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Spinal Cord and Spinal Trauma 

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  1. Open Access 01-12-2024 | Biomarkers | ReviewPaper

    Pathobiology of traumatic spinal cord injury: an overview

    Traumatic spinal cord injury (SCI) or traumatic myelopathy is a devastating neurological condition and a heavy burden on the health system. There are inflammatory and structural biomarkers with well-defined profiles, and useful for determining the …

  2. Open Access 01-12-2024 | OriginalPaper

    SP1 transcriptionally activates HTR2B to aggravate traumatic spinal cord injury by shifting microglial M1/M2 polarization

    Spinal cord injury (SCI), as the name suggests, refers to damage to the spinal cord, which is a crucial part of the central nervous system responsible for controlling movement and sensation in the body. It can lead to impairment in function and …

  3. 19-04-2024 | Biomarkers | Online First

    Letter to the Editor in regards to the article “Prognosticating acute traumatic spinal cord injury using Neurofilament (NF), Neuron Specific Enolase (NSE), Matrix Metalloproteinases (MMPs), and S-100B as biomarkers”

  4. Open Access 13-11-2023 | OriginalPaper

    Guidelines for neuroprognostication in adults with traumatic spinal cord injury

    According to the 2016 Global Burden of Disease study, the age-standardized incidence rate of traumatic spinal cord injury (tSCI) is estimated to be 13 cases per 100,000 people, or a total of 930,000 new cases worldwide. The global prevalence of …

  5. 24-11-2023 | Urinary Tract Infection | OriginalPaper

    Quality of in-hospital care in traumatic spinal column and cord injuries (TSC/SCI) in I.R Iran

    In 2015, the World Health Organization (WHO) office in Iran reported 24,896 fatal road traffic crashes (FRTCs) out of a population of 77 million (i.e., 32.3 per 100,000) [ 1 ]. Over the same period, the incidence was 10.6 per 100,000 in the USA [ 2 …]. The high rate of FRTCs could predispose victims to a higher incidence of spine and spinal cord injuries in Iran than in other settings. The incidence of traumatic spinal cord injury (TSCI) in Iran has been reported as 4.4/10,000 population/year [

  6. 11-01-2024 | Spinal Injury | OriginalPaper

    Prognostic value of the systemic inflammatory index (SII) and systemic inflammatory response index (SIRI) in patients with traumatic spinal cord injury

    Traumatic spinal cord injury (tSCI) constitutes a considerable portion of the global injury burden. It is estimated to have caused 9.5 million years of life lived with disability in 2016, imposing an immense burden on health-care systems and …

  7. 14-09-2023 | Ultrasound | OriginalPaper

    Predictive value of intraoperative contrast-enhanced ultrasound in functional recovery of non-traumatic cervical spinal cord injury

    Degenerative cervical myelopathy (DCM) is the most common cause of chronic non-traumatic spinal cord injury worldwide and leads to neurological functional disabilities in adults [ 1 , 2 ]. Chronic mechanical compression applied to the spinal cord

  8. 02-08-2023 | Biomarkers | OriginalPaper

    Prognosticating acute traumatic spinal cord injury using Neurofilament (NF), Neuron Specific Enolase (NSE), Matrix Metalloproteinases (MMPs), and S-100B as biomarkers

    Spinal cord injury (SCI) is a deplorable state and can result in lifelong disability. The worldwide prevalence is estimated to be around 15 to 40 cases per million annually. The causes of these injuries range from roadside accidents, fall from …

  9. Open Access 01-12-2024 | Polytrauma | OriginalPaper

    Early management of adult traumatic spinal cord injury in patients with polytrauma: a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)

    Traumatic spinal cord injury (tSCI) is a devastating condition associated with high mortality and morbidity [ 1 , 2 ]. Falls from height and road traffic collisions are the most frequent causes of tSCI [ 1 , 2 ]. In the latter scenario, an …

  10. 19-10-2023 | Central Nervous System Trauma | OriginalPaper

    Evaluation of clinical outcomes and employment status in veterans with dual diagnosis of traumatic brain injury and spinal cord injury

    The occurrence of traumatic brain injury (TBI) is common in Veterans from the Iraq/Afghanistan-era military operations. As such, screening for TBI and understanding sequelae after TBI among U.S. military service members and Veterans has been a …

  11. 09-10-2023 | Pediatrics | ReviewPaper

    A systematic review and meta-analysis of the global epidemiology of pediatric traumatic spinal cord injuries

    Despite being relatively rare, pediatric traumatic spinal cord injury (TSCI) is a debilitating event with high morbidity and long-term damage and dependency. This study aims to provide insight on the epidemiological characteristics of pediatric …

  12. Open Access 01-12-2023 | OriginalPaper

    Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization

    Spinal cord injury (SCI) is a devastating injury that may result in permanent motor impairment. The active ingredients of medications are unable to reach the affected area due to the blood‒brain barrier. Elamipretide (SS-31) is a new and …

  13. Open Access 01-12-2023 | Ultrasound | OriginalPaper

    Spinal cord perfusion pressure correlates with breathing function in patients with acute, cervical traumatic spinal cord injuries: an observational study

    Traumatic spinal cord injury (TSCI) is a devastating event, with annual global age-standardised incidence rate estimated at 13 patients per 100,000 people in 2016 [ 1 ]. There are no neuro-intensive care unit (NICU) treatments proved to improve …

  14. Open Access 01-12-2023 | Tracheostomy | OriginalPaper

    Predicting extubation in patients with traumatic cervical spinal cord injury using the diaphragm electrical activity during a single maximal maneuver

    Patients with traumatic cervical spinal cord injury (CSCI) typically require mechanical ventilation due to complete or partial denervation of the diaphragm and intercostal muscles, paralysis of the thoracic and abdominal walls during their acute …

  15. Open Access 01-12-2023 | Biomarkers | OriginalPaper

    Serum glucose/potassium ratio as a clinical risk factor for predicting the severity and prognosis of acute traumatic spinal cord injury

    In recent years, acute traumatic spinal cord injury (TSCI) has become a major global health concern, and TSCI is now considered the second leading cause after traumatic brain injury in terms of morbidity and disability [ 1 ]. Such injuries not only …

  16. 03-05-2024 | Online First

    Acellular spinal cord scaffold containing quercetin-encapsulated nanoparticles plays an anti-inflammatory role in functional recovery from spinal cord injury in rats

    Inflammatory responses play a crucial role in the pathophysiology of spinal cord injury (SCI) and developing new approaches to establish an anti-inflammatory environment for the promotion of neuroregeneration holds promise as a potential approach.

  17. Open Access 01-12-2023 | Neuropathic Pain | OriginalPaper

    The impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injury

    Traumatic spinal cord injury (SCI) is a devastating neurological disorder often accompanied by neuropathic pain (NeP), significantly affecting patients' quality of life. This retrospective study aimed to investigate the impact of the time from …

  18. 09-04-2024 | Online First

    Mertk Reduces Blood-Spinal Cord Barrier Permeability Through the Rhoa/Rock1/P-MLC Pathway After Spinal Cord Injury

    Disruption of the blood-spinal cord barrier (BSCB) is a critical event in the secondary injury following spinal cord injury (SCI). Mertk has been reported to play an important role in regulating inflammation and cytoskeletal dynamics. However, the …

  19. 10-05-2024 | Online First

    Retraction Note: Prediction of patient’s neurological recovery from cervical spinal cord injury through XGBoost learning approach

  20. 29-03-2024 | Online First

    Long non-coding RNA DANCR increases spinal cord neuron apoptosis and inflammation of spinal cord injury by mediating the microRNA-146a-5p/MAPK6 axis

    Spinal cord injury (SCI) is a debilitating neurological and pathological condition that leads to significant impairments in motor, sensory, and autonomic functions [ 1 ]. The standard treatment approach typically involves surgical decompression and …

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