Issue 1/2013
Content (157 Articles)
Critical role of p38 MAPK for regeneration of the sciatic nerve following crush injury in vivo
Naoki Kato, Masahito Matsumoto, Masakazu Kogawa, Gerald J Atkins, David M Findlay, Takahiko Fujikawa, Hiromi Oda, Masato Ogata
Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer’s disease mice model
Peng Jin, Jin-A Kim, Dong-Young Choi, Young-Jung Lee, Heon Sang Jung, Jin Tae Hong
Two new cases of anti-Ca (anti-ARHGAP26/GRAF) autoantibody-associated cerebellar ataxia
Sven Jarius, Pedro Martínez-García, Adelaida León Hernandez, Jan Christoph Brase, Kathrin Borowski, Jens Ulrich Regula, Hans Michael Meinck, Winfried Stöcker, Brigitte Wildemann, Klaus-Peter Wandinger
Lack of transient receptor potential vanilloid 1 channel modulates the development of neurogenic bladder dysfunction induced by cross-sensitization in afferent pathways
Qi Lei, Xiao-Qing Pan, Antonio N Villamor, Tirsit S Asfaw, Shaohua Chang, Steven A Zderic, Anna P Malykhina
Monocyte chemoattractant protein-1 affects migration of hippocampal neural progenitors following status epilepticus in rats
Yu-Wen Hung, Ming-Tsong Lai, Yi-Jhan Tseng, Chien-Chen Chou, Yung-Yang Lin
Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions
Avanita S Prabowo, Anand M Iyer, Jasper J Anink, Wim GM Spliet, Peter C van Rijen, Eleonora Aronica
MyD88 is crucial for the development of a protective CNS immune response to Toxoplasma gondii infection
Marbel Torres, Rachel Guiton, Sonia Lacroix-Lamandé, Bernhard Ryffel, Samuel Leman, Isabelle Dimier-Poisson
Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia
Catarina Gomes, Raquel Ferreira, Jimmy George, Rui Sanches, Diana I Rodrigues, Nélio Gonçalves, Rodrigo A Cunha
TWEAK/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier
Delphine Stephan, Oualid Sbai, Jing Wen, Pierre-Olivier Couraud, Chaim Putterman, Michel Khrestchatisky, Sophie Desplat-Jégo
A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion
Helena W Morrison, Jessica A Filosa
Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia
Linli Yao, Enci Mary Kan, Jia Lu, Aijun Hao, S Thameem Dheen, Charanjit Kaur, Eng-Ang Ling
Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells
Dennis Y Chuang, Ming-Huan Chan, Yijia Zong, Wenwen Sheng, Yan He, Jing Hua Jiang, Agnes Simonyi, Zezong Gu, Kevin L Fritsche, Jiankun Cui, James C Lee, William R Folk, Dennis B Lubahn, Albert Y Sun, Grace Y Sun
Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma
Irene Paterniti, Daniela Impellizzeri, Rosalia Crupi, Rossana Morabito, Michela Campolo, Emanuela Esposito, Salvatore Cuzzocrea
Interleukin-10 modulates the synthesis of inflammatory mediators in the sensory circumventricular organs: implications for the regulation of fever and sickness behaviors
Lois M Harden, Christoph Rummel, Giamal N Luheshi, Stephen Poole, Rüdiger Gerstberger, Joachim Roth
Correction: Transcriptomics and proteomics analyses of the PACAP38 influenced ischemic brain in permanent middle cerebral artery occlusion model mice
Motohide Hori, Tomoya Nakamachi, Randeep Rakwal, Junko Shibato, Tetsuo Ogawa, Toshihiro Aiuchi, Tatsuaki Tsuruyama, Keiji Tamaki, Seiji Shioda
Absence of IL-1β positively affects neurological outcome, lesion development and axonal plasticity after spinal cord injury
Francesco Boato, Karen Rosenberger, Sofie Nelissen, Lies Geboes, Eva M Peters, Robert Nitsch, Sven Hendrix
Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion
Sandy R Shultz, Feng Bao, Lynne C Weaver, Donald P Cain, Arthur Brown
Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury
Huang Fang, Peng-Fei Wang, Yu Zhou, Yan-Chun Wang, Qing-Wu Yang
Mechanisms of action of naturally occurring antibodies against β-amyloid on microglia
Maike Gold, David Mengel, Stephan Röskam, Richard Dodel, Jan-Philipp Bach
Cerebral ischemia initiates an immediate innate immune response in neonates during cardiac surgery
Selma O Algra, Kathelijne M Groeneveld, Alvin WL Schadenberg, Felix Haas, Fabiola CM Evens, Jenny Meerding, Leo Koenderman, Nicolaas JG Jansen, Berent J Prakken
Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain
Young Se Kwon, Eduardo Pineda, Stéphane Auvin, Don Shin, Andrey Mazarati, Raman Sankar
Correction: Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
Johann Steiner, Martin Walter, Tomasz Gos, Gilles J Guillemin, Hans-Gert Bernstein, Zoltán Sarnyai, Christian Mawrin, Ralf Brisch, Hendrik Bielau, Louise M zu Schwabedissen, Bernhard Bogerts, Aye-Mu Myint
Amelioration of autoimmune neuroinflammation by the fusion molecule Fn14·TRAIL
Hodaya Prinz-Hadad, Tehila Mizrachi, Michal Irony-Tur-Sinai, Tatyana B Prigozhina, Alexandra Aronin, Talma Brenner, Michal Dranitzki-Elhalel
Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats
Evi Vlassaks, Eveline Strackx, Johan SH Vles, Maria Nikiforou, Pilar Martinez-Martinez, Boris W Kramer, Antonio WD Gavilanes
An autoinflammatory neurological disease due to interleukin 6 hypersecretion
Ettore Salsano, Ambra Rizzo, Gloria Bedini, Loris Bernard, Valentina Dall’Olio, Sara Volorio, Monica Lazzaroni, Isabella Ceccherini, Dejan Lazarevic, Davide Cittaro, Elia Stupka, Rosina Paterra, Laura Farina, Mario Savoiardo, Davide Pareyson, Francesca L Sciacca
Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology
Maria I Fonseca, Susan O McGuire, Scott E Counts, Andrea J Tenner
Hypothermia enhances induction of protective protein metallothionein under ischemia
Youn Hee Park, Young Mi Lee, Dong Sun Kim, Jaechan Park, Kyoungho Suk, Jong Kun Kim, Hyung Soo Han
Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators
Hyeon-Sook Suh, Meng-Liang Zhao, Leandra Derico, Namjong Choi, Sunhee C Lee
BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy
Michael R Pranzatelli, Elizabeth D Tate, Nathan R McGee, Anna L Travelstead, Jerry A Colliver, Jayne M Ness, Richard M Ransohoff
Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep
Reint K Jellema, Valéria Lima Passos, Alex Zwanenburg, Daan RMG Ophelders, Stephanie De Munter, Joris Vanderlocht, Wilfred TV Germeraad, Elke Kuypers, Jennifer JP Collins, Jack PM Cleutjens, Ward Jennekens, Antonio WD Gavilanes, Matthias Seehase, Hans J Vles, Harry Steinbusch, Peter Andriessen, Tim GAM Wolfs, Boris W Kramer
In vivo temporal and spatial profile of leukocyte adhesion and migration after experimental traumatic brain injury in mice
Susanne M Schwarzmaier, Ricarda Zimmermann, Niamh B McGarry, Raimund Trabold, Seong-Woong Kim, Nikolaus Plesnila
Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
Daphne YS Vogel, Elly JF Vereyken, Judith E Glim, Priscilla DAM Heijnen, Martina Moeton, Paul van der Valk, Sandra Amor, Charlotte E Teunissen, Jack van Horssen, Christine D Dijkstra
Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response
Haiyun Luan, Zechun Kan, Yong Xu, Changjun Lv, Wanglin Jiang
Ghrelin inhibits LPS-induced release of IL-6 from mouse dopaminergic neurones
Amy L Beynon, M Rowan Brown, Rhiannon Wright, Mark I Rees, I Martin Sheldon, Jeffrey S Davies
TNF-α promotes cerebral pericyte remodeling in vitro, via a switch from α1 to α2 integrins
Ulrich Tigges, Amin Boroujerdi, Jennifer V Welser-Alves, Richard Milner
Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder
Valerio Napolioni, Benjamin Ober-Reynolds, Szabolcs Szelinger, Jason J Corneveaux, Traci Pawlowski, Sharman Ober-Reynolds, Janet Kirwan, Antonio M Persico, Raun D Melmed, David W Craig, Christopher J Smith, Matthew J Huentelman
Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
Celina Wu, Soo Y Leong, Craig S Moore, Qiao Ling Cui, Pavel Gris, Louis-Philippe Bernier, Trina A Johnson, Philippe Séguéla, Timothy E Kennedy, Amit Bar-Or, Jack P Antel
Focal brain inflammation and autism
Theoharis C Theoharides, Shahrzad Asadi, Arti B Patel
Neuroinflammation and psychiatric illness
Souhel Najjar, Daniel M Pearlman, Kenneth Alper, Amanda Najjar, Orrin Devinsky
Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation
Akio Kimura, Takeo Sakurai, Nobuaki Yoshikura, Yuichi Hayashi, Masao Takemura, Hitoshi Takahashi, Takashi Inuzuka
Celecoxib reduces brain dopaminergic neuronaldysfunction, and improves sensorimotor behavioral performance in neonatal rats exposed to systemic lipopolysaccharide
Asuka Kaizaki, Lu-Tai Tien, Yi Pang, Zhengwei Cai, Sachiko Tanaka, Satoshi Numazawa, Abhay J Bhatt, Lir-Wan Fan
Brucella abortus induces TNF-α-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases
M Cruz Miraglia, Romina Scian, Clara García Samartino, Paula Barrionuevo, Ana M Rodriguez, Andrés E Ibañez, Lorena M Coria, Lis N Velásquez, Pablo C Baldi, Juliana Cassataro, M Victoria Delpino, Guillermo H Giambartolomei
Erratum to: Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB
Sen Lin, Yajie Liang, Jiqiang Zhang, Chen Bian, Hongli Zhou, Qiang Guo, Ying Xiong, Shurong Li, Bingyin Su
Poly(ADP-ribose) polymerase 2 contributes to neuroinflammation and neurological dysfunction in mouse experimental autoimmune encephalomyelitis
Amit Kamboj, Ping Lu, Michael B Cossoy, Jillian L Stobart, Brian A Dolhun, Tiina M Kauppinen, Gilbert de Murcia, Christopher M Anderson
Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment
Shannon Dallas, Michelle L Block, Deborah M Thompson, Marcelo G Bonini, Patrick T Ronaldson, Reina Bendayan, David S Miller
Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1 −/− mice
Thi A Nguyen, Tamy Frank-Cannon, Terina N Martinez, Kelly A Ruhn, Marian Marvin, Bradford Casey, Isaac Treviño, John J Hong, Matthew S Goldberg, Malú G Tansey
Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve
Petr Dubový, Václav Brázda, Ilona Klusáková, Ivana Hradilová-Svíženská
Differential expression of interferon-γ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune response
Geoffrey C Owens, My N Huynh, Julia W Chang, David L McArthur, Michelle J Hickey, Harry V Vinters, Gary W Mathern, Carol A Kruse
Acute and subacute IL-1β administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration
Cai Song, Ye Zhang, Yilong Dong
Exercise-induced hippocampal anti-inflammatory response in aged rats
Sérgio Gomes da Silva, Priscila Santos Rodrigues Simões, Renato Arruda Mortara, Fulvio Alexandre Scorza, Esper Abrão Cavalheiro, Maria da Graça Naffah-Mazzacoratti, Ricardo Mario Arida
Cerebrospinal fluid neopterin decay characteristics after initiation of antiretroviral therapy
Aylin Yilmaz, Constantin T Yiannoutsos, Dietmar Fuchs, Richard W Price, Kathryn Crozier, Lars Hagberg, Serena Spudich, Magnus Gisslén
Innate immunity in the Grid2 Lc/+ mouse model of cerebellar neurodegeneration: glial CD95/CD95L plays a non-apoptotic role in persistent neuron loss-associated inflammatory reactions in the cerebellum
Béatrice Vernet-der Garabedian, Paul Derer, Yannick Bailly, Jean Mariani
Different actions of endothelin-1 on chemokine production in rat cultured astrocytes: reduction of CX3CL1/fractalkine and an increase in CCL2/MCP-1 and CXCL1/CINC-1
Yutaka Koyama, Mao Kotani, Tadateru Sawamura, Miho Kuribayashi, Rika Konishi, Shotaro Michinaga
Genetic variability in the rat Aplec C-type lectin gene cluster regulates lymphocyte trafficking and motor neuron survival after traumatic nerve root injury
Rickard PF Lindblom, Shahin Aeinehband, Roham Parsa, Mikael Ström, Faiez Al Nimer, Xing-Mei Zhang, Cecilia A Dominguez, Sevasti Flytzani, Margarita Diez, Fredrik Piehl
Transmigration of polymorphnuclear neutrophils and monocytes through the human blood-cerebrospinal fluid barrier after bacterial infection in vitro
Ulrike Steinmann, Julia Borkowski, Hartwig Wolburg, Birgit Schröppel, Peter Findeisen, Christel Weiss, Hiroshi Ishikawa, Christian Schwerk, Horst Schroten, Tobias Tenenbaum
Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice
Marcus A Lawson, Robert H McCusker, Keith W Kelley
Effects of ethanol on immune response in the brain: region-specific changes in aged mice
Cynthia JM Kane, Kevin D Phelan, James C Douglas, Gail Wagoner, Jennifer Walker Johnson, Jihong Xu, Paul D Drew
The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis
Petra D Cravens, Bernd C Kieseier, Rehana Hussain, Emily Herndon, Benjamine Arellano, Li-Hong Ben, Brenda C Timmons, Cyd Castro-Rojas, Hans-Peter Hartung, Bernhard Hemmer, Martin S Weber, Scott S Zamvil, Olaf Stüve
Beneficial effect of TNF-α inhibition on diabetic peripheral neuropathy
Xiaohong Shi, Yinghui Chen, Lubna Nadeem, Guoxiong Xu
Protective and therapeutic potency of N-acetyl-cysteine on propionic acid-induced biochemical autistic features in rats
Abeer M Aldbass, Ramesa Shafi Bhat, Afaf El-Ansary
Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia
Jacqueline R Dauch, Diane E Bender, Lucía A Luna-Wong, Wilson Hsieh, Brandon M Yanik, Zachary A Kelly, Hsinlin T Cheng
Impaired toll-like receptor 8 signaling in multiple sclerosis
Tory P Johnson, Richa Tyagi, Karan Patel, Nicoline Schiess, Peter A Calabresi, Avindra Nath
Amyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes
Eun Ok Lee, Ji Hye Yang, Keun-A Chang, Yoo-Hun Suh, Young Hae Chong
Toll-like receptor stimulation increases phagocytosis of Cryptococcus neoformans by microglial cells
Sandra Redlich, Sandra Ribes, Sandra Schütze, Helmut Eiffert, Roland Nau
Nutraceutical agents with anti-inflammatory properties prevent dietary saturated-fat induced disturbances in blood–brain barrier function in wild-type mice
Ryusuke Takechi, Menuka M Pallebage-Gamarallage, Virginie Lam, Corey Giles, John C Mamo
The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion
Starlee Lively, Lyanne C Schlichter
Improved neurocognitive functions correlate with reduced inflammatory burden in atrial fibrillation patients treated with intensive cholesterol lowering therapy
Knut Tore Lappegård, Monica Pop-Purceleanu, Waander van Heerde, Joe Sexton, Indira Tendolkar, Gheorghe Pop
Delayed brain ischemia tolerance induced by electroacupuncture pretreatment is mediated via MCP-induced protein 1
Zhuqing Jin, Jian Liang, Jing Wang, Pappachan E Kolattukudy
Elevated serum levels of macrophage-derived chemokine and thymus and activation-regulated chemokine in autistic children
Laila Yousef AL-Ayadhi, Gehan Ahmed Mostafa
Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system
Martin Palus, Jarmila Vojtíšková, Jiří Salát, Jan Kopecký, Libor Grubhoffer, Marie Lipoldová, Peter Demant, Daniel Růžek
Disruption of the blood–brain barrier after generalized tonic-clonic seizures correlates with cerebrospinal fluid MMP-9 levels
Ya-Jun Li, Zheng-Hai Wang, Bei Zhang, Xiao Zhe, Ming-Jue Wang, Shao-Ting Shi, Jing Bai, Tao Lin, Chang-Jiang Guo, Shi-Jun Zhang, Xiang-Li Kong, Xing Zuo, Hang Zhao
Primary blast injury-induced lesions in the retina of adult rats
Ying-Ying Zou, Enci Mary Kan, Jia Lu, Kian Chye Ng, Mui Hong Tan, Linli Yao, Eng-Ang Ling
Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer’s disease mice
Baptiste Lacoste, Xin-Kang Tong, Karim Lahjouji, Réjean Couture, Edith Hamel
Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice
Gareth R Howell, Ileana Soto, Margaret Ryan, Leah C Graham, Richard S Smith, Simon WM John
Dual effects of noradrenaline on astroglial production of chemokines and pro-inflammatory mediators
Ara E Hinojosa, Javier R Caso, Borja García-Bueno, Juan C Leza, José LM Madrigal
DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson’s disease
Kiyoka Kinugawa, Yann Monnet, Catherine Béchade, Daniel Alvarez-Fischer, Etienne C Hirsch, Alain Bessis, Stéphane Hunot
Reduction of microglial activity in a model of multiple sclerosis by dipyridamole
Scott Sloka, Luanne M Metz, Walter Hader, Yves Starreveld, V Wee Yong
Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain
Maj-Linda B Selenica, Jennifer A Alvarez, Kevin R Nash, Daniel C Lee, Chuanhai Cao, Xiaoyang Lin, Patrick Reid, Peter R Mouton, Dave Morgan, Marcia N Gordon
Sunitinib enhances neuronal survival in vitro via NF-κB-mediated signaling and expression of cyclooxygenase-2 and inducible nitric oxide synthase
Alma Sanchez, Debjani Tripathy, Xiangling Yin, Jinhua Luo, Joseph M Martinez, Paula Grammas
A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury
Irene Paterniti, Daniela Impellizzeri, Rosanna Di Paola, Michele Navarra, Salvatore Cuzzocrea, Emanuela Esposito
M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia
Amy M Smith, Hannah M Gibbons, Robyn L Oldfield, Peter M Bergin, Edward W Mee, Maurice A Curtis, Richard L M Faull, Mike Dragunow
Involvement of glial P2Y1 receptors in cognitive deficit after focal cerebral stroke in a rodent model
Yo Chin, Mayo Kishi, Masaki Sekino, Fukiko Nakajo, Yoshifumi Abe, Yasushi Terazono, Ohsaki Hiroyuki, Fusao Kato, Schuichi Koizumi, Christian Gachet, Tatsuhiro Hisatsune
3H-Deprenyl and 3H-PIB autoradiography show different laminar distributions of astroglia and fibrillar β-amyloid in Alzheimer brain
Amelia Marutle, Per-Göran Gillberg, Assar Bergfors, Wenfeng Yu, Ruiqing Ni, Inger Nennesmo, Larysa Voytenko, Agneta Nordberg
Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis
Francesco Lolli, Helene Martini, Alessandra Citro, Debora Franceschini, Emilio Portaccio, Maria Pia Amato, Rosella Mechelli, Viviana Annibali, John Sidney, Alessandro Sette, Marco Salvetti, Vincenzo Barnaba
T-cell reconstitution during murine acquired immunodeficiency syndrome (MAIDS) produces neuroinflammation and mortality in animals harboring opportunistic viral brain infection
Manohar B Mutnal, Scott J Schachtele, Shuxian Hu, James R Lokensgard
Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis
Donna M Wilcock, W Sue T Griffin
The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from dorsal root ganglia
Geeta Ramesh, Lenay Santana-Gould, Fiona M Inglis, John D England, Mario T Philipp
Chronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responses
Heela Sarlus, Xiuzhe Wang, Angel Cedazo-Minguez, Marianne Schultzberg, Mircea Oprica
Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation
Magnus Gram, Snjolaug Sveinsdottir, Karsten Ruscher, Stefan R Hansson, Magnus Cinthio, Bo Åkerström, David Ley
The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage
Khalid A Hanafy
Inhibition of astroglial NF-kappaB enhances oligodendrogenesis following spinal cord injury
Valerie Bracchi-Ricard, Kate L Lambertsen, Jerome Ricard, Lubov Nathanson, Shaffiat Karmally, Joshua Johnstone, Ditte G Ellman, Beata Frydel, Dana M McTigue, John R Bethea
Compound 49b protects against blast-induced retinal injury
Youde Jiang, Li Liu, Jayaprakash Pagadala, Duane D Miller, Jena J Steinle
Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury
Run Zhang, Yi Liu, Ke Yan, Lei Chen, Xiang-Rong Chen, Peng Li, Fan-Fan Chen, Xiao-Dan Jiang
In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway
Justin A Green, Lucinda Rand, Rachel Moores, Shruti Dholakia, Theodore Pezas, Paul T Elkington, Jon S Friedland
Tumor necrosis factor alpha antagonism improves neurological recovery in murine intracerebral hemorrhage
Beilei Lei, Hana N Dawson, Briana Roulhac-Wilson, Haichen Wang, Daniel T Laskowitz, Michael L James
TLR-3 receptor activation protects the very immature brain from ischemic injury
Hui Shi, Nadia Gabarin, Edward Hickey, Rand Askalan
Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors
Marcus A Lawson, Jennifer M Parrott, Robert H McCusker, Robert Dantzer, Keith W Kelley, Jason C O’Connor
Fractalkine (CX3CL1) enhances hippocampal N-methyl-d-aspartate receptor (NMDAR) function via d-serine and adenosine receptor type A2 (A2AR) activity
Maria Scianni, Letizia Antonilli, Giuseppina Chece, Gloria Cristalli, Maria Amalia Di Castro, Cristina Limatola, Laura Maggi
Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 allele
Hiramani Dhungana, Taisia Rolova, Ekaterina Savchenko, Sara Wojciechowski, Kaisa Savolainen, Anna-Kaisa Ruotsalainen, Patrick M Sullivan, Jari Koistinaho, Tarja Malm
PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1
Sheetal Bodhankar, Yingxin Chen, Arthur A Vandenbark, Stephanie J Murphy, Halina Offner
Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi
LiZe Gu, BaoSheng Huang, Wei Shen, Li Gao, ZhengZheng Ding, HuiWen Wu, Jun Guo
Involvement of neuronal IL-1β in acquired brain lesions in a rat model of neonatal encephalopathy
Alexandre Savard, Karine Lavoie, Marie-Elsa Brochu, Djordje Grbic, Martin Lepage, Denis Gris, Guillaume Sebire
Different TLR4 expression and microglia/macrophage activation induced by hemorrhage in the rat spinal cord after compressive injury
Yu-Kai Zhang, Jin-Tao Liu, Zheng-Wu Peng, Hong Fan, An-Hui Yao, Peng Cheng, Ling Liu, Gong Ju, Fang Kuang
HIV infection and drugs of abuse: role of acute phase proteins
Thangavel Samikkannu, Kurapati VK Rao, Adriana Y Arias, Aarthi Kalaichezian, Vidya Sagar, Changwon Yoo, Madhavan PN Nair
Altered inflammatory responsiveness in serotonin transporter mutant rats
Flavia Macchi, Judith R Homberg, Francesca Calabrese, Claudia Zecchillo, Giorgio Racagni, Marco A Riva, Raffaella Molteni
The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment
Yusuke Egashira, Yukiya Suzuki, Yukio Azuma, Toshinori Takagi, Keisuke Mishiro, Sou Sugitani, Kazuhiro Tsuruma, Masamitsu Shimazawa, Shinichi Yoshimura, Masanori Kashimata, Toru Iwama, Hideaki Hara
Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice
Rachel A Kohman, Tushar K Bhattacharya, Elzbieta Wojcik, Justin S Rhodes
Toll-like receptor 9 promoter polymorphism is associated with decreased risk of Alzheimer’s disease in Han Chinese
Ying-Li Wang, Meng-Shan Tan, Jin-Tai Yu, Wei Zhang, Nan Hu, Hui-Fu Wang, Teng Jiang, Lan Tan
Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis
Fabiola Puentes, Baukje J van der Star, Marion Victor, Markus Kipp, Cordian Beyer, Regina Peferoen-Baert, Kimberley Ummenthum, Gareth Pryce, Wouter Gerritsen, Ruth Huizinga, Arie Reijerkerk, Paul van der Valk, David Baker, Sandra Amor
Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model
Lioba Horstmann, Heiko Schmid, André P Heinen, Florian C Kurschus, H Burkhard Dick, Stephanie C Joachim
Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients
Dunja Westhoff, Joost Witlox, Leo Koenderman, Kees J Kalisvaart, Jos F M de Jonghe, Mireille F M van Stijn, Alexander P J Houdijk, Inge C M Hoogland, Alasdair M J MacLullich, David J van Westerloo, Diederik van de Beek, Piet Eikelenboom, Willem A van Gool
Suppression of experimental autoimmune encephalomyelitis by interleukin-10 transduced neural stem/progenitor cells
Juliane Klose, Nils Ole Schmidt, Arthur Melms, Makoto Dohi, Jun-ichi Miyazaki, Felix Bischof, Bernhard Greve
The plasminogen activator system: involvement in central nervous system inflammation and a potential site for therapeutic intervention
Devorah Gur-Wahnon, Tehila Mizrachi, Florence-Yehudith Maaravi-Pinto, Athanasis Lourbopoulos, Nikolaos Grigoriadis, Abd -Al Roof Higazi, Talma Brenner
Leukocyte infiltration in experimental stroke
Nina Vindegaard Grønberg, Flemming Fryd Johansen, Uffe Kristiansen, Henrik Hasseldam
A novel autoantibody against ephrin type B receptor 2 in acute necrotizing encephalopathy
Tsuyoshi Shirai, Hiroshi Fujii, Masao Ono, Ryu Watanabe, Yuko Shirota, Shinichiro Saito, Tomonori Ishii, Masato Nose, Hideo Harigae
Excitotoxic neuronal cell death during an oligodendrocyte-directed CD8+ T cell attack in the CNS gray matter
Nico Melzer, Gordon Hicking, Stefan Bittner, Nicole Bobak, Kerstin Göbel, Alexander M Herrmann, Heinz Wiendl, Sven G Meuth
Inflammation induces neuro-lymphatic protein expression in multiple sclerosis brain neurovasculature
Ganta Vijay Chaitanya, Seiichi Omura, Fumitaka Sato, Nicholas E Martinez, Alireza Minagar, Murali Ramanathan, Bianca Weinstock Guttman, Robert Zivadinov, Ikuo Tsunoda, Jonathan S Alexander
TSG (2,3,4’ ,5-tetrahydroxystilbene 2-O-β-D-glucoside) suppresses induction of pro-inflammatory factors by attenuating the binding activity of nuclear factor-κB in microglia
Chao Huang, Yuzhe Wang, Jia Wang, Wenjuan Yao, Xiangfan Chen, Wei Zhang
Astrocytes acquire resistance to iron-dependent oxidative stress upon proinflammatory activation
Romina Macco, Ilaria Pelizzoni, Alessandra Consonni, Ilaria Vitali, Giacomo Giacalone, Filippo Martinelli Boneschi, Franca Codazzi, Fabio Grohovaz, Daniele Zacchetti
Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer’s brain
Wesley M Williams, Sandy Torres, Sandra L Siedlak, Rudy J Castellani, George Perry, Mark A Smith, Xiongwei Zhu
ADAMTS proteoglycanases in the physiological and pathological central nervous system
Sighild Lemarchant, Mathilde Pruvost, Joan Montaner, Evelyne Emery, Denis Vivien, Katja Kanninen, Jari Koistinaho
The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice
Ming-Hsuan Ou-Yang, William E Van Nostrand
Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways
Mohitkumar R Gangwani, Richard J Noel Jr, Ankit Shah, Vanessa Rivera-Amill, Anil Kumar
Increased interleukin-17 in the cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease: a case-control study of rapidly progressive dementia
Koji Fujita, Naoko Matsui, Yukitoshi Takahashi, Yasushi Iwasaki, Mari Yoshida, Tatsuhiko Yuasa, Yuishin Izumi, Ryuji Kaji
Optical tomographic imaging of near infrared imaging agents quantifies disease severity and immunomodulation of experimental autoimmune encephalomyelitis in vivo
Valerie L Eaton, Kristine O Vasquez, Gwendolyn E Goings, Zoe N Hunter, Jeffrey D Peterson, Stephen D Miller
Activation of the inflammatory transcription factor nuclear factor interleukin-6 during inflammatory and psychological stress in the brain
Franziska Fuchs, Jelena Damm, Rüdiger Gerstberger, Joachim Roth, Christoph Rummel
Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence
Souhel Najjar, Daniel M Pearlman, Orrin Devinsky, Amanda Najjar, David Zagzag
Activation of microglia induces symptoms of Parkinson’s disease in wild-type, but not in IL-1 knockout mice
Sachiko Tanaka, Atsuko Ishii, Hirokazu Ohtaki, Seiji Shioda, Takemi Yoshida, Satoshi Numazawa
Increased expression of T cell immunoglobulin and mucin domain 3 aggravates brain inflammation via regulation of the function of microglia/macrophages after intracerebral hemorrhage in mice
ChangJun Xu, Tao Wang, Si Cheng, YuGuang Liu
Yokukansan promotes hippocampal neurogenesis associated with the suppression of activated microglia in Gunn rat
Motohide Furuya, Tsuyoshi Miyaoka, Toshiko Tsumori, Kristian Liaury, Sadayuki Hashioka, Rei Wake, Keiko Tsuchie, Michiyo Fukushima, Satoko Ezoe, Jun Horiguchi
Targeting platelet-derived soluble CD40 ligand: a new treatment strategy for HIV-associated neuroinflammation?
Donna C Davidson, Joseph W Jackson, Sanjay B Maggirwar
Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain
Adam D Bachstetter, Scott J Webster, Linda J Van Eldik, Franca Cambi
L-arginine abolishes the hypothalamic serotonergic activation induced by central interleukin-1β administration to normal rats
Anderson Iuras, Mônica M Telles, Iracema S Andrade, Gianni MS Santos, Lila M Oyama, Cláudia MO Nascimento, Vera LF Silveira, Eliane B Ribeiro
Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury
Steven F Abcouwer, Cheng-mao Lin, Sumathi Shanmugam, Arivalagan Muthusamy, Alistair J Barber, David A Antonetti
Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer’s disease pathology in TgSwDI and 3xTg mouse models
Fernando Goñi, Krystal Herline, Daniel Peyser, Kinlung Wong, Yong Ji, Yanjie Sun, Pankaj Mehta, Thomas Wisniewski
Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer’s disease
Arnaud François, Faraj Terro, Thierry Janet, Agnès Rioux Bilan, Marc Paccalin, Guylène Page
LPS and TNF alpha modulate AMPA/NMDA receptor subunit expression and induce PGE2 and glutamate release in preterm fetal ovine mixed glial cultures
Luke Weaver-Mikaere, Alistair J Gunn, Murray D Mitchell, Laura Bennet, Mhoyra Fraser
Cellular and temporal expression of NADPH oxidase (NOX) isotypes after brain injury
Sean J Cooney, Sara L Bermudez-Sabogal, Kimberly R Byrnes
Inflammasome induction in Rasmussen’s encephalitis: cortical and associated white matter pathogenesis
Vijay Ramaswamy, John G Walsh, D Barry Sinclair, Edward Johnson, Richard Tang-Wai, B Matt Wheatley, William Branton, Ferdinand Maingat, Thomas Snyder, Donald W Gross, Christopher Power
The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activity
Mahdia Benkhoucha, Nicolas Molnarfi, Gregory Schneiter, Paul R Walker, Patrice H Lalive
Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling
Xuebo Sun, Chengyuan Ji, Tong Hu, Zhong Wang, Gang Chen
Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice
Jennifer A Stokes, Jonathan Cheung, Kelly Eddinger, Maripat Corr, Tony L Yaksh
Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor
Sarah C Hellewell, Edwin B Yan, Dasuni S Alwis, Nicole Bye, M Cristina Morganti-Kossmann
Dysregulation of the complement cascade in the hSOD1G93Atransgenic mouse model of amyotrophic lateral sclerosis
John D Lee, Nur A Kamaruzaman, Jenny NT Fung, Stephen M Taylor, Bradley J Turner, Julie D Atkin, Trent M Woodruff, Peter G Noakes
Immunological and clinical consequences of splenectomy in a multiple sclerosis patient treated with natalizumab
De-Hyung Lee, Anne Waschbisch, Alexandra B Lämmer, Arnd Doerfler, Stefan Schwab, Ralf A Linker
Glatiramer acetate treatment effects on gene expression in monocytes of multiple sclerosis patients
Madhan Thamilarasan, Michael Hecker, Robert Hermann Goertsches, Brigitte Katrin Paap, Ina Schröder, Dirk Koczan, Hans-Jürgen Thiesen, Uwe Klaus Zettl
Scolopendra subspinipes mutilans attenuates neuroinflammation in symptomatic hSOD1G93Amice
MuDan Cai, Sun-Mi Choi, Bong Keun Song, Ilhong Son, Sungchul Kim, Eun Jin Yang
Prostaglandin F2α FP receptor antagonist improves outcomes after experimental traumatic brain injury
Alexander V Glushakov, Sean W Robbins, Connor L Bracy, Shuh Narumiya, Sylvain Doré
Involvement of NT3 and P75NTRin photoreceptor degeneration following selective Müller cell ablation
Weiyong Shen, Ling Zhu, So-Ra Lee, Sook H Chung, Mark C Gillies
Toll-like receptor 4 signaling in trigeminal ganglion neurons contributes tongue-referred pain associated with tooth pulp inflammation
Kinuyo Ohara, Kohei Shimizu, Shingo Matsuura, Bunnai Ogiso, Daisuke Omagari, Masatake Asano, Yoshiyuki Tsuboi, Masamichi Shinoda, Koichi Iwata
Traumatic axonal injury in the mouse is accompanied by a dynamic inflammatory response, astroglial reactivity and complex behavioral changes
Sara Ekmark-Lewén, Johanna Flygt, Olivia Kiwanuka, Bengt J Meyerson, Anders Lewén, Lars Hillered, Niklas Marklund
Human marrow stromal cells reduce microglial activation to protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis
Chang Zhou, Chen Zhang, Renliang Zhao, Song Chi, Ping Ge, Cheng Zhang
Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients
Marcelo Ananias Teocchi, Ana Érika Dias Ferreira, Evandro Pinto da Luz de Oliveira, Helder Tedeschi, Lília D’Souza-Li