Published in:
Open Access
01-12-2010 | Oral presentation
Most HIV DNA in PBMC is present in non-gut homing, resting memory CD4+ T cells with a ß7-CD38-CD127 high phenotype
Authors:
KK Koelsch, Y Xu, M Bailey, K McBride, N Seddiki, K Suzuki, J Murray, DA Cooper, AD Kelleher, J Zaunders
Published in:
Journal of the International AIDS Society
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Special Issue 3/2010
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Excerpt
Recent studies report that most CD4+ T cell depletion occurs in gut-associated lymphoid tissue (GALT), inferring that most viral replication occurs in these tissues. Memory CD4 T lymphocytes in peripheral blood comprise two main subsets: those with integrins α4ß7 that recirculate through GALT; and those with α4ß1 that do not access GALT. We tested the hypothesis that α4ß7+ CD4 T cells are preferentially infected with HIV DNA. …