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Molecular Neurodegeneration
Published in: Molecular Neurodegeneration 1/2019

Open Access 01-12-2019 | Alzheimer's Disease | Review

Dementia with Lewy bodies: an update and outlook

Authors: Tiago Fleming Outeiro, David J. Koss, Daniel Erskine, Lauren Walker, Marzena Kurzawa-Akanbi, David Burn, Paul Donaghy, Christopher Morris, John-Paul Taylor, Alan Thomas, Johannes Attems, Ian McKeith

Published in: Molecular Neurodegeneration | Issue 1/2019

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Abstract

Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson’s disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies.
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Metadata
Title
Dementia with Lewy bodies: an update and outlook
Authors
Tiago Fleming Outeiro
David J. Koss
Daniel Erskine
Lauren Walker
Marzena Kurzawa-Akanbi
David Burn
Paul Donaghy
Christopher Morris
John-Paul Taylor
Alan Thomas
Johannes Attems
Ian McKeith
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Molecular Neurodegeneration / Issue 1/2019
Electronic ISSN: 1750-1326
DOI
https://doi.org/10.1186/s13024-019-0306-8

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