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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 3/2010

Open Access 01-12-2010 | Oral presentation

The role of the ubiquitin-proteasome pathway in rhTRIM5α restriction of HIV-1

Authors: CM Danielson, TJ Hope

Published in: Journal of the International AIDS Society | Special Issue 3/2010

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Excerpt

rhTRIM5α is a restriction factor that blocks HIV-1 infection by interacting with the capsid core early after entry. Although rhTRIM5α blocks accumulation of reverse transcription products, proteasome inhibitors rescue reverse transcription while maintaining a block to infection, supporting the involvement of the proteasome in the mechanism of restriction. …
Metadata
Title
The role of the ubiquitin-proteasome pathway in rhTRIM5α restriction of HIV-1
Authors
CM Danielson
TJ Hope
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S3-O9

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