Issue 6/2022
Content (12 Articles)
Acknowledgement to Referees
Is Monitoring of the Intracellular Active Metabolite Levels of Nucleobase and Nucleoside Analogs Ready for Precision Medicine Applications?
Shenjia Huang, Yicong Bian, Chenrong Huang, Liyan Miao
Interchangeability between Generic and Reference Products: Limits of Average Bioequivalence Methodology
Philippe Lechat
Combined Semi-mechanistic Target-Mediated Drug Disposition and Pharmacokinetic–Pharmacodynamic Models of Alirocumab, PCSK9, and Low-Density Lipoprotein Cholesterol in a Pooled Analysis of Randomized Phase I/II/III Studies
Patrick Nolain, Nassim Djebli, Aurélie Brunet, David Fabre, Sonia Khier
Results From Drug–Drug Interaction Studies In Vitro and In Vivo Investigating the Inhibitory Effect of Finerenone on the Drug Transporters BCRP, OATP1B1, and OATP1B3
Roland Heinig, Robert Fricke, Sebastian Wertz, Johannes Nagelschmitz, Stephanie Loewen
Phase 1 Study to Assess the Safety and Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor in Subjects Without Cystic Fibrosis With Moderate Hepatic Impairment
Lakshmi Viswanathan, Eric Bachman, Simon Tian, Neil Ahluwalia, Yaohua Zhang, Harold S. Bernstein, Paul Panorchan
Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial
Caroline Simoens, Koenraad Philippaert, Caroline Wuyts, Séverine Goscinny, Els Van Hoeck, Joris Van Loco, Jaak Billen, Jan de Hoon, Els Ampe, Roman Vangoitsenhoven, Ann Mertens, Rudi Vennekens, Bart Van der Schueren
Development and Validation of a Length- and Habitus-Based Method of Ideal and Lean Body Weight Estimation for Adults Requiring Urgent Weight-Based Medical Intervention
Mike Wells, Lara Nicole Goldstein, Giles Cattermole
Evaluating Islatravir Administered Via Microneedle Array Patch for Long-Acting HIV Pre-exposure Prophylaxis Using Physiologically Based Pharmacokinetic Modelling
Hannah Kinvig, Nicolas Cottura, Andrew Lloyd, Collrane Frivold, Jessica Mistilis, Courtney Jarrahian, Marco Siccardi
Involvement of Autophagy in the Protective Effects of Ginsenoside Rb1 in a Rat Model of Traumatic Brain Injury
Shufeng Zou, Wei Chen, Han Ding, Yuanyuan Qi, Zhigang Wang, Jun Fu, Dabin Ren, Jian Duan, Bixia Jiang, Jiugeng Feng
Metabolic Profiling of Glabridin in Rat Plasma, Urine, Bile, and Feces After Intragastric and Intravenous Administration
Shundi Liu, Hao Lin, Yu Chen, Yuzhen Wang, Xiaoshan Zhang, Zheng Xiang, Xiaojun Cai
Dual Inhibition of CYP3A4 by Voriconazole and Clarithromycin Influences Tacrolimus Pharmacokinetics: Case Series Study
Toshinori Hirai, Kazuko Ino, Makoto Ikejiri, Isao Tawara, Takuya Iwamoto