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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 3/2010

Open Access 01-12-2010 | Oral presentation

Purging the HIV-1 reservoir through the disruption of the PD-1 pathway

Authors: S DaFonseca, N Chomont, M El Far, R Boulassel, J Routy, R Sékaly

Published in: Journal of the International AIDS Society | Special Issue 3/2010

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Excerpt

The main obstacle to HIV-1 eradication is a small pool of TCM (central memory) and TTM (transitional memory) latently infected CD4+ T cells that persist in patients receiving HAART. The mechanisms implicated in the establishment and persistence of the HIV reservoir are still unknown. The PD-1 receptor is expressed by CD4+ T cells from HIV-infected patients, and efficiently inhibits T cell proliferation. Here, we investigate a possible role for this receptor in the establishment and maintenance of a cellular reservoir for HIV. …
Metadata
Title
Purging the HIV-1 reservoir through the disruption of the PD-1 pathway
Authors
S DaFonseca
N Chomont
M El Far
R Boulassel
J Routy
R Sékaly
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S3-O15

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