Pancreatic ductal adenocarcinoma (PDAC) remains a formidable clinical challenge with a dismal 5-year survival rate around 13% [ 1 , 2 ]. Contributing factors to this bleak prognosis include delayed diagnosis and therapeutic resistance. Metabolic …
T lymphocytes are indispensable for the host systems of defense against pathogens, tumors, and environmental threats. The therapeutic potential of harnessing the cytotoxic properties of T lymphocytes for antigen-specific cell elimination is both …
Authors:
Fengling Wang, Yong Huang, JiaQian Li, Weilin Zhou, Wei Wang
Primary liver cancer ranks as the sixth most commonly diagnosed cancer (906,000 new cases) and the third leading cause of cancer-related deaths (830,000 deaths) worldwide, as reported in global cancer statistics for 2020 [ 1 ]. Notably …
Gastric cancer (GC) is a malignant tumor with one of the lowest five-year survival rates. Traditional first-line treatment regimens, such as platinum drugs, have limited therapeutic efficacy in treating advanced GC and significant side effects …
Authors:
Dike Shi, Zihan Yang, Yanna Cai, Hongbo Li, Lele Lin, Dan Wu, Shengyu Zhang, Qingqu Guo
During the past decade, the field of immuno-oncology has dramatically advanced. Variety of immunotherapy approaches are introduced to the clinic to enhance durable immunity against solid tumours. However, high immunotoxicity and low immunogenicity …
Authors:
Siavash Mashhouri, Amirhossein Rahmati, Ako Azimi, Roy A. Fava, Ismail Hassan Ismail, John Walker, Shokrollah Elahi
Despite chimeric antigen receptor (CAR) T-cell therapy has achieved great advances in recent year, approximately 50% of relapsed/refractory B cell acute lymphoblastic leukemia (r/r B-ALL) patients treated with CAR-T experience relapse 6 months …
Authors:
Yangzi Li, Qingya Cui, Sining Liu, Lingling Liu, Megyn Li, Jun Gao, Zheng Li, Wei Cui, Xiaming Zhu, Liqing Kang, Lei Yu, Depei Wu, Xiaowen Tang
Breast cancer (BC) is currently the most prevalent malignancy among women globally, and accounts for approximately 25.4% of all cancers in women [ 1 , 2 ]. The mortality rate of BC patients in 2019 was 1.34 per million, and tumor metastasis is the …
Chordoma is a rare (one in a million per year) [ 1 , 2 ], slow-growing malignant tumor with a phenotype that recapitulates notochord differentiation [ 3 ]. For example, chordoma cells express brachyury (T), a notochordal T-box transcription factor …
Osteosarcoma is recognized as the predominant primary malignant bone tumor in the adolescent population, with an incidence rate of approximately 8.7 per million individuals [ 1 ]. This malignancy exhibits a high level of severity, characterized by …
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with a propensity for early metastatic spread [ 1 ]. Approximately 80% of PDAC patients are diagnosed at an advanced stage with a dismal prognosis [ 2 , 3 ].
Authors:
Soon-Chan Kim, Ha-Young Seo, Ja-Oh Lee, Ju Eun Maeng, Young-Kyoung Shin, Sang Hyub Lee, Jin-Young Jang, Ja-Lok Ku
Coactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing arginine methylation of histone and non-histone proteins, plays a crucial role in developing various cancers. CARM1 was initially recognized as a transcriptional …
Lung cancer continues to be the foremost cause of global cancer-related mortality and constitutes 22.7% of malignant tumors [ 1 , 2 ]. Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell lung cancer (NSCLC) and …
Authors:
Shengqiang Mao, Yilong Wang, Ningning Chao, Lingyan Zeng, Li Zhang
Hepatocellular carcinoma (HCC) is a primary liver cancer type that remains a significant global health concern due to the high mortality rates and limited effective therapies [ 1 , 2 ]. HCC commonly metastasizes (spreads to other organs) and …
Dexmedetomidine (DEX), a highly selective α 2 -adrenoceptor agonist, is commonly used during cancer surgeries for both sedation and analgesia. Recent clinical data suggest that perioperative use of DEX is associated with cancer metastasis and …
Authors:
Jing Dong, Ji Che, Yuanyuan Wu, Yixu Deng, Xuliang Jiang, Zhiyong He, Jun Zhang
Lung cancer is a highly prevalent malignancy worldwide [ 1 ], with non-small cell lung cancer (NSCLC) being the most common subtype, accounting for approximately 80-85% of all lung cancer cases [ 2 ]. The development of NSCLC is profoundly …
Chimeric antigen receptor (CAR)-T cells therapy offers unprecedented efficacy for patients with hematologic malignancies. CD19 CAR-T cells have been approved as the standard of care in relapsed/refractory (r/r) diffuse large B-cell lymphoma …
Authors:
Xiangke Xin, Xiaojian Zhu, Yang Yang, Na Wang, Jue Wang, Jinhuan Xu, Jia Wei, Liang Huang, Miao Zheng, Yi Xiao, Chunrui Li, Yang Cao, Fankai Meng, Lijun Jiang, Yicheng Zhang
A higher incidence of aggressive endometrial cancer (EC) has been reported in the Martinique population, with 25% of patients with uterine papillary serous carcinoma (UPSC), 12% of with uterine carcinosarcoma (UCS), and 3% with uterine clearcell …
As the fourth leading cause of tumor-related death, pancreatic ductal adenocarcinoma (PDAC) is still the most malignant cancer in the world, with a 5-year overall survival (OS) rate lower than 7% [ 1 , 2 ]. At present, surgical resection is the …
