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Published in: Journal of the International AIDS Society 3/2010

Open Access 01-12-2010 | Oral presentation

Epigenetic drug Gar1041 in combination with antiretroviral therapy transiently reduces the proviral DNA reservoir in SIVmac251-infected macaques

Authors: MG Lewis, S Norelli, N Chomont, S De Fonseca, M Sgarbanti, M Collins, B Chirullo, J Yalley-Ogunro, J Greenhouse, AT Palamara, E Garaci, A Savarino

Published in: Journal of the International AIDS Society | Special Issue 3/2010

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Excerpt

It was recently hypothesized that the lentiviral reservoir in central memory (TCM) and transitional memory (TTM) CD4+ cells could be restricted by new therapies targeting pathways downstream of homeostatic proliferation or pathways associated with “stem cell–ness”, such as those developed for the treatment of leukemias. Gar1041 is one such epigenetic drug adopted in the experimental treatment of certain types of leukemia. …
Metadata
Title
Epigenetic drug Gar1041 in combination with antiretroviral therapy transiently reduces the proviral DNA reservoir in SIVmac251-infected macaques
Authors
MG Lewis
S Norelli
N Chomont
S De Fonseca
M Sgarbanti
M Collins
B Chirullo
J Yalley-Ogunro
J Greenhouse
AT Palamara
E Garaci
A Savarino
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S3-O14

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