsushi Kurosu, Koichiro Tatsumi
Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts
Dedmer Schaafsma, Karol D McNeill, Mark M Mutawe, Saeid Ghavami, Helmut Unruh, Eric Jacques, Michel Laviolette, Jamila Chakir, Andrew J Halayko
Interactions between HIV infection and chronic obstructive pulmonary disease: Clinical and epidemiological aspects
Christine Raynaud, Nicolas Roche, Christos Chouaid
Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury
Lian Willetts, Kimberly Parker, Lewis J Wesselius, Cheryl A Protheroe, Elizabeth Jaben, P Graziano, Redwan Moqbel, Kevin O Leslie, Nancy A Lee, James J Lee
Treatment of allergic asthma: Modulation of Th2 cells and their responses
Berislav Bosnjak, Barbara Stelzmueller, Klaus J Erb, Michelle M Epstein
Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect
Donatella Peca, Stefania Petrini, Chryssoula Tzialla, Renata Boldrini, Francesco Morini, Mauro Stronati, Virgilio P Carnielli, Paola E Cogo, Olivier Danhaive
High frequency chest wall oscillation for asthma and chronic obstructive pulmonary disease exacerbations: a randomized sham-controlled clinical trial
Amit K Mahajan, Gregory B Diette, Umur Hatipoğlu, Andrew Bilderback, Alana Ridge, Vanessa Walker Harris, Vijay Dalapathi, Sameer Badlani, Stephanie Lewis, Jeff T Charbeneau, Edward T Naureckas, Jerry A Krishnan
Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with post-bronchiolitis wheeze
Annemieke Schuurhof, Riny Janssen, Hanneke de Groot, Hennie M Hodemaekers, Arja de Klerk, Jan LL Kimpen, Louis Bont
Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD
Irene H Heijink, Simone M Brandenburg, Jacobien A Noordhoek, Dirk-Jan Slebos, Dirkje S Postma, Antoon J van Oosterhout
Two-year home-based nocturnal noninvasive ventilation added to rehabilitation in chronic obstructive pulmonary disease patients: A randomized controlled trial
Marieke L Duiverman, Johan B Wempe, Gerrie Bladder, Judith M Vonk, Jan G Zijlstra, Huib AM Kerstjens, Peter J Wijkstra
Mucin granule-associated proteins in human bronchial epithelial cells: the airway goblet cell "granulome"
Kimberly L Raiford, Joungjoa Park, Ko-Wei Lin, Shijing Fang, Anne L Crews, Kenneth B Adler
Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation
Ian P Lewkowich, Scottie B Day, John R Ledford, Ping Zhou, Krista Dienger, Marsha Wills-Karp, Kristen Page
Withdrawal of inhaled corticosteroids in individuals with COPD - a systematic review and comment on trial methodology
Nighat J Nadeem, Stephanie JC Taylor, Sandra M Eldridge
TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways
Frederic Perros, Bart N Lambrecht, Hamida Hammad
Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
Peter Dorfmüller, Marie-Camille Chaumais, Maria Giannakouli, Ingrid Durand-Gasselin, Nicolas Raymond, Elie Fadel, Olaf Mercier, Frédéric Charlotte, David Montani, Gérald Simonneau, Marc Humbert, Frédéric Perros
Adverse health consequences in COPD patients with rapid decline in FEV1 - evidence from the UPLIFT trial
Steven Kesten, Bartolome Celli, Marc Decramer, Dacheng Liu, Donald Tashkin
Profibrotic potential of Prominin-1+epithelial progenitor cells in pulmonary fibrosis
Przemyslaw Blyszczuk, Davide Germano, Sokrates Stein, Holger Moch, Christian M Matter, Beatrice Beck-Schimmer, Thomas F Lüscher, Urs Eriksson, Gabriela Kania
Krüppel-like Factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension
Audrey Courboulin, Véronique L Tremblay, Marjorie Barrier, Jolyane Meloche, Maria Helena Jacob, Mathilde Chapolard, Malik Bisserier, Roxane Paulin, Caroline Lambert, Steeve Provencher, Sébastien Bonnet
High resolution CT and histological findings in idiopathic pleuroparenchymal fibroelastosis: Features and differential diagnosis
Sara Piciucchi, Sara Tomassetti, Gianluca Casoni, Nicola Sverzellati, Angelo Carloni, Alessandra Dubini, Giampaolo Gavelli, Alberto Cavazza, Marco Chilosi, Venerino Poletti
Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease
Sukhwinder S Sohal, David Reid, Amir Soltani, Chris Ward, Steven Weston, H Konrad Muller, Richard Wood-Baker, E Haydn Walters
Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin
Keita Yamauchi, Yoshitoshi Kasuya, Fuminobu Kuroda, Kensuke Tanaka, Junichi Tsuyusaki, Shunsuke Ishizaki, Hirofumi Matsunaga, Chiaki Iwamura, Toshinori Nakayama, Koichiro Tatsumi
Attenuation of antigen-induced airway hyperresponsiveness and inflammation in CXCR3 knockout mice
Yi Lin, Haibo Yan, Yu Xiao, Hongmei Piao, Ruolan Xiang, Lei Jiang, Huaxia Chen, Kewu Huang, Zijian Guo, Wexun Zhou, Bao Lu, Jinming Gao
Conditional deletion of epithelial IKKβ impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis
Vedang A Londhe, Tiffany M Maisonet, Benjamin Lopez, Jade-Ming Jeng, Jing Xiao, Changgong Li, Parviz Minoo
Pre- and post-bronchodilator lung function as predictors of mortality in the Lung Health Study
David M Mannino, Enrique Diaz-Guzman, Sonia Buist
Airflow limitation or static hyperinflation: which is more closely related to dyspnea with activities of daily living in patients with COPD?
Koichi Nishimura, Maya Yasui, Takashi Nishimura, Toru Oga
The clinical features of the overlap between COPD and asthma
Megan Hardin, Edwin K Silverman, R Graham Barr, Nadia N Hansel, Joyce D Schroeder, Barry J Make, James D Crapo, Craig P Hersh
Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment
Serena E O'Neil, Brigita Sitkauskiene, Agne Babusyte, Algirda Krisiukeniene, Kristina Stravinskaite-Bieksiene, Raimundas Sakalauskas, Carina Sihlbom, Linda Ekerljung, Elisabet Carlsohn, Jan Lötvall
Activated MCTC mast cells infiltrate diseased lung areas in cystic fibrosis and idiopathic pulmonary fibrosis
Cecilia K Andersson, Annika Andersson-Sjöland, Michiko Mori, Oskar Hallgren, Annie Pardo, Leif Eriksson, Leif Bjermer, Claes-Göran Löfdahl, Moises Selman, Gunilla Westergren-Thorsson, Jonas S Erjefält
VIP and endothelin receptor antagonist: An effective combination against experimental pulmonary arterial hypertension
Sayyed A Hamidi, Richard Z Lin, Anthony M Szema, Sergey Lyubsky, Ya Ping Jiang, Sami I Said
Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells
Omar F Ali, Ellena J Growcott, Ghazwan S Butrous, John Wharton
Lung glutathione adaptive responses to cigarette smoke exposure
Neal S Gould, Elysia Min, Steve Gauthier, Richard J Martin, Brian J Day
IFN-γ-inducible protein of 10 kDa upregulates the effector functions of eosinophils through β2integrin and CXCR3
Yotaro Takaku, Kazuyuki Nakagome, Takehito Kobayashi, Koichi Hagiwara, Minoru Kanazawa, Makoto Nagata
Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment
Arata Azuma, Yoshio Taguchi, Takashi Ogura, Masahito Ebina, Hiroyuki Taniguchi, Yasuhiro Kondoh, Moritaka Suga, Hiroki Takahashi, Koichiro Nakata, Atsuhiko Sato, Shoji Kudoh, Toshihiro Nukiwa
Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial
Ashley Woodcock, Eric D Bateman, William W Busse, Jan Lötvall, Neil G Snowise, Richard Forth, Loretta Jacques, Brett Haumann, Eugene R Bleecker
Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
Gail M Gauvreau, Louis-Philippe Boulet, Christine Schmid-Wirlitsch, Johanne Côté, MyLinh Duong, Kieran J Killian, Joanne Milot, Francine Deschesnes, Tara Strinich, Richard M Watson, Dirk Bredenbröker, Paul M O'Byrne
Exogenous interleukin-6, interleukin-13, and interferon-gamma provoke pulmonary abnormality with mild edema in enterovirus 71-infected mice
Szu-Wei Huang, Yi-Ping Lee, Yu-Ting Hung, Chun-Hung Lin, Jih-Ing Chuang, Huan-Yao Lei, Ih-Jen Su, Chun-Keung Yu
Dynamic hyperinflation is associated with a poor cardiovascular response to exercise in COPD patients
Panagiota Tzani, Marina Aiello, Davide Elia, Luca Boracchia, Emilio Marangio, Dario Olivieri, Enrico Clini, Alfredo Chetta
Epilysin (matrix metalloproteinase-28) contributes to airway epithelial cell survival
Anne M Manicone, Susanna Harju-Baker, Laura K Johnston, Ann J Chen, William C Parks
Multidimensional prognostic indices for use in COPD patient care. A systematic review
Wouter D van Dijk, Lisette van den Bemt, Saskia van den Haak-Rongen, Erik Bischoff, Chris van Weel, Johannes CCM in 't Veen, Tjard RJ Schermer
Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma
Umesh CS Yadav, Leopoldo Aguilera-Aguirre, Istvan Boldogh, Kota V Ramana, Satish K Srivastava
E pluribus plurima: Multidimensional indices and clinical phenotypes in COPD
Andrea Rossi, Erika Zanardi
Relationship between the anti-inflammatory properties of salmeterol/fluticasone and the expression of CD4+CD25+Foxp3+regulatory T cells in COPD
Li Yang, Qian-li Ma, Wei Yao, Qiao Zhang, Hua-ping Chen, Guan-song Wang, Chang-zheng Wang
COPD association and repeatability of blood biomarkers in the ECLIPSE cohort
Jennifer A Dickens, Bruce E Miller, Lisa D Edwards, Edwin K Silverman, David A Lomas, Ruth Tal-Singer
Acute intratracheal Pseudomonas aeruginosa infection in cystic fibrosis mice is age-independent
Antje Munder, Florian Wölbeling, Tanja Kerber-Momot, Dirk Wedekind, Ulrich Baumann, Erich Gulbins, Burkhard Tümmler
Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8+T cells in chronic obstructive pulmonary disease
Jessica Nadigel, David Préfontaine, Carolyn J Baglole, François Maltais, Jean Bourbeau, David H Eidelman, Qutayba Hamid
Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts
Dongwei Zhang, Chuangfang Huang, Changfu Yang, Renzuo J Liu, Jifeng Wang, Jianzhao Niu, Dieter Brömme
Disturbance of the OPG/RANK/RANKL pathway and systemic inflammation in COPD patients with emphysema and osteoporosis
Peng Bai, Yongchang Sun, Jianmin Jin, Jia Hou, Ran Li, Qing Zhang, Yang Wang
Efficacy and safety of once-daily NVA237 in patients with moderate-to-severe COPD: the GLOW1 trial
Anthony D'Urzo, Gary T Ferguson, Jan A van Noord, Kazuto Hirata, Carmen Martin, Rachael Horton, Yimeng Lu, Donald Banerji, Tim Overend
Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females
Yvonne Dempsie, Margaret Nilsen, Kevin White, Kirsty M Mair, Lynn Loughlin, Noona Ambartsumian, Marlene Rabinovitch, Margaret R MacLean
Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma
Ashley Woodcock, Eugene R Bleecker, William W Busse, Jan Lötvall, Neil G Snowise, Lucy Frith, Loretta Jacques, Brett Haumann, Eric D Bateman
Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis
Jing Zhang, Hanssa Summah, Ying-gang Zhu, Jie-Ming Qu
Aerosolized adenovirus-vectored vaccine as an alternative vaccine delivery method
Chad J Roy, Alida Ault, Satheesh K Sivasubramani, J Patrick Gorres, Chih-Jen Wei, Hanne Andersen, Jason Gall, Mario Roederer, Srinivas S Rao
Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostaglandin E2
Megan N Ballinger, Marc Peters-Golden, Bethany B Moore
Correlating changes in lung function with patient outcomes in chronic obstructive pulmonary disease: a pooled analysis
Paul W Jones, James F Donohue, Jerry Nedelman, Steve Pascoe, Gregory Pinault, Cheryl Lassen
Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study
Taehoon Lee, Yoon Su Lee, Yun-Jeong Bae, Tae-Bum Kim, Seon Ok Kim, Sang-Heon Cho, Hee-Bom Moon, You Sook Cho
Attenuated expression of tenascin-c in ovalbumin-challenged STAT4-/- mice
Anna Meuronen, Piia Karisola, Marina Leino, Terhi Savinko, Kristiina Sirola, Marja-Leena Majuri, Päivi Piirilä, Ismo Virtanen, Mika Mäkelä, Annika Laitinen, Lauri A Laitinen, Harri Alenius
Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD
Khaled Al-shair, Umme Kolsum, Rachel Dockry, Julie Morris, Dave Singh, Jørgen Vestbo
Some ABCA3 mutations elevate ER stress and initiate apoptosis of lung epithelial cells
Nina Weichert, Eva Kaltenborn, Andreas Hector, Markus Woischnik, Andrea Schams, Andreas Holzinger, Sunčana Kern, Matthias Griese
Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis
Laura L Jones, Ahmed Hashim, Tricia McKeever, Derek G Cook, John Britton, Jo Leonardi-Bee
Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial
Nicola A Hanania, Amir Sharafkhaneh, Bartolome Celli, Marc Decramer, Ted Lystig, Steven Kesten, Donald Tashkin
Determinants of elevated healthcare utilization in patients with COPD
Tzahit Simon-Tuval, Steven M Scharf, Nimrod Maimon, Barbara J Bernhard-Scharf, Haim Reuveni, Ariel Tarasiuk
A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screening
Steven S An, Peter S Askovich, Thomas I Zarembinski, Kwangmi Ahn, John M Peltier, Moritz von Rechenberg, Sudhir Sahasrabudhe, Jeffrey J Fredberg
Epidemiology, radiology, and genetics of nicotine dependence in COPD
Deog Kyeom Kim, Craig P Hersh, George R Washko, John E Hokanson, David A Lynch, John D Newell, James R Murphy, James D Crapo, Edwin K Silverman
Analysing the eosinophil cationic protein - a clue to the function of the eosinophil granulocyte
Jonas Bystrom, Kawa Amin, David Bishop-Bailey
Airway inflammation and mannitol challenge test in COPD
Selma B de Nijs, Niki Fens, Rene Lutter, Erica Dijkers, Frans H Krouwels, Barbara S Smids-Dierdorp, Reindert P van Steenwijk, Peter J Sterk
Overexpression of sICAM-1 in the Alveolar Epithelial Space Results in an Exaggerated Inflammatory Response and Early Death in Gram Negative Pneumonia
Michael P Mendez, Yeni K Monroy, Ming Du, Angela M Preston, Leslie Tolle, Yujing Lin, Kelli L VanDussen, Linda C Samuelson, Theodore J Standiford, Jeffery L Curtis, James M Beck, Paul J Christensen, Robert Paine III
Lack of cathepsin activities alter or prevent the development of lung granulomas in a mouse model of sarcoidosis
Andriy O Samokhin, Jacques Yves Gauthier, M David Percival, Dieter Brömme
Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2/3 and increasing MYL-9 expression
Wujian Xu, Weijun Hong, Yan Shao, Yunye Ning, Zailong Cai, Qiang Li
Phenotypic characteristics of human type II alveolar epithelial cells suitable for antigen presentation to T lymphocytes
Véronique Corbière, Violette Dirix, Sarah Norrenberg, Mattéo Cappello, Myriam Remmelink, Françoise Mascart
Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study
Riccardo Polosa, Cristina Russo, Pasquale Caponnetto, Gaetano Bertino, Maria Sarvà, Tjana Antic, Stefania Mancuso, Wael K Al-Delaimy
Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung
Michelle Sands, Katherine Howell, Christine M Costello, Paul McLoughlin
Reduction of exacerbations by the PDE4 inhibitor roflumilast - the importance of defining different subsets of patients with COPD
Stephen I Rennard, Peter MA Calverley, Udo M Goehring, Dirk Bredenbröker, Fernando J Martinez
Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma
Michelle L North, Hajera Amatullah, Nivedita Khanna, Bruce Urch, Hartmut Grasemann, Frances Silverman, Jeremy A Scott
Inhibition of granulocyte migration by tiotropium bromide
Gabriela Vacca, Winfried J Randerath, Adrian Gillissen
Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4
Karine Botturi, Yannick Lacoeuille, Arnaud Cavaillès, Daniel Vervloet, Antoine Magnan
Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model
Yun Wang, Lei Jing, Xiao-Min Zhao, Ji-Ju Han, Zuo-Li Xia, Shu-Cun Qin, Ya-Ping Wu, Xue-Jun Sun
Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of β-receptor affinity in murine models of asthma
Lennart KA Lundblad, Lisa M Rinaldi, Matthew E Poynter, Erik P Riesenfeld, Min Wu, Steven Aimi, Leesa M Barone, Jason HT Bates, Charles G Irvin
The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis
Xiang Lu, Nan Wang, Xiao-Bo Long, Xue-Jun You, Yong-Hua Cui, Zheng Liu
Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
Carla Winkler, Elena N Atochina-Vasserman, Olaf Holz, Michael F Beers, Veit J Erpenbeck, Norbert Krug, Stefan Roepcke, Gereon Lauer, Martin Elmlinger, Jens M Hohlfeld
The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer
Christian Herr, Timm Greulich, Rembert A Koczulla, Silke Meyer, Tetyana Zakharkina, Meret Branscheidt, Rebecca Eschmann, Robert Bals
Level of daily physical activity in individuals with COPD compared with healthy controls
Sigrid NW Vorrink, Helianthe SM Kort, Thierry Troosters, Jan-Willem J Lammers