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Selective Estrogen Receptor Modulator 

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  1. 19-01-2024 | Selective Estrogen Receptor Modulator | OriginalPaper

    Selective estrogen receptor modulators (SERMs) with vitamin D composite agent can prevent fracture better than SERMs treatment: based on the National Health Claims Database 2017–2019

    Osteoporotic fractures are associated with impaired function and a high mortality rate [ 1 ], thus becoming a major health concern in rapidly aging societies including the Republic of Korea [ 2 ]. Pharmacologic agents have been developed to improve …

  2. Open Access 01-12-2023 | Selective Estrogen Receptor Modulator | OriginalPaper

    Selective estrogen receptor modulators and deep venous thrombosis after an emergent operation in senior women

    Deep venous thrombosis (DVT) in the lower extremities is a relatively rare complication after surgery. However, it has the potential to develop into a pulmonary embolism. Thus, prophylaxis of DVT after surgery is an important issue during the …

  3. 01-12-2023 | Prostate Cancer | ReviewPaper

    The clinical effectiveness of denosumab (Prolia®) in patients with hormone-sensitive cancer receiving endocrine therapy, compared to bisphosphonates, selective estrogen receptor modulators (SERM), and placebo: a systematic review and network meta-analysis

    Patients with hormone-sensitive cancers receiving endocrine therapy are at an increased risk of secondary osteoporosis [ 1 – 3 ]. Secondary osteoporosis is a common bone disorder that is characterized by a decrease in bone mineral density (BMD) and …

  4. Open Access 01-12-2022 | Raloxifene | OriginalPaper

    A combined treatment with selective androgen and estrogen receptor modulators prevents bone loss in orchiectomized rats

    In men, hypogonadism and an age-related decline in gonadal hormone levels are associated with a decrease in bone mass, deterioration of bone structure, and the development of osteoporosis [ 1 ]. Furthermore, the pharmacological deprivation or …

  5. Open Access 01-08-2022 | Raloxifene | OriginalPaper

    Combination of selective androgen and estrogen receptor modulators in orchiectomized rats

    In the world’s aging population, a decline in muscle mass and function is of increasing importance. Due to the subsequent physical limitations of the elderly, the risk of falling is heightened. Hormonal changes in the aging organism, especially …

  6. 16-07-2022 | Estrogens | OriginalPaper

    Estrogen and Progesterone Receptors in Fibroadenoma in Response to Centchroman — a Selective Oestrogen Receptor Modulator (SERM)

    The fibroadenoma is considered as a manifestation of aberration in normal development and involution (ANDI); however, its exact etiopathogenesis is poorly understood. We investigated the role of oestrogen (ER) and progesterone receptors (PR) in …

  7. 05-04-2023 | Bisphosphonate | ReviewPaper

    The Clinical Effectiveness of Denosumab (Prolia®) for the Treatment of Osteoporosis in Postmenopausal Women, Compared to Bisphosphonates, Selective Estrogen Receptor Modulators (SERM), and Placebo: A Systematic Review and Network Meta-Analysis

    To assess the effectiveness and safety of denosumab (Prolia®) compared to bisphosphonates (alendronate, ibandronate, risedronate, zoledronate), selective estrogen receptor modulators (SERMs; bazedoxifene, raloxifene) or placebo, for the treatment …

  8. Open Access 01-09-2019 | Pharmacokinetics | OriginalPaper

    Pharmacogenomic–pharmacokinetic study of selective estrogen-receptor modulators with intra-patient dose escalation in breast cancer

    The relationship between CYP2D6 polymorphisms and the therapeutic effects of tamoxifen (TAM) has been studied for a decade, but the results are contradictory and inconclusive. Regarding the question raised in the article [ 1 ], “How predictive is …

  9. 01-05-1999 | OriginalPaper

    Selective Estrogen Receptor Modulators

    A Look Ahead

    Selective estrogen receptor modulators (SERMs) are structurally diverse compounds that bind to estrogen receptors (ER) and elicit agonist or antagonist responses depending on the target tissue and hormonal milieu. They are being evaluated …

  10. 01-02-2006 | ReviewPaper

    Emerging Selective Estrogen Receptor Modulators

    Special Focus on Effects on Coronary Heart Disease in Postmenopausal Women

    Menopause, regardless of age at onset, is associated with a marked increase in coronary heart disease (CHD) risk. On the basis of epidemiological studies that demonstrated mainly positive effects of postmenopausal hormone therapy on CHD as well as …

  11. 01-09-1998 | OriginalPaper

    Raloxifene: the first selective estrogen receptor modulator for postmenopausal osteoporosis

  12. 01-02-1999 | Erratum

    Erratum to Raloxifene: the first selective estrogen receptor modulator for postmenopausal osteoporosis

  13. 01-12-2001 | ReviewPaper

    Comparative Tolerability of First-Generation Selective Estrogen Receptor Modulators in Breast Cancer Treatment and Prevention

    In general, the selective estrogen receptor modulators (SERMs) currently indicated for the treatment and prevention of breast cancer, i.e. tamoxifen and toremifene, are fairly well tolerated. However, tamoxifen has been shown to induce …

  14. Open Access 01-12-2017 | OriginalPaper

    Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats

    The rupture of cerebral aneurysms elicits devastating subarachnoid hemorrhage (SAH). Surgical and endovascular treatments can be preventive but are associated with inherent risks and complications [ 1 ]. Therefore, medical therapy with lower risks …

  15. 01-11-2016 | ReviewPaper

    Estrogens and selective estrogen receptor modulators in acromegaly

    Despite recent advances in acromegaly treatment by surgery, drugs, and radiotherapy, hormonal control is still not achieved by some patients. The impairment of IGF-1 generation by estrogens in growth hormone deficient patients is well known.

  16. Open Access 01-12-2016 | OriginalPaper

    Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators

    Ovarian cancer (OVCA) is the most lethal gynecological malignancy and fifth leading cause of cancer-related death in women [ 1 ]. The fallopian tube epithelium (referred to as oviduct epithelium in all species except primates) is one of the likely …

  17. Open Access 01-12-2017 | OriginalPaper

    The effect and safety of postmenopausal hormone therapy and selective estrogen receptor modulators on kidney outcomes in women: a protocol for systematic review and meta-analysis

  18. 01-05-2016 | ReviewPaper

    The selective estrogen receptor modulators in breast cancer prevention

    Several breast cancer risk factors have been identified. These are broadly classified as modifiable and non-modifiable risks. Modifiable risk factors include diet, alcohol consumption, body mass index, exogenous estrogen use, smoking, and physical …

  19. 01-06-2003 | OriginalPaper

    Estrogen and selective estrogen receptor modulators

    Neuroprotection in the women’s health initiative era

    Estrogen has been comprehensively studied as a neuroprotective agent in women, animals, and a variety of in vitro models of neural injury and degeneration. Most data suggest that estrogen can benefit the ischemic brain and reduce cell death.

  20. Open Access 01-12-2006 | OriginalPaper

    Estrogens, selective estrogen receptor modulators, and a selective estrogen receptor down-regulator inhibit endothelial production of tissue factor pathway inhibitor 1

    Hormone therapy (HT) [ 1 – 4 ], oral contraceptives (OCs) [ 5 , 6 ], raloxifene[ 7 ] and tamoxifen[ 8 ] are all associated with increased risk of venous thromboembolism (VTE). HT [ 9 ] and OCs [ 10 , 11 ] also increase the risk of arterial …

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