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Seminars in Immunopathology
Published in: Seminars in Immunopathology 4/2019

Open Access 01-07-2019 | Insulins | Review

Islet inflammation in type 2 diabetes

Authors: Marianne Böni-Schnetzler, Daniel T. Meier

Published in: Seminars in Immunopathology | Issue 4/2019

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Abstract

Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell failure is a major component of the pathogenesis of type 2 diabetes. It is now well established that increased numbers of innate immune cells, cytokines, and chemokines have detrimental effects on islets in these chronic conditions. Recently, evidence emerged which points to initially adaptive and restorative functions of inflammatory factors and immune cells in metabolism. In the following review, we provide an overview on the features of islet inflammation in diabetes and models of prediabetes. We separately emphasize what is known on islet inflammation in humans and focus on in vivo animal models and how they are used to elucidate mechanistic aspects of islet inflammation. Further, we discuss the recently emerging physiologic signaling role of cytokines during adaptation and normal function of islet cells.
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Metadata
Title
Islet inflammation in type 2 diabetes
Authors
Marianne Böni-Schnetzler
Daniel T. Meier
Publication date
01-07-2019
Publisher
Springer Berlin Heidelberg
Published in
Seminars in Immunopathology / Issue 4/2019
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-019-00745-4

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