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BMC Medicine
Published in: BMC Medicine 1/2016

Open Access 01-12-2016 | Review

Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis

Authors: Alimuddin Zumla, Martin Rao, Ernest Dodoo, Markus Maeurer

Published in: BMC Medicine | Issue 1/2016

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Abstract

Treatment of multidrug-resistant tuberculosis (MDR-TB) is extremely challenging due to the virulence of the etiologic strains of Mycobacterium tuberculosis (M. tb), the aberrant host immune responses and the diminishing treatment options with TB drugs. New treatment regimens incorporating therapeutics targeting both M. tb and host factors are urgently needed to improve the clinical management outcomes of MDR-TB. Host-directed therapies (HDT) could avert destructive tuberculous lung pathology, facilitate eradication of M. tb, improve survival and prevent long-term functional disability. In this review we (1) discuss the use of HDT for cancer and other infections, drawing parallels and the precedent they set for MDR-TB treatment, (2) highlight preclinical studies of pharmacological agents commonly used in clinical practice which have HDT potential, and (3) outline developments in cellular therapy to promote clinically beneficial immunomodulation to improve treatment outcomes in patients with pulmonary MDR-TB. The use of HDTs as adjuncts to MDR-TB therapy requires urgent evaluation.
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Metadata
Title
Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis
Authors
Alimuddin Zumla
Martin Rao
Ernest Dodoo
Markus Maeurer
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2016
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-016-0635-1

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