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Acta Neuropathologica
Published in: Acta Neuropathologica 6/2017

Open Access 01-12-2017 | Review

Alpha-synuclein oligomers: a new hope

Authors: Nora Bengoa-Vergniory, Rosalind F. Roberts, Richard Wade-Martins, Javier Alegre-Abarrategui

Published in: Acta Neuropathologica | Issue 6/2017

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Abstract

Alpha-synuclein is a protein implicated in Parkinson’s disease and thought to be one of the main pathological drivers in the disease, although it remains unclear how this protein elicits its neurotoxic effects. Recent findings indicate that the assembly of toxic oligomeric species of alpha-synuclein may be one of the key processes for the pathology and spread of the disease. The absence of a sensitive in situ detection method has hindered the study of these oligomeric species and the role they play in the human brain until recently. In this review, we assess the evidence for the toxicity and prion-like activity of oligomeric forms of alpha-synuclein and discuss the advances in our understanding of the role of alpha-synuclein in Parkinson’s disease that may be brought about by the specific and sensitive detection of distinct oligomeric species in post-mortem patient brain. Finally, we discuss current approaches being taken to therapeutically target alpha-synuclein oligomers and their implications.
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Metadata
Title
Alpha-synuclein oligomers: a new hope
Authors
Nora Bengoa-Vergniory
Rosalind F. Roberts
Richard Wade-Martins
Javier Alegre-Abarrategui
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Acta Neuropathologica / Issue 6/2017
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-017-1755-1

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