Published in:
Open Access
01-12-2010 | Oral presentation
Epigenetic drug Gar1041 in combination with antiretroviral therapy transiently reduces the proviral DNA reservoir in SIVmac251-infected macaques
Authors:
MG Lewis, S Norelli, N Chomont, S De Fonseca, M Sgarbanti, M Collins, B Chirullo, J Yalley-Ogunro, J Greenhouse, AT Palamara, E Garaci, A Savarino
Published in:
Journal of the International AIDS Society
|
Special Issue 3/2010
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Excerpt
It was recently hypothesized that the lentiviral reservoir in central memory (TCM) and transitional memory (TTM) CD4+ cells could be restricted by new therapies targeting pathways downstream of homeostatic proliferation or pathways associated with “stem cell–ness”, such as those developed for the treatment of leukemias. Gar1041 is one such epigenetic drug adopted in the experimental treatment of certain types of leukemia. …