Issue 6/2023
Content (49 Articles)
Pharmacological potentiation of monocyte-derived dendritic cell cancer immunotherapy
Alexandre Poirier, Michel L. Tremblay
First-line therapy for elderly patients with advanced renal cell carcinoma in the immuno-oncology era: a network meta-analysis
Yu Fujiwara, Hirotaka Miyashita, Bobby C. Liaw
Complete remissions following immunotherapy or immuno-oncology combinations in cancer patients: the MOUSEION-03 meta-analysis
Matteo Santoni, Alessandro Rizzo, Jakub Kucharz, Veronica Mollica, Matteo Rosellini, Andrea Marchetti, Elisa Tassinari, Fernando Sabino Marques Monteiro, Andrey Soares, Javier Molina-Cerrillo, Enrique Grande, Nicola Battelli, Francesco Massari
Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: the MOUSEION-05 study
Alessandro Rizzo, Veronica Mollica, Valentina Tateo, Elisa Tassinari, Andrea Marchetti, Matteo Rosellini, Raffaele De Luca, Matteo Santoni, Francesco Massari
Treatment options for unresectable hepatocellular carcinoma with hepatitis virus infection following sorafenib failure
Xiaomi Li, Xiaoyan Ding, Wei Li, Jinglong Chen
A phase 1b single-arm trial of intratumoral oncolytic virus V937 in combination with pembrolizumab in patients with advanced melanoma: results from the CAPRA study
Ann W. Silk, Steven J. O’Day, Howard L. Kaufman, Jennifer Bryan, Jacqueline T. Norrell, Casey Imbergamo, Daniella Portal, Edwin Zambrano-Acosta, Marisa Palmeri, Seymour Fein, Cai Wu, Leslie Guerreiro, Daniel Medina, Praveen K. Bommareddy, Andrew Zloza, Bernard A. Fox, Carmen Ballesteros-Merino, Yixin Ren, Darren Shafren, Mark Grose, Joshua A. Vieth, Janice M. Mehnert
Different effects of NK cells and NK-derived soluble factors on cell lines derived from primary or metastatic pancreatic cancers
Piera Filomena Fiore, Anna Laura Di Pace, Libenzio Adrian Conti, Nicola Tumino, Francesca Besi, Silvia Scaglione, Enrico Munari, Lorenzo Moretta, Paola Vacca
Refurbishment of NK cell effector functions through their receptors by depleting the activity of nTreg cells in Dalton’s Lymphoma-induced tumor microenvironment: an in vitro and in vivo study
Munendra Singh Tomar, Rishi Kant Singh, Ilya V. Ulasov, Kaushalendra, Arbind Acharya
Anti-4-1BB immunotherapy enhances systemic immune effects of radiotherapy to induce B and T cell-dependent anti-tumor immune activation and improve tumor control at unirradiated sites
Alexandra L. Martin, Chase Powell, Mate Z. Nagy, Patrick Innamarato, John Powers, Derek Nichols, Carmen M. Anadon, Ricardo A. Chaurio, Sungjune Kim, Min-hsuan Wang, Bing Gong, Xianzhe Wang, Thomas J. Scheutz, Scott J. Antonia, Jose R. Conejo-Garcia, Bradford A. Perez
Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate
Adam L. Burrack, Ellen J. Spartz, Meagan R. Rollins, Ebony A. Miller, Maria Firulyova, Eduardo Cruz, Michael F. Goldberg, Iris X. Wang, Hezkiel Nanda, Steven Shen, Konstantin Zaitsev, Ingunn M. Stromnes
CXCL9 influences the tumor immune microenvironment by stimulating JAK/STAT pathway in triple-negative breast cancer
Lei Wu, Shengnan Sun, Fei Qu, Meili Sun, Xiuxiu Liu, Quanye Sun, Lin Cheng, Yan Zheng, Guohai Su
Combination of magnetic hyperthermia and immunomodulators to drive complete tumor regression of poorly immunogenic melanoma
Ami Nishikawa, Yutaro Suzuki, Masahiro Kaneko, Akira Ito
Intratumoral tertiary lymphoid structures promote patient survival and immunotherapy response in head neck squamous cell carcinoma
Zhonglong Liu, Xiaoyan Meng, Xiao Tang, Weili Zou, Yue He
Porphyromonas gingivalis promotes the progression of oral squamous cell carcinoma by activating the neutrophil chemotaxis in the tumour microenvironment
Zhi-chen Guo, Si-li Jing, Sakendeke Jumatai, Zhong-cheng Gong
Prevalence of mismatch repair genes mutations and clinical activity of PD-1 therapy in Chinese prostate cancer patients
Bangwei Fang, Yu Wei, Hao Zeng, Yonghong Li, Shouzhen Chen, Tingwei Zhang, Jian Pan, Beihe Wang, Junlong Wu, Shengming Jin, Hualei Gan, Mengna Hu, Ding Zhang, Dingwei Ye, Yao Zhu
The common HLA class I-restricted tumor-infiltrating T cell response in HPV16-induced cancer
Saskia J. Santegoets, Marij J. P. Welters, Deborah S. Schrikkema, Manon R. Freriks, Hanna Kok, Bianca Weissbrich, Anouk van den Branden, Carsten Linnemann, Ton N. Schumacher, Sabina Adhikary, Gavin Bendle, Sjoerd H. van der Burg
CD20/TNFR1 dual-targeting antibody enhances lysosome rupture-mediated cell death in B cell lymphoma
Jeong Ryeol Kim, Donghyuk Lee, Yerim Kim, Joo Young Kim
TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses
Rebecca Harris, Mahinbanu Mammadli, Shannon Hiner, Liye Suo, Qi Yang, Jyoti Misra Sen, Mobin Karimi
BAP1 and PTEN mutations shape the immunological landscape of clear cell renal cell carcinoma and reveal the intertumoral heterogeneity of T cell suppression: a proof-of-concept study
Jana Friedhoff, Felix Schneider, Christina Jurcic, Volker Endris, Martina Kirchner, Angela Sun, Iulia Bolnavu, Laura Pohl, Miriam Teroerde, Maximilian Kippenberger, Constantin Schwab, Adam Kaczorowski, Stefanie Zschäbitz, Dirk Jäger, Markus Hohenfellner, Albrecht Stenzinger, Anette Duensing, Stefan Duensing
Response to neoadjuvant immune checkpoint inhibitors and chemotherapy in Chinese patients with esophageal squamous cell carcinoma: the role of tumor immune microenvironment
Xiaoyuan Wang, Xiaodong Ling, Changhong Wang, Jinfeng Zhang, Yingnan Yang, Hao Jiang, Yanzhong Xin, Luquan Zhang, Hao Liang, Chengyuan Fang, Dayong Zheng, Jinhong Zhu, Jianqun Ma
Tumoral CD105 promotes immunosuppression, metastasis, and angiogenesis in renal cell carcinoma
Mariam Oladejo, Hong-My Nguyen, Hannah Seah, Arani Datta, Laurence M. Wood
NLRP3 in tumor-associated macrophages predicts a poor prognosis and promotes tumor growth in head and neck squamous cell carcinoma
Lei Chen, Shu-Cheng Wan, Liang Mao, Cong-Fa Huang, Lin-Lin Bu, Zhi-Jun Sun
Effects of the STAMP-inhibitor asciminib on T cell activation and metabolic fitness compared to tyrosine kinase inhibition by imatinib, dasatinib, and nilotinib
Lukas Häselbarth, Axel Karow, Kristin Mentz, Martin Böttcher, Oisin Roche-Lancaster, Manuela Krumbholz, Regina Jitschin, Dimitrios Mougiakakos, Markus Metzler
A nanotherapeutic system for gastric cancer suppression by synergistic chemotherapy and immunotherapy based on iPSCs and DCs exosomes
Yezhou Li, Leilei Tian, Tiancheng Zhao, Jiayu Zhang
Interaction of glioma-associated microglia/macrophages and anti-PD1 immunotherapy
Chunhua Wang, Quan Chen, Meiqing Chen, Sizhen Guo, Ping Hou, Yulian Zou, Jun Wang, Bailin He, Qiuyu Zhang, Lieping Chen, Liqun Luo
Predictive value of p53 and AXL immunostaining for the efficacy of immune checkpoint inhibitor-based therapy after osimertinib treatment in patients with epidermal growth factor-mutant non-small cell lung cancer
Kenji Morimoto, Tadaaki Yamada, Ryo Sawada, Koichi Azuma, Yasuhiro Goto, Taishi Harada, Shinsuke Shiotsu, Nobuyo Tamiya, Yusuke Chihara, Takayuki Takeda, Osamu Hiranuma, Isao Hasegawa, Satomi Tanaka, Akihiro Yoshimura, Masahiro Iwasaku, Shinsaku Tokuda, Young Hak Kim, Koichi Takayama
Determinants of activity and efficacy of anti-PD1/PD-L1 therapy in patients with advanced solid tumors recruited in a clinical trials unit: a longitudinal prospective biomarker-based study
Javier García-Corbacho, Alberto Indacochea, Azucena E. González Navarro, Iván Victoria, Débora Moreno, David Pesántez, Laura Angelats, Andrea Modrego-Sanchez, Esther Sanfeliu, Oleguer Castillo, Paula Blasco, Laura Mezquita, Nuria Viñolas, Miquel Nogué, Patricia Galván, Barbara Adamo, Neus Basté, Tamara Sauri, Manel Juan, Aleix Prat, Francesco Schettini
Correction to: Determinants of activity and efficacy of anti-PD1/PD-L1 therapy in patients with advanced solid tumors recruited in a clinical trials unit: a longitudinal prospective biomarker-based study
Javier García-Corbacho, Alberto Indacochea, Azucena E. González Navarro, Iván Victoria, Débora Moreno, David Pesántez, Laura Angelats, Andrea Modrego-Sanchez, Esther Sanfeliu, Oleguer Castillo, Paula Blasco, Laura Mezquita, Nuria Viñolas, Miquel Nogué, Patricia Galván, Barbara Adamo, Neus Basté, Tamara Sauri, Manel Juan, Aleix Prat, Francesco Schettini
Association between pre-treatment chest imaging and pulmonary function abnormalities and immune checkpoint inhibitor pneumonitis
Alex Wong, Maria Riley, Songzhu Zhao, Jing Gennie Wang, Vince Esguerra, Mingjia Li, Gabrielle Lopez, Gregory A. Otterson, Kari Kendra, Carolyn J. Presley, Lai Wei, Dwight H. Owen, Kevin Ho
Correction: Association between pre‑treatment chest imaging and pulmonary function abnormalities and immune checkpoint inhibitor pneumonitis
Alex Wong, Maria Riley, Songzhu Zhao, Jing Gennie Wang, Vince Esguerra, Mingjia Li, Gabrielle Lopez, Gregory A. Otterson, Kari Kendra, Carolyn J. Presley, Lai Wei, Dwight H. Owen, Kevin Ho
Endosialin-positive tumor-derived pericytes promote tumor progression through impeding the infiltration of CD8+ T cells in clear cell renal cell carcinoma
Tong Lu, Jiayu Zhang, Shiqi Lu, Fa Yang, Lunbiao Gan, Xinjie Wu, Hongtao Song, Shaojie Liu, Chao Xu, Donghui Han, Bo Yang, Weihong Wen, Weijun Qin, Lijun Yang
Correction to: Endosialin‑positive tumor‑derived pericytes promote tumor progression through impeding the infiltration of CD8+ T cells in clear cell renal cell carcinoma
Tong Lu, Jiayu Zhang, Shiqi Lu, Fa Yang, Lunbiao Gan, Xinjie Wu, Hongtao Song, Shaojie Liu, Chao Xu, Donghui Han, Bo Yang, Weihong Wen, Weijun Qin, Lijun Yang
Real-world experience of postoperative adjuvant chemoimmunotherapy in patients with perihilar cholangiocarcinoma at high risk of recurrence
Qin-qin Liu, Xiang-de Shi, Yan-fang Ye, Qi-bin Tang, Hao-ming Lin, Xian-huan Yu, Rui Zhang, Chao Liu
Comprehensive analysis of immune subtypes reveals the prognostic value of cytotoxicity and FAP+ fibroblasts in stomach adenocarcinoma
Xin Wang, Sun Hui, Cong Tan, Zhenzhong Deng, Xu Wang, Weiwei Weng, Meng Zhang, Shujuan Ni, Lei Wang, Dan Huang, Wenfeng Wang, Midie Xu, Weiqi Sheng
Prognostic role of the innate immune signature CD163 and “eat me” signal calreticulin in clear cell renal cell carcinoma
Tadatsugu Anno, Nobuyuki Tanaka, Kimiharu Takamatsu, Kyohei Hakozaki, Ryohei Kufukihara, Yuto Baba, Toshikazu Takeda, Kazuhiro Matsumoto, Shinya Morita, Takeo Kosaka, Shuji Mikami, Hiroshi Nishihara, Ryuichi Mizuno, Mototsugu Oya
Exploring the potential of combining IL-2-activated NK cells with an anti-PDL1 monoclonal antibody to target multiple myeloma-associated macrophages
Femke A. I. Ehlers, Niken M. Mahaweni, Annet van de Waterweg Berends, Thara Saya, Gerard M. J. Bos, Lotte Wieten
Human γδ T cells induce CD8+ T cell antitumor responses via antigen-presenting effect through HSP90-MyD88-mediated activation of JNK
Shengdong Wang, Hengyuan Li, Tao Chen, Hao Zhou, Wenkan Zhang, Nong Lin, Xiaohua Yu, Yu Lou, Binghao Li, Eloy Yinwang, Zenan Wang, Keyi Wang, Yucheng Xue, Hao Qu, Peng Lin, Hangxiang Sun, Wangsiyuan Teng, Haochen Mou, Xupeng Chai, Zhijian Cai, Zhaoming Ye
Preventive effect of tertiary lymphoid structures on lymph node metastasis of lung adenocarcinoma
Sho Wakasu, Tetsuzo Tagawa, Naoki Haratake, Fumihiko Kinoshita, Yuka Oku, Yuki Ono, Tomoyoshi Takenaka, Yoshinao Oda, Mototsugu Shimokawa, Masaki Mori
LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma
Fen Zhao, Hui Tian, Yungang Wang, Jianbo Zhang, Fang Liu, Lei Fu
Low on-treatment levels of serum soluble CD8 (sCD8) predict better outcomes in advanced non-small cell lung cancer patients treated with atezolizumab
Anna Siemiątkowska, Maciej Bryl, Katarzyna Kosicka-Noworzyń, Jakub Tvrdoň, Iwona Gołda-Gocka, Franciszek K. Główka
Radiotherapy enhances CXCR3highCD8+ T cell activation through inducing IFNγ-mediated CXCL10 and ICAM-1 expression in lung cancer cells
Chih-Liang Wang, Ai-Sheng Ho, Chun-Chao Chang, Zong-Lin Sie, Cheng-Liang Peng, Jungshan Chang, Chun-Chia Cheng
Real-world multicentre cohort of first-line pembrolizumab alone or in combination with platinum-based chemotherapy in non-small cell lung cancer PD-L1 ≥ 50%
E. Pons-Tostivint, P. Hulo, V. Guardiolle, L. Bodot, A. Rabeau, M. Porte, S. Hiret, P. Demontrond, H. Curcio, A. Boudoussier, R. Veillon, M. Mayenga, C. Dumenil, T. Chatellier, P. A. Gourraud, J. Mazieres, J. Bennouna
Correction to: Real-world multicentre cohort of first-line pembrolizumab alone or in combination with platinum-based chemotherapy in non-small cell lung cancer PD-L1 ≥ 50%
E. Pons-Tostivint, P. Hulo, V. Guardiolle, L. Bodot, A. Rabeau, M. Porte, S. Hiret, P. Demontrond, H. Curcio, A. Boudoussier, R. Veillon, M. Mayenga, C. Dumenil, T. Chatellier, P. A. Gourraud, J. Mazieres, J. Bennouna
Using EGFR amplification to stratify recurrent glioblastoma treated with immune checkpoint inhibitors
Joshua S. Friedman, Tomi Jun, Omid Rashidipour, Kuan-lin Huang, Ethan Ellis, Priyanka Kadaba, Puneet Belani, Kambiz Nael, Nadejda M. Tsankova, Robert Sebra, Adília Hormigo
Effect of genetic polymorphisms on outcomes following nivolumab for advanced renal cell carcinoma in the SNiP-RCC trial
Masaki Shiota, Hideaki Miyake, Masayuki Takahashi, Mototsugu Oya, Norihiko Tsuchiya, Naoya Masumori, Hideyasu Matsuyama, Wataru Obara, Nobuo Shinohara, Kiyohide Fujimoto, Masahiro Nozawa, Kojiro Ohba, Chikara Ohyama, Katsuyoshi Hashine, Shusuke Akamatsu, Tomomi Kamba, Koji Mita, Momokazu Gotoh, Shuichi Tatarano, Masato Fujisawa, Yoshihiko Tomita, Shoichiro Mukai, Keiichi Ito, Tokiyoshi Tanegashima, Shoji Tokunaga, Masatoshi Eto
Lactate from glycolysis regulates inflammatory macrophage polarization in breast cancer
Chao Wang, Linxuan Xue, Wenqiang Zhu, Lina Liu, Shuhua Zhang, Daya Luo
PD-1 expression, among other immune checkpoints, on tumor-infiltrating NK and NKT cells is associated with longer disease-free survival in treatment-naïve CRC patients
Mohammad A. Al-Mterin, Khaled Murshed, Eyad Elkord
Effect of metformin on outcomes of patients treated with immune checkpoint inhibitors: a retrospective cohort study
Cho-Han Chiang, Yuan-Jen Chen, Cho-Hsien Chiang, Cheng-Ying Chen, Yu-Cheng Chang, Shih-Syuan Wang, Xin Ya See, Chuan-Sheng Horng, Chun-Yu Peng, Yuan Ping Hsia, Cheng-Ming Peng, Cho-Hung Chiang