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Gastroenterology and Hepatology

Editor's Choice

High burden of alcohol-related liver disease revealed across USA

The prevalence of alcohol-related liver disease and metabolic dysfunction-associated alcohol-related liver disease has been underestimated in the USA.

Organ transplantation in people with HIV

Advances in therapeutics and immunosuppression have improved solid organ transplantation outcomes in people with HIV but a heightened rejection risk and unique management complexities remain. Here is what you need to know.

PSC-associated IBD: a distinct colitis phenotype?

Emerging data support the concept that PSC-associated IBD be viewed as a distinct colitis phenotype that is pathophysiologically linked to PSC rather than as a subtype of ulcerative colitis.

Histology-guided biologics in active ulcerative colitis?

Successful use of mirikizumab in three patients with active ulcerative colitis was guided by clinical presentation plus high neutrophilic infiltration of the colonic epithelium (Geboes Grade 3.2).

LSM independently predicts mortality risk in type 2 diabetes

Liver stiffness measurement is an independent risk factor for overall mortality in people with type 2 diabetes, even over just 2 years of follow-up.

Identifying hydatid cysts

Explore current imaging, serological, and immunological techniques for identifying hydatid cysts in cystic echinococcosis as well as the recent breakthroughs in recombinant antigen-based assays and nanobiosensors.

GLP-1 and GIP agonists should be paused prior to upper endoscopy

Study confirms that continuing GLP-1 or GLP-1/GIP agonists before elective upper endoscopy raises residual gastric volume risk, supporting guidance to pause therapy prior to procedures.

Colonic metastasis from breast cancer

Although colonic metastases from breast cancer are extremely rare, it is important for patients with a history of breast cancer who present with GI symptoms to undergo prompt endoscopic evaluation.

Advancing liver transplantation for hepatocellular carcinoma

Early experience with donation after circulatory death grafts in people with HCC raised concerns about outcomes and recurrence, but they are an increasing share of liver transplants thanks to advanced perfusion technologies.

What was the cause of obstructive shock in this patient?

An inferior vena cava filter was deployed in this patient with decompensated liver cirrhosis. However, while receiving invasive mechanical ventilation in the ICU, the patient developed obstructive shock. CT revealed a large hemopericardium with tamponade, but what was the cause?

GI cancers in women: the role of sex hormones

The relationship between sex hormones and GI cancers in women is complex, with hormones being protective or predisposing. Understanding how hormonal, genetic, and environmental factors interact could improve GI cancer care for women.

Tips and tricks with underwater endoscopic submucosal dissection

U-ESD provides natural traction and enhanced visualization that aids removal of complex GI lesions. With ongoing refinements in the technique, U-ESD may become the standard in advanced therapeutic endoscopy.

IBD flare or an infectious complication?

A woman taking adalimumab for ileocolic Crohn’s disease presented with symptoms mimicking a flare. CT revealed extensive venous thrombosis, but respiratory symptoms developed and disseminated tuberculosis was diagnosed.

Immediate high-energy nutrition may increase adverse outcomes in acute pancreatitis

The GOULASH study finds no justification for a high-energy approach to early nutrition in patients with acute pancreatitis.

A new therapeutic dawn for ulcerative colitis?

A significant proportion of people with ulcerative colitis don’t respond to the currently available treatments or lose response over time. Could repurposed medications offer a new way forward and how might they be used?

Adjuvant imatinib may be beneficial for GIST with KIT exon 9 mutations

Postoperative treatment with imatinib could significantly delay recurrence and improve survival among individuals with gastrointestinal stromal tumors carrying KIT exon 9 mutations.

Reproductive health in adolescent and young women with IBD

IBD impacts adolescents and young women during prime developmental and reproductive years. By understanding how IBD impacts puberty, menses, contraception, fertility, and pregnancy, gastroenterologists can help optimize whole-person care.

Cholecystectomy outcomes improving for US patients

The risk for surgical complications from minimally invasive laparoscopic or robotic cholecystectomy has significantly declined in the USA despite an increase in patient complexity.

Eosinophilic ascites: an underrecognized entity

Eosinophilic ascites is a rare but clinically significant manifestation of eosinophilic gastroenteritis, often misdiagnosed as malignancy, tuberculosis, or cirrhosis. Accurate and timely diagnosis and treatment with corticosteroids are key.

Deciphering Whipple disease

The latest insights into Whipple disease, from epidemiology and pathophysiology to clinical manifestations and treatment. Explore confounding factors in diagnosis and management, and current treatment limitations.

Image Credits
Alcoholic drinks on a bar/© Michael Piazza / Photodisc / Getty Images, Organ transplantation surgery/© sturti / E+ / Getty (symbolic image with models), Representative endoscopic images of PSC-associated IBD/© 2026, Haruka Okada et al, J Gastroenterol (CC-BY-4.0), Pretreatment findings in a patient with active ulcerative colitis/© 2026, Ichitaro Horiuchi et al, Clin J Gastroenterol (CC BY 4.0), Measurement of liver stiffness/© Casanowe / iStock / Getty Images Plus (symbolic image with models), 3D illustration of hydatid cyst of Echinococcus granulosus/© Dr_Microbe / stock.adobe.com, 3D render of a red pause button on yellow background/© spawns / iStock / Getty Images Plus, Abdominal CT of breast cancer patient with colonic metastasis/© 2026, Matteo Matteucci et al, Int J Colorectal Dis, Papercut liver being held in adult hands/© Ekaterina / stock.adobe.com, CT scan showing a metallic fragment penetrating the inferior right ventricle wall/© 2026, Anaïs Curtiaud et al, Intensive Care Med, Family of women looking at a photo album/© FG Trade Latin / Getty Images (symbolic image with models), Underwater endocopic submucosal dissection /© 2026, Mia Kamiya et al, Curr Gastroenterol Rep, Multiple pseudonodular lesions in both lung fields/© 2026, Germán Ramírez-Olivencia et al, Clin J Gastroenterol, Enteral nutrition feeding bag hung on an IV pole/© BlindTurtle / Getty Images / iStock, Sunrise illustration/© Annandistock / iStock / Getty Images Plus, DNA mutation illustration/© Design Cells / Getty Images / iStock, Healthcare professional talking to a mother and teenage daughter/© monkeybusinessimages / Getty Images / iStock (symbolic image with models), Laparoscopic abdominal surgery/© Iryna / stock.adobe.com (symbolic image with models), Man lying on a bed with stomach/abdominal pain/© Prostock-studio / stock.adobe.com (symbolic image with model), Tropheryma whipplei illustration/© Kateryna Kon / Science Photo Library / Getty Images