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Cardiovascular Diabetology

Issue 1/2014

Content (162 Articles)

Open Access Original investigation

National trends in utilization and outcomes of coronary revascularization procedures among people with and without type 2 diabetes in Spain (2001–2011)

Ana Lopez-de-Andres, Rodrigo Jimenez-García, Valentin Hernandez-Barrera, Napoleon Perez-Farinos, Jose M de Miguel-Yanes, Manuel Mendez-Bailon, Isabel Jimenez-Trujillo, Angel Gil de Miguel, Carmen Gallardo Pino, Pilar Carrasco-Garrido

Open Access Original investigation

Relationship of obesity and insulin resistance with the cerebrovascular reactivity: a case control study

Marcela Rodríguez-Flores, Eduardo García-García, Claudia Vanessa Cano-Nigenda, Carlos Cantú-Brito

Open Access Original investigation

Increased Th1 and suppressed Th2 serum cytokine levels in subjects with diabetic coronary artery disease

Haridoss Madhumitha, Viswanathan Mohan, Mohan Deepa, Subash Babu, Vivekanandhan Aravindhan

Open Access Original investigation

High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome

Ken Kishida, Yasuhiko Nakagawa, Hironori Kobayashi, Toru Mazaki, Hiroyoshi Yokoi, Koji Yanagi, Tohru Funahashi, Iichiro Shimomura

Open Access Original investigation

Vitamin D manipulates miR-181c, miR-20b and miR-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment

Tali Zitman-Gal, Janice Green, Metsada Pasmanik-Chor, Eliezer Golan, Jacques Bernheim, Sydney Benchetrit

Open Access Original investigation

Leptin is associated with vascular endothelial function in overweight patients with type 2 diabetes

Tomoaki Morioka, Masanori Emoto, Yuko Yamazaki, Naoya Kawano, Satoshi Imamura, Ryutaro Numaguchi, Hiromi Urata, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Hidenori Koyama, Tetsuo Shoji, Masaaki Inaba

Open Access Original investigation

Low serum docosahexaenoic acid is associated with progression of coronary atherosclerosis in statin-treated patients with diabetes mellitus: results of the treatment with statin on atheroma regression evaluated by intravascular ultrasound with virtual histology (TRUTH) study

Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Kazuki Fukui, Shigeo Umezawa, Yuko Onishi, Tomoyuki Kunishima, Akira Sato, Toshihiro Nozato, Shogo Miyake, Youichi Takeyama, Yoshihiro Morino, Takao Yamauchi, Toshiya Muramatsu, Kiyoshi Hibi, Mitsuyasu Terashima, Ichiro Michishita

Open Access Original investigation

The co-occurrence of myocardial dysfunction and peripheral insensate neuropathy in a streptozotocin-induced rat model of diabetes

Maria N Marangoni, Scott T Brady, Shamim A Chowdhury, Mariann R Piano

Open Access Original investigation

A randomised controlled trial of increasing fruit and vegetable intake and how this influences the carotenoid concentration and activities of PON-1 and LCAT in HDL from subjects with type 2 diabetes

Jane-Ann Daniels, Ciara Mulligan, David McCance, Jayne V Woodside, Christopher Patterson, Ian S Young, Jane McEneny

Open Access Original investigation

Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris

Kyung Mook Choi, Soon Young Hwang, Ho Chel Hong, Hae Yoon Choi, Hye Jin Yoo, Byung-Soo Youn, Sei Hyun Baik, Hong Seog Seo

Open Access Original investigation

Effects of saxagliptin on early microvascular changes in patients with type 2 diabetes

Christian Ott, Ulrike Raff, Stephanie Schmidt, Iris Kistner, Stefanie Friedrich, Peter Bramlage, Joanna M Harazny, Roland E Schmieder

Open Access Review

Do incretins improve endothelial function?

Jun-ichi Oyama, Yukihito Higashi, Koichi Node

Open Access Original investigation

Earlier age at menarche is associated with higher diabetes risk and cardiometabolic disease risk factors in Brazilian adults: Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Noel T Mueller, Bruce B Duncan, Sandhi M Barreto, Dora Chor, Marina Bessel, Estela ML Aquino, Mark A Pereira, Maria Inês Schmidt

Open Access Original investigation

Flow-mediated-paradoxical vasoconstriction is independently associated with asymptomatic myocardial ischemia and coronary artery disease in type 2 diabetic patients

Minh Tuan Nguyen, Isabelle Pham, Paul Valensi, Hélène Rousseau, Eric Vicaut, Christelle Laguillier-Morizot, Alain Nitenberg, Emmanuel Cosson

Open Access Original investigation

Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK

Hui Li, Xi Wang, Yiqing Mao, Ruobi Hu, Wei Xu, Zhen Lei, Na Zhou, Ling Jin, Tingting Guo, Zhixin Li, David M Irwin, Gang Niu, Huanran Tan

Open Access Methodology

An accelerated mouse model for atherosclerosis and adipose tissue inflammation

Angelika Neuhofer, Bernhard Wernly, Lukas Leitner, Alisina Sarabi, Nicole G Sommer, Günther Staffler, Maximilian Zeyda, Thomas M Stulnig

Open Access Reviewer acknowledgement

Annual acknowledgement of manuscript reviewers

Alexander Tenenbaum, Enrique Fisman

Open Access Original investigation

CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models

Tharappel M Anil, Chandrashekaran Harish, Mudigere N Lakshmi, KrishnaReddy Harsha, Mallappa Onkaramurthy, Venkatesh Sathish Kumar, Nitya Shree, Venkatachalaiah Geetha, Gundalmandikal V Balamurali, Aralakuppe S Gopala, Bobbili Madhusudhan Reddy, Madabosse K Govind, Mammen O Anup, Yoganand Moolemath, Marikunte V Venkataranganna, Madanahalli R Jagannath, Baggavalli P Somesh

Open Access Original investigation

Associations of metabolic syndrome and diabetes mellitus with 16-year survival after CABG

Ville Hällberg, Ari Palomäki, Jorma Lahtela, Seppo Voutilainen, Matti Tarkka, Matti Kataja

Open Access Original investigation

The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus

David ZI Cherney, Bruce A Perkins, Nima Soleymanlou, Ronnie Har, Nora Fagan, Odd Erik Johansen, Hans-Juergen Woerle, Maximilian von Eynatten, Uli C Broedl

Open Access Original investigation

Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet

Cristiane Aoqui, Stefan Chmielewski, Elias Scherer, Ruth Eißler, Daniel Sollinger, Irina Heid, Rickmer Braren, Christoph Schmaderer, Remco TA Megens, Christian Weber, Uwe Heemann, Matthias Tschöp, Marcus Baumann

Open Access Original investigation

The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK- and MAPK-dependent mechanisms

Yanmei Zeng, Chenzhong Li, Meiping Guan, Zongji Zheng, Jingjing Li, Wenwei Xu, Ling Wang, Feiying He, Yaoming Xue

Open Access Original investigation

Kir6.2-containing ATP-sensitive K+ channel is required for cardioprotection of resveratrol in mice

Ren-Hong Du, Ting Dai, Wen-Jing Cao, Ming Lu, Jian-hua Ding, Gang Hu

Open Access Original investigation

Assessment of the cardiovascular safety of saxagliptin in patients with type 2 diabetes mellitus: pooled analysis of 20 clinical trials

Nayyar Iqbal, Artist Parker, Robert Frederich, Mark Donovan, Boaz Hirshberg

Open Access Original investigation

Extracellular vesicle markers in relation to obesity and metabolic complications in patients with manifest cardiovascular disease

Mariëtte EG Kranendonk, Dominique PV de Kleijn, Eric Kalkhoven, Danny A Kanhai, Cuno SPM Uiterwaal, Yolanda van der Graaf, Gerard Pasterkamp, Frank LJ Visseren

Open Access Review

Residual macrovascular risk in 2013: what have we learned?

Jean-Charles Fruchart, Jean Davignon, Michel P Hermans, Khalid Al-Rubeaan, Pierre Amarenco, Gerd Assmann, Philip Barter, John Betteridge, Eric Bruckert, Ada Cuevas, Michel Farnier, Ele Ferrannini, Paola Fioretto, Jacques Genest, Henry N Ginsberg, Antonio M Gotto Jr, Dayi Hu, Takashi Kadowaki, Tatsuhiko Kodama, Michel Krempf, Yuji Matsuzawa, Jesús Millán Núñez-Cortés, Carlos Calvo Monfil, Hisao Ogawa, Jorge Plutzky, Daniel J Rader, Shaukat Sadikot, Raul D Santos, Evgeny Shlyakhto, Piyamitr Sritara, Rody Sy, Alan Tall, Chee Eng Tan, Lale Tokgözoğlu, Peter P Toth, Paul Valensi, Christoph Wanner, Alberto Zambon, Junren Zhu, Paul Zimmet

Open Access Original investigation

Inflammatory biomarkers in type 2 diabetic patients: effect of glycemic control and impact of ldl subfraction phenotype

Irene Vinagre, José Luis Sánchez-Quesada, Juan Sánchez-Hernández, David Santos, Jordi Ordoñez-Llanos, Alberto De Leiva, Antonio Pérez

Open Access Original investigation

Plasma level of cyclophilin A is increased in patients with type 2 diabetes mellitus and suggests presence of vascular disease

Surya Ramachandran, Anila Venugopal, V Raman Kutty, Vinitha A, Divya G, V Chitrasree, Ajit Mullassari, N S Pratapchandran, K R Santosh, M Radhakrishna Pillai, C C Kartha

Open Access Original investigation

Changes in liraglutide-induced body composition are related to modifications in plasma cardiac natriuretic peptides levels in obese type 2 diabetic patients

Chun-Jun Li, Qian Yu, Pei Yu, Tie-Lian Yu, Qiu-Mei Zhang, Shan Lu, De-Min Yu

Open Access Original investigation

Vaspin inhibits cytokine-induced nuclear factor-kappa B activation and adhesion molecule expression via AMP-activated protein kinase activation in vascular endothelial cells

Chang Hee Jung, Min Jung Lee, Yu Mi Kang, Yoo La Lee, Hae Kyeong Yoon, Sang-Wook Kang, Woo Je Lee, Joong-Yeol Park

Open Access Original investigation

Differential gene expression in Lin-/VEGF-R2+ bone marrow-derived endothelial progenitor cells isolated from diabetic mice

Daniel Barthelmes, Ling Zhu, Weiyong Shen, Mark C Gillies, Mohammad R Irhimeh

Open Access Original investigation

Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats

Toru Miyoshi, Kazufumi Nakamura, Masashi Yoshida, Daiji Miura, Hiroki Oe, Satoshi Akagi, Hiroki Sugiyama, Kaoru Akazawa, Tomoko Yonezawa, Jun Wada, Hiroshi Ito

Open Access Original investigation

Opposite effects of angiotensins receptors type 2 and type 4 on streptozotocin induced diabetes vascular alterations in mice

Mohamad Nasser, Nicolas Clere, Laurent Botelle, James Javellaud, Nicole Oudart, Sébastien Faure, Jean-Michel Achard

Open Access Original investigation

Evaluation of carotid artery elasticity changes in patients with type 2 diabetes

Li Zhang, Ji-Kai Yin, Yun-You Duan, Xi Liu, Lei Xu, Jia Wang, Yi-Lin Yang, Li-Jun Yuan, Tie-Sheng Cao

Open Access Original investigation

Vitamin D and 1-hour post-load plasma glucose in hypertensive patients

Angela Sciacqua, Maria Perticone, Nadia Grillo, Tania Falbo, Giuseppe Bencardino, Elvira Angotti, Franco Arturi, Giuseppe Parlato, Giorgio Sesti, Francesco Perticone

Open Access Original investigation

Differential transendothelial transport of adiponectin complexes

Joseph M Rutkowski, Nils Halberg, Qiong A Wang, William L Holland, Jonathan Y Xia, Philipp E Scherer

Open Access Original investigation

Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study

Naoko Mukai, Miho Yasuda, Toshiharu Ninomiya, Jun Hata, Yoichiro Hirakawa, Fumie Ikeda, Masayo Fukuhara, Taeko Hotta, Masafumi Koga, Udai Nakamura, Dongchon Kang, Takanari Kitazono, Yutaka Kiyohara

Open Access Original investigation

Impaired dopamine D1 receptor-mediated vasorelaxation of mesenteric arteries in obese Zucker rats

Jinjuan Fu, Yu Han, Hongyong Wang, Zhen Wang, Yukai Liu, Xingjian Chen, Yue Cai, Weiwei Guan, Di Yang, Laureano D Asico, Lin Zhou, Pedro A Jose, Chunyu Zeng

Open Access Original investigation

The relationship between serum hypoxia-inducible factor 1α and coronary artery calcification in asymptomatic type 2 diabetic patients

Gang Li, Wei-hua Lu, Rong Ai, Jian-hong Yang, Fang Chen, Zhong-zhi Tang

Open Access Original investigation

N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes

Hoda Moazzen, Xiangru Lu, Noelle L Ma, Thomas J Velenosi, Brad L Urquhart, Lambertus J Wisse, Adriana C Gittenberger-de Groot, Qingping Feng

Open Access Original investigation

High glucose induces human endothelial dysfunction through an Axl-dependent mechanism

Chien-Hsing Lee, Yi-Shing Shieh, Fone-Ching Hsiao, Feng-Chih Kuo, Chih-Yuan Lin, Chang-Hsun Hsieh, Yi-Jen Hung

Open Access Original investigation

Liraglutide decreases carotid intima-media thickness in patients with type 2 diabetes: 8-month prospective pilot study

Manfredi Rizzo, Manisha Chandalia, Angelo Maria Patti, Vittoria Di Bartolo, Ali A Rizvi, Giuseppe Montalto, Nicola Abate

Open Access Original investigation

AGEs breaking and antioxidant treatment improves endothelium-dependent dilation without effect on flow-mediated remodeling of resistance arteries in old Zucker diabetic rats

Mohamed L Freidja, Emilie Vessières, Bertrand Toutain, Anne-Laure Guihot, Marc-Antoine Custaud, Laurent Loufrani, Céline Fassot, Daniel Henrion

Open Access Commentary

Cardiovascular guidelines: separate career may help attenuate controversy

Katherine Esposito, Antonio Ceriello, Stefano Genovese, Dario Giugliano

Open Access Original investigation

Reduced circulating sTWEAK levels are associated with metabolic syndrome in elderly individuals at high cardiovascular risk

Andrés Díaz-López, Mònica Bulló, Matilde R Chacón, Ramón Estruch, Joan Vendrell, Javier Díez-Espino, Montserrat Fitó, Dolores Corella, Jordi Salas-Salvadó

Open Access Original investigation

Gender disparity in LDL-induced cardiovascular damage and the protective role of estrogens against electronegative LDL

An-Sheng Lee, Wei-Yu Chen, Hua-Chen Chan, Jing-Fang Hsu, Ming-Yi Shen, Chia-Ming Chang, Henry Bair, Ming-Jai Su, Kuan-Cheng Chang, Chu-Huang Chen

Open Access Review

Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease

Shruti Rawal, Patrick Manning, Rajesh Katare

Open Access Original investigation

Novel unbiased equations to calculate triglyceride-rich lipoprotein cholesterol from routine non-fasting lipids

Michel P Hermans, Sylvie A Ahn, Michel F Rousseau

Open Access Original investigation

Differential association of visceral adipose tissue with coronary plaque characteristics in patients with and without diabetes mellitus

Kazuhiro Osawa, Toru Miyoshi, Yasushi Koyama, Shuhei Sato, Noriaki Akagi, Yusuke Morimitsu, Motoki Kubo, Hiroki Sugiyama, Kazufumi Nakamura, Hiroshi Morita, Susumu Kanazawa, Hiroshi Ito

Open Access Original investigation

Exenatide induces aortic vasodilation increasing hydrogen sulphide, carbon monoxide and nitric oxide production

Eszter Sélley, Szilárd Kun, István András Szijártó, Boglárka Laczy, Tibor Kovács, Ferenc Fülöp, István Wittmann, Gergő A Molnár

Open Access Original investigation

Subclinical vascular inflammation in subjects with normal weight obesity and its association with body Fat: an 18 F-FDG-PET/CT study

Shinae Kang, Chanhee Kyung, Jong Suk Park, Sohee Kim, Seung-Pyo Lee, Min Kyung Kim, Hye Kyung Kim, Kyung Rae Kim, Tae Joo Jeon, Chul Woo Ahn

Open Access Original investigation

Bezafibrate improves postprandial hypertriglyceridemia and associated endothelial dysfunction in patients with metabolic syndrome: a randomized crossover study

Yuko Ohno, Toru Miyoshi, Yoko Noda, Hiroki Oe, Norihisa Toh, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Morita, Hiroshi Ito

Open Access Original investigation

Acute insulin resistance in ST-segment elevation myocardial infarction in non-diabetic patients is associated with incomplete myocardial reperfusion and impaired coronary microcirculatory function

Danijela Trifunovic, Sanja Stankovic, Dragana Sobic-Saranovic, Jelena Marinkovic, Marija Petrovic, Dejan Orlic, Branko Beleslin, Marko Banovic, Bosiljka Vujisic-Tesic, Milan Petrovic, Ivana Nedeljkovic, Jelena Stepanovic, Ana Djordjevic-Dikic, Milorad Tesic, Nina Djukanovic, Olga Petrovic, Olga Vasovic, Emilija Nestorovic, Jelena Kostic, Arsen Ristic, Miodrag Ostojic

Open Access Original investigation

Osteocalcin attenuates high fat diet-induced impairment of endothelium-dependent relaxation through Akt/eNOS-dependent pathway

Jianxin Dou, Huating Li, Xiaojing Ma, Mingliang Zhang, Qichen Fang, Meiyun Nie, Yuqian Bao, Weiping Jia

Open Access Original investigation

Progressive decay of Ca2+ homeostasis in the development of diabetic cardiomyopathy

Shu-Mei Zhao, Yong-Liang Wang, Chun-Yan Guo, Jin-Ling Chen, Yong-Quan Wu

Open Access Original investigation

Analysis of common and coding variants with cardiovascular disease in the diabetes heart study

Jeremy N Adams, Laura M Raffield, Barry I Freedman, Carl D Langefeld, Maggie CY Ng, J Jeffrey Carr, Amanda J Cox, Donald W Bowden

Open Access Original investigation

Myocardial blood flow under general anaesthesia with sevoflurane in type 2 diabetic patients: a pilot study

Carolien SE Bulte, Charissa E van den Brom, Stephan A Loer, Christa Boer, R Arthur Bouwman

Open Access Original investigation

Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study

Kohei Kaku, Hirotaka Watada, Yasuhiko Iwamoto, Kazunori Utsunomiya, Yasuo Terauchi, Kazuyuki Tobe, Yukio Tanizawa, Eiichi Araki, Masamichi Ueda, Hideki Suganami, Daisuke Watanabe

Open Access Original investigation

Contribution of subcutaneous abdominal fat on ultrasonography to carotid atherosclerosis in patients with type 2 diabetes mellitus

Chan-Hee Jung, Bo-Yeon Kim, Kyu-Jin Kim, Sang-Hee Jung, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok

Open Access Original investigation

Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction

Regis R Lamberts, Shivanjali J Lingam, Heng-Yu Wang, Ilse AE Bollen, Gillian Hughes, Ivor F Galvin, Richard W Bunton, Andrew Bahn, Rajesh Katare, J Chris Baldi, Michael JA Williams, Pankaj Saxena, Sean Coffey, Peter P Jones

Open Access Review

On the potential of acarbose to reduce cardiovascular disease

Eberhard Standl, Michael J Theodorakis, Michael Erbach, Oliver Schnell, Jaakko Tuomilehto

Open Access Original investigation

Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway

Xuwei Hou, Zhaohui Hu, Hanying Xu, Jian Xu, Shunrong Zhang, Yigang Zhong, Xiuying He, Ningfu Wang

Open Access Original investigation

Streptozotocin-induced diabetes prolongs twitch duration without affecting the energetics of isolated ventricular trabeculae

June-Chiew Han, Kenneth Tran, Poul MF Nielsen, Andrew J Taberner, Denis S Loiselle

Open Access Original investigation

The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus

Xunliang Tong, Pu Lv, Anna V Mathew, Donghui Liu, Chenguang Niu, Yan Wang, Liang Ji, Jizhao Li, Zhiwei Fu, Bing Pan, Subramaniam Pennathur, Lemin Zheng, Yining Huang

Open Access Original investigation

Impact of serum omentin-1 levels on cardiac prognosis in patients with heart failure

Taro Narumi, Tetsu Watanabe, Shinpei Kadowaki, Daisuke Kinoshita, Miyuki Yokoyama, Yuki Honda, Yoichiro Otaki, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Isao Kubota

Open Access Original investigation

Insulin resistance and subclinical abnormalities of global and regional left ventricular function in patients with aortic valve sclerosis

Hiroto Utsunomiya, Hideya Yamamoto, Eiji Kunita, Takayuki Hidaka, Yasuki Kihara

Open Access Original investigation

Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle

Sefaa Al-aryahi, Danielle Kamato, Robel Getachew, Wenhua Zheng, Simon J Potocnik, Neale Cohen, Daniel Guidone, Narin Osman, Peter J Little

Open Access Original investigation

Influence of a family history of type 2 diabetes, demographic and clinical data on carotid intima-media thickness in patients with type 1 diabetes: a cross-sectional study

Carlos Roberto Moraes de Andrade Junior, Eliete Leão Clemente Silva, Maria de Fátima Bevilaqua da Matta, Marcia Bueno Castier, Maria Luiza Garcia Rosa, Marília de Brito Gomes

Open Access Original investigation

Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein

Sophie Liabeuf, Bourron Olivier, Cees Vemeer, Elke Theuwissen, Elke Magdeleyns, Carole Elodie Aubert, Michel Brazier, Romuald Mentaverri, Agnes Hartemann, Ziad A Massy

Open Access Original investigation

High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy

Antoinette Bugyei-Twum, Andrew Advani, Suzanne L Advani, Yuan Zhang, Kerri Thai, Darren J Kelly, Kim A Connelly

Open Access Original investigation

PLA1A2 platelet polymorphism predicts mortality in prediabetic subjects of the population based KORA S4-Cohort

Bernd Stratmann, Tao Xu, Christa Meisinger, Barbara Menart, Michael Roden, Christian Herder, Harald Grallert, Annette Peters, Wolfgang Koenig, Thomas Illig, Heinz-Erich Wichmann, Rui Wang-Sattler, Wolfgang Rathmann, Diethelm Tschoepe

Open Access Original investigation

Effects of metformin and exercise training, alone or in association, on cardio-pulmonary performance and quality of life in insulin resistance patients

Christian Cadeddu, Silvio Nocco, Lucia Cugusi, Martino Deidda, Alessandro Bina, Orru Fabio, Stefano Bandinu, Efisio Cossu, Marco Giorgio Baroni, Giuseppe Mercuro

Open Access Original investigation

The dipeptidyl peptidase-4 inhibitor Saxagliptin improves function of circulating pro-angiogenic cells from type 2 diabetic patients

Nicol Poncina, Mattia Albiero, Lisa Menegazzo, Roberta Cappellari, Angelo Avogaro, Gian Paolo Fadini

Open Access Original investigation

Safety and tolerability of canakinumab, an IL-1β inhibitor, in type 2 diabetes mellitus patients: a pooled analysis of three randomised double-blind studies

Campbell Howard, Adele Noe, Andrej Skerjanec, Björn Holzhauer, Margaret Wernsing, Monica Ligueros-Saylan, Tom Thuren

Open Access Original investigation

Different angiotensin receptor blockers and incidence of diabetes: a nationwide population-based cohort study

Chia-Hsuin Chang, Yi-Cheng Chang, Li-Chiu Wu, Jou-Wei Lin, Lee-Ming Chuang, Mei-Shu Lai

Open Access Original investigation

Multiple risk factor intervention reduces carotid atherosclerosis in patients with type 2 diabetes

Norbert J Tripolt, Sophie H Narath, Michaela Eder, Thomas R Pieber, Thomas C Wascher, Harald Sourij

Open Access Original investigation

A pilot three-month sitagliptin treatment increases serum adiponectin level in Japanese patients with type 2 diabetes mellitus- a randomized controlled trial START-J study

Toshiyuki Hibuse, Norikazu Maeda, Ken Kishida, Takekazu Kimura, Tomoko Minami, Eriko Takeshita, Ayumu Hirata, Yasuhiko Nakagawa, Susumu Kashine, Akemi Oka, Masumi Hayashi, Hitoshi Nishizawa, Tohru Funahashi, Iichiro Shimomura

Open Access Original investigation

Neck circumference and early stage atherosclerosis: the cardiometabolic risk in Chinese (CRC) study

Jun Liang, Yu Wang, Hongyan Li, Xuekui Liu, Qinqin Qiu, Lu Qi

Open Access Original investigation

High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury

Ruduwaan Salie, Barbara Huisamen, Amanda Lochner

Open Access Original investigation

Effects of pitavastatin versus atorvastatin on the peripheral endothelial progenitor cells and vascular endothelial growth factor in high-risk patients: a pilot prospective, double-blind, randomized study

Liang-Yu Lin, Chin-Chou Huang, Jia-Shiong Chen, Tao-Cheng Wu, Hsin-Bang Leu, Po-Hsun Huang, Ting-Ting Chang, Shing-Jong Lin, Jaw-Wen Chen

Open Access Original investigation

p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity

Yi Yu, Angana G Rajapakse, Jean-Pierre Montani, Zhihong Yang, Xiu-Fen Ming

Open Access Original investigation

GLP-1 (7–36) amide restores myocardial insulin sensitivity and prevents the progression of heart failure in senescent beagles

Melissa Chen, Franca S Angeli, You-tang Shen, Richard P Shannon

Open Access Original investigation

Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: effects of a 3-month lifestyle intervention program

Juan Serrano-Ferrer, Guillaume Walther, Edward Crendal, Agnès Vinet, Frédéric Dutheil, Geraldine Naughton, Bruno Lesourd, Robert Chapier, Daniel Courteix, Philippe Obert

Open Access Original investigation

DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: EDGE study

Kazufumi Nakamura, Hiroki Oe, Hajime Kihara, Kenei Shimada, Shota Fukuda, Kyoko Watanabe, Tsutomu Takagi, Kei Yunoki, Toru Miyoshi, Kumiko Hirata, Junichi Yoshikawa, Hiroshi Ito

Open Access Original investigation

High or low calcium intake increases cardiovascular disease risks in older patients with type 2 diabetes

Jui-Hua Huang, Leih-Ching Tsai, Yu-Chen Chang, Fu-Chou Cheng

Open Access Original investigation

Sinoatrial node dysfunction induces cardiac arrhythmias in diabetic mice

Ewa Soltysinska, Tobias Speerschneider, Sine V Winther, Morten B Thomsen

Open Access Original investigation

Younger age, higher body mass index and lower adiponectin concentration predict higher serum thromboxane B2 level in aspirin-treated patients with type 2 diabetes: an observational study

Agnieszka Kaplon-Cieslicka, Marek Postula, Marek Rosiak, Michal Peller, Agnieszka Kondracka, Agnieszka Serafin, Ewa Trzepla, Grzegorz Opolski, Krzysztof J Filipiak

Open Access Original investigation

Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies

Shang-Hung Chang, Lung-Sheng Wu, Meng-Jiun Chiou, Jia-Rou Liu, Kuang-Hui Yu, Chang-Fu Kuo, Ming-Shien Wen, Wei-Jan Chen, Yung-Hsin Yeh, Lai-Chu See

Open Access Original investigation

Serum levels of retinol-binding protein-4 are associated with the presence and severity of coronary artery disease

Vaia Lambadiari, Nikolaos PE Kadoglou, Vassilios Stasinos, Eirini Maratou, Aias Antoniadis, Fotios Kolokathis, John Parissis, Erifili Hatziagelaki, Efstathios K Iliodromitis, George Dimitriadis

Open Access Original investigation

A score to quantify coronary plaque vulnerability in high-risk patients with type 2 diabetes: an optical coherence tomography study

Mathias Burgmaier, Martin Hellmich, Nikolaus Marx, Sebastian Reith

Open Access Original investigation

Cardiac contractile function and mitochondrial respiration in diabetes-related mouse models

Camille Marciniak, Xavier Marechal, David Montaigne, Remi Neviere, Steve Lancel

Open Access Original investigation

Clinical utility of brachial-ankle pulse wave velocity in the prediction of cardiovascular events in diabetic patients

Naoto Katakami, Takeshi Osonoi, Mitsuyoshi Takahara, Miyoko Saitou, Taka-aki Matsuoka, Yoshimitsu Yamasaki, Iichiro Shimomura

Open Access Original investigation

Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3

Yasuo M Tsutsumi, Rie Tsutsumi, Eisuke Hamaguchi, Yoko Sakai, Asuka Kasai, Yoshihiro Ishikawa, Utako Yokoyama, Katsuya Tanaka

Open Access Original investigation

Circulating adiponectin and cardiovascular mortality in patients with type 2 diabetes mellitus: evidence of sexual dimorphism

Claudia Menzaghi, Min Xu, Lucia Salvemini, Concetta De Bonis, Giuseppe Palladino, Tao Huang, Massimiliano Copetti, Yan Zheng, Yanping Li, Grazia Fini, Frank B Hu, Simonetta Bacci, Lu Qi, Vincenzo Trischitta

Open Access Original investigation

Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes

Antonysunil Adaikalakoteswari, Ramamurthy Jayashri, Nithya Sukumar, Hema Venkataraman, Rajendra Pradeepa, Kuppan Gokulakrishnan, Ranjit Mohan Anjana, Philip G McTernan, Gyanendra Tripathi, Vinod Patel, Sudhesh Kumar, Viswanathan Mohan, Ponnusamy Saravanan

Open Access Original investigation

Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal

Syed M Qadri, Yang Su, Francisco S Cayabyab, Lixin Liu

Open Access Original investigation

Biomarkers of endothelial dysfunction in relation to impaired carbohydrate metabolism following pregnancy with gestational diabetes mellitus

Christian S Göbl, Latife Bozkurt, Rajashri Yarragudi, Thomas Prikoszovich, Andrea Tura, Giovanni Pacini, Renate Koppensteiner, Alexandra Kautzky-Willer

Open Access Original investigation

Visceral adiposity index and risks of cardiovascular events and mortality in prevalent hemodialysis patients

Hung-Yuan Chen, Yen-Ling Chiu, Yi-Fang Chuang, Shih-Ping Hsu, Mei-Fen Pai, Ju-Yeh Yang, Yu-Sen Peng

Open Access Original investigation

Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats

Christiane Malfitano, Catarina Andrade Barboza, Cristiano Mostarda, Renata Kelly da Palma, Camila Paixão dos Santos, Bruno Rodrigues, Sarah Cristina Ferreira Freitas, Adriane Belló-Klein, Susana Llesuy, Maria-Cláudia Irigoyen, Kátia De Angelis

Open Access Original investigation

Influence of insulin and glargine on outgrowth and number of circulating endothelial progenitor cells in type 2 diabetes patients: a partially double-blind, randomized, three-arm unicenter study

Dimitrios Oikonomou, Stefan Kopf, Rüdiger von Bauer, Zdenka Djuric, Rita Cebola, Anja Sander, Stefan Englert, Spiros Vittas, Asa Hidmark, Michael Morcos, Grigorios Korosoglou, Peter P Nawroth, Per M Humpert

Open Access Original investigation

Plasma triglycerides predict ten-years all-cause mortality in outpatients with type 2 diabetes mellitus: a longitudinal observational study

Maria-Agata Miselli, Edoardo Dalla Nora, Angelina Passaro, Franco Tomasi, Giovanni Zuliani

Open Access Original investigation

Obesity attenuates gender differences in cardiovascular mortality

Xin Song, Adam G Tabák, Björn Zethelius, John S Yudkin, Stefan Söderberg, Tiina Laatikainen, Coen DA Stehouwer, Rachel Dankner, Pekka Jousilahti, Altan Onat, Peter M Nilsson, Ilhan Satman, Olga Vaccaro, Jaakko Tuomilehto, Qing Qiao

Open Access Original investigation

Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance

Tingting Du, Gang Yuan, Muxun Zhang, Xinrong Zhou, Xingxing Sun, Xuefeng Yu

Open Access Original investigation

Normal weight diabetic patients versus obese diabetics: relation of overall and abdominal adiposity to vascular health

Alla Lukich, Dov Gavish, Marina Shargorodsky

Open Access Review

Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists

Francisco Kerr Saraiva, Andrei C Sposito

Open Access Original investigation

Aortic reservoir characteristics and brain structure in people with type 2 diabetes mellitus; a cross sectional study

Rachel ED Climie, Velandai Srikanth, Richard Beare, Laura J Keith, James Fell, Justin E Davies, James E Sharman

Open Access Original investigation

Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice

Bowen Lin, Nobutaka Koibuchi, Yu Hasegawa, Daisuke Sueta, Kensuke Toyama, Ken Uekawa, MingJie Ma, Takashi Nakagawa, Hiroaki Kusaka, Shokei Kim-Mitsuyama

Open Access Original investigation

Association between carotid intima-media thickness and index of central fat distribution in middle-aged and elderly Chinese

Chenxi Ren, Jie Zhang, Yu Xu, Baihui Xu, Wanwan Sun, Jichao Sun, Tiange Wang, Min Xu, Jieli Lu, Weiqing Wang, Yufang Bi, Yuhong Chen

Open Access Original investigation

Chemerin is a novel biomarker of acute coronary syndrome but not of stable angina pectoris

Qingwei Ji, Yingzhong Lin, Zhishan Liang, Kunwu Yu, Yuyang Liu, Zhe Fang, Ling Liu, Ying Shi, Qiutang Zeng, Chao Chang, Meng Chai, Yujie Zhou

Open Access Original investigation

Association of impaired fasting glucose, diabetes and their management with the presentation and outcome of peripheral artery disease: a cohort study

Jonathan Golledge, Frank Quigley, Ramesh Velu, Phillip J Walker, Joseph V Moxon

Open Access Original investigation

PPARγ activation but not PPARγ haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors

Jerzy Kotlinowski, Anna Grochot-Przeczek, Hevidar Taha, Magdalena Kozakowska, Bartosz Pilecki, Klaudia Skrzypek, Aleksandra Bartelik, Rafal Derlacz, Anton J G Horrevoets, Attila Pap, Laszlo Nagy, Jozef Dulak, Alicja Jozkowicz

Open Access Original investigation

Immunization with advanced glycation end products modified low density lipoprotein inhibits atherosclerosis progression in diabetic apoE and LDLR null mice

Lin Zhu, Zhiqing He, Feng Wu, Ru Ding, Qixia Jiang, Jiayou Zhang, Min Fan, Xing Wang, Bengtsson Eva, Nilsson Jan, Chun Liang, Zonggui Wu

Open Access Original investigation

The protective effect of the Mediterranean diet on endothelial resistance to GLP-1 in type 2 diabetes: a preliminary report

Antonio Ceriello, Katherine Esposito, Lucia La Sala, Gemma Pujadas, Valeria De Nigris, Roberto Testa, Loredana Bucciarelli, Maurizio Rondinelli, Stefano Genovese

Open Access Original investigation

Exenatide can inhibit calcification of human VSMCs through the NF-kappaB/RANKL signaling pathway

Jun-Kun Zhan, Pan Tan, Yan-Jiao Wang, Yi Wang, Jie-Yu He, Zhi-Yong Tang, Wu Huang, You-Shuo Liu

Open Access Original investigation

Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury

Yuichi Terawaki, Takashi Nomiyama, Takako Kawanami, Yuriko Hamaguchi, Hiroyuki Takahashi, Tomoko Tanaka, Kunitaka Murase, Ryoko Nagaishi, Makito Tanabe, Toshihiko Yanase

Open Access Original investigation

Association of secreted frizzled-related protein 4 (SFRP4) with type 2 diabetes in patients with stable coronary artery disease

Michael M Hoffmann, Christian Werner, Michael Böhm, Ulrich Laufs, Karl Winkler

Open Access Original investigation

Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice

Qing He, Jun Pu, Ancai Yuan, Tianbao Yao, Xiaoying Ying, Yichao Zhao, Longwei Xu, Huan Tong, Ben He

Open Access Original investigation

DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure

Nobutaka Koibuchi, Yu Hasegawa, Tetsuji Katayama, Kensuke Toyama, Ken Uekawa, Daisuke Sueta, Hiroaki Kusaka, MingJie Ma, Takashi Nakagawa, Bowen Lin, Shokei Kim-Mitsuyama

Open Access Original investigation

Asymmetric dimethylarginine and long-term adverse cardiovascular events in patients with type 2 diabetes: relation with the glycemic control

Chiao-Po Hsu, Pai-Feng Hsu, Ming-Yi Chung, Shing-Jong Lin, Tse-Min Lu

Open Access Review

Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor

Alexander Tenenbaum, Robert Klempfner, Enrique Z Fisman

Open Access Original investigation

Increased haemodynamic adrenergic load with isoflurane anaesthesia in type 2 diabetic and obese rats in vivo

Carol T Bussey, Anne E de Leeuw, Regis R Lamberts

Open Access Original investigation

Prediction of mortality using a multi-bed vascular calcification score in the Diabetes Heart Study

Amanda J Cox, Fang-Chi Hsu, Subhashish Agarwal, Barry I Freedman, David M Herrington, J Jeffrey Carr, Donald W Bowden

Open Access Original investigation

The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats

Susana Vallejo, Erika Palacios, Tania Romacho, Laura Villalobos, Concepción Peiró, Carlos F Sánchez-Ferrer

Open Access Original investigation

Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice

Jian Cai, Shuai Lu, Zheng Yao, Ya-Ping Deng, Ling-Di Zhang, Jia-Wen Yu, Guo-Fei Ren, Fu-Ming Shen, Guo-Jun Jiang

Open Access Original investigation

Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage

Almudena Gómez-Hernández, Liliana Perdomo, Natalia de las Heras, Nuria Beneit, Óscar Escribano, Yolanda F Otero, Carlos Guillén, Sabela Díaz-Castroverde, Beatriz Gozalbo-López, Victoria Cachofeiro, Vicente Lahera, Manuel Benito

Open Access Original investigation

EphA2-receptor deficiency exacerbates myocardial infarction and reduces survival in hyperglycemic mice

Augustin DuSablon, Susan Kent, Anita Coburn, Jitka Virag

Open Access Original investigation

Nestin downregulation in rat vascular smooth muscle cells represents an early marker of vascular disease in experimental type I diabetes

Kim Tardif, Vanessa Hertig, Camille Dumais, Louis Villeneuve, Louis Perrault, Jean-François Tanguay, Angelino Calderone

Open Access Original investigation

Omentin changes following bariatric surgery and predictive links with biomarkers for risk of cardiovascular disease

Marc Lapointe, Paul Poirier, Julie Martin, Marjorie Bastien, Audrey Auclair, Katherine Cianflone

Open Access Original investigation

Does glycemic control reverse dispersion of ventricular repolarization in type 2 diabetes?

Takayuki Miki, Toshiyuki Tobisawa, Tatsuya Sato, Masaya Tanno, Toshiyuki Yano, Hiroshi Akasaka, Atsushi Kuno, Makoto Ogasawara, Hiromichi Murase, Shigeyuki Saitoh, Tetsuji Miura

Open Access Original investigation

Caffeic acid phenethyl amide ameliorates ischemia/reperfusion injury and cardiac dysfunction in streptozotocin-induced diabetic rats

Yi-Jin Ho, An-Sheng Lee, Wen-Pin Chen, Wei-Lung Chang, Ying-Kang Tsai, Hsi-Lin Chiu, Yueh-Hsiung Kuo, Ming-Jai Su

Open Access Original investigation

Low levels of 1,5-anhydro-D-glucitol are associated with vascular endothelial dysfunction in type 2 diabetes

Keiichi Torimoto, Yosuke Okada, Hiroko Mori, Yoshiya Tanaka

Open Access Original investigation

Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation

Shaoping Zhang, Hong Liu, Greeshma V Amarsingh, Carlos C H Cheung, Sebastian Hogl, Umayal Narayanan, Lin Zhang, Selina McHarg, Jingshu Xu, Deming Gong, John Kennedy, Bernard Barry, Yee Soon Choong, Anthony R J Phillips, Garth J S Cooper

Open Access Study protocol

Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME™)

Bernard Zinman, Silvio E Inzucchi, John M Lachin, Christoph Wanner, Roberto Ferrari, David Fitchett, Erich Bluhmki, Stefan Hantel, Joan Kempthorne-Rawson, Jennifer Newman, Odd Erik Johansen, Hans-Juergen Woerle, Uli C Broedl

Open Access Original investigation

Dopamine D4 receptors inhibit proliferation and migration of vascular smooth muscle cells induced by insulin via down-regulation of insulin receptor expression

Changqing Yu, Zhen Wang, Yu Han, Yukai Liu, Wei Eric Wang, Caiyu Chen, Hongyong Wang, Pedro A Jose, Chunyu Zeng

Open Access Original investigation

Reduced levels of circulating endothelial progenitor cells in acute myocardial infarction patients with diabetes or pre-diabetes: accompanying the glycemic continuum

Natália António, Rosa Fernandes, Ana Soares, Francisco Soares, Ana Lopes, Tiago Carvalheiro, Artur Paiva, Guilherme Mariano Pêgo, Luís A Providência, Lino Gonçalves, Carlos Fontes Ribeiro

Open Access Original investigation

The afterload-dependent peak efficiency of the isolated working rat heart is unaffected by streptozotocin-induced diabetes

June-Chiew Han, Soyeon Goo, Carolyn J Barrett, Kimberley M Mellor, Andrew J Taberner, Denis S Loiselle

Open Access Original investigation

Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial

Dolores Corella, Jose V Sorlí, José I González, Carolina Ortega, Montserrat Fitó, Monica Bulló, Miguel Angel Martínez-González, Emilio Ros, Fernando Arós, José Lapetra, Enrique Gómez-Gracia, Lluís Serra-Majem, Valentina Ruiz-Gutierrez, Miquel Fiol, Oscar Coltell, Ernest Vinyoles, Xavier Pintó, Amelia Martí, Carmen Saiz, José M Ordovás, Ramón Estruch

Open Access Original investigation

Exercise increases serum endostatin levels in female and male patients with diabetes and controls

Michael Sponder, Daniela Dangl, Stephanie Kampf, Monika Fritzer-Szekeres, Jeanette Strametz-Juranek

Open Access Original investigation

Possible effects of glimepiride beyond glycemic control in patients with type 2 diabetes: a preliminary report

Ikuko Nakamura, Jun-ichi Oyama, Hiroshi Komoda, Aya Shiraki, Yoshiko Sakamoto, Isao Taguchi, Atsushi Hiwatashi, Aiko Komatsu, Masayoshi Takeuchi, Sho-ichi Yamagishi, Teruo Inoue, Koichi Node

Open Access Original investigation

Body adiposity dictates different mechanisms of increased coronary reactivity related to improved in vivo cardiac function

Evangelia Mourmoura, Valérie Chaté, Karine Couturier, Brigitte Laillet, Guillaume Vial, Jean-Paul Rigaudiere, Béatrice Morio, Corinne Malpuech-Brugère, Kasra Azarnoush, Luc Demaison

Open Access Original investigation

Altered glucose metabolism rather than naive type 2 diabetes mellitus (T2DM) is related to vitamin D status in severe obesity

Mattia Bellan, Gabriele Guzzaloni, Maura Rinaldi, Elena Merlotti, Carlotta Ferrari, Antonella Tagliaferri, Mario Pirisi, Gianluca Aimaretti, Massimo Scacchi, Paolo Marzullo

Open Access Original investigation

Distribution of cardiovascular disease and retinopathy in patients with type 2 diabetes according to different classification systems for chronic kidney disease: a cross-sectional analysis of the renal insufficiency and cardiovascular events (RIACE) Italian multicenter study

Giuseppe Pugliese, Anna Solini, Enzo Bonora, Emanuela Orsi, Gianpaolo Zerbini, Cecilia Fondelli, Gabriella Gruden, Franco Cavalot, Olga Lamacchia, Roberto Trevisan, Monica Vedovato, Giuseppe Penno

Open Access Original investigation

Differential impact of subclinical carotid artery disease on cerebral structure and functioning in type 1 diabetes patients with versus those without proliferative retinopathy

Eelco van Duinkerken, Richard G IJzerman, Nynke J van der Zijl, Frederik Barkhof, Petra JW Pouwels, Menno M Schoonheim, Annette C Moll, Jeannette Boerop, Alette M Wessels, Martin Klein, Frank J Snoek, Michaela Diamant

Open Access Original investigation

Predictive value of high-sensitivity troponin-I for future adverse cardiovascular outcome in stable patients with type 2 diabetes mellitus

Kai-Hang Yiu, Kui-Kai Lau, Chun-Ting Zhao, Yap-Hang Chan, Yan Chen, Zhe Zhen, Arthur Wong, Chu-Pak Lau, Hung-Fat Tse

Open Access Original investigation

Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1

Andrew Moore, Amol Shindikar, Ingrid Fomison-Nurse, Federica Riu, Pujika E Munasinghe, Thrishila Parshu Ram, Pankaj Saxena, Sean Coffey, Richard W Bunton, Ivor F Galvin, Michael JA Williams, Costanza Emanueli, Paolo Madeddu, Rajesh Katare

Open Access Original investigation

Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes

Bainian Chen, Qing Zhao, Rui Ni, Futian Tang, Limei Shan, Inga Cepinskas, Gediminas Cepinskas, Wang Wang, Peter W Schiller, Tianqing Peng

Open Access Original investigation

Group-based activities with on-site childcare and online support improve glucose tolerance in women within 5 years of gestational diabetes pregnancy

Anne-Sophie Brazeau, Aaron Leong, Sara J Meltzer, Rani Cruz, Deborah DaCosta, Mary Hendrickson-Nelson, Lawrence Joseph, Kaberi Dasgupta

Open Access Erratum

Erratum to: CYP2J3 gene delivery reduces insulin resistance via upregulation of eNOS in fructose-treated rats

Xizhen Xu, Ling Tu, Luyun Wang, Xiaosai Fang, Dao Wen Wang

Open Access Original investigation

Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population

Takahiro Fuseya, Masato Furuhashi, Satoshi Yuda, Atsuko Muranaka, Mina Kawamukai, Tomohiro Mita, Shutaro Ishimura, Yuki Watanabe, Kyoko Hoshina, Marenao Tanaka, Kohei Ohno, Hiroshi Akasaka, Hirofumi Ohnishi, Hideaki Yoshida, Shigeyuki Saitoh, Kazuaki Shimamoto, Tetsuji Miura

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.