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Pharmacokinetics 

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  1. Open Access 13-03-2024 | Warfarin | OriginalPaper

    Effect of Daridorexant on the Pharmacokinetics of Midazolam, and on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Male Subjects

    Daridorexant is a selective and potent dual orexin receptor antagonist, acting equipotently on both orexin receptor type 1 and type 2 in wake-promoting brain regions [ 1 ]. It antagonizes the activation of orexin receptors by the orexin …

  2. 04-05-2024 | Pharmacokinetics | Online First

    Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review

    Intravenous (IV) lidocaine exhibits significant pharmacokinetic (PK) variability among individuals and has a low threshold for toxicity. However, several studies have reported an unclear or weak correlation between plasma concentrations and the …

  3. 23-03-2024 | Pharmacokinetics | Report

    Pharmacology and pharmacokinetics of tazemetostat

    Tazemetostat, a novel oral selective inhibitor of enhancer of zeste homolog 2 (EZH2), was approved by the Food and Drug Administration (FDA) in 2020 for use in patients with advanced epithelioid sarcoma or relapsed/refractory (R/R) EZH2-mutated …

  4. Open Access 14-03-2024 | Naloxone | ReviewPaper

    Clinical Pharmacokinetics and Pharmacodynamics of Naloxone

    Naloxone is a World Health Organization (WHO)-listed essential medicine and is the first choice for treating the respiratory depression of opioids, also by lay-people witnessing an opioid overdose. Naloxone acts by competitive displacement of …

  5. 02-05-2024 | Fabry Disease | Online First

    Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral AL01211 in Healthy Chinese Volunteers

    Glycosphingolipids (GSLs) are an essential component of the outer leaflet of cell membranes. Glycosphingolipids are continuously recycled through their degradation within lysosomes by a set of glycohydrolases and accessory glycoproteins [ 1 ].

  6. Open Access 25-04-2024 | Hemophagocytic Lymphohistiocytosis | Online First

    Population Pharmacokinetics of the Anti-Interferon-Gamma Monoclonal Antibody Emapalumab: An Updated Analysis

    Hemophagocytic lymphohistiocytosis (HLH) is a rare, aggressive, and potentially fatal syndrome characterized by excessive, uncontrolled immune activation and systemic hyperinflammation [ 1 – 3 ]. Primary HLH is associated with genetic defects and …

  7. Open Access 24-04-2024 | Pharmacokinetics | Online First

    Safety, Tolerability, and Pharmacokinetics of Oral BI 1358894 in Healthy Japanese Male Volunteers

    Major depressive disorder (MDD) is a psychiatric condition characterized by depressed mood, loss of interest or pleasure, insomnia or hypersomnia, reduced concentration and attention, reduced self-confidence, and suicidal ideation [ 1 , 2 ].

  8. 04-05-2024 | Pharmacokinetics | Online First

    Effect of food on the pharmacokinetics and safety profiles of a new PARP inhibitor fuzuloparib capsules in healthy volunteers

    The Poly (ADP-Ribose) polymerases (PARPs) family protein repair single-strand breaks (SSBs) in DNA by base excision repair (BER) prior to DNA replication and reduce double-strand breaks (DSBs) caused by single-strand breaks in replication [ 1 – 3 …

  9. 08-03-2024 | Artificial Intelligence | ReviewPaper

    Predicting Pharmacokinetics of Drugs Using Artificial Intelligence Tools: A Systematic Review

    The term pharmacokinetics was initially introduced in 1953 [ 1 ]. Pharmacokinetics pertain to the changes in concentration or quantities of a metabolite within a biological system over time. It encompasses the processes of absorption, distribution …

  10. Open Access 13-04-2024 | Milrinone | Online First

    Time-Varying Clearance in Milrinone Pharmacokinetics from Premature Neonates to Adolescents

    Milrinone is a type III phosphodiesterase inhibitor that increases cardiac contractility and myocardial relaxation rate, and decreases systemic vascular resistance. It does not raise myocardial oxygen consumption nor increase heart rate, which are …

  11. 28-04-2024 | Pharmacokinetics | Online First

    Adjust antimicrobial agent regimens in older patients to correct for changes in pharmacokinetics and to avoid adverse events

    Treating infections with antimicrobial agents in older patients can be challenging. Physiological changes associated with aging can alter the pharmacokinetics of antimicrobial agents; dose adjustments may be required to provide effective and safe …

  12. 10-03-2024 | Fremanezumab | ReviewPaper

    Anti-calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Clinical Pharmacokinetics

    The calcitonin gene-related peptide transmission was the target for recent development of drugs that effectively prevent attacks of both episodic and chronic migraine. The aim of this narrative review was to offer deeper insight into …

  13. Open Access 07-04-2024 | Infliximab | Online First

    Pharmacokinetics of Monoclonal Antibodies Throughout Pregnancy: A Systematic Literature Review

    Monoclonal antibodies (mAbs) are an important therapeutic modality for conditions that commonly affect women of child-bearing potential, such as autoimmune disorders [ 1 ]. Although relatively little information is available on the pharmacokinetics

  14. 01-03-2024 | Interferon | Letter

    Pharmacokinetics of Baricitinib in Cerebrospinal Fluid and Plasma in a Patient with SPENCD

    We read with great interest the article by Fremond et al. [ 1 ] reporting their experience with JAK1/2 inhibitors in a cohort of Aicardi-Goutières Syndrome (AGS) patients ( n  = 11). The reported clinical and radiological features, Type I …

  15. 29-04-2024 | Online First

    Comparison of the Pharmacokinetics of Gadolinium-Based and Iron Oxide-Based Contrast Agents inside the Lymphatic Structure using Magnetic Resonance Lymphangiography

    Magnetic resonance lymphangiography (MRL) has emerged as a valuable imaging technique for lymphatic system imaging, employing the advantageous features of magnetic resonance imaging (MRI) [ 1 – 6 ]. MRL has several advantages, such as having …

  16. Open Access 17-04-2024 | Adalimumab | Online First

    Population Pharmacokinetics of Adalimumab in Juvenile Idiopathic Arthritis Patients: A Retrospective Cohort Study Using Clinical Care Data

    Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children, characterized by chronic joint inflammation, persisting for at least 6 weeks without any identifiable cause in children younger than 16 years [ 1 ]. The most …

  17. Open Access 04-05-2024 | COVID-19 | Online First

    Efficacy, Safety, and Pharmacokinetics of AZD7442 (Tixagevimab/Cilgavimab) for Prevention of Symptomatic COVID-19: 15-Month Final Analysis of the PROVENT and STORM CHASER Trials

    This article is published with digital features, including a graphical abstract, to facilitate understanding of the article. To view digital features for this article, go to https://doi.org/10.6084/m9.figshare.25499122 .

  18. 06-05-2024 | Lamotrigine | Online First

    Influence of UGT2B7, UGT1A4 and ABCG2 Polymorphisms on the Pharmacokinetics and Therapeutic Efficacy of Lamotrigine in Patients with Epilepsy

    Lamotrigine, a second-generation antiepileptic drug (AED), has been widely prescribed for generalized and focal onset epilepsy, exhibiting favorable therapeutic efficacy [ 1 ]. Its mechanism of action likely involves the modulation of …

  19. Open Access 25-04-2024 | Pharmacokinetics | Online First

    A Phase 1a Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7303509, an Anti-TGFβ3 Antibody, in Healthy Volunteers

    Fibrosis is defined as the progressive accumulation of fibrous connective tissue that occurs when the normal wound-healing process becomes dysregulated [ 1 – 5 ]. The excessive accumulation of extracellular matrix (ECM) components replaces normal …

  20. 02-04-2024 | Trastuzumab | OriginalPaper

    A Phase I Clinical Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of GB221 Injection and Trastuzumab (Herceptin®) in Healthy Chinese Adults

    Breast cancer is the most commonly diagnosed cancer and the primary cause of cancer-related death among women [ 1 ]. About 20% of breast cancer patients overexpress human epidermal growth factor receptor 2 (HER2), and the over-expression of HER2 is …

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