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Cardiovascular Diabetology
Published in: Cardiovascular Diabetology 1/2014

Open Access 01-12-2014 | Original investigation

Possible effects of glimepiride beyond glycemic control in patients with type 2 diabetes: a preliminary report

Authors: Ikuko Nakamura, Jun-ichi Oyama, Hiroshi Komoda, Aya Shiraki, Yoshiko Sakamoto, Isao Taguchi, Atsushi Hiwatashi, Aiko Komatsu, Masayoshi Takeuchi, Sho-ichi Yamagishi, Teruo Inoue, Koichi Node

Published in: Cardiovascular Diabetology | Issue 1/2014

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Abstract

Background

The purpose of this study was to elucidate the effects of glimepiride on the levels of biomarkers related to cardiovascular regulation in patients with type 2 diabetes mellitus.

Methods and results

Thirty-four patients with type 2 diabetes received glimepiride for 24 weeks. Significant decreases in the levels of glyceraldehyde-derived advanced glycation end products, (glycer-AGE: toxic AGE), eotaxin and fibroblast growth factor (FGF)-2 were recognized after the administration of glimepiride. Moreover, there were trends for there to be increases in the levels of granulocyte-colony stimulating factor (G-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF), and decreases in the levels of fractalkine, soluble CD40 ligand (sCD40L), macrophage inflammatory protein (MIP)-β, vascular endothelial growth factor (VEGF) and soluble receptor for AGE (sRAGE).

Conclusions

Glimepiride may have potent anti-oxidative, anti-inflammatory and angiogenic properties and it may potentially repair tissue damage by decreasing the levels of toxic AGE and increasing colony-stimulating factors.
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Metadata
Title
Possible effects of glimepiride beyond glycemic control in patients with type 2 diabetes: a preliminary report
Authors
Ikuko Nakamura
Jun-ichi Oyama
Hiroshi Komoda
Aya Shiraki
Yoshiko Sakamoto
Isao Taguchi
Atsushi Hiwatashi
Aiko Komatsu
Masayoshi Takeuchi
Sho-ichi Yamagishi
Teruo Inoue
Koichi Node
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2014
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/1475-2840-13-15

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