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Journal of the International AIDS Society

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Open Access 01-12-2010 | Meeting report

Workshop report: “Towards a Cure: HIV Reservoirs and Strategies to Control Them”

Author: Richard J Jefferys

Published in: Journal of the International AIDS Society | Special Issue 3/2010

Abstract

On 16 and 17 July 2010, immediately prior to the XVIII International AIDS Conference in Vienna, Austria, the International AIDS Society held a workshop on the important topic of moving beyond antiretroviral therapy and addressing HIV persistence. “Towards a Cure: HIV Reservoirs and Strategies to Control Them” was chaired by Nobel laureate Françoise Barré-Sinoussi and co-sponsored by the French National Agency for Research on AIDS and Viral Hepatitis, Bundesministerium für Wissenschaft und Forschung, the National Institutes of Health, Sidaction and the Treatment Action Group. This article gives an overview of the findings presented at the workshop; complete abstracts are included in this supplement to the Journal of the International AIDS Society.

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Dinoso JB, Kim SY, Wiegand AM, Palmer SE, Gange SJ, Cranmer L, O'Shea A, Callender M, Spivak A, Brennan T, Kearney MF, Proschan MA, Mican JM, Rehm CA, Coffin JM, Mellors JW, Siliciano RF, Maldarelli F: Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci USA. 2009, 106 (23): 9403-9408. 10.1073/pnas.0903107106.PubMedCentralCrossRefPubMed

McMahon D, Jones J, Wiegand A, Gange SJ, Kearney M, Palmer S, McNulty S, Metcalf JA, Acosta E, Rehm C, Coffin JM, Mellors JW, Maldarelli F: Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy. Clin Infect Dis. 2010, 50 (6): 912-919. 10.1086/650749.PubMedCentralCrossRefPubMed

10.

Kaplan R, Sinclair E, Landay A, Lurain N, Gange S, Sharrett R, Xue N, Hunt P, Hodis H, Deeks S: T Cell Senescence and T Cell Activation Predict Carotid Atherosclerosis in HIV-infected Women. 17th Conference on Retroviruses and Opportunistic Infections. 2010, San Francisco, USA, Paper #709

11.

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12.

Chun TW, Nickle DC, Justement JS, Large D, Semerjian A, Curlin ME, O'Shea MA, Hallahan CW, Daucher M, Ward DJ, Moir S, Mullins JI, Kovacs C, Fauci AS: HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J Clin Invest. 2005, 115 (11): 3250-3255. 10.1172/JCI26197.PubMedCentralCrossRefPubMed

13.

Yukl S, Sinclair E, Epling L, Li Q, Shergill A, McQuaid K, Duan L, Hare B, Lampiris H, Haase A, Havlir D, Wong J: CD4+ T cell reconstitution, T cell activation, and memory T cell subset composition in blood and gut of HIV-negative and ART-suppressed HIV-positive patients: implications for HIV persistence in the gut [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O1-PubMedCentralCrossRef

14.

Koelsch KK, Xu Y, Bailey M, McBride K, Seddiki N, Suzuki K, Murray J, Cooper DA, Kelleher AD, Zaunders J: Most HIV DNA in PBMC is present in non-gut homing, resting memory CD4+ T cells with a ß7-CD38-CD127 high phenotype [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O2-PubMedCentralCrossRef

15.

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16.

Schnell G, Joseph S, Spudich S, Price R, Swanstrom R: Where are macrophage-tropic viruses? [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O3-PubMedCentralCrossRef

17.

Marcello A, Kula A, Dieudonne M, Knezevich A, Maiuri P: Novel pathways of transcriptional and post-transcriptional regulation of post-integrative HIV-1 latency [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O4-PubMedCentralCrossRef

18.

Cherrier T, Marban C, Schwartz C, Redel L, Van Lint C, Rohr O: The cellular cofactor CTIP2 is a key regulator of HIV-1 latency [Abstract]. XVIII International AIDS Conference. 2010, Vienna, Austria, TUPE0004

19.

Sobhian B, Laguette N, Yatim A, Nakamura M, Levy Y, Kiernan R, Benkirane M: HIV-1 Tat complexes reveal subunit composition of active P-TEFb and stable association with 7SKsnRNP [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O5-PubMedCentralCrossRef

20.

Hütter G, Nowak D, Mossner M, Ganepola S, Müssig A, Allers K, Schneider T, Hofmann J, Kücherer C, Blau O, Blau IW, Hofmann WK, Thiel E: Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009, 360 (7): 692-698. 10.1056/NEJMoa0802905.CrossRefPubMed

21.

Bosque A, Planelles V: Homeostatic proliferation of memory T cells and expansion of the HIV-1 latent reservoir [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O6-PubMedCentralCrossRef

22.

Evans VA, Saleh S, Haddad EK, Cameron PU, Sekaly R-P, Lewin SR: Myeloid dendritic cells induce HIV-1 latency in non-proliferating CD4+ T cells [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O7-PubMedCentralCrossRef

23.

Fellay J, Shianna KV, Colombo S, Ledergerber B, Cirulli ET, Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-lepri A, De Luca A, Easterborrk P, Günthard HF, Mallal S, Mussini C, Dalmau J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ, Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE, Beckmann JS, O’Brien JS, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Feng S, Telenti A, Goldstein DB, NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI): Common genetic variation and the control of HIV-1 in humans. PLoS Genet. 2009, 5 (12): e1000791-10.1371/journal.pgen.1000791.PubMedCentralCrossRefPubMed

24.

Kuhl B, Sloan R, Donahue D, Bar-Magen T, Liang C, Wainberg M: Tetherin restricts direct cell-cell viral transfer and transmission of HIV-1 [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O8-PubMedCentralCrossRef

25.

Danielson C, Hope T: The role of the ubiquitin-proteasome pathway in rhTRIM5 restriction of HIV-1 [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O9-PubMedCentralCrossRef

26.

Schrijvers RLG, De Rijck J, Gijsbers R, Ronen K, Bushman FD, Debyser Z: LEDGF/p75 is critical but not essential for multiple round HIV-1 replication [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O10-PubMedCentralCrossRef

27.

Bignami F, Pilotti E, Bertoncelli L, Ronzi P, Gulli M, Marmiroli N, Magnani G, Pinti M, Mussini C, Lopalco L, Ruotolo R, Galli M, Cossarizza A, Casoli C: Changes in CD4+ cells' miRNA expression following exposure to HIV-1 [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O11-PubMedCentralCrossRef

28.

Garrido C, Rallón N, Zahonero N, de la O López M, Soriano V, de Mendoza C, Benito JM: Benito JM: Impact of Raltegravir on immune reconstitution and thymopoiesis in HIV-1-infected patients with undetectable viremia [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O12-PubMedCentralCrossRef

29.

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Díaz L, Gutiérrez C, Page C, Lorente R, Hernández-Novoa B, Vallejo A, Domínguez E, Abad M, Madrid N, Moreno A, Pérez-Elías MJ, Rubio R, Muñoz-Fernández MA, Moreno S: Effect of 24 weeks of intensification with a CCR5-antagonist on the decay of the HIV-1 latent reservoir [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O13-PubMedCentralCrossRef

31.

DaFonseca S, Chomont N, El Far M, Boulassel R, Routy J, Sékaly R: Purging the HIV-1 reservoir through the disruption of the PD-1 pathway [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O15-PubMedCentralCrossRef

32.

Mexas A, Graf E, Agosto L, Yu JJ, Pace M, Liszewski M, Migueles S, Connors M, O'Doherty U: Measurements of total and integrated HIV DNA demonstrate sporadic blips of unintegrated HIV DNA in HIV-positive patients on HAART [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O16-PubMedCentralCrossRef

33.

Lewis MG, Norelli S, Chomont N, De Fonseca S, Sgarbanti M, Collins M, Chirullo B, Yalley-Ogunro J, Greenhouse J, Palamara AT, Garaci E, Savarino A: Epigenetic drug Gar1041 in combination with antiretroviral therapy transiently reduces the proviral DNA reservoir in SIVmac251-infected macaques [Abstract]. Journal of the International AIDS Society. 2010, 13 (Suppl 4): O14-PubMedCentralCrossRef

34.

Lohse N, Hansen AB, Pedersen G, Kronborg G, Gerstoft J, Sørensen HT, Vaeth M, Obel N: Survival of persons with and without HIV infection in Denmark, 1995-2005. Ann Intern Med. 2007, 146 (2): 87-95.CrossRefPubMed

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DiMasi JA, Hansen RW, Grabowski HG: The price of innovation: new estimates of drug development costs. Journal of Health Economics. 2003, 22: 151-185. 10.1016/S0167-6296(02)00126-1.CrossRefPubMed

Title: Workshop report: “Towards a Cure: HIV Reservoirs and Strategies to Control Them”
Author: Richard J Jefferys
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Journal of the International AIDS Society / Issue Special Issue 3/2010
Electronic ISSN: 1758-2652
DOI: https://doi.org/10.1186/1758-2652-13-S3-I1

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Other articles of this Special Issue 3/2010

Tetherin restricts direct cell-cell viral transfer and transmission of HIV-1

CD4+ T cell reconstitution, T cell activation, and memory T cell subset composition in blood and gut of HIV-negative and ART-suppressed HIV-positive patients: implications for HIV persistence in the gut

Most HIV DNA in PBMC is present in non-gut homing, resting memory CD4+ T cells with a ß7-CD38-CD127 high phenotype

Measurements of total and integrated HIV DNA demonstrate sporadic blips of unintegrated HIV DNA in HIV-positive patients on HAART

Purging the HIV-1 reservoir through the disruption of the PD-1 pathway

Impact of Raltegravir on immune reconstitution and thymopoiesis in HIV-1-infected patients with undetectable viremia

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Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

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