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Cellular Oncology

Open Access 15-04-2024 | Biomarkers | Review

The emerging role of CARM1 in cancer

Authors: Zizhuo Xie, Yuan Tian, Xiaohan Guo, Na Xie

Published in: Cellular Oncology

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Abstract

Coactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing arginine methylation of histone and non-histone proteins, plays a crucial role in developing various cancers. CARM1 was initially recognized as a transcriptional coregulator by orchestrating chromatin remodeling, transcription regulation, mRNA splicing and stability. This diverse functionality contributes to the recruitment of transcription factors that foster malignancies. Going beyond its established involvement in transcriptional control, CARM1-mediated methylation influences a spectrum of biological processes, including the cell cycle, metabolism, autophagy, redox homeostasis, and inflammation. By manipulating these physiological functions, CARM1 becomes essential in critical processes such as tumorigenesis, metastasis, and therapeutic resistance. Consequently, it emerges as a viable target for therapeutic intervention and a possible biomarker for medication response in specific cancer types. This review provides a comprehensive exploration of the various physiological functions of CARM1 in the context of cancer. Furthermore, we discuss potential CARM1-targeting pharmaceutical interventions for cancer therapy.
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Metadata
Title
The emerging role of CARM1 in cancer
Authors
Zizhuo Xie
Yuan Tian
Xiaohan Guo
Na Xie
Publication date
15-04-2024
Publisher
Springer Netherlands
Keyword
Biomarkers
Published in
Cellular Oncology
Print ISSN: 2211-3428
Electronic ISSN: 2211-3436
DOI
https://doi.org/10.1007/s13402-024-00943-9
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