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Current Osteoporosis Reports

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01-06-2019 | Prostate Cancer | Cancer-induced Musculoskeletal Diseases (E Keller and J Sterling, Section editors)

MicroRNAs in Bone Metastasis

Authors: Eric Hesse, Hanna Taipaleenmäki

Published in: Current Osteoporosis Reports | Issue 3/2019

Abstract

Purpose of Review

This review provides an update on the recent literature describing the role of microRNAs (miRNAs) in cancer formation and bone metastasis. We confined our focus on osteosarcoma, breast cancer, prostate cancer, and epithelial-mesenchymal transition.

Recent Findings

In all areas covered, major discoveries on the role of miRNAs in tumorigenesis and metastasis have been made. Novel signaling networks were identified with miRNAs having a central function. Potential improvements in the diagnosis of malignant diseases and the long-term follow-up might become possible by the use of miRNAs. Furthermore, miRNAs also have disease-modifying properties and might emerge as a new class of therapeutic molecules.

Summary

MiRNAs are novel and important regulators of multiple cellular and molecular events. Due to their functions, miRNAs might become useful to improve the diagnosis, follow-up and treatment of cancer, and metastases. Thus, miRNAs are molecules of great interest in translational medicine.

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Title: MicroRNAs in Bone Metastasis
Authors: Eric Hesse
Hanna Taipaleenmäki
Publication date: 01-06-2019
Publisher: Springer US
Keywords: Prostate Cancer
osteosarcoma
Metastasis
Breast Cancer
Prostate Cancer
Breast Cancer
Osteosarcoma
Bone Metastasis
Biomarkers
Chondrosarcoma
Published in: Current Osteoporosis Reports / Issue 3/2019
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-019-00510-4

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

MicroRNAs in Bone Metastasis

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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