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Open Access 01-12-2016 | Minireview

Advances in immunotherapy for melanoma

Authors: Jason M. Redman, Geoffrey T. Gibney, Michael B. Atkins

Published in: BMC Medicine | Issue 1/2016

Abstract

In recent years, the introduction and Federal Drug Administration approval of immune checkpoint inhibitor antibodies has dramatically improved the clinical outcomes for patients with advanced melanoma. These antagonist monoclonal antibodies are capable of unleashing dormant or exhausted antitumor immunity, which has led to durable complete and partial responses in a large number of patients. Ipilimumab targets the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) receptor. Nivolumab and pembrolizumab target programmed cell death protein 1 (PD-1) receptors and have proven to be superior to ipilimumab alone. The combination of ipilimumab and nivolumab has yielded higher response rates, greater tumor shrinkage, and longer progression-free survival than either monotherapy alone. As other promising immunotherapies for melanoma proceed through clinical trials, future goals include defining the role of immune checkpoint inhibitors as adjuvant therapy, identifying optimal combination strategies, and developing reliable predictive biomarkers to guide treatment selection for individual patients.

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Title: Advances in immunotherapy for melanoma
Authors: Jason M. Redman
Geoffrey T. Gibney
Michael B. Atkins
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: BMC Medicine / Issue 1/2016
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/s12916-016-0571-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Advances in immunotherapy for melanoma

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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