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Open Access 01-12-2016 | Review

Clinical use of whole genome sequencing for Mycobacterium tuberculosis

Authors: Adam A. Witney, Catherine A. Cosgrove, Amber Arnold, Jason Hinds, Neil G. Stoker, Philip D. Butcher

Published in: BMC Medicine | Issue 1/2016

Abstract

Drug-resistant tuberculosis (TB) remains a major challenge to global health and to healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of which 1.4 % were multidrug-resistant TB (MDR-TB). Extensively drug-resistant TB (XDR-TB) occurs at a much lower rate, but the impact on the patient and hospital is severe. Current diagnostic methods such as drug susceptibility testing and targeted molecular tests are slow to return or examine only a limited number of target regions, respectively. Faster, more comprehensive diagnostics will enable earlier use of the most appropriate drug regimen, thus improving patient outcomes and reducing overall healthcare costs. Whole genome sequencing (WGS) has been shown to provide a rapid and comprehensive view of the genotype of the organism, and thus enable reliable prediction of the drug susceptibility phenotype within a clinically relevant timeframe. In addition, it provides the highest resolution when investigating transmission events in possible outbreak scenarios. However, robust software and database tools need to be developed for the full potential to be realized in this specialized area of medicine.

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Title: Clinical use of whole genome sequencing for Mycobacterium tuberculosis
Authors: Adam A. Witney
Catherine A. Cosgrove
Amber Arnold
Jason Hinds
Neil G. Stoker
Philip D. Butcher
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: BMC Medicine / Issue 1/2016
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/s12916-016-0598-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical use of whole genome sequencing for Mycobacterium tuberculosis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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