Top

Japanese Journal of Radiology

Published in:

01-05-2021 | Original Article

Age-related changes in the distribution of intravenously administered gadolinium-based contrast agents leaked into the cerebrospinal fluid in patients with suspected endolymphatic hydrops

Authors: Toshio Ohashi, Shinji Naganawa, Saeko Iwata, Kayao Kuno

Published in: Japanese Journal of Radiology | Issue 5/2021

Abstract

Purpose

The purpose of this retrospective study was to investigate the relationship between age and leakage of intravenously administered gadolinium-based contrast agents (GBCAs) into the cerebrospinal fluid (CSF) by volumetric segmentation of the whole-cranium CSF.

Materials and methods

In 30 patients clinically diagnosed with suspected endolymphatic hydrops, the three-dimensional real inversion recovery (3D-real IR) images were obtained at pre- and 4 h post-intravenous administration of a single dose of GBCA. The volume of interest was set on the whole-cranium CSF in the 3D-real IR image. The signal intensity (SI)-increase of the ventricular CSF and the extra-ventricular CSF at 4 h post-administration of GBCA compared to pre-administration was measured. The relationship between the age of the patient and the SI-increase was evaluated.

Results

A correlation between age and the SI-increase was observed in the whole-cranium CSF. The correlation coefficient between age and the SI-increase in the ventricular CSF was higher than that in the extra-ventricular CSF.

Conclusion

An age-related leakage of the intravenously administered GBCAs was found in the whole-brain CSF. The age-related change in the distribution of the GBCA leakage was more prominent in the ventricular CSF than in the extra-ventricular CSF.

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. A perivascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med. 2012;4:147ra111.CrossRef

Naganawa S, Suzuki K, Yamazaki M, Sakurai Y. Serial scans in healthy volunteers following intravenous administration of gadoteridol: time course of contrast enhancement in various cranial fluid spaces. Magn Reson Med Sci. 2014;13:7–13.CrossRef

Naganawa S, Nakane T, Kawai H, Taoka T. Gd-based contrast enhancement of the perivascular spaces in the basal ganglia. Magn Reson Med Sci. 2017;16:61–5.CrossRef

Naganawa S, Kawai H, Sone M, Nakashima T. Increased sensitivity to low concentration gadolinium contrast by optimized heavily T2-weighted 3D-FLAIR to visualize endolymphatic space. Magn Reson Med Sci. 2010;9:73–80.CrossRef

Kanda T, Ishii K, Kawaguchi H, Kitajima K, Takenaka D. High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolinium-based contrast material. Radiology. 2014;270:834–41.CrossRef

Weinmann HJ, Brasch RC, Press WR, Wesbey GE. Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. Am J Roentgenol. 1984;142:619–24.CrossRef

Taoka T, Naganawa S. Gadolinium-based contrast media, cerebrospinal fluid and the glymphatic system: possible mechanisms for the deposition of gadolinium in the brain. Magn Reson Med Sci. 2018;17:111–9.CrossRef

Taoka T, Jost G, Naganawa S, Pietsch H. Impact of the glymphatic system on the kinetic and distribution of gadodiamide in the rat brain: observations by dynamic MR imaging and effect of circadian rhythm on tissue gadolinium concentrations. Investig Radiol. 2018;53:529–34.CrossRef

Naganawa S, Nakane T, Kawai H, Taoka T. Age dependence of gadolinium leakage from the cortical veins into the cerebrospinal fluid assessed with whole brain 3D-real inversion recovery MR imaging. Magn Reson Med Sci. 2019;18:163–9.CrossRef

10.

Ohashi T, Naganawa S, Ogawa E, Katagiri T, Kuno K. Signal intensity of the cerebrospinal fluid after intravenous administration of gadolinium-based contrast agents: strong contrast enhancement around the vein of Labbe. Magn Reson Med Sci. 2019;18:194–9.CrossRef

11.

Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523:337–41.CrossRef

12.

Naganawa S, Ito R, Taoka T, Yoshida T, Sone M. The space between the pial sheath and the cortical venous wall may connect to the meningeal lymphatics. Magn Reson Med Sci. 2020;19:1–4.CrossRef

13.

Ohashi T, Naganawa S, Katagiri T, Kuno K. Relationship between contrast enhancement of the perivascular space in the basal ganglia and endolymphatic volume ratio. Magn Reson Med Sci. 2018;17:67–72.CrossRef

14.

Naganawa S, Ito R, Kawai H, Taoka T, Yoshida T, Sone M. Confirmation of age-dependence in the leakage of contrast medium around the cortical veins into cerebrospinal fluid after intravenous administration of gadolinium-based contrast agent. Magn Reson Med Sci. 2020. https://doi.org/10.2463/mrms.mp.2019-0182.CrossRefPubMedPubMedCentral

15.

Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018;17:1016–24.CrossRef

16.

Naganawa S, Kawai H, Taoka T, Sone M. Improved 3D-real inversion recovery: a robust imaging technique for endolymphatic hydrops after intravenous administration of gadolinium. Magn Reson Med Sci. 2019;18:105–8.CrossRef

17.

Ohashi T, Naganawa S, Takeuchi A, Katagiri T, Kuno K. Quantification of endolymphatic space volume after intravenous administration of a single dose of gadolinium-based contrast agent: 3D-real inversion recovery versus HYDROPS-Mi2. Magn Reson Med Sci. 2020;19:119–24.CrossRef

18.

Ohashi T, Naganawa S, Iwata S, Kuno K. Distribution of gadolinium-based contrast agent after leaking into the cerebrospinal fluid: comparison between the cerebral cisterns and the lateral ventricles. Magn Reson Med Sci. 2020. https://doi.org/10.2463/mrms.mp.2020-0016.CrossRefPubMed

19.

Naganawa S, Ohashi T, Kanou M, Kuno K, Sone M, Ikeda M. Volume quantification of endolymph after intravenous administration of a single dose of gadolinium contrast agent: comparison of 18- versus 8-minute imaging protocols. Magn Reson Med Sci. 2015;14:257–62.CrossRef

20.

Orešković D, Radoš M, Klarica M. Role of choroid plexus in cerebrospinal fluid hydrodynamics. Neuroscience. 2017;354:69–87.CrossRef

21.

Nehra AK, McDonald RJ, Bluhm AM, Gunderson TM, Murray DL, Jannetto PJ, et al. Accumulation of gadolinium in human cerebrospinal fluid after gadobutrol-enhanced MR imaging: a prospective observational cohort study. Radiology. 2018;288:416–23.CrossRef

22.

Erdő F, Denes L, de Lange E. Age-associated physiological and pathological changes at the blood–brain barrier: a review. J Cereb Blood Flow Metab. 2017;37:4–24.CrossRef

23.

Sakai K, Yamada K, Mori S, Sugimoto N, Nishimura T. Age-dependent brain temperature decline assessed by diffusion-weighted imaging thermometry. NMR Biomed. 2011;24:1063–7.CrossRef

24.

Kuriyama N, Yamada K, Sakai K, Tokuda T, Akazawa K, Tomii Y, et al. Ventricular temperatures in idiopathic normal pressure hydrocephalus (iNPH) measured with DWI-based MR thermometry. Magn Reson Med Sci. 2015;14(4):305–12.CrossRef

25.

Asgari N, Flanagan EP, Fujihara K, Kim HJ, Skejoe HP, Wuerfel J, et al. Disruption of the leptomeningeal blood barrier in neuromyelitis optica spectrum disorder. Neurol Neuroimmunol Neuroinflamm. 2017;4:e343.CrossRef

26.

Aso T, Sugihara G, Murai T, Ubukata S, Urayama SI, Ueno T, et al. A venous mechanism of ventriculomegaly shared between traumatic brain injury and normal ageing. Brain. 2020;143:1843–56.CrossRef

27.

Gibson WP. Hypothetical mechanism for vertigo in Meniere’s disease. Otolaryngol Clin N Am. 2010;43:1019–27.CrossRef

Title: Age-related changes in the distribution of intravenously administered gadolinium-based contrast agents leaked into the cerebrospinal fluid in patients with suspected endolymphatic hydrops
Authors: Toshio Ohashi
Shinji Naganawa
Saeko Iwata
Kayao Kuno
Publication date: 01-05-2021
Publisher: Springer Singapore
Published in: Japanese Journal of Radiology / Issue 5/2021
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-020-01079-0

At a glance: The STEP trials

Springer Medicine

Age-related changes in the distribution of intravenously administered gadolinium-based contrast agents leaked into the cerebrospinal fluid in patients with suspected endolymphatic hydrops

Abstract

Purpose

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 5/2021

Pulmonary vascular enlargement and lesion extent on computed tomography are correlated with COVID-19 disease severity

Texture analysis of delayed contrast-enhanced computed tomography to diagnose cardiac sarcoidosis

Magnetic resonance imaging findings in 11 cases of dedifferentiated endometrial carcinoma of the uterus

There are no three physiological narrowings in the upper urinary tract: a new concept of the retroperitoneal anatomy around the ureter

Whole-liver transcatheter arterial chemoinfusion and bland embolization with fine-powder cisplatin and trisacryl gelatin microspheres for treating unresectable multiple hepatocellular carcinoma

Reviewing applications of structural and functional MRI for bipolar disorder