Published in:
Open Access
01-12-2010 | Oral presentation
CD4+ T cell reconstitution, T cell activation, and memory T cell subset composition in blood and gut of HIV-negative and ART-suppressed HIV-positive patients: implications for HIV persistence in the gut
Authors:
S Yukl, E Sinclair, L Epling, Q Li, A Shergill, K McQuaid, L Duan, B Hare, H Lampiris, A Haase, D Havlir, J Wong
Published in:
Journal of the International AIDS Society
|
Special Issue 3/2010
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Excerpt
HIV DNA and RNA levels in the gut exceed those in the blood up to 10-fold. The ileum and rectum differ in HIV levels and responses to intensification, suggesting that mechanisms of persistence may vary between sites. HIV persistence could be impacted by T cell activation, absolute CD4 levels, or composition of memory T cell subsets. …