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Cancer and Metastasis Reviews

Issue 1/2024 Defining and Understanding Cancer Cell Plasticity in Therapy Resistant

Content (24 Articles)

Preface

Hifzur R Siddique, Ajaikumar B Kunnumakkara

The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies

Sabrean Farhan Jawad, Farag M. A. Altalbawy, Radhwan M. Hussein, Ali Abdulhussain Fadhil, Mohammed Abed Jawad, Rahman S. Zabibah, Tasneem Younus Taraki, Chakrabhavi Dhananjaya Mohan, Kanchugarakoppal S. Rangappa

Resveratrol as sensitizer in colorectal cancer plasticity

Aranka Brockmueller, Anjana Sajeev, Lenka Koklesova, Samson Mathews Samuel, Peter Kubatka, Dietrich Büsselberg, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei

Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling

Peter Kubatka, Lenka Koklesova, Alena Mazurakova, Aranka Brockmueller, Dietrich Büsselberg, Martin Kello, Mehdi Shakibaei

B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention

Elizabeth Varghese, Samson Mathews Samuel, Aranka Brockmueller, Mehdi Shakibaei, Peter Kubatka, Dietrich Büsselberg

Epigenetic reprogramming of T cells: unlocking new avenues for cancer immunotherapy

Vipin Singh, Sandhik Nandi, Aritra Ghosh, Santanu Adhikary, Shravanti Mukherjee, Siddhartha Roy, Chandrima Das

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance

Gh Rasool Bhat, Itty Sethi, Hana Q. Sadida, Bilal Rah, Rashid Mir, Naseh Algehainy, Ibrahim Altedlawi Albalawi, Tariq Masoodi, Gowtham Kumar Subbaraj, Farrukh Jamal, Mayank Singh, Rakesh Kumar, Muzafar A. Macha, Shahab Uddin, Ammira S. Al-Shabeeb Akil, Mohammad Haris, Ajaz A. Bhat

Targeting the key players of phenotypic plasticity in cancer cells by phytochemicals

Sajad Fakhri, Seyed Zachariah Moradi, Fatemeh Abbaszadeh, Farahnaz Faraji, Roshanak Amirian, Dona Sinha, Emily G. McMahon, Anupam Bishayee

Lipid metabolism and its implications in tumor cell plasticity and drug resistance: what we learned thus far?

Ravichandran Vishwa, Bandari BharathwajChetty, Sosmitha Girisa, Babu Santha Aswani, Mohammed S. Alqahtani, Mohamed Abbas, Mangala Hegde, Ajaikumar B. Kunnumakkara

Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics

  • REVIEW

Bandari BharathwajChetty, Anjana Sajeev, Ravichandran Vishwa, Babu Santha Aswani, Mohammed S. Alqahtani, Mohamed Abbas, Ajaikumar B. Kunnumakkara

Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance

Aliye Tabatabaee, Behjat Nafari, Armin Farhang, Amirali Hariri, Arezoo Khosravi, Ali Zarrabi, Mina Mirian

Clusterin: a marker and mediator of chemoresistance in colorectal cancer

Sara Hlavca, Wing Hei Chan, Rebekah M. Engel, Helen E. Abud

Deciphering cellular plasticity in pancreatic cancer for effective treatments

Md. Hafiz Uddin, Dingqiang Zhang, Irfana Muqbil, Bassel F. El-Rayes, Herbert Chen, Philip A. Philip, Asfar S. Azmi

From modulation of cellular plasticity to potentiation of therapeutic resistance: new and emerging roles of MYB transcription factors in human malignancies

  • REVIEW

Shashi Anand, Kunwar Somesh Vikramdeo, Sarabjeet Kour Sudan, Amod Sharma, Srijan Acharya, Mohammad Aslam Khan, Seema Singh, Ajay Pratap Singh

Sam68 is a druggable vulnerability point in cancer stem cells

  • Open Access
  • Review

Amanda Mendes da Silva, Veronika Yevdokimova, Yannick D. Benoit

Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response

Nasim Ebrahimi, Mahdokht Sadat Manavi, Ferdos Faghihkhorasani, Siavash Seifollahy Fakhr, Fatemeh Jafari Baei, Fereshteh Faghih Khorasani, Mohammad Mehdi Zare, Nazanin Pazhouhesh Far, Fatemeh Rezaei-Tazangi, Jun Ren, Russel J. Reiter, Noushin Nabavi, Amir Reza Aref, Chu Chen, Yavuz Nuri Ertas, Qi Lu

2025 ESMO Congress hub

Unlock your free and exclusive access to expert interviews, news, and more from the annual congress of the European Society for Medical Oncology.

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Keynote webinar | Spotlight on progress in colorectal cancer

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  • Webinar | 11-12-2025 | 18:00 (CET)

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Watch it live: Thursday 11 December 2025, 18:00-19:30 (CET)

Prof. Antoni Castells
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Developed by: Springer Medicine
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Image Credits
Cancer cell screening and treatment concept/© artacet / iStock / Getty Images Plus, Colon cancer illustration/© (M) KATERYNA KON/SCIENCE PHOTO LIBRARY / Getty Images