Skip to main content
Top
Published in: Journal of the International AIDS Society 3/2010

Open Access 01-12-2010 | Oral presentation

Most HIV DNA in PBMC is present in non-gut homing, resting memory CD4+ T cells with a ß7-CD38-CD127 high phenotype

Authors: KK Koelsch, Y Xu, M Bailey, K McBride, N Seddiki, K Suzuki, J Murray, DA Cooper, AD Kelleher, J Zaunders

Published in: Journal of the International AIDS Society | Special Issue 3/2010

Login to get access

Excerpt

Recent studies report that most CD4+ T cell depletion occurs in gut-associated lymphoid tissue (GALT), inferring that most viral replication occurs in these tissues. Memory CD4 T lymphocytes in peripheral blood comprise two main subsets: those with integrins α4ß7 that recirculate through GALT; and those with α4ß1 that do not access GALT. We tested the hypothesis that α4ß7+ CD4 T cells are preferentially infected with HIV DNA. …
Metadata
Title
Most HIV DNA in PBMC is present in non-gut homing, resting memory CD4+ T cells with a ß7-CD38-CD127 high phenotype
Authors
KK Koelsch
Y Xu
M Bailey
K McBride
N Seddiki
K Suzuki
J Murray
DA Cooper
AD Kelleher
J Zaunders
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S3-O2

Other articles of this Special Issue 3/2010

Journal of the International AIDS Society 3/2010 Go to the issue