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01-06-2010 | Original Paper

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

Authors: Thomas G. Beach, Charles H. Adler, Lucia I. Sue, Linda Vedders, LihFen Lue, Charles L. White III, Haru Akiyama, John N. Caviness, Holly A. Shill, Marwan N. Sabbagh, Douglas G. Walker, Arizona Parkinson’s Disease Consortium

Published in: Acta Neuropathologica | Issue 6/2010

Abstract

A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest.

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Title: Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
Authors: Thomas G. Beach
Charles H. Adler
Lucia I. Sue
Linda Vedders
LihFen Lue
Charles L. White III
Haru Akiyama
John N. Caviness
Holly A. Shill
Marwan N. Sabbagh
Douglas G. Walker
Arizona Parkinson’s Disease Consortium
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Acta Neuropathologica / Issue 6/2010
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-010-0664-3

At a glance: The STEP trials

Springer Medicine

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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