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Nephrology

Case Studies

Concomitant dermatomyositis and IgA nephropathy

An extremely rare case of dermatomyositis concomitant with IgA nephropathy. Although the possibility of coincidental co-occurrence cannot be ruled out, it seems more likely that a common pathologic mechanism plays a role.

Macrophage activation syndrome following varicella

Common infections can trigger macrophage activation syndrome. This case of a 10-year-old girl developing MAS during the convalescence period after varicella highlights the complexities of MAS diagnosis.

Extreme thrombocytosis as initial presentation of vasculitis

This case highlights that extreme reactive thrombocytosis may be part of the initial presentation of microscopic polyangiitis, potentially serving as an early diagnostic clue in the context of systemic inflammation. 

Cushing syndrome and arginine vasopressin disorder in pregnancy

Polyuria in pregnant women with Cushing syndrome can be due to hypercortisolism-induced AVP resistance and increased renal clearance. In this case, polyuria resolved postpartum and left adrenalectomy was performed.

Misdiagnosis of diabetic ketoacidosis

A woman with abdominal pain was diagnosed with ureteral stones, but her pain persisted despite stent placement. A prior diagnosis of type 2 diabetes led to diabetic ketoacidosis being identified as the cause of the pain. 

Coexistence of ADH1 with Bartter syndrome and CML

Autosomal dominant hypocalcemia 1 and Bartter syndrome in a man with lifelong hypoparathyroidism contributed to worsened control of hypoparathyroidism during earlier tyrosine kinase inhibitor treatment for chronic myeloid leukemia.

Infective endocarditis mimicking ANCA-associated vasculitis

Patients with infective endocarditis and antineutrophil cytoplasmic antibody positivity may present with symptoms and laboratory abnormalities suggestive of ANCA-associated vasculitis. A high index of suspicion is required when diagnosing such cases.

Unusual presentation of SLE

The diagnosis of systemic lupus erythematosus in this 15-year-old girl was delayed because she presented with gastrointestinal symptoms that occurred and receded concomitantly with her menstrual cycle.

Hypoparathyroidism with cardiovascular complications

Hypoparathyroidism-induced hypocalcemia accompanied by an interventricular septal dissecting aneurysm in a 45-year-old woman who presented with worsening paroxysmal chest tightness and palpitations.

Serious complication in patient with CNS lymphoma

A patient with primary central nervous system lymphoma receiving a high-dose methotrexate regimen developed capillary leak syndrome, which ultimately led to acute kidney injury. There should be a high suspicion for this rare but serious complication.

Kidney involvement in VEXAS syndrome

VEXAS syndrome is a recently identified genetic autoinflammatory disorder. This case highlights its under-recognized renal manifestations and underscores the need for heightened clinical suspicion and earlier intervention.

Primary aldosteronism diagnosed in intensive care

Severe sepsis and septic shock in the ICU typically present with metabolic acidosis. In this case, the atypical presentation of resistant hypokalemia and alkalosis led to a diagnosis of primary aldosteronism.

SLE presenting with bilateral retinal vasculitis

A unique case of bilateral retinal vasculitis as the initial manifestation of systemic lupus erythematosus. Recognizing the possibility of such atypical presentations allows clinicians to maintain a high index of suspicion for SLE.

Managing septic shock in a pediatric AML patient

A 10-year-old boy exhibited persistent pancytopenia following treatment for mucormycosis, with further diagnosis revealing AML. Septic shock soon followed, but was successfully managed with combined CRRT and CytoSorb therapy.

Is abdominal pain signaling acute intermittent porphyria?

AIP can easily be overlooked in its early stages. When a patient presents with central, peripheral, or autonomic nervous system symptoms and common causes are ruled out, AIP should be considered.

Multimodality imaging features of systemic amyloidosis

Myocardial amyloidosis is often missed in the early stages. Understand the importance of multimodal imaging in diagnosing systemic AL amyloidosis, particularly when patients present with extra-cardiac symptoms.

LADA and Graves disease preceded by minimal change nephrotic syndrome in childhood

A young woman diagnosed with minimal change nephrotic syndrome in childhood developed latent autoimmune diabetes in adults and Graves disease. HLA testing was performed to investigate her genetic background.

A hypokalemic hypertension mystery

Reninoma should be considered in young people with hypokalemic hypertension when common causes have been excluded. Excision can cure hypertension and prevent morbidity and mortality.

Extreme euglycemic ketoacidosis managed with hemodialysis

A patient with pancreatogenic diabetes developed life-threatening euglycemic ketoacidosis following re-exposure to an SGLT2 inhibitor and alcohol excess. Early renal replacement therapy was successful.

Rare complication in a patient with seminoma

A patient treated with carboplatin for stage I seminoma developed hematuria and acute kidney injury. It is crucial to recognize this rare but serious complication and start treatment promptly to prevent further kidney damage.

Image Credits
Hand of patient with IgA nephropathy and dermatomyositis/© 2025, Md. Gias Uddin et al, under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature, Rheumatol Int, Confluent hemorrhagic rashes around ankle joint /© 2025, H. Mateiko et al, J Med Case Reports, Renal biopsy of patient with thrombocytosis and ANCA-associated vasculitis/© 2025, Andrés Hormaza-Jaramillo et al, BMC Rheumatol, Resected left adrenal tumor/© (M) 2025, Shinnosuke Hata et al, BMC Endocr Disord, Woman with abdominal pain/© Srisakorn / iStock / Getty Images Plus (symbolic image with model), DNA mutation concept image/© Andrii Yalanskyi / iStock / Getty Images Plus, Document under magnifying glass/© Sandwish / Getty Images / iStock, Analysis of kidney biopsy of SLE patient presenting with abdominal pain/© 2025, Chloe Kupelian et al, J Med Case Reports, CT angiography of an ventricular septum-inferior wall aortic dissecting aneurysm/© 2025, Ronghua Huang et al, BMC Endocr Disord, Immunohistology of patient with CNS lymphoma and capillary leak syndrome/© 2025, Wenpeng Li et al, under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature, Cancer Chemother Pharmacol, Immunohistochemistry of patient with kidney involvement in VEXAS syndrome/© 2025, Gabriel Ştefan et al, Clin Rheumatol, CT scan indicating left adrenal adenoma/© (M) 2025, Yug Garg et al, J Med Case Reports, Fundus fluorescein angiogram of SLE patient with retinal vasculitis/© 2025, Chirath Priyanga Madurapperuma et al, J Med Case Reports, Soft tissue cellulitis with central necrosis in pediatric patient/© 2025, Amir Saeed et al, BMC Infect Dis, Patient with acute intermittent porphyria, indicating significant atrophy in the bilateral upper limb muscles/© 2025, Jing Wang et al, BMC Neurol, TTE showing left and right ventricular myocardial hypertrophy/© 2025, Yi Yu et al. BMC Cardiovasc Disord , Woman at a medical appointment/© kazuma seki / Getty Images / iStock, Microscopy image of a reninoma/© 2024, NSW Pathirana et al, BMC Endocr Disord, Hemodialysis machine/© saengsuriya13 / stock.adobe.com (symbolic image with model), CT scan of seminoma patient with carboplatin-induced hematuria/© 2024, Patricia Capdevila et al, J Med Case Reports