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Current Neurology and Neuroscience Reports
Published in: Current Neurology and Neuroscience Reports 10/2018

Open Access 01-10-2018 | Dementia (K S Marder, Section Editor)

The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions

Authors: Tatiana Orme, Rita Guerreiro, Jose Bras

Published in: Current Neurology and Neuroscience Reports | Issue 10/2018

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Abstract

Purpose of Review

Dementia with Lewy bodies (DLB) is a neurodegenerative disease that can be clinically and pathologically similar to Parkinson’s disease (PD) and Alzheimer’s disease (AD). Current understanding of DLB genetics is insufficient and has been limited by sample size and difficulty in diagnosis. The first genome-wide association study (GWAS) in DLB was performed in 2017; a time at which the post-GWAS era has been reached in many diseases.

Recent Findings

DLB shares risk loci with AD, in the APOE E4 allele, and with PD, in variation at GBA and SNCA. Interestingly, the GWAS suggested that DLB may also have genetic risk factors that are distinct from those in AD and PD.

Summary

Although off to a slow start, recent studies have reinvigorated the field of DLB genetics and these results enable us to start to have a more complete understanding of the genetic architecture of this disease.
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Metadata
Title
The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions
Authors
Tatiana Orme
Rita Guerreiro
Jose Bras
Publication date
01-10-2018
Publisher
Springer US
Published in
Current Neurology and Neuroscience Reports / Issue 10/2018
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-018-0874-y

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