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Current Pain and Headache Reports

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01-09-2019 | Central Nervous System Trauma | Secondary Headache (M Robbins, Section Editor)

Linking Traumatic Brain Injury, Sleep Disruption and Post-Traumatic Headache: a Potential Role for Glymphatic Pathway Dysfunction

Authors: Juan Piantino, Miranda M. Lim, Craig D. Newgard, Jeffrey Iliff

Published in: Current Pain and Headache Reports | Issue 9/2019

Abstract

Purpose of the Review

Traumatic brain injury (TBI) is a major public health concern in the USA and worldwide. Sleep disruption and headaches are two of the most common problems reported by patients after TBI. In this manuscript, we review the current knowledge regarding the relation between post-traumatic sleep disruption and headaches. We also describe the role of the glymphatic system as a potential link between TBI, sleep, and headaches.

Recent Findings

Recent studies show a reciprocal relation between post-traumatic sleep disruption and headaches: patients with sleep disruption after TBI report more headaches, and post-traumatic headaches are a risk factor for developing disrupted sleep. Despite this clinical association, the exact mechanisms linking post-traumatic sleep disruption and headaches are not well understood. The glymphatic pathway, a newly described brain–wide network of perivascular spaces that supports the clearance of interstitial solutes and wastes from the brain, is active primarily during sleep, and becomes dysfunctional after TBI. We propose a model where changes in glymphatic function caused by TBI and post-traumatic sleep disruption may impair the clearance of neuropeptides involved in the pathogenesis of post-traumatic headaches, such as CGRP.

Summary

The relation between TBI, post-traumatic sleep disruption, and post-traumatic headaches, although well documented in the literature, remains poorly understood. Dysfunction of the glymphatic system caused by TBI offers a novel and exiting explanation to this clinically observed phenomenon. The proposed model, although theoretical, could provide important mechanistic insights to the TBI-sleep-headache association.

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Title: Linking Traumatic Brain Injury, Sleep Disruption and Post-Traumatic Headache: a Potential Role for Glymphatic Pathway Dysfunction
Authors: Juan Piantino
Miranda M. Lim
Craig D. Newgard
Jeffrey Iliff
Publication date: 01-09-2019
Publisher: Springer US
Keywords: Central Nervous System Trauma
Migraine
Traumatic Brain Injuries
Tension Headache
Headache
Published in: Current Pain and Headache Reports / Issue 9/2019
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI: https://doi.org/10.1007/s11916-019-0799-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Linking Traumatic Brain Injury, Sleep Disruption and Post-Traumatic Headache: a Potential Role for Glymphatic Pathway Dysfunction

Abstract

Purpose of the Review

Recent Findings

Summary

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose of the Review

Recent Findings

Summary

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