Issue 1/2016
Content (216 Articles)
Cancer and fertility preservation: international recommendations from an expert meeting
Matteo Lambertini, Lucia Del Mastro, Maria C. Pescio, Claus Y. Andersen, Hatem A. Azim Jr., Fedro A. Peccatori, Mauro Costa, Alberto Revelli, Francesca Salvagno, Alessandra Gennari, Filippo M. Ubaldi, Giovanni B. La Sala, Cristofaro De Stefano, W. Hamish Wallace, Ann H. Partridge, Paola Anserini
Infection prevention and control of the Ebola outbreak in Liberia, 2014–2015: key challenges and successes
Catherine Cooper, Dale Fisher, Neil Gupta, Rose MaCauley, Carmem L. Pessoa-Silva
Ethnic variations in asthma hospital admission, readmission and death: a retrospective, national cohort study of 4.62 million people in Scotland
Aziz Sheikh, Markus F. C. Steiner, Genevieve Cezard, Narinder Bansal, Colin Fischbacher, Colin R. Simpson, Anne Douglas, Raj Bhopal
Is statin-modified reduction in lipids the most important preventive therapy for cardiovascular disease? A pro/con debate
FD Richard Hobbs, Maciej Banach, Dimitri P. Mikhailidis, Aseem Malhotra, Simon Capewell
The need for pragmatic clinical trials in low and middle income settings – taking essential neonatal interventions delivered as part of inpatient care as an illustrative example
Mike English, Jamlick Karumbi, Michuki Maina, Jalemba Aluvaala, Archna Gupta, Merrick Zwarenstein, Newton Opiyo
Predicting dementia risk in primary care: development and validation of the Dementia Risk Score using routinely collected data
K. Walters, S. Hardoon, I. Petersen, S. Iliffe, R. Z. Omar, I. Nazareth, G. Rait
Public availability of results of observational studies evaluating an intervention registered at ClinicalTrials.gov
Marie Baudart, Philippe Ravaud, Gabriel Baron, Agnes Dechartres, Romana Haneef, Isabelle Boutron
Wasted research when systematic reviews fail to provide a complete and up-to-date evidence synthesis: the example of lung cancer
Perrine Créquit, Ludovic Trinquart, Amélie Yavchitz, Philippe Ravaud
Cognitive remission: a novel objective for the treatment of major depression?
Beatrice Bortolato, Kamilla W. Miskowiak, Cristiano A. Köhler, Michael Maes, Brisa S. Fernandes, Michael Berk, André F. Carvalho
Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature
Igho J. Onakpoya, Carl J. Heneghan, Jeffrey K. Aronson
Long- versus short-interval follow-up of cytologically benign thyroid nodules: a prospective cohort study
Marco Medici, Xiaoyun Liu, Norra Kwong, Trevor E. Angell, Ellen Marqusee, Matthew I. Kim, Erik K. Alexander
Clinical utility of RAS mutations in thyroid cancer: a blurred picture now emerging clearer
Mingzhao Xing
Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study
Tilman Kühn, Anna Floegel, Disorn Sookthai, Theron Johnson, Ulrike Rolle-Kampczyk, Wolfgang Otto, Martin von Bergen, Heiner Boeing, Rudolf Kaaks
Heterogeneous dynamics, robustness/fragility trade-offs, and the eradication of the macroparasitic disease, lymphatic filariasis
Edwin Michael, Brajendra K. Singh
Annual acknowledgement of BMC Medicine manuscript reviewers
Sabina Alam
A scoping review of competencies for scientific editors of biomedical journals
James Galipeau, Virginia Barbour, Patricia Baskin, Sally Bell-Syer, Kelly Cobey, Miranda Cumpston, Jon Deeks, Paul Garner, Harriet MacLehose, Larissa Shamseer, Sharon Straus, Peter Tugwell, Elizabeth Wager, Margaret Winker, David Moher
Going “social” to access experimental and potentially life-saving treatment: an assessment of the policy and online patient advocacy environment for expanded access
Tim K. Mackey, Virginia J. Schoenfeld
Treatment of idiopathic pulmonary fibrosis: a network meta-analysis
Bram Rochwerg, Binod Neupane, Yuan Zhang, Carlos Cuello Garcia, Ganesh Raghu, Luca Richeldi, Jan Brozek, Joseph Beyene, Holger Schünemann
Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials
Patrick P. J. Phillips, Carl M. Mendel, Divan A. Burger, Angela M. Crook, Andrew J. Nunn, Rodney Dawson, Andreas H. Diacon, Stephen H. Gillespie
Advances in immunotherapy for melanoma
Jason M. Redman, Geoffrey T. Gibney, Michael B. Atkins
Interpreting whole genome sequencing for investigating tuberculosis transmission: a systematic review
Hollie-Ann Hatherell, Caroline Colijn, Helen R. Stagg, Charlotte Jackson, Joanne R. Winter, Ibrahim Abubakar
Idiopathic pulmonary fibrosis – clinical management guided by the evidence-based GRADE approach: what arguments can be made against transparency in guideline development?
Bram Rochwerg, Holger J. Schünemann, Ganesh Raghu
Guidelines or guidance for better idiopathic pulmonary fibrosis management?
Jürgen Behr
Successful external validation of a model to predict other cause mortality in localized prostate cancer
Matthew Kent, David F. Penson, Peter C. Albertsen, Michael Goodman, Ann S. Hamilton, Janet L. Stanford, Antoinette M. Stroup, Behfar Ehdaie, Peter T. Scardino, Andrew J. Vickers
HbA1c levels in non-diabetic older adults – No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies
Ben Schöttker, W. Rathmann, C. Herder, B. Thorand, T. Wilsgaard, I. Njølstad, G. Siganos, E. B. Mathiesen, K. U. Saum, A. Peasey, E. Feskens, P. Boffetta, A. Trichopoulou, K. Kuulasmaa, F. Kee, H. Brenner
Policing of gut microbiota by the adaptive immune system
Laurent Dollé, Hao Q. Tran, Lucie Etienne-Mesmin, Benoit Chassaing
Drug safety: withdrawn medications are only part of the picture
Nigel S. B. Rawson
How to review a surgical paper: a guide for junior referees
Philip F. Stahel, Ernest E. Moore
Rationing tests for drug-resistant tuberculosis – who are we prepared to miss?
Laura J. Martin, Martha H. Roper, Louis Grandjean, Robert H. Gilman, Jorge Coronel, Luz Caviedes, Jon S. Friedland, David A. J. Moore
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
Jody Phelan, Francesc Coll, Ruth McNerney, David B. Ascher, Douglas E. V. Pires, Nick Furnham, Nele Coeck, Grant A. Hill-Cawthorne, Mridul B. Nair, Kim Mallard, Andrew Ramsay, Susana Campino, Martin L. Hibberd, Arnab Pain, Leen Rigouts, Taane G. Clark
Quantifying the economic impact of government and charity funding of medical research on private research and development funding in the United Kingdom
Jon Sussex, Yan Feng, Jorge Mestre-Ferrandiz, Michele Pistollato, Marco Hafner, Peter Burridge, Jonathan Grant
Scandinavian guidelines for initial management of minor and moderate head trauma in children
Ramona Astrand, Christina Rosenlund, Johan Undén
Cost and quality of life analysis of HIV self-testing and facility-based HIV testing and counselling in Blantyre, Malawi
Hendramoorthy Maheswaran, Stavros Petrou, Peter MacPherson, Augustine T. Choko, Felistas Kumwenda, David G. Lalloo, Aileen Clarke, Elizabeth L. Corbett
What is a clinical pathway? Refinement of an operational definition to identify clinical pathway studies for a Cochrane systematic review
Adegboyega K. Lawal, Thomas Rotter, Leigh Kinsman, Andreas Machotta, Ulrich Ronellenfitsch, Shannon D. Scott, Donna Goodridge, Christopher Plishka, Gary Groot
Erratum to: Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials
Patrick P. J. Phillips, Carl M. Mendel, Divan A. Burger, Angela M. Crook, Andrew J. Nunn, Rodney Dawson, Andreas H. Diacon, Stephen H. Gillespie
Diagnostic ‘omics’ for active tuberculosis
Carolin T. Haas, Jennifer K. Roe, Gabriele Pollara, Meera Mehta, Mahdad Noursadeghi
Measures to assess commonly experienced symptoms for people with dementia in long-term care settings: a systematic review
Clare Ellis-Smith, Catherine J. Evans, Anna E. Bone, Lesley A. Henson, Mendwas Dzingina, Pauline M. Kane, Irene J. Higginson, Barbara A. Daveson
(R)evolution: toward a new paradigm of policy and patient advocacy for expanded access to experimental treatments
Melissa Hogan
Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial
Bronner P. Gonçalves, Alfred B. Tiono, Alphonse Ouédraogo, Wamdaogo M. Guelbéogo, John Bradley, Issa Nebie, Débé Siaka, Kjerstin Lanke, Alice C. Eziefula, Amidou Diarra, Helmi Pett, Edith C. Bougouma, Sodiomon B. Sirima, Chris Drakeley, Teun Bousema
The impact of being homeless on the unsuccessful outcome of treatment of pulmonary TB in São Paulo State, Brazil
Otavio T. Ranzani, Carlos R. R. Carvalho, Eliseu A. Waldman, Laura C. Rodrigues
Policy implications of marked reversals of population life expectancy caused by substance use
Jürgen Rehm, Peter Anderson, Benedikt Fischer, Antoni Gual, Robin Room
Reporting transparency: making the ethical mandate explicit
Stuart G. Nicholls, Sinéad M. Langan, Eric I. Benchimol, David Moher
The timing of tuberculosis after isoniazid preventive therapy among gold miners in South Africa: a prospective cohort study
Sabine M. Hermans, Alison D. Grant, Violet Chihota, James J. Lewis, Emilia Vynnycky, Gavin J. Churchyard, Katherine L. Fielding
Clinical use of whole genome sequencing for Mycobacterium tuberculosis
Adam A. Witney, Catherine A. Cosgrove, Amber Arnold, Jason Hinds, Neil G. Stoker, Philip D. Butcher
Uniting to end the TB epidemic: advances in disease control from prevention to better diagnosis and treatment
Ibrahim Abubakar, Marc Lipman, Timothy D. McHugh, Helen Fletcher
The impact of migration on tuberculosis epidemiology and control in high-income countries: a review
Manish Pareek, Christina Greenaway, Teymur Noori, Jose Munoz, Dominik Zenner
Zika virus and neurologic autoimmunity: the putative role of gangliosides
Juan-Manuel Anaya, Carolina Ramirez-Santana, Ignacio Salgado-Castaneda, Christopher Chang, Aftab Ansari, M. Eric Gershwin
Tuberculosis incidence is high in HIV-infected African children but is reduced by co-trimoxazole and time on antiretroviral therapy
Angela M. Crook, Anna Turkova, Victor Musiime, Mutsa Bwakura-Dangarembizi, Sabrina Bakeera-Kitaka, Patricia Nahirya-Ntege, Margaret Thomason, Peter Mugyenyi, Philippa Musoke, Adeodata Kekitiinwa, Paula Munderi, Kusum Nathoo, Andrew J. Prendergast, A. Sarah Walker, Diana M. Gibb
A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP)
Patrick P. J. Phillips, Kelly E. Dooley, Stephen H. Gillespie, Norbert Heinrich, Jason E. Stout, Payam Nahid, Andreas H. Diacon, Rob E. Aarnoutse, Gibson S. Kibiki, Martin J. Boeree, Michael Hoelscher
Towards better guidance on caseload thresholds to promote positive tuberculosis treatment outcomes: a cohort study
Helen R. Stagg, Ibrahim Abubakar, James Brown, Maeve K. Lalor, H. Lucy Thomas, Tehreem Mohiyuddin, Debora Pedrazzoli, Corinne S. Merle
Detection of lipoarabinomannan (LAM) in urine is an independent predictor of mortality risk in patients receiving treatment for HIV-associated tuberculosis in sub-Saharan Africa: a systematic review and meta-analysis
Ankur Gupta-Wright, Jurgens A. Peters, Clare Flach, Stephen D. Lawn
‘”Why me, why now?” Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infection
M. Alexandra Lake, Lyn R. Ambrose, Marc C. I. Lipman, David M. Lowe
World TB Day 2016: an interview with leading experts in tuberculosis research
Patrick P. J. Phillips, Helen A. Fletcher, Ibrahim Abubakar, Marc C. I. Lipman, Timothy D. McHugh
TIME Impact – a new user-friendly tuberculosis (TB) model to inform TB policy decisions
R. M. G. J. Houben, M. Lalli, T. Sumner, M. Hamilton, D. Pedrazzoli, F. Bonsu, P. Hippner, Y. Pillay, M. Kimerling, S. Ahmedov, C. Pretorius, R. G. White
Antibiotics, obesity and the link to microbes - what are we doing to our children?
Olli Turta, Samuli Rautava
Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis?
Paul Forsythe, Wolfgang Kunze, John Bienenstock
Living cumulative network meta-analysis to reduce waste in research: A paradigmatic shift for systematic reviews?
Per Olav Vandvik, Romina Brignardello-Petersen, Gordon H. Guyatt
Analysis of vaccination campaign effectiveness and population immunity to support and sustain polio elimination in Nigeria
Alexander M. Upfill-Brown, Arend Voorman, Guillaume Chabot-Couture, Faisal Shuaib, Hil M. Lyons
Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaboration
Caroline A. Sabin, Peter Reiss, Lene Ryom, Andrew N. Phillips, Rainer Weber, Matthew Law, Eric Fontas, Amanda Mocroft, Stephane de Wit, Colette Smith, Francois Dabis, Antonella d’Arminio Monforte, Wafaa El-Sadr, Jens D. Lundgren
Quantification of the smoking-associated cancer risk with rate advancement periods: meta-analysis of individual participant data from cohorts of the CHANCES consortium
José Manuel Ordóñez-Mena, Ben Schöttker, Ute Mons, Mazda Jenab, Heinz Freisling, Bas Bueno-de-Mesquita, Mark G. O’Doherty, Angela Scott, Frank Kee, Bruno H. Stricker, Albert Hofman, Catherine E. de Keyser, Rikje Ruiter, Stefan Söderberg, Pekka Jousilahti, Kari Kuulasmaa, Neal D. Freedman, Tom Wilsgaard, Lisette CPGM de Groot, Ellen Kampman, Niclas Håkansson, Nicola Orsini, Alicja Wolk, Lena Maria Nilsson, Anne Tjønneland, Andrzej Pająk, Sofia Malyutina, Růžena Kubínová, Abdonas Tamosiunas, Martin Bobak, Michail Katsoulis, Philippos Orfanos, Paolo Boffetta, Antonia Trichopoulou, Hermann Brenner
Sharing all types of clinical data and harmonizing journal standards
Corrado Barbui
What can we offer to 3 million MDRTB household contacts in 2016?
David A. J. Moore
Primaquine plus artemisinin combination therapy for reduction of malaria transmission: promise and risk
Chandy C. John
Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort
Carolina Bonilla, Sarah J. Lewis, Richard M. Martin, Jenny L. Donovan, Freddie C. Hamdy, David E. Neal, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G. Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A. Haiman, Johanna Schleutker, Børge G. Nordestgaard, Ruth C. Travis, Nora Pashayan, Kay-Tee Khaw, Janet L. Stanford, William J. Blot, Stephen Thibodeau, Christiane Maier, Adam S. Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R. Teixeira, Hardev Pandha, Mark Lathrop, George Davey Smith
Incorporation of tissue-based genomic biomarkers into localized prostate cancer clinics
Marco Moschini, Martin Spahn, Agostino Mattei, John Cheville, R. Jeffrey Karnes
Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy
Isobella Honeyborne, Timothy D. McHugh, Iitu Kuittinen, Anna Cichonska, Dimitrios Evangelopoulos, Katharina Ronacher, Paul D. van Helden, Stephen H. Gillespie, Delmiro Fernandez-Reyes, Gerhard Walzl, Juho Rousu, Philip D. Butcher, Simon J. Waddell
The three-legged stool of evidence-based practice in eating disorder treatment: research, clinical, and patient perspectives
Carol B. Peterson, Carolyn Black Becker, Janet Treasure, Roz Shafran, Rachel Bryant-Waugh
Erratum to: Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study
Joachim Schmutzhard, Peter Lackner, Raimund Helbok, Helene Verena Hurth, Fabian Cedric Aregger, Veronika Muigg, Josua Kegele, Sebastian Bunk, Lukas Oberhammer, Natalie Fischer, Leyla Pinggera, Allan Otieno, Bernards Ogutu, Tsiri Agbenyega, Daniel Ansong, Ayola A. Adegnika, Saadou Issifou, Patrick Zorowka, Sanjeev Krishna, Benjamin Mordmüller, Erich Schmutzhard, Peter Kremsner
Enhanced antibiotic distribution strategies and the potential impact of facial cleanliness and environmental improvements for the sustained control of trachoma: a modelling study
Amy Pinsent, Matthew J. Burton, Manoj Gambhir
Mirror, mirror on the wall: which microbiomes will help heal them all?
Renuka R. Nayak, Peter J. Turnbaugh
Cancer immunotherapy: the beginning of the end of cancer?
Sofia Farkona, Eleftherios P. Diamandis, Ivan M. Blasutig
Contact heat sensitivity and reports of unpleasantness in communicative people with mild to moderate cognitive impairment in Alzheimer’s disease: a cross-sectional study
Todd B. Monroe, Stephen J. Gibson, Stephen P. Bruehl, John C. Gore, Mary S. Dietrich, Paul Newhouse, Sebastian Atalla, Ronald L. Cowan
Ethical priority setting for universal health coverage: challenges in deciding upon fair distribution of health services
Ole F. Norheim
Human newborn bacille Calmette–Guérin vaccination and risk of tuberculosis disease: a case-control study
Helen A. Fletcher, Ali Filali-Mouhim, Elisa Nemes, Anthony Hawkridge, Alana Keyser, Samuel Njikan, Mark Hatherill, Thomas J. Scriba, Brian Abel, Benjamin M. Kagina, Ashley Veldsman, Nancy Marín Agudelo, Gilla Kaplan, Gregory D. Hussey, Rafick-Pierre Sekaly, Willem A. Hanekom
Differences in the distribution of stroke subtypes in a UK black stroke population – final results from the South London Ethnicity and Stroke Study
Giosue Gulli, Loes C. A. Rutten-Jacobs, Lalit Kalra, Anthony G. Rudd, Charles D. A. Wolfe, Hugh S. Markus
Research impact: a narrative review
Trisha Greenhalgh, James Raftery, Steve Hanney, Matthew Glover
Flexible, dual-form nicotine replacement therapy or varenicline in comparison with nicotine patch for smoking cessation: a randomized controlled trial
Heather E. Tulloch, Andrew L. Pipe, Charl Els, Matthew J. Clyde, Robert D. Reid
The importance of collecting structured clinical information on multiple sclerosis
Tjalf Ziemssen, Jan Hillert, Helmut Butzkueven
The gut microbiome in human immunodeficiency virus infection
Gili Zilberman-Schapira, Niv Zmora, Shlomik Itav, Stavros Bashiardes, Hila Elinav, Eran Elinav
Understanding Zika virus pathogenesis: an interview with Catherine Spong
Catherine Y. Spong
Impact of interventions to improve the quality of peer review of biomedical journals: a systematic review and meta-analysis
Rachel Bruce, Anthony Chauvin, Ludovic Trinquart, Philippe Ravaud, Isabelle Boutron
Modeling hormonal and inflammatory contributions to preterm and term labor using uterine temporal transcriptomics
Roberta Migale, David A. MacIntyre, Stefano Cacciatore, Yun S. Lee, Henrik Hagberg, Bronwen R. Herbert, Mark R. Johnson, Donald Peebles, Simon N. Waddington, Phillip R. Bennett
Modifiable causes of premature death in middle-age in Western Europe: results from the EPIC cohort study
David C. Muller, Neil Murphy, Mattias Johansson, Pietro Ferrari, Konstantinos K. Tsilidis, Marie-Christine Boutron-Ruault, Francoise Clavel, Laureen Dartois, Kuanrong Li, Rudolf Kaaks, Cornelia Weikert, Manuela Bergmann, Heiner Boeing, Anne Tjønneland, Kim Overvad, M. Luisa Redondo, Antonio Agudo, Elena Molina-Portillo, Jone M. Altzibar, Lluís Cirera, Eva Ardanaz, Kay-Tee Khaw, Nicholas J. Wareham, Timothy J. Key, Ruth C. Travis, Christina Bamia, Philippos Orfanos, Antonia Trichopoulou, Domenico Palli, Valeria Pala, Rosario Tumino, Paolo Vineis, Salvatore Panico, H. Bas Bueno-de-Mesquita, W. M. Monique Verschuren, Ellen A. Struijk, Petra H. Peeters, Gunnar Engström, Olle Melander, Malin Sund, Elisabete Weiderpass, Guri Skeie, Eiliv Lund, Teresa Norat, Marc Gunter, Elio Riboli, Paul Brennan
The CARE Plus study – a whole-system intervention to improve quality of life of primary care patients with multimorbidity in areas of high socioeconomic deprivation: exploratory cluster randomised controlled trial and cost-utility analysis
Stewart W. Mercer, Bridie Fitzpatrick, Bruce Guthrie, Elisabeth Fenwick, Eleanor Grieve, Kenny Lawson, Nicki Boyer, Alex McConnachie, Suzanne M. Lloyd, Rosaleen O’Brien, Graham C. M. Watt, Sally Wyke
Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis
Alimuddin Zumla, Martin Rao, Ernest Dodoo, Markus Maeurer
Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and meta-analysis
Delan Devakumar, Caroline H. D. Fall, Harshpal Singh Sachdev, Barrie M. Margetts, Clive Osmond, Jonathan C. K. Wells, Anthony Costello, David Osrin
No effects of oral vitamin D supplementation on non-alcoholic fatty liver disease in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial
Ilaria Barchetta, Maria Del Ben, Francesco Angelico, Michele Di Martino, Antonio Fraioli, Giuseppe La Torre, Rosella Saulle, Ludovica Perri, Sergio Morini, Claudio Tiberti, Laura Bertoccini, Flavia Agata Cimini, Francesca Panimolle, Carlo Catalano, Marco Giorgio Baroni, Maria Gisella Cavallo
How important is gametocyte clearance after malaria therapy?
Harin A. Karunajeewa, Ivo Mueller
Beyond viral suppression of HIV – the new quality of life frontier
Jeffrey V. Lazarus, Kelly Safreed-Harmon, Simon E. Barton, Dominique Costagliola, Nikos Dedes, Julia del Amo Valero, Jose M. Gatell, Ricardo Baptista-Leite, Luís Mendão, Kholoud Porter, Stefano Vella, Jürgen Kurt Rockstroh
Modeling the spread of polio in an IPV-vaccinated population: lessons learned from the 2013 silent outbreak in southern Israel
Rami Yaari, Ehud Kaliner, Itamar Grotto, Guy Katriel, Jacob Moran-Gilad, Danit Sofer, Ella Mendelson, Elizabeth Miller, Amit Huppert, E. Anis, E. Kopel, Y. Manor, O. Mor, L. Shulman, R. Singer, M. Weil
RAMESES II reporting standards for realist evaluations
Geoff Wong, Gill Westhorp, Ana Manzano, Joanne Greenhalgh, Justin Jagosh, Trish Greenhalgh
Real-world data in the United Kingdom: opportunities and challenges
Laura McDonald, Dimitra Lambrelli, Radek Wasiak, Sreeram V. Ramagopalan
Fast and accurate dynamic estimation of field effectiveness of meningococcal vaccines
Lorenzo Argante, Michele Tizzoni, Duccio Medini
Burden of respiratory tract infections at post mortem in Zambian children
Matthew Bates, Aaron Shibemba, Victor Mudenda, Charles Chimoga, John Tembo, Mwila Kabwe, Moses Chilufya, Michael Hoelscher, Markus Maeurer, Sylvester Sinyangwe, Peter Mwaba, Nathan Kapata, Alimuddin Zumla
Association between trial registration and treatment effect estimates: a meta-epidemiological study
Agnès Dechartres, Philippe Ravaud, Ignacio Atal, Carolina Riveros, Isabelle Boutron
Individualised benefit–harm balance of aspirin as primary prevention measure – a good proof-of-concept, but could have been better…
Mangesh A. Thorat
Frugal innovation in medicine for low resource settings
Viet-Thi Tran, Philippe Ravaud
The role of peptides in bone healing and regeneration: a systematic review
Ippokratis Pountos, Michalis Panteli, Anastasios Lampropoulos, Elena Jones, Giorgio Maria Calori, Peter V. Giannoudis
An external validation of models to predict the onset of chronic kidney disease using population-based electronic health records from Salford, UK
Paolo Fraccaro, Sabine van der Veer, Benjamin Brown, Mattia Prosperi, Donal O’Donoghue, Gary S. Collins, Iain Buchan, Niels Peek
The morning after: what now for psychiatry research?
Simon Wessely, Krista Nicholson
“Delirium Day”: a nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool
Giuseppe Bellelli, Alessandro Morandi, Simona G. Di Santo, Andrea Mazzone, Antonio Cherubini, Enrico Mossello, Mario Bo, Angelo Bianchetti, Renzo Rozzini, Ermellina Zanetti, Massimo Musicco, Alberto Ferrari, Nicola Ferrara, Marco Trabucchi, Stefano Boffelli, Fabio Di Stefano, Francesco De Filippi, Fabio Guerini, Erik Bertoletti, Albert March, Alessandro Margiotta, Patrizia Mecocci, Desireè Addesi, Fausto Fantò, Gianluca Isaia, Babette Dijik, Paola Porrino, Antonino Maria Cotroneo, Giovanni Galli, Amalia Cecilia Bruni, Bruno Bernardini, Carla Corsini, Annachiara Cagnin, Amedeo Zurlo, Giuseppe Barbagallo, Maria Lia Lunardelli, Emilio Martini, Giuseppe Battaglia, Raffaele Latella, Donatella Petritola, Elena Sinforiani, Alberto Cester, Marino Formilan, Pasqualina Carbone, Ildebrando Appollonio, Diletta Cereda, Lucio Tremolizzo, Edo Bottacchi, Lucio Lucchetti, Claudio Mariani, Piero Rapazzini, Giuseppe Romanelli, Alessandra Marengoni, Giovanni Zuliani, Lara Bianchi, Teresa Suardi, Ettore Muti, Renato Bottura, Giovanni Sgrò, Antonella Mandas, Luca Serchisu, Patrizia Crippa, Claudio Ivaldi, Andrea Ungar, Daniele Villani, Clara Raimondi, Chiara Mussi, Giancarlo Isaia, Giuseppe Provenzano, Daniela Mari, Patrizio Odetti, Fiammetta Monacelli, Raffaele Antonelli Incalzi, Alice Pluderi, Claudio Bellamoli, Luciano Terranova, Elio Scarpini, Ferdinando D’Amico, Maria Chiara Cavallini, Gianbattista Guerrini, Anna Maria Scotuzzi, Antonino Chiarello, Alberto Pilotto, Sara Tognini, Giuseppina Dell’Aquila, Gabriele Toigo, Giuliano Ceschia, Maristella Piccinini, Andrea Fabbo, Marco Zoli, Paola Forti, Christian Wenter, Giorgio Basile, Anna Lasagni, Alessandro Padovani, Luca Rozzini, Maria Cottino, Silvia Vitali, Gabriele Tripi, Stefano Avanzi, Giorgio Annoni, Giovanni Ruotolo, Federica Boschi, Paolo Bonino, Niccolò Marchionni, Maria C. Cavallini, Sara Fascendini, Gabriele Noro, Renato Turco, Maria C. Ubezio, Carlo Serrati, Maria Infante, Simona Gentile, Luigi M. Pernigotti, Carlo A. Biagini, Enzo Canonico, Pietro Bonati, Pietro Gareri, Paolo Caffarra, Arcangelo Ceretti, Rosanna Castiglia, Carlo Gabelli, Mario Lo Storto, Paolo Putzu, Giuseppe Bellelli, Alessandro Morandi, Simona Di Santo, Andrea Mazzone, Renzo Rozzini, Ermellina Zanetti, Angelo Bianchetti, Mario Bo, Enrico Mossello, Antonio Cherubini, Nicola Ferrara, Alberto Ferrari, Massimo Musicco, Marco Trabucchi
Low levels of IgM antibodies recognizing oxidation-specific epitopes are associated with human non-alcoholic fatty liver disease
Tim Hendrikx, Martin L. Watzenböck, Sofie M. A. Walenbergh, Shahzada Amir, Sabrina Gruber, Maria Ozsvar Kozma, Heike I. Grabsch, Ger H. Koek, Marieke J. Pierik, Katharina Staufer, Michael Trauner, Satish C. Kalhan, Daisy Jonkers, Marten H. Hofker, Christoph J. Binder, Ronit Shiri-Sverdlov
The potential to expand antiretroviral therapy by improving health facility efficiency: evidence from Kenya, Uganda, and Zambia
Laura Di Giorgio, Mark W. Moses, Nancy Fullman, Alexandra Wollum, Ruben O. Conner, Jane Achan, Tom Achoki, Kelsey A. Bannon, Roy Burstein, Emily Dansereau, Brendan DeCenso, Kristen Delwiche, Herbert C. Duber, Emmanuela Gakidou, Anne Gasasira, Annie Haakenstad, Michael Hanlon, Gloria Ikilezi, Caroline Kisia, Aubrey J. Levine, Mashekwa Maboshe, Felix Masiye, Samuel H. Masters, Chrispin Mphuka, Pamela Njuguna, Thomas A. Odeny, Emelda A. Okiro, D. Allen Roberts, Christopher J. L. Murray, Abraham D. Flaxman
Reporting guidelines for realist evaluations seek to improve clarity and transparency
Vivian A. Welch, Andrea C. Tricco
Major milestones in translational oncology
Tommaso A. Dragani, Antoni Castells, Vathany Kulasingam, Eleftherios P. Diamandis, Helena Earl, Wade T. Iams, Christine M. Lovly, J. P. Michiel Sedelaar, Jack A. Schalken
Twenty-year trajectories of alcohol consumption during midlife and atherosclerotic thickening in early old age: findings from two British population cohort studies
Annie Britton, Rebecca Hardy, Diana Kuh, John Deanfield, Marietta Charakida, Steven Bell
The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact
Phillipe Boeuf, Heidi E. Drummer, Jack S. Richards, Michelle J. L. Scoullar, James G. Beeson
The epidemiology, healthcare and societal burden and costs of asthma in the UK and its member nations: analyses of standalone and linked national databases
Mome Mukherjee, Andrew Stoddart, Ramyani P. Gupta, Bright I. Nwaru, Angela Farr, Martin Heaven, Deborah Fitzsimmons, Amrita Bandyopadhyay, Chantelle Aftab, Colin R. Simpson, Ronan A. Lyons, Colin Fischbacher, Christopher Dibben, Michael D. Shields, Ceri J. Phillips, David P. Strachan, Gwyneth A. Davies, Brian McKinstry, Aziz Sheikh
Antimicrobial agents – optimising the ecological balance
Sze-Ann Woon, Dale Fisher
Transforming healthcare through regenerative medicine
Zita M. Jessop, Ayesha Al-Sabah, Wendy R. Francis, Iain S. Whitaker
Improving comfort in people with dementia and pneumonia: a cluster randomized trial
Tessa van der Maaden, Henrica C. W. de Vet, Wilco P. Achterberg, Froukje Boersma, Jos M. G. A. Schols, David R. Mehr, Francisca Galindo-Garre, Cees M. P. M. Hertogh, Raymond T. C. M. Koopmans, Jenny T. van der Steen
Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance
Giovanni Satta, Adam A. Witney, Robert J. Shorten, Magdalena Karlikowska, Marc Lipman, Timothy D. McHugh
Evaluation in alcohol use disorders – insights from the nalmefene experience
Florian Naudet, Clément Palpacuer, Rémy Boussageon, Bruno Laviolle
Erratum to: Modeling the spread of polio in an IPV-vaccinated population: lessons learned from the 2013 silent outbreak in southern Israel
Rami Yaari, Ehud Kaliner, Itamar Grotto, Guy Katriel, Jacob Moran-Gilad, Danit Sofer, Ella Mendelson, Elizabeth Miller, Amit Huppert
Investigating the pertussis resurgence in England and Wales, and options for future control
Yoon Hong Choi, Helen Campbell, Gayatri Amirthalingam, Albert Jan van Hoek, Elizabeth Miller
Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study
Neil Basu, Xingzi Yang, Robert N. Luben, Daniel Whibley, Gary J. Macfarlane, Nicholas J. Wareham, Kay-Tee Khaw, Phyo Kyaw Myint
Investments in tuberculosis research – what are the gaps?
Mishal S. Khan, Helen Fletcher, Richard Coker
Medicine shortages: a commentary on causes and mitigation strategies
Swathi Iyengar, Lisa Hedman, Gilles Forte, Suzanne Hill
Serum levels of mitochondrial inhibitory factor 1 are independently associated with long-term prognosis in coronary artery disease: the GENES Study
Annelise Genoux, Laeticia Lichtenstein, Jean Ferrières, Thibaut Duparc, Vanina Bongard, Paul-Louis Vervueren, Guillaume Combes, Dorota Taraszkiewicz, Meyer Elbaz, Michel Galinier, Bertrand Nassar, Jean-Bernard Ruidavets, Bertrand Perret, Laurent O. Martinez
Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening
Paul A. Cohen, Nicola Flowers, Stephen Tong, Natalie Hannan, Mark D. Pertile, Lisa Hui
The efficiency of chronic disease care in sub-Saharan Africa
Pascal Geldsetzer, Katrina Ortblad, Till Bärnighausen
Development and external validation of a faecal immunochemical test-based prediction model for colorectal cancer detection in symptomatic patients
Joaquín Cubiella, Pablo Vega, María Salve, Marta Díaz-Ondina, Maria Teresa Alves, Enrique Quintero, Victoria Álvarez-Sánchez, Fernando Fernández-Bañares, Jaume Boadas, Rafel Campo, Luis Bujanda, Joan Clofent, Ángel Ferrandez, Leyanira Torrealba, Virginia Piñol, Daniel Rodríguez-Alcalde, Vicent Hernández, Javier Fernández-Seara, Joaquín Cubiella, Pablo Vega, María Salve, Marta Díaz-Ondina, Irene Blanco, Pedro Macía, Eloy Sánchez, Javier Fernández-Seara, María Teresa Alves, Enrique Quintero, Natalia González-López, Victoria Álvarez Sánchez, José Mera, Juan Turnes, Fernando Fernández-Bañares, Victoria Gonzalo, Mar Pujals, Josepa Ribes, Ramón Cleries, Xavier Sanz, Jaume Boadas, Sara Galter, Rafel Campo, Marta Pujol, Eva Martínez-Bauer, Antonio Alsius, Luis Bujanda, Jesús Bañales, María J. Perugorria, Joan Clofent, Ana Garayoa, Ángel Ferrández, Marina Solano Sánchez, Leyanira Torrealba, Virginia Piñol, Daniel Rodriguez-Alcalde, Jorge López-Vicente, Vicent Hernández, Felipe Iglesias
Post-mortem assessment in vascular dementia: advances and aspirations
Kirsty E. McAleese, Irina Alafuzoff, Andreas Charidimou, Jacques De Reuck, Lea T. Grinberg, Atticus H. Hainsworth, Tibor Hortobagyi, Paul Ince, Kurt Jellinger, Jing Gao, Raj N. Kalaria, Gabor G. Kovacs, Enikö Kövari, Seth Love, Mara Popovic, Olivia Skrobot, Ricardo Taipa, Dietmar R. Thal, David Werring, Stephen B. Wharton, Johannes Attems
Spatiotemporal dynamics of the Ebola epidemic in Guinea and implications for vaccination and disease elimination: a computational modeling analysis
Marco Ajelli, Stefano Merler, Laura Fumanelli, Ana Pastore y Piontti, Natalie E. Dean, Ira M. Longini Jr., M. Elizabeth Halloran, Alessandro Vespignani
Should all acutely ill children in primary care be tested with point-of-care CRP: a cluster randomised trial
Jan Y. Verbakel, Marieke B. Lemiengre, Tine De Burghgraeve, An De Sutter, Bert Aertgeerts, Bethany Shinkins, Rafael Perera, David Mant, Ann Van den Bruel, Frank Buntinx
Infectious diseases epidemic threats and mass gatherings: refocusing global attention on the continuing spread of the Middle East Respiratory syndrome coronavirus (MERS-CoV)
Alimuddin Zumla, Abdulaziz N. Alagaili, Matthew Cotten, Esam I. Azhar
Urine metabolome profiling of immune-mediated inflammatory diseases
Arnald Alonso, Antonio Julià, Maria Vinaixa, Eugeni Domènech, Antonio Fernández-Nebro, Juan D. Cañete, Carlos Ferrándiz, Jesús Tornero, Javier P. Gisbert, Pilar Nos, Ana Gutiérrez Casbas, Lluís Puig, Isidoro González-Álvaro, José A. Pinto-Tasende, Ricardo Blanco, Miguel A. Rodríguez, Antoni Beltran, Xavier Correig, Sara Marsal, Emilia Fernández, Raimon Sanmartí, Jordi Gratacós, Víctor Manuel Martínez-Taboada, Fernando Gomollón, Esteban Daudén, Joan Maymó, Rubén Queiró, Francisco Javier López-Longo, Esther Garcia-Planella, José Luís Sánchez-Carazo, Mercedes Alperi-López, Carlos Montilla, José Javier Pérez-Venegas, Benjamín Fernández-Gutiérrez, Juan L. Mendoza, José Luís López-Estebaranz, Àlex Olivé, Juan Carlos Torre-Alonso, Manuel Barreiro-de Acosta, David Moreno-Ramírez, Hèctor Corominas, Santiago Muñoz-Fernández, José Luis Andreu, Fernando Muñoz, Pablo de la Cueva, Alba Erra, Carlos M. González, María Ángeles Aguirre-Zamorano, Maribel Vera, Francisco Vanaclocha, Daniel Roig, Paloma Vela, Cristina Saro, Enrique Herrera, Pedro Zarco, Joan M. Nolla, Maria Esteve, José Luis Marenco de la Fuente, José María Pego-Reigosa, Valle García-Sánchez, Julián Panés, Eduardo Fonseca, Francisco Blanco, Jesús Rodríguez-Moreno, Patricia Carreira, Julio Ramírez, Gabriela Ávila, Laia Codó, Josep Lluís Gelpí, Andrés C. García-Montero, Núria Palau, María López-Lasanta, Raül Tortosa
Oral, frozen fecal microbiota transplant (FMT) capsules for recurrent Clostridium difficile infection
Ilan Youngster, Jasmin Mahabamunuge, Hannah K. Systrom, Jenny Sauk, Hamed Khalili, Joanne Levin, Jess L. Kaplan, Elizabeth L. Hohmann
Prospective association of the Mediterranean diet with cardiovascular disease incidence and mortality and its population impact in a non-Mediterranean population: the EPIC-Norfolk study
Tammy Y. N. Tong, Nicholas J. Wareham, Kay-Tee Khaw, Fumiaki Imamura, Nita G. Forouhi
Risk factors for hospital re-presentation among older adults following fragility fractures: a systematic review and meta-analysis
Saira A. Mathew, Elise Gane, Kristiann C. Heesch, Steven M. McPhail
Risk of serious infections with immunosuppressive drugs and glucocorticoids for lupus nephritis: a systematic review and network meta-analysis
Jasvinder A. Singh, Alomgir Hossain, Ahmed Kotb, George Wells
The potential impact of BCG vaccine supply shortages on global paediatric tuberculosis mortality
Rebecca C. Harris, Peter J. Dodd, Richard G. White
Diagnostic work-up of patients presenting in primary care with lower abdominal symptoms: which faecal test and triage strategy should be used?
Callum G. Fraser
Predictive validity of the UKCAT for medical school undergraduate performance: a national prospective cohort study
Paul A. Tiffin, Lazaro M. Mwandigha, Lewis W. Paton, H. Hesselgreaves, John C. McLachlan, Gabrielle M. Finn, Adetayo S. Kasim
Is there an added value of faecal calprotectin and haemoglobin in the diagnostic work-up for primary care patients suspected of significant colorectal disease? A cross-sectional diagnostic study
Sjoerd G. Elias, Liselotte Kok, Niek J. de Wit, Ben J. M Witteman, Jelle G. Goedhard, Mariëlle J. L. Romberg-Camps, Jean W. M. Muris, Karel G. M. Moons
Undernutrition and malaria in pregnancy – a dangerous dyad?
Holger W. Unger, Per Ashorn, Jordan E. Cates, Kathryn G. Dewey, Stephen J. Rogerson
The effect of declining exposure on T cell-mediated immunity to Plasmodium falciparum – an epidemiological “natural experiment”
Yaw Bediako, Joyce Mwongeli Ngoi, George Nyangweso, Juliana Wambua, Michael Opiyo, Eunice Wambui Nduati, Philip Bejon, Kevin Marsh, Francis Maina Ndungu
A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens
Damien R. Drew, Danny W. Wilson, Salenna R. Elliott, Nadia Cross, Ulrich Terheggen, Anthony N. Hodder, Peter M. Siba, Kiprotich Chelimo, Arlene E. Dent, James W. Kazura, Ivo Mueller, James G. Beeson
The role of health-related behavioural factors in accounting for inequalities in coronary heart disease risk by education and area deprivation: prospective study of 1.2 million UK women
Sarah Floud, Angela Balkwill, Kath Moser, Gillian K. Reeves, Jane Green, Valerie Beral, Benjamin J. Cairns, Emily Banks, Valerie Beral, Lucy Carpenter, Carol Dezateux, Jane Green, Julietta Patnick, Richard Peto, Cathie Sudlow, Hayley Abbiss, Simon Abbott, Miranda Armstrong, Krys Baker, Angela Balkwill, Isobel Barnes, Valerie Beral, Judith Black, Kathryn Bradbury, Anna Brown, Benjamin Cairns, Dexter Canoy, Andrew Chadwick, Dave Ewart, Sarah Ewart, Lee Fletcher, Sarah Floud, Toral Gathani, Laura Gerrard, Adrian Goodill, Jane Green, Lynden Guiver, Alicia Heath, Michal Hozak, Carol Hermon, Isobel Lingard, Sau Wan Kan, Nicky Langston, Kath Moser, Kirstin Pirie, Gillian Reeves, Keith Shaw, Emma Sherman, Helena Strange, Sian Sweetland, Sarah Tipper, Claire Wotton, Lucy Wright, Owen Yang, Heather Young
Reporting studies on time to diagnosis: proposal of a guideline by an international panel (REST)
Elise Launay, Jérémie F. Cohen, Patrick M. Bossuyt, Pierre Buekens, Jonathan Deeks, Timothy Dye, Richard Feltbower, Andrea Ferrari, Michael Kramer, Mariska Leeflang, David Moher, Karel G. Moons, Erik von Elm, Philippe Ravaud, Martin Chalumeau
Birth weight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analyses
Lazaros Belbasis, Makrina D. Savvidou, Chidimma Kanu, Evangelos Evangelou, Ioanna Tzoulaki
Maternal pre-pregnancy body mass index and newborn telomere length
Dries S. Martens, Michelle Plusquin, Wilfried Gyselaers, Immaculata De Vivo, Tim S. Nawrot
The disease of corruption: views on how to fight corruption to advance 21st century global health goals
Tim K. Mackey, Jillian Clare Kohler, William D. Savedoff, Frank Vogl, Maureen Lewis, James Sale, Joshua Michaud, Taryn Vian
Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study
Layal Chaker, Symen Ligthart, Tim I. M. Korevaar, Albert Hofman, Oscar H. Franco, Robin P. Peeters, Abbas Dehghan
Back to the basics of ovarian aging: a population-based study on longitudinal anti-Müllerian hormone decline
A. C. de Kat, Y. T. van der Schouw, M. J. C. Eijkemans, G. C. Herber-Gast, J. A. Visser, W. M. M. Verschuren, F. J. M. Broekmans
Current state of ethics literature synthesis: a systematic review of reviews
Marcel Mertz, Hannes Kahrass, Daniel Strech
Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial
Mark Ng Tang Fui, Luke A. Prendergast, Philippe Dupuis, Manjri Raval, Boyd J. Strauss, Jeffrey D. Zajac, Mathis Grossmann
Increasing the evidence base in journalology: creating an international best practice journal research network
David Moher, Philippe Ravaud
Long-term effects on luminal and mucosal microbiota and commonly acquired taxa in faecal microbiota transplantation for recurrent Clostridium difficile infection
Jonna Jalanka, Eero Mattila, Hanne Jouhten, Jorn Hartman, Willem M. de Vos, Perttu Arkkila, Reetta Satokari
Benefits of the Mediterranean diet beyond the Mediterranean Sea and beyond food patterns
Miguel A. Martínez-González
Meta-analysis of the prognostic and clinical value of tumor-associated macrophages in adult classical Hodgkin lymphoma
Baoping Guo, Hong Cen, Xiaohong Tan, Qing Ke
The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance
Florian Gehre, Jacob Otu, Lindsay Kendall, Audrey Forson, Awewura Kwara, Samuel Kudzawu, Aderemi O. Kehinde, Oludele Adebiyi, Kayode Salako, Ignatius Baldeh, Aisha Jallow, Mamadou Jallow, Anoumou Dagnra, Kodjo Dissé, Essosimna A. Kadanga, Emmanuel Oni Idigbe, Catherine Onubogu, Nneka Onyejepu, Aissatou Gaye-Diallo, Awa Ba-Diallo, Paulo Rabna, Morto Mane, Moumine Sanogo, Bassirou Diarra, Zingue Dezemon, Adama Sanou, Madikay Senghore, Brenda A. Kwambana-Adams, Edward Demba, Tutty Faal-Jawara, Samrat Kumar, Leopold D. Tientcheu, Adama Jallow, Samba Ceesay, Ifedayo Adetifa, Assan Jaye, Mark J. Pallen, Umberto D’Alessandro, Beate Kampmann, Richard A. Adegbola, Souleymane Mboup, Tumani Corrah, Bouke C. de Jong, Martin Antonio
Vascular depression consensus report – a critical update
Howard J. Aizenstein, Andrius Baskys, Maura Boldrini, Meryl A. Butters, Breno S. Diniz, Manoj Kumar Jaiswal, Kurt A. Jellinger, Lev S. Kruglov, Ivan A. Meshandin, Milija D. Mijajlovic, Guenter Niklewski, Sarah Pospos, Keerthy Raju, Kneginja Richter, David C. Steffens, Warren D. Taylor, Oren Tene
Is the time ripe for new diagnostic criteria of cognitive impairment due to cerebrovascular disease? Consensus report of the International Congress on Vascular Dementia working group
Robert Perneczky, Oren Tene, Johannes Attems, Panteleimon Giannakopoulos, M. Arfan Ikram, Antonio Federico, Marie Sarazin, Lefkos T. Middleton
Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells
Margarida Ferreira-Teixeira, Daniela Paiva-Oliveira, Belmiro Parada, Vera Alves, Vitor Sousa, Obinna Chijioke, Christian Münz, Flávio Reis, Paulo Rodrigues-Santos, Célia Gomes
Assessing the burden of medical impoverishment by cause: a systematic breakdown by disease in Ethiopia
Stéphane Verguet, Solomon Tessema Memirie, Ole Frithjof Norheim
Association of circulating neuregulin 4 with metabolic syndrome in obese adults: a cross-sectional study
Chengfu Cai, Mingzhu Lin, Yanfang Xu, Xuejun Li, Shuyu Yang, Huijie Zhang
Obesity and type 2 diabetes in sub-Saharan Africans – Is the burden in today’s Africa similar to African migrants in Europe? The RODAM study
Charles Agyemang, Karlijn Meeks, Erik Beune, Ellis Owusu-Dabo, Frank P. Mockenhaupt, Juliet Addo, Ama de Graft Aikins, Silver Bahendeka, Ina Danquah, Matthias B. Schulze, Joachim Spranger, Tom Burr, Peter Agyei-Baffour, Stephen K. Amoah, Cecilia Galbete, Peter Henneman, Kerstin Klipstein-Grobusch, Mary Nicolaou, Adebowale Adeyemo, Jan van Straalen, Liam Smeeth, Karien Stronks
Efficacy of artemether-lumefantrine in relation to drug exposure in children with and without severe acute malnutrition: an open comparative intervention study in Mali and Niger
Lise Denoeud-Ndam, Alassane Dicko, Elisabeth Baudin, Ousmane Guindo, Francesco Grandesso, Halimatou Diawara, Sibiri Sissoko, Koualy Sanogo, Seydou Traoré, Sekouba Keita, Amadou Barry, Martin de Smet, Estrella Lasry, Michiel Smit, Lubbe Wiesner, Karen I. Barnes, Abdoulaye A. Djimde, Philippe J. Guerin, Rebecca F. Grais, Ogobara K. Doumbo, Jean-François Etard
Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set
Jason Roszik, Lauren E. Haydu, Kenneth R. Hess, Junna Oba, Aron Y. Joon, Alan E. Siroy, Tatiana V. Karpinets, Francesco C. Stingo, Veera Baladandayuthapani, Michael T. Tetzlaff, Jennifer A. Wargo, Ken Chen, Marie-Andrée Forget, Cara L. Haymaker, Jie Qing Chen, Funda Meric-Bernstam, Agda K. Eterovic, Kenna R. Shaw, Gordon B. Mills, Jeffrey E. Gershenwald, Laszlo G. Radvanyi, Patrick Hwu, P. Andrew Futreal, Don L. Gibbons, Alexander J. Lazar, Chantale Bernatchez, Michael A. Davies, Scott E. Woodman
Medicine and the future of health: reflecting on the past to forge ahead
Dale Fisher, Paul Wicks, Zaheer-Ud-Din Babar
Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone
Christine Jungk, Andreas Mock, Janina Exner, Christoph Geisenberger, Rolf Warta, David Capper, Amir Abdollahi, Sara Friauf, Bernd Lahrmann, Niels Grabe, Philipp Beckhove, Andreas von Deimling, Andreas Unterberg, Christel Herold-Mende
An optimised age-based dosing regimen for single low-dose primaquine for blocking malaria transmission in Cambodia
Rithea Leang, Naw Htee Khu, Mavuto Mukaka, Mark Debackere, Rupam Tripura, Soy Ty Kheang, Say Chy, Neeraj Kak, Philippe Buchy, Arnaud Tarantola, Didier Menard, Arantxa Roca-Felterer, Rick M. Fairhurst, Sim Kheng, Sinoun Muth, Song Ngak, Arjen M. Dondorp, Nicholas J. White, Walter Robert John Taylor
Inhibiting the proton pump: mechanisms, benefits, harms, and questions
Jeffrey K. Aronson
Immuno-psychiatry: an agenda for clinical practice and innovative research
Marion Leboyer, Michael Berk, Robert H. Yolken, Ryad Tamouza, David Kupfer, Laurent Groc
Neuroimaging in vascular cognitive impairment: a state-of-the-art review
Wolf-Dieter Heiss, Gary A. Rosenberg, Alexander Thiel, Rok Berlot, Jacques de Reuck
It’s a long shot, but it just might work! Perspectives on the future of medicine
Paul Wicks, Matthew Hotopf, Vaibhav A. Narayan, Ethan Basch, James Weatherall, Muir Gray
Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study
Léa Maitre, Cristina M. Villanueva, Matthew R. Lewis, Jesús Ibarluzea, Loreto Santa-Marina, Martine Vrijheid, Jordi Sunyer, Muireann Coen, Mireille B. Toledano
Differing association of alcohol consumption with different stroke types: a systematic review and meta-analysis
Susanna C. Larsson, Alice Wallin, Alicja Wolk, Hugh S. Markus
Effective and safe proton pump inhibitor therapy in acid-related diseases – A position paper addressing benefits and potential harms of acid suppression
Carmelo Scarpignato, Luigi Gatta, Angelo Zullo, Corrado Blandizzi, Carmelo Scarpignato, Corrado Blandizzi, Luigi Gatta, Angelo Zullo, Anna Kohn, Gioacchino Leandro, Antonio Balzano, Alberto Chiriatti, Walter Marocco
Gout: will the “King of Diseases” be the first rheumatic disease to be cured?
Jasvinder A. Singh
Renal function estimation and Cockcroft–Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart ‘OMics’ in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives
João Pedro Ferreira, Nicolas Girerd, Pierpaolo Pellicori, Kevin Duarte, Sophie Girerd, Marc A. Pfeffer, John J. V. McMurray, Bertram Pitt, Kenneth Dickstein, Lotte Jacobs, Jan A. Staessen, Javed Butler, Roberto Latini, Serge Masson, Alexandre Mebazaa, Hans Peter Brunner-La Rocca, Christian Delles, Stephane Heymans, Naveed Sattar, J. Wouter Jukema, John G. Cleland, Faiez Zannad, Patrick Rossignol
MEN1 redefined, a clinical comparison of mutation-positive and mutation-negative patients
Joanne M. de Laat, Rob B. van der Luijt, Carolina R. C. Pieterman, Maria P. Oostveen, Ad R. Hermus, Olaf M. Dekkers, Wouter W. de Herder, Anouk N. van der Horst-Schrivers, Madeleine L. Drent, Peter H. Bisschop, Bas Havekes, Menno R. Vriens, Gerlof D. Valk
How do you design randomised trials for smaller populations? A framework
Mahesh K. B. Parmar, Matthew R. Sydes, Tim P. Morris
Prevalence, aetiology, treatment and outcomes of shock in children admitted to Kenyan hospitals
George Mbevi, Philip Ayieko, Grace Irimu, Samuel Akech, Mike English, Samuel Ng’arng’ar, Nick Aduro, Loice Mutai, David Kimutai, Caren Emadau, Cecilia Mutiso, Celia Muturi, Charles Nzioki, Francis Kanyingi, Agnes Mithamo, Magdalene Kuria, Sam Otido, Anne Kamunya, Alice Kariuki, Peris Njiiri, Rachel Inginia, Melab Musabi, Barnabas Kigen, Grace Akech, Lydia Thuranira, Morris Ogero, Thomas Julius, Boniface Makone, Mercy Chepkirui, Wycliffe Nyachiro, James Wafula
Heterogeneous response and progression patterns reveal phenotypic heterogeneity of tyrosine kinase inhibitor response in metastatic renal cell carcinoma
Shanthini M. Crusz, Yen Zhi Tang, Shah-Jalal Sarker, Warner Prevoo, Irfan Kiyani, Luis Beltran, John Peters, Anju Sahdev, Axel Bex, Thomas Powles, Marco Gerlinger
Genomic profiling for copy number changes in plasma of ovarian cancer patients – a new era for cancer diagnostics?
Vathany Kulasingam, Eleftherios P. Diamandis
Modelling the effect of short-course multidrug-resistant tuberculosis treatment in Karakalpakstan, Uzbekistan
James M. Trauer, Jay Achar, Nargiza Parpieva, Atadjan Khamraev, Justin T. Denholm, Dennis Falzon, Ernesto Jaramillo, Anita Mesic, Philipp du Cros, Emma S. McBryde
The inevitable colonisation of Singapore by Zika virus
Dale Fisher, Jeffery Cutter
Physical multimorbidity and psychosis: comprehensive cross sectional analysis including 242,952 people across 48 low- and middle-income countries
Brendon Stubbs, Ai Koyanagi, Nicola Veronese, Davy Vancampfort, Marco Solmi, Fiona Gaughran, André F. Carvalho, John Lally, Alex J. Mitchell, James Mugisha, Christoph U. Correll
Evaluation of computer-based computer tomography stratification against outcome models in connective tissue disease-related interstitial lung disease: a patient outcome study
Joseph Jacob, Brian J. Bartholmai, Srinivasan Rajagopalan, Anne Laure Brun, Ryoko Egashira, Ronald Karwoski, Maria Kokosi, Athol U. Wells, David M. Hansell
Post-marketing withdrawal of anti-obesity medicinal products because of adverse drug reactions: a systematic review
Igho J. Onakpoya, Carl J. Heneghan, Jeffrey K. Aronson
Reporting of statistically significant results at ClinicalTrials.gov for completed superiority randomized controlled trials
Agnes Dechartres, Elizabeth G. Bond, Jordan Scheer, Carolina Riveros, Ignacio Atal, Philippe Ravaud
Alcohol and stroke: the splitters win again
Arthur L. Klatsky, H. Nicole Tran
Adult-onset Still’s disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centers
Piero Ruscitti, Paola Cipriani, Francesco Masedu, Daniela Iacono, Francesco Ciccia, Vasiliki Liakouli, Giuliana Guggino, Francesco Carubbi, Onorina Berardicurti, Paola Di Benedetto, Marco Valenti, Giovanni Triolo, Gabriele Valentini, Roberto Giacomelli
A framework: make it useful to guide and improve practice of clinical trial design in smaller populations
Kit C. B. Roes
Identifying and prioritizing lower value services from Dutch specialist guidelines and a comparison with the UK do-not-do list
Joost Johan Godert Wammes, M. Elske van den Akker-van Marle, Eva W. Verkerk, Simone A. van Dulmen, Gert P. Westert, Antoinette D. I. van Asselt, R. B. Kool
Cumulative subgroup analysis to reduce waste in clinical research for individualised medicine
Fujian Song, Max O. Bachmann
Outcomes of notifications to health practitioner boards: a retrospective cohort study
Matthew J. Spittal, David M. Studdert, Ron Paterson, Marie M. Bismark
Impact of a web-based tool (WebCONSORT) to improve the reporting of randomised trials: results of a randomised controlled trial
Sally Hopewell, Isabelle Boutron, Douglas G. Altman, Ginny Barbour, David Moher, Victor Montori, David Schriger, Jonathan Cook, Stephen Gerry, Omar Omar, Peter Dutton, Corran Roberts, Eleni Frangou, Lei Clifton, Virginia Chiocchia, Ines Rombach, Karolina Wartolowska, Philippe Ravaud
Cost-effectiveness of screening for ovarian cancer amongst postmenopausal women: a model-based economic evaluation
Ben Kearns, Jim Chilcott, Sophie Whyte, Louise Preston, Susi Sadler
Tumour response in metastatic renal cell carcinoma treated with tyrosine kinase inhibitors – assessment of intra-tumour heterogeneity
Viktoria Stühler, Jens Bedke
Achieving development goals for HIV, tuberculosis and malaria in sub-Saharan Africa through integrated antenatal care: barriers and challenges
Freya J. I. Fowkes, Bridget L. Draper, Margaret Hellard, Mark Stoové
How effective are volunteers at supporting people in their last year of life? A pragmatic randomised wait-list trial in palliative care (ELSA)
Catherine Walshe, Steven Dodd, Matt Hill, Nick Ockenden, Sheila Payne, Nancy Preston, Guillermo Perez Algorta
Taking advantage of unexpected WebCONSORT results
Erik Cobo, José Antonio González
Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence
Qin Wang, Peter Würtz, Kirsi Auro, Ville-Petteri Mäkinen, Antti J. Kangas, Pasi Soininen, Mika Tiainen, Tuulia Tynkkynen, Jari Jokelainen, Kristiina Santalahti, Marko Salmi, Stefan Blankenberg, Tanja Zeller, Jorma Viikari, Mika Kähönen, Terho Lehtimäki, Veikko Salomaa, Markus Perola, Sirpa Jalkanen, Marjo-Riitta Järvelin, Olli T. Raitakari, Johannes Kettunen, Debbie A. Lawlor, Mika Ala-Korpela
Cognition in chronic kidney disease: a systematic review and meta-analysis
Israel Berger, Sunny Wu, Philip Masson, Patrick J. Kelly, Fiona A. Duthie, William Whiteley, Daniel Parker, David Gillespie, Angela C. Webster
Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies
Dagfinn Aune, NaNa Keum, Edward Giovannucci, Lars T. Fadnes, Paolo Boffetta, Darren C. Greenwood, Serena Tonstad, Lars J. Vatten, Elio Riboli, Teresa Norat
Mapping the decision pathways of acute infection management in secondary care among UK medical physicians: a qualitative study
Timothy Miles Rawson, Esmita Charani, Luke Stephen Prockter Moore, Bernard Hernandez, Enrique Castro-Sánchez, Pau Herrero, Pantelis Georgiou, Alison Helen Holmes
What works for whom in pharmacist-led smoking cessation support: realist review
Trisha Greenhalgh, Fraser Macfarlane, Liz Steed, Robert Walton
Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose–response meta-analysis of prospective cohort studies
Xuexian Fang, Kai Wang, Dan Han, Xuyan He, Jiayu Wei, Lu Zhao, Mustapha Umar Imam, Zhiguang Ping, Yusheng Li, Yuming Xu, Junxia Min, Fudi Wang
Impact of pneumococcal conjugate vaccines on pneumococcal meningitis cases in France between 2001 and 2014: a time series analysis
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